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Cendekia Journal of Pharmacy
Published by Institut Teknologi Kesehatan Cendekia Utama Kudus
ISSN : 25992163     EISSN : 25992155     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Cendekia Journal of Pharmacy published by the Program Studi Farmasi STIKES Cendekia Utama Kudus with registered number ISSN 2599-2163 (Print) and for ISSN (Online) is 2599-2155. This journal is published twice a year, in November and May.
Arjuna Subject : -
Articles 212 Documents
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RASIONALITAS PENGGUNAAN ANTIMIKROBA RESERVE DI RUANG INTENSIVE CARE UNIT RUMAH SAKIT DI BALI PASCA PROGRAM PENGENDALIAN RESISTENSI ANTIMIKROBA Erma Ariningsih, Ida Ayu Made; Hartayu, TB. Titien Siwi
Cendekia Journal of Pharmacy Vol 9, No 2 (2025): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v9i2.329

Abstract

Antimicrobials are used to treat patient with infectious diseases. Inappropriate use oof antimicrobials can trigger bacteria that are resistant to antimicrobials. Reserve group of antimicrobials are antimicrobials which is reserved and are used for the treatment of patients with MDRO. In an effort to increase the rational use of antimicrobials, the government formed KPRA which us tasked with controlling the use of antimicrobials in hospitals, One of the private hospital in Bali has also formed KPRA since 2018. The use of antimicrobials in the ICU is quite high, but there is no data regarding antimicrobial control rate in the ICU, so it is important to analyze the use of antimicrobials in the ICU after KPRA. This study aims to determine the rationality of using reserve group antimicrobials in the ICU. This research is a descriptive analytical study, quasi-experimental design. Data was taken retrospectively from June 2017-May 2021. The study population was all hospital inpatient during the study period. The research subjects were all patients in the ICU. Data source from patient medical records and HIS. The sample size is the total that meets the criteria. Inclusion criteria were all patient in the ICU with reserve antimicrobials group in the period June 20017-May 2029 (pre-PPRA) and June 2019-May 2021 (post PPRA). Exclusion criteria were all patients in the ICU but the data was incomplete. Data analysis uses DDD calculations and the Gyssen method. The result showed that the DDD rate did not change significantly. The most widely used antimicrobials are Ceftriaxone 1G, Levofloxacin 500mg, Levofloxacin 750mg, and Meropenem 1G. The number of vials used for antimicrobials in the ICU decreased by 75.46%. Rational use of reserve group antimicrobials after PPRA implementation increased by 42.85%. The rationality of using reserve group antimicrobials in the ICU after PPRA increase.
POTENSI GENUS ARTOCARPUS SEBAGAI AGEN CARDIOVASCULAR PROTECTIVE: TINJAUAN AKTIVITAS ANTIKOAGULAN, ANTIPLATELET, DAN ANTIHIPERTENSI Ramdani, Muhammad Raafi; Indratmoko, Septiana; Wardani, Tri Kusuma
Cendekia Journal of Pharmacy Vol 9, No 3 (2025): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v9i3.376

Abstract

Penyakit kardiovaskular (CVD) merupakan penyebab kematian utama di dunia, dengan lebih dari 17 juta kasus setiap tahun. Terapi farmakologis modern seperti antikoagulan, antiplatelet, dan antihipertensi telah terbukti efektif, namun sering menimbulkan efek samping jangka panjang. Oleh karena itu, eksplorasi bahan alam sebagai alternatif terapi yang lebih aman menjadi penting. Review ini bertujuan untuk meninjau potensi genus Artocarpus sebagai agen pelindung kardiovaskular melalui aktivitas antikoagulan, antiplatelet, dan antihipertensi. Pendekatan yang digunakan adalah Systematic Literature Review (SLR) berdasarkan pedoman PRISMA 2020 dengan sumber data dari Scopus. Dari 50 artikel yang ditemukan, 7 artikel memenuhi kriteria inklusi dan dianalisis lebih lanjut. Hasil telaah menunjukkan bahwa Artocarpus altilis, A. heterophyllus, dan A. lakoocha mengandung senyawa bioaktif seperti flavonoid, stilbenoid, dan oxyresveratrol yang mampu menurunkan tekanan darah, menghambat agregasi trombosit, serta mencegah pembekuan darah. Ketiga aktivitas ini bekerja secara sinergis dalam menjaga elastisitas pembuluh darah dan mencegah aterosklerosis. Dengan demikian, genus Artocarpus memiliki potensi besar untuk dikembangkan sebagai kandidat fitofarmaka alami yang aman dan efektif dalam pencegahan serta pengelolaan penyakit kardiovaskular.

Page 22 of 22 | Total Record : 212

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