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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 11 Documents
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Search results for , issue "Vol. 8 No.1 (2025)" : 11 Documents clear
Toxicity and Antioxidant Activity of Teabags of Mangrove Lenggadai (Bruguiera parviflora) and Stevia (Stevia rbaudiana Bertoni) Leaves Andjelie, Tiara; Lubis, Minda Sari; Nasution, Haris Munandar; Rani, Zulmai
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.52548

Abstract

Introduction: Mangrove plants are known to have a lot of potential as medicine. One of the most commonly found mangroves is the lenggadai mangrove (Bruguiera parviflora).  Utilization of herbal drinks is made to prevent the onset of various diseases. The mixed teabag of mangrove lenggadai leaves and stevia leaves (Stevia rbaudiana bertoni) is named Mangrove Lenggadai Stevia (MLS) teabag. Aims: the purpose of this study is to see which MLS teabag formulation has good antioxidant activity and toxicity activity. Methods: The research conducted was experimental in nature. The data collected are quantitative and qualitative data which are taken from the results of sample collection, physical characteristics of MLS teabag quality, phytochemical screening of simplisia, antioxidant activity test using DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, toxicity test using Brine Shrimp Lethality Test (BSLT) method on Artemia salina Leach shrimp larvae, stability and hedonic level Result: MLS teabags have characteristics according to the quality requirements of SNI 4324:2014. The results of determining the antioxidant activity of MLS teabags obtained an IC50 value of 13.38 µg/mL. The results of the toxicity test of MLS teabags obtained an LC50 value of 8.74 µg/mL. Conclusion: MLS tea bags have physical quality characteristics that meet the requirements of SNI 4324: 2014 and have the potential as antioxidants and toxicity activity against Artemia salina Leach.
Acute Antinflammatory Effect of Marsdenia tinctoria Leaf Water Extract in Carragenan-induced Rats Supito, Sarasvati Sekar Ayu; Sutjiatmo, Afifah Bambang; Kusumawardhana, Gelar Taufiq; Vikasari, Suci Nar
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.52967

Abstract

Introduction: Tarum areuy (Marsdenia tinctoria) is a plant whose efficacy has not been widely explored. Traditionally used for infections and inflammation related disease.. Aims: To determine the anti-inflammatory effect of M. tinctoria leaf water extract on animals induced by carrageenan.Methods: Extract preparation by boiling in water. Animals were divided into groups, namely control, comparison (diclofenac sodium 4.5 mg/kgBW) and M. tinctoria leaf water extract (20, 40, 80 mg/kgBW). Induction of 0.1 mL of 1% carrageenan was given as much as intraplantar and the test preparation was given orally. Inflammatory and inflammatory inhibition percentages were measured every 30 minutes for 240 minutes. The t-test was utilized in data analysis.  Result: All test doses of M. tinctoria leaf water extract was effective to reduce inflammation in comparison to the control (p<0.05). A dose of 20 mg/kgBW was the optimal anti-inflammatory.. Conclusion: M. tinctoria leaf water extract has the potential as an anti-inflammatory.
Development of Captopril Analysis Method in Traditional Antihypertensive Medicine by Densitometry Risthanti, Reine; Sumartha, I Gede Ari; Alkindi, Fawandi Fuad; Budiono, Ryanto; Ananda, Rizka Widya
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.53926

Abstract

Introduction: The utilisation of traditional medicine to address health concerns is on the rise. One such traditional medicine product is antihypertensive herbal medicine. The Indonesian Food and Drug Authority (BPOM) has identified the presence of medicinal chemicals in traditional medicinal products, which has the potential to pose a significant risk to consumers. Captopril is one of the antihypertensive drugs that may be added as BKO in herbal medicine. Aims: The objective of this study was to develop a method for the analysis of the chemical content of captopril in antihypertensive herbs sold online under the following brands: A, B, C, and D. Method: The analytical method used was TLC-densitometry, utilising a mobile phase of chloroform: methanol (7:3). Result: The results show that the method used has fulfilled the requisite validation criteria for linearity, limit of detection (LOD), limit of quantitation (LOQ), accuracy, and precision parameters. The results of the analysis demonstrated that the sample did not contain any detectable quantities of captopril. Conclusion: The developed method has been proven to be effective for the analysis of captopril in antihypertensive herbal products and it can be confirmed that there is no presence of captopril medicinal chemicals in samples from brands A, B, C, and D
Comparison of Caffeine Compound Levels in Brewed and Boiled Oolong Tea Leaves (Camellia sinensis (L.) Kuntze) Based on Different Processing Methods Styawan, Anita Agustina; Aristhasari Putri; Ocha Ardela Fitria Kresnaya
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.54457

Abstract

Introduction: Tea contains many compounds that are beneficial for the body, namely caffeine. The process of brewing tea with a time and temperature that is not optimal can affect the caffeine content in it. And the brewing process by heating can widen the distance between the molecules in the tea. The higher the temperature and the longer the brewing time, the higher the caffeine content.. Aims: This study aims to analyze the caffeine content of brewed and boiled oolong tea, then compare the caffeine content of oolong tea with brewing (without heating) and boiled (with heating) processes. Methods: The research method used is experimental. This study used dried samples of oolong tea leaves (Camellia sinensis (L.) Kuntze). Quantitative analysis using UV-Vis Spectrophotometry. Result: Quantitatively, the caffeine content in brewed oolong tea was 3.522% w/w and the caffeine content in boiled oolong tea was 4.001% w/w. The conclusion of this study is that there is no significant difference in caffeine levels in brewed and boiled oolong tea with a significant value of P> 0.05.
Antihyperuricemia Effectiveness of Ethanol Extract Combination of Bitter Melon (Momordica charantia) and Moringa (Moringa oleifera L.) in Caffeine-Induced Rats (Rattus norvegicus) Mahmudah, Rifa'atul; Yusuf , Muhammad Ilyas; Risnawati, Risnawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.55482

Abstract

Introduction: Hyperuricemia is a condition characterized by elevated blood uric acid levels exceeding normal limits. Herbal medicines, such as bitter melon (Momordica charantia) and moringa (Moringa oleifera), have potential efficacy in reducing uric acid levels. This study aims to evaluate the effectiveness of a combination of BME (Bitter Melon Extract) and MLE (Moringa Leaf Extract) as an anti-hyperuricemia treatment. Aims: This experimental study assesses the quality standardization of the extracts, including specific and non-specific parameters. The effectiveness of the combined extracts was tested on caffeine-induced hyperuricemic rats, which were divided into six groups: negative control (Na.CMC 0.5%), positive control (Allopurinol), and four treatment groups receiving different doses of BME and MLE (D1, D2, D3, D4).  Result: The results showed that the combination of BME and MLE met the quality standard parameters. All four dosage variations demonstrated a reduction in uric acid levels. Among them, D3 (1.8 mg/kg BW of BME and 600 mg/kg BW of MLE) was the most effective, with a 41.3% reduction in uric acid levels. Statistical analysis using the Least Significant Difference (LSD) method indicated a significant difference between the negative control group and the treatment groups on the 7th day. Conclusion: The combination of BME and MLE has proven to be effective as an anti-hyperuricemia agent. Further research is needed to explore the potential of herbal medicines as alternative treatments for hyperuricemia.
Antiobesity Effect of NADES (Natural Deep Eutectic Solvent) Extract of Purslane Herb (Portulaca oleracea L.) on Male Rats (Rattus norvegicus) Azizah, Rizqi Nur; Santi, Irma; Awali, Muhammad Noer; Putra, Bayu; , Faradiba
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.56230

Abstract

Introduction: Obesity is a metabolic disorder characterized by excessive fat accumulation, leading to various health complications. One potential approach to managing obesity is through natural products, such as medicinal plants. Aims: This study evaluates the anti-obesity activity of purslane (Portulaca oleracea L.) extract obtained using the green extraction method in male rats (Rattus norvegicus). Method: A total of 18 male rats were divided into six groups: normal control, negative control (Na-CMC + NADES), positive control (orlistat), and three treatment groups receiving NADES Purslane Herb Extract (NPHE) at doses of 50, 100, and 200 mg/kg BW. The treatment groups were induced with a high-fat diet for 30 days, followed by 14 days of therapy. Result: Statistical analysis using One-Way ANOVA and Bonferroni post-hoc test showed that NADES purslane herb extract exhibited significant anti-obesity effects, with the most effective dose being 200 mg/kg BW, which reduced body weight by 13.004% and BMI by 17.935% in male rats. Conclusion: These findings suggest that purslane extract has potential as a natural anti-obesity agent. Further research is needed to explore its bioactive compounds and mechanisms of action, supporting its potential development in pharmaceutical and nutraceutical applications.
Effect of Aerobic Fermentation on Total Phenolic, Flavonoid, and Antioxidant Activity of Leucaena leucocephala (Lam.) de Wit Dewantara, Jeisen Pajar; Marpaung, Mauritz Pandapotan; Khairunnisa; Hidayati, Nurul; Setiawansyah, Arif
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57063

Abstract

Introduction: Leucaena leucocephala (Lam.) de Wit., commonly known as the petai cina plant, contains significant concentrations of bioactive compounds, particularly flavonoids and phenolic compounds, and demonstrates substantial antioxidant properties. These beneficial compounds, however, can be significantly influenced by various processing methods, with fermentation during simplicia preparation being a notable factor. Aims: This research investigated the impact of fermentation on three key characteristics of petai cina leaf extract: total flavonoid content, total phenolic content, and antioxidant activity. Methods: The study utilized experimental methodology, incorporating both qualitative and quantitative analyses to evaluate these properties. The results revealed that five days fermentation demonstrated the highest value of TFC, TPC, and antioxidant activity. Result: The extract yielded a TFC of 279.08 mg QE/g, while TPC measured 282.34 mg GAE/g. The antioxidant activity demonstrated notable potency, with an IC50 and AAI values of 69.66 µg/mL and 0.574. Conclusion: These findings conclusively demonstrate that the fermentation process significantly influences the concentration of flavonoids and phenolic compounds, yet unsignificant impact antioxidant activity in the extract. This enhanced understanding of fermentation's effects on bioactive compounds in L. leucocephala provides valuable insights for optimizing processing methods to maximize the plant's therapeutic potential.
Prediction Activity Pharmacology and Molecular Docking of Secondary Metabolite Compounds of Tamarind Leaves (Tamarindus indica) as Anticancer Muslikh, Faisal Akhmal; Riwanti, Pramudita; Alrayan, Reza
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57090

Abstract

Introduction: Cancer remains one of the leading causes of morbidity and mortality worldwide, with incidence and death rates increasing annually. One of the most effective therapeutic targets for cancer is the Epidermal Growth Factor Receptor (EGFR). However, the use of synthetic EGFR inhibitors is often associated with significant side effects.  Aims: This study aims to evaluate the potential of compounds derived from Tamarindus indica (tamarind) leaves as anticancer agents through an in silico approach, including pharmacological activity prediction (PASS) and molecular docking against the EGFR receptor.  Methods: Pharmacological activities were predicted using the Way2Drug webtool, while molecular docking analysis was performed using Molegro Virtual Docker (MVD).  Result: The PASS prediction results indicated that the compounds in Tamarindus indica leaves possess a broad spectrum of anticancer activities. Docking analysis revealed that isovitexin exhibited the lowest rerank score among the test compounds and controls (erlotinib and the native ligand), indicating stronger binding affinity to EGFR. Conclusion: These findings support the potential of tamarind leaves, particularly isovitexin, as a promising computationally-predicted anticancer therapeutic candidate.
Anti-inflammatory Potential of Tithonia diversifolia Leaves in Carrageenan-Induced Edema Model in Mice (Mus Musculus) Indrisari, Maulita; Khairi, Nur; Muslimin, Lukman; Aksa, Rahmat; Amriani, Amriani; Rahimah, Sitti; Rahayu, Riska
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57119

Abstract

Introduction: Edema is a common sign of inflammation characterized by increased tissue volume. Tithonia diversifolia leaves have traditionally been used as anti-inflammatory agents because they contain active compounds such as flavonoids, alkaloids, steroids, terpenoids, tannins, sesquiterpenoids, phenolic acids, and saponins. Aims: Determine the anti-inflammatory effects of ethanol extract of Tithonia diversifolia leaves on rats (Mus musculus) induced by carrageenan. Method: Extraction was carried out using maceration. The experimental design was pre- and post-test with five groups: healthy controls, positive controls (sodium diclofenac), and three treatment groups receiving 12.5 mg/30 gBW, 25 mg/30 gBW, and 37.5 mg/30 gBW of Tithonia diversifolia leaf extract. Edema was induced with carrageenan and measured using a plethysmometer at certain intervals. Result: The results showed that a dose of 37.5 mg/30 gBW significantly decreased edema volume, comparable to the diclofenac group (p>0.05). Conclusion: The ethanol extract of paitan leaves at this dose can function as an effective anti-inflammatory agent.
Beyond The Skin Barrier: How Transfersomes and Transethosomes are Revolutionizing Topical Therapies Widayanti Supraba; Husni, Patihul; Chaerunisaa, Anis Yohana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57146

Abstract

Introduction: The fundamental challenge of effective skin permeation has long limited the therapeutic potential of topical drug delivery systems. Conventional formulations frequently fail to achieve adequate penetration through the skin barrier, necessitating innovative approaches to enhance drug bioavailability while maintaining targeted delivery to specific skin layers.  Aims: This review evaluates the transformative impact of transfersomes and transethosomes as advanced nanovesicular systems designed to overcome traditional limitations in topical drug delivery. Methods: The review examines ultra-deformable nanovesicle technologies through comprehensive analysis of their operational mechanisms, including osmotic gradient exploitation in transfersomes and ethanol-facilitated lipid fluidization in transethosomes. Performance comparisons with conventional formulations across various therapeutic applications were conducted to assess clinical efficacy and delivery capabilities. Result: These nanovesicular systems demonstrate superior performance in delivering diverse therapeutic agents to targeted skin layers while effectively minimizing systemic absorption. The analysis reveals significant advantages over traditional formulations, with enhanced penetration capabilities that extend to macromolecular therapeutics and biologics when integrated with complementary technologies such as microneedle arrays and iontophoresis. Current research developments focus on addressing existing limitations through lyophilization techniques, hybrid polymer systems, and advanced manufacturing processes. Conclusion: Transfersomes and transethosomes represent a significant advancement in topical drug delivery technology, offering promising solutions to longstanding permeation challenges. The future trajectory toward personalized formulations and sustainable production methods using plant-derived components indicates their potential to fundamentally redefine treatment approaches in dermatology, oncology, and pain management, establishing minimally invasive yet highly effective therapeutic options as the standard in patient care.

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