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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 270 Documents
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Pengaruh Kontrol Glikemik dengan Konversi Sputum BTA pada Pasien Diabetes Melitus dengan Tuberkulosis Septa, Della; Surjadi, Lily Marliany
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.62-70

Abstract

Background Diabetic people have a 2-3 times higher risk of tuberculosis than non-diabetic people. Immunocompromised conditions due to diabetes increase the risk of therapeutic failure and delayed sputum conversion, which may cause by poor glycemic control. This study was conducted to determine the glycemic control effect on AFB conversion in diabetic patients with tuberculosis. Methods A cross-sectional study has been conducted on 100 diabetic patients with the new emergence of pulmonary tuberculosis. All patients were in intensive phase treatment of tuberculosis for two months at Bhayangkara R. Said Sukanto's Hospital. Data collected from medical records were random blood glucose level, percentage of random blood glucose decrement, HbA1C, and the microscopic AFB sputum smear. Fisher exact test analysis was conducted to determine the effect of random blood glucose level, percentage of blood glucose decrement and HbA1C to AFB smear results using SPSS V25.0 software for Windows with a significance level of 0.05. Results The analysis between glycemic control and AFB sputum smear conversion using random blood glucose, percentage of random blood glucose decrement and HbA1C showed a p-value of 0.000, indicating a significant relationship (p<0.05), so it showed that glycemic control affects AFB sputum smear conversion. Conclusions A significant relationship exists between glycemic control and AFB-negative conversion in patients with DM and TB. RBG showed the best sensitivity and specificity as a glycemic control parameter compared to others.
Analisa Kelelahan Kerja dan Usulan Perbaikan dengan Menggunakan Metode Bourdon Wiersma dan New Seven Tools Devani, Vera; Maypando, Abim Wahyu
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.179-189

Abstract

Background Employees of Public Relations work for 8 hours starting at 08.00-16.00, so it can lead to the work fatigue. Work fatigue is the condition of decreased efficiency and resilience of a person at work. Work fatigue can be caused by internal factors and external factors.The research that will be carried out is to analyze work fatigue and proposed improvements using the Bourdon Wiersma method and the New Seven Tools. Methods The method used to solve the problem is the Bourdon Wiersma method and New Seven Tools, using the Bourdon Wiersma Type Test GBT questionnaire.  The respondents were 8 employees of the Public Relations division who work using computers. The aim of this research is to determine the level of speed, level of accuracy and level of consistency before and after activities, and work fatigue. Data analysis using several tools from New Seventools, namely Relationship Diagrams and Tree Diagrams. Results Based on research, the average fatigue score for speed before work  was found that the average time speed for before work is 9.69 seconds with the value of speed interpretation (value 9, and WS = 14) including group B (Good), for after work was 10.05 seconds with a speed interpretation value (8.5, and WS = 13) including the CB class (Good Enough). The average accuracy for before work is 22.4 seconds with an interpretation accuracy value (value 5, and WS = -) including group R (Doubtful), for after work was 23 with an interpretation accuracy value (value 4.5, and WS = 7) included to group K (less). The average constant for before work was 11.58 with a constant interpretation value (value 5, and WS = -) including group R (Doubtful), for after work was 7.59 seconds with a constant interpretation value (value 5.5, and WS = 8) belongs to group R (Doubtful). Based on the Anova Test, the correlation value on the velocity variable was 0.937 with a very strong correlation level. The correlation value on the accuracy variable was 0.666 with a strong correlation level. The correlation value of the constant variable was 0.797 with a strong correlation level. Conclusions The main cause of fatigue in Public Relations employees is workload. The main cause of burnout in Public Relations employees is workload. The proposed improvement uses a Tree Diagram to reduce fatigue in Public Relations employees.
Risiko Reaktivasi Tuberkulosis Laten pada Terapi COVID-19 Abas, Ghina Mutiara; Sjatha, Fithriyah; Rosana, Yeva
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.363-372

Abstract

The high mortality rate among COVID-19 patients in the acute respiratory distress syndrome (ARDS) phase led to the administration of immunosuppressive drugs. Corticosteroids could block inflammation caused by cytokine storm, and prevent pneumonia, edema, fibrosis, and ARDS. Even though it was believed to have beneficial effects, corticosteroids can suppress T CD4+ and CD8+ cell-mediated immunity reaction through decreased IFNγ production thus leading to reactivation of latent Tuberculosis (LTBI). Therefore, the usage of corticosteroids in the ARDS phase of COVID-19 patients should be carefully given; pre-screening of LTBI may be done to avoid Tuberculosis reactivation.
Zoonois, dan Gelombang Pandemi COVID-19 Parwanto, ML Edy
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.1-4

Abstract

Zoonoses are a group of diseases that can be transmitted to humans by non-human vertebrate animals. The source of zoonoses is a large number of domesticated and wild animals. Causes of zoonoses include viruses, bacteria, parasites, and fungi. Initially, it was stated that COVID-19 was caused by the novel coronavirus 2019 (nCoV-2019), then WHO stated that the name that caused COVID-19 was severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 caused by SARS-CoV-2 has been classified as a zoonotic disease, no animal reservoir has been found, so the classification is premature. The proposed term for COVID-19 is classified as an “emerging infectious disease (EID) of probable animal origin.” Transmission of COVID-19 is exclusively in the form of human-human transmission, so it is not in accordance with the zoonotic definition of WHO.
Pengaruh Pemberian Ekstrak Kecambah Kacang Hijau (Phaseolus Radiatus L.) Terhadap Kadar Katalase Pada Tikus Jantan Galur Wistar Yang Diinduksi Herbisida Paraquat Sundawa, Angga Pria; Trisnasdi, Reza Adityas; Hikmah, Annisa Nurul
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.171-178

Abstract

Background Exposure to herbicide paraquat affects the body's organs of antioxidants that can exceed the capacity of antioxidant enzymes in the human body which causes the production of Reactive Oxygen Species (ROS). cause oxidative stress. This causes the endogenous antioxidants to decrease so prevention requires exogenous antioxidants such as mung bean sprout supplements. The effect of mung bean sprouts can reduce oxidative stress caused by the herbicide paraquat. This study aimed to determine the effect of mung bean sprout extract on catalase levels in male Wistar rats induced with paraquat herbicide. Methods This research is experimental with a posttest-only controlled Group Design. The research subjects were 25 male Wistar rats randomly divided into 5 groups, namely K1, K2, K3, K4, and K5. Groups K3, K4, and K5 were given a green bean sprout extract supplement at 21.6 mg/200 g BW/day, 43.2 mg/200 g BW/day, and 86.4 mg/200 g BW/day. 16 blood samples were taken for examination of catalase levels. Data were analyzed using the Kruskal-Wallis test. Results The mean catalase level was highest in the K1 group compared to the K3, K4, and K5 groups. The results of the Kruskal-Wallis test on catalase levels showed a significant difference between groups (p=0.000). Conclusions Supplementing green bean sprout extract with doses of 21.6 mg/200 g BW/day, 43.2 mg/200 g BW/day and 86.4 mg/200 g BW/day could increase catalase levels in male Wistar rats induced by paraquat herbicide.
Hubungan Penggunaan Air Gambut dengan Keluhan Kulit yang Terjadi pada Masyarakat Desa Handil Sohor, Indonesia Nawan, Nawan; Wulandari, Intan Wahyu; Alexandra, Francisca Diana; Handayani, Septi
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.170-177

Abstract

Background The use of peat water as a water source, especially in areas with large peatlands, such as in central Kalimantan, is still common. Handil Sohor is one of the villages in Central Kalimantan Province where the community still uses peat water for daily needs. Peat water, which does not fulfill the health requirement, is used for daily needs such as bathing and washing; therefore it can cause health complaints on the skin. Purpose of this study was to determine the correlation between peat water and skin disease complaints that happened in society. Methods The research type used is an analytical descriptive method with a cross-sectional design. The samples used in this research are 116 people taken with the purposive sampling technique and peat water samples. This research is conducted in June - October 2022. Results This research results showed that in a society with a contact duration of more than 60 minutes/day experienced skin disease complaints are 32 respondents in a society with a frequency of using peat water more than three times/day who experienced skin disease complaints are 41 respondents. The statistical test results through the chi-square test obtained the results for the contact duration variable with scores (p-value = 0,007) and (OR = 2,857). Conclusions Contact duration and frequency of use of peat water correlate with skin disease complaints.
Hemolisis pada Produk Packed Red Cells dari Pendonor Obesitas Artini, Dyah; Danarsih, Dwi Eni; Purnamaningsih, Nur'Aini
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.55-63

Abstract

Background Obesity may affect the quality of transfused blood while it's being stored in the blood bag, according to studies. Through various pathways, obesity can alter the metabolism of red blood cells, increasing their vulnerability to hemolysis. Obese donors are currently not prohibited from donating blood by the Blood Transfusion Unit's donor selection examination. Therefore, there is still a substantial chance that blood products from obese donors will degrade in quality. The rate of hemolysis of blood components increases in direct proportion to the rise in the donor's body mass index (BMI). By using hemolysis as the primary metric, this study aims to investigate how obesity impacts the storage quality of PRC blood products. Methods The primary objective of this experimental study is to investigate the effect of fat donors on the quality of PRC blood products at the PMI Blood Donor Unit in Sleman Regency. The study included eight donors, divided into two groups: obese and non-obese. 350 cc of blood from each donor was processed into a platelet-rich plasma (PRC) component. The PRC component was subsequently examined hemologically and found to be hemolyzed. The Student T-Test was then used to explore the exam outcomes for each group. Results Both groups' PRC samples' hemolysis values and plasma hemoglobin levels increased during storage. There was an increase in plasma hemoglobin of 0.41 g/dL and a hemolysis value of 0.59% in the blood sample from the obese donor. When compared to the increase in the non-obese group, which was 0.34 g/dL and 0.47%, the value of this increase was higher. The analysis's results showed that there was no statistically significant difference between the sample groups' increase in hemolysis (p value = 0.732). Conclusions The study's findings showed that there is no statistically significant relationship between obesity and hemolysis in PRC products.
Deteksi gen secara Epidemiologi Molekuler pada Isolat Klinik Klebsiella pneumoniae dari Pasien Dewasa dengan komorbid di Rumah Sakit Baghdad Kudaer, Nuha B; Risan, Mohsen Hashim; Raheem, Rasha; Zainulabdeen, Khalid; Salman, Israa; Hairunisa, Nany; Amalia, Husnun; Hameed, Seenar; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.196-215

Abstract

Background Klebsiella species is one of the most worldwide opportunistic pathogens in the world that cause infections at multiple sites like lung, urinary tract, bloodstream, wound or surgical site, and brain. Klebsiella pneumoniae has many types of virulence factors that give the bacteria the ability to invade the host and cause infections. Methods A total of (105) human clinical samples were collected from different patients with different cases. Klebsiella pneumonia were isolated from 30 samples. The bacteria were identified by biochemical tests and certified by using VITEK 2 system and genetically by amplify using PCR for 16 rRNA gene. One of the Klebsiella pneumoniae virulence factors is the capsule that is responsible for the macrophage resistance and its also responsible for serotype. So to confirm the strains isolated, PCR Gene detection of, MagA, K2A, RmpA, and Kfu, where (magA, k2A, rmpA, kfu) gens are responsible for capsule synthesis of Klebsiella pneumonia have been done. Results There were 30 strains of Klebsiella pneumoniae were identified. Epidemiological studies show that infections are preceded by gastrointestinal colonization, with the gastrointestinal tract being the most important reservoir for transmission. The primary bacterial isolates were identified based on their cultural, microscopic, and biochemical traits. The API system (API 20E) and VITEK 2 systems were used to confirm the identity of the bacterial isolates. Colony morphology revealed that Klebsiella pneumonia was Gram-negative, non-motile, microscopic straight rods grouped singly or in pairs. Biochemical tests showed that neutral end products prevailed over acidic end products, with Klebsiella producing negative results for indole. The Kligler Iron Agar (KIA) test showed that Klebsiella isolates changed the color of the slant and butt, producing an acidic slant and acid butt, along with gas production. The urease test for Klebsiella distinguishes between Enterobacter and Klebsiella isolates, as Klebsiella can manufacture the urease enzyme. The indole test distinguishes K. pneumonia from K. pneumonia from K. mobiliz. The API 20E system was used for biochemical testing, and the VITEK 2 system was used for identification. The VITEK 2 system was used to test for biochemical and antibiotic susceptibility, and the results supported the findings from morphological and biochemical analyses. PCR amplification was used for molecular detection, and all nine isolates tested positive for the magA and k2A genes. The ferric iron uptake system gene (kfu) and the extracapsular polysaccharide synthesis regulator gene (rmpA) were amplified using specific primer pairs. The VITEK 2 system demonstrated promising outcomes for K. pneumoniae identification. However, standard diagnostic methods are costly and time-consuming. Conclusions Navigating the complex landscape of infectious diseases, collaborative research projects have become indispensable in unraveling the mysteries surrounding pathogens. The project in Baghdad, having stood as a shining example of such collaboration, provided valuable insights into the identification, characterization, and molecular aspects of Klebsiella pneumoniae strains. The findings, have not only contributed to the scientific community's understanding of bacterial infections but also paved the way for enhanced strategies in diagnosis and treatment.
Memberdayakan Ayah Indonesia: Dampak Edukasi Laktasi secara Daring Terhadap Literasi Kesehatan dan Breastfeeding Self-Efficacy Hidayat, Agus Rahmat; Handayani, Sarah; Pramudho, PA Kodrat; Nuryati, Tati; Putri Deli, Aragar
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.36-50

Abstract

Background Breastfeeding is vital for the health of both mothers and infants. However, only 51.5% of infants under six months are exclusively breastfed in Indonesia. Research has consistently demonstrated the positive impact of engaging fathers in breastfeeding programs, leading to improved breastfeeding outcomes. However, lactation education activities for fathers in Indonesia are limited. By measuring the impact of the intervention on fathers' health literacy and self-efficacy, this research aims to contribute to enhancing breastfeeding practices and support in Indonesia. Methods This quasi-experimental study aimed to evaluate the impact of online lactation classes on breastfeeding health literacy and fathers' self-efficacy. Participants (N=35) were randomly assigned to the treatment or control group, and pre-and post-tests were conducted. The intervention group received two-day online lactation education via Zoom, while the control group received a breastfeeding e-poster on WhatsApp. Data analysis involved univariate analysis for variable characterization and bivariate analysis using statistical tests such as Paired Sample T-Test, Wilcoxon, and Mann-Whitney tests, with a significance level of p<0.05. Results The study's findings demonstrate the efficacy of the online lactation classes in the intervention group compared to the control group, as evidenced by significant improvements in fathers' health literacy (p=0.035) and self-efficacy (p=0.005) in supporting exclusive breastfeeding by their wives. Conclusions The research found that online breastfeeding classes for fathers positively affect their health literacy and self-efficacy in supporting breastfeeding. This approach was more effective than electronic posters via a WhatsApp group in increasing health literacy, but the signs positively affected fathers' self-confidence.
Studi Faktor-Faktor yang Berhubungan dengan HIV pada Perempuan di Kalimantan Barat, Indonesia Hairunisa, Nany; Sabrina, Isra; Amalia, Husnun; Mashabi, Yasmine; Zaina, Nashita Amira; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.89-107

Abstract

Background According to national data, West Kalimantan is one of the ten top provinces that reported AIDS cases, ranked eighth. Until December 2019, based on data recorded in the Provincial Health Office that reported to the Indonesia Ministry of Health, the AIDS case rate in West Kalimantan was 49.35, showing over the national AIDS case rate (38.93). In this study, an unmatched case-control determines the factors associated with HIV/AIDS among women in West Kalimantan, Indonesia. Methods The study was conducted among 90 women who tested positive for HIV/AIDS (cases) and 90 who tested negative for HIV/AIDS (controls). Data were collected using questionnaires from June 2019 to August 2019 at three community health centres in West Kalimantan. Data were analyzed using IBM Statistical Package Social Science (SPSS) 19. Descriptive analyses and Multivariate logistic regression analysis were used to examine the factors associated with HIV/AIDS. Results: This study has found a significant association between crucial aspects such as marital status, occupation, knowledge about HIV/AIDS, HIV treatment, and VCT (Voluntary Counseling and Testing) service program with cases of HIV/AIDS. A significant association between marital statuses with HIV/AIDS suggests that divorced/widowed have a higher risk of having HIV/AIDS, followed by the married group. Women with good educational backgrounds will likely know how to prevent HIV infection and take preventive measures to protect themselves. Results This study found a significant relationship between several important aspects such as marital status, occupation, knowledge of HIV/AIDS, HIV treatment, and the VCT (Voluntary Counseling and Testing) service program with HIV/AIDS cases. The significant relationship between marital status and HIV/AIDS shows that divorced/widows have a higher risk of contracting HIV/AIDS, followed by the married group. Women with a good educational background tend to know about HIV infection prevention measures and take precautions to protect themselves. Conclusions Some factors are significantly related to HIV/AIDS. Thus, educating women about sex could potentially decrease the number of HIV/AIDS cases.

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