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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 116 Documents
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PERBANDINGAN FENOLIK TOTAL PADA EKSTRAK BIJI BUAH WALI (BRUCEA JAVANICA L. MERR) DENGAN METODE EKSTRAKSI MASERASI DAN SONIKASI Baiq Rizkia Dwiyana Meliandari; Wahida Hajrin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29317

Abstract

Wali Fruit Seed (Brucea javanica L. Merr) is one of the traditional medicines in Indonesia that has acted as an antidiabetic, antioxidant, and anti-inflammatory. Phenolic compounds play a role in acting as a drug. The amount of phenolic can be influenced by the extraction method used. The purpose of this study was to compare the total phenolic content of wali fruit seed extract with maceration and sonication extraction methods. The advantage of maceration was the simplest and most economical method, while sonication had a short extraction time. The method of this research is the extraction process by maceration and sonication. Screening of phenolic compounds with FeCl3 reagent and determination of total phenolics by the Folin-Ciocalteau method. The results obtained were the total phenolic value with the maceration method was 61,1927±0,1560 mg GAE/g extract, while the total phenolic value with the sonication method was 67,9854±0,0968 mg GAE/g extract. This value was significantly different (p<0.05) statistically. Thus, it was found that the total phenolic by the sonication method was greater than the maceration method. KEYWORDS: wali seeds, maceration, sonication, phenolic
Flavonoids: A Review On Extraction, Identification, Quantification, and Antioxidant Activity Doloking, Haeria; Tahar, Nurshalati; Mukhriani; Surya Ningsi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29329

Abstract

Flavonoids are polyphenolic compounds with a fifteen carbon basic skeleton (C6-C3-C6) composed of two benzene rings, A and B, connected by a pyran-C heterocyclic ring. The high interest in flavonoid research appears due to the numerous benefits of this compound based on its antioxidant activity. Various authors reported multiple studies in this regard. The research on methods of extraction, identification, quantification, and testing of antioxidant activity is compiled in this review. The most important part of this study is a review of the antioxidant activity assay method, which is equipped with the reaction mechanism.
Analgesic and Antipyretic Effects of Jamblang (Syzygium cumini (l). Skeel) Leaves Ethanol Extract Suwahyuni Mus; Sitti Rahimah; Fadhilla Maryam
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.31579

Abstract

Analgesic-antipyretic is a compound used to reduce pain and fever. This study aims to determine whether the ethanol extract of Syzygiumium cumini leaves has analgesic and antipyretic activity in mice (Mus musculus) induced by acetic acid and peptone. The method used was the Writhing method with acetic acid induction fanalgesiasic and the rectal temperature measurement method for antipyretic testing. This research was started by extracting Syzygium cumini (L.) Skeels leaves with 70% ethanol solvent by maceration. Syzygium cumini (L.) Skeels leaves extract was then tested in 5 groups the s, positive control growth as up given paracetamol for antipyretic testing and mefenamic acid for analgesic testing, negative control group ( Na.CMC suspension), a dose of 6 mg/Kg, 9 mg/Kg and 12 mg/Kg of body weight. The results indicate that the ethanol extract Syzygiumium cumini leaves has analgesic and antipyretic activity at all treatment doses and the most effectivect is at a dose of 6 kg BW KEYWORD : Syzygium cumini (L) Skeels, Mice, Analgesic, Antipyretic
The Effectiveness of Ethanol Extract Botto’-Botto’ Leaves (Chromolaena Odorata L.) in Transdermal Patch Formulation as Medication in Wound Healing Anshari Masri; Nurfadilah; Zulkifli; Muhammad Taufiq Duppa; Muhammad Subhan A Sibadu
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.31676

Abstract

Botto'-botto' plant (Chromolaena odorata L.) is a native Indonesian plant that belongs to the Asteraceae family and is known to have a high flavonoid content and antioxidant activity that can slow down the oxidation process to prevent infection while accelerating wound healing. botto'-botto' is designed as a patch to make it easier to use and provide the most effective treatment. The purpose of this study was to make a patch preparation and to investigate its effects on wound healing. The patch was formulated and then tested for physical properties (organoleptic, superficial pH, moisture loss, thickness, weight uniformity, and folding endurance test) and their activity against wounds experimentally using rabbits as an animal test with 4 (four) treatment groups, namely the control group, botto'-botto’ patch 10%, 20%, and 30%. Wounds were made with an area of 2 cm and 0.1 cm deep. The wound was plastered with a patch and observed for 18 days. Data were analyzed statistically using ANOVA. The results showed that the patch formulation of leaves extract botto'-botto’ affects for wound healing in rabbits significantly, with p<0.05. Furthermore, the patch formulation of ethanol extract botto’-botto’ with a concentration of 30% had the best and fastest healing effect among all formulas. KEYWORDS: Botto’-botto’, wound healing, transdermal patch
The Nano Curcumin - The Little One with The Big Impact : A Review Tanfil. T, Ardy; Setiadi, Feri; Ridhayanah, Muthiah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.29539

Abstract

Curcumin is a compound contained in Curcuma longa, and this compound has many health benefits. One of the problems of this compound is its poor bioavailability, but methods to solve this problem have been found. One way to overcome the problem of curcumin bioavailability is to make curcumin in nano dosage forms. This article discusses the potential of curcumin nano as a future therapy for various diseases. We take a variety of sources by considering the source based on the index owned by the source. Scopus, Web of Science and Sinta are our main parameters. Articles not indexed by all three indexers are included in our rating. In conclusion, we found that curcumin in nano form has a very good potential to be used as a future therapy. However, further research is still needed to see the side effects of nano curcumin if used in the long term
HMG-CoA Reductase Inhibitory Activity Potential of Iota-, Kappa-, and Lambda-carrageenan: A Molecular Docking Approach Setiawansyah, Arif; Muh Ikhlas Arsul; Adliani, Nur; Wismayani, Leni
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.32721

Abstract

HMG-CoA reductase is an essential enzyme responsible for the biosynthesis of cholesterol. Hyperactivity of HMG-CoA reductase will increase cholesterol production, leading to the elevation of blood cholesterol levels. Inhibition of HMG-CoA reductase is one way to block cholesterol biosynthesis to lower blood cholesterol levels. This study evaluated the inhibitory potential of iota-, kappa-, and lambda-carrageenan against HMG-CoA reductase. The study was undertaken by in silico method using a molecular docking approach via Autodock 4.2 assisted by ADT graphical user interface. HMG-CoA reductase co-crystal structure was used as the target, and iota-, kappa-, and lambda-carrageenan as the test ligands. The result revealed that iota- and lambda-carrageenan possess an excellent affinity to HMG-CoA reductase with the free binding energy of -12.44 and -11.87 kcal/mol and Ki value of 0.765 and 2.01 nM, respectively, which is found to be better than Simvastatin and the native ligand. The compounds' chemical properties influenced the molecules' molecular interactions affecting their affinity. The number of SO4 groups is assumed to affect the HMG-CoA reductase inhibitory activity of iota-, kappa-, and lambda-carrageenan. KEYWORDS: iota-, kappa-, and lambda-carrageenan; HMG-CoA reductase; inhibitory activity; molecular docking
Formulation and Effectivity of Henna Leaves (Lawsonia inermis L.) Extract Ointment Against Burn Healing of Rabbit (Orctolagus cuniculus) Wandira, Ayu; Astriani, Dian; Wahyudin, Munifah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.36124

Abstract

Burns are tissue injury resulting from contact with a source of heat. The henna leaves extract (Lawsonia inermis L.) contains tannin, which acts as an astringent to treat wounds. This research seeks to determine the efficacy and quality of henna leaves ointment (Lawsonia inermis L.). The extraction method for henna leaves (Lawsonia inermis L.) entailed maceration with a 96% ethanol solvent. The phytochemical analysis of the 96% ethanol extract of henna leaves revealed the presence of flavonoids, tannins, saponins, and terpenoids. Variable concentrations of henna leaves extract were used to formulate ointments: 2.5% (F1); 5% (F2); 10% (F3); negative control (C-); and bioplacenton® as the positive control. Organoleptic assays, homogeneity, pH, spreadability, and adhesion were used to evaluate the quality of the formulations. In rabbits with inflicted burns, administer ointments F1, F2, F3, C-, and C+ to determine the efficacy of burn treatment. The healing effect is evaluated based on the time it takes for the wound to close (maturation phase), which is characterised by the incision being covered with new tissue. The ointment made from 96% ethanol extract of henna leaves with various concentrations of F1, F2, and F3 met the test requirements for organoleptic, homogeneity, pH, spreadability, and adhesion, according to the results of the ointment quality test. The ANOVA analysis of the effect test revealed that F1, F2, and F3 had a healing effect on wounds. The lesion healing effect of Formula F3 (10%) was not significantly different from the positive control after 11 days
Formulation and Antibacterial Activity of Bidara (Ziziphus mauritiana Lamk.) Leaf Toothpaste Against Streptococcus mutans Hurria Hurria; Arifuddin Yunus
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.36355

Abstract

Bidara (Ziziphus mauritiana Lamk.) is a native plant of Central Asia that has been widely cultivated in Indonesia. Bidara leaves contain many flavonoids, polyphenolic hydrolysable tannins, triterpenoids, sterols, and alkaloids. Bidara has potential as an antibacterial and has been widely used. The antibacterial activities of Bidara are used to formulate toothpaste against bacteria in the mouth. The study aimed to formulate a toothpaste from bidara leaves that have good physical stability and can be against Streptococcus mutans which causes dental plaque. This type of research is an experimental laboratory using the maceration method and formulated into toothpaste. After that, the physical stability of the toothpaste was tested, and antibacterial activity against S. mutans using the agar diffusion method. Bidara leaves can be used to formulate toothpaste against S. mutans bacteria. The research produced a toothpaste formula from Bidara leaf extract. Formula III is the best formula based on physical stability tests and Streptococcus mutans anti-bacterial tests.
Antioxidant Activity Study of Zingiber Zerumbet Rhizome Extract and Fraction Haeria Doloking; Mukhriani; Rima Amalia; Andri Anugrah Pratama
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37351

Abstract

Zingiber zerumbet is a member of the Zingiberaceae family with known pharmacological potentials. This study aims to characterize the phytochemical elements and evaluate the antioxidant potential of the methanol extract, soluble ethyl acetate, and n-hexane-soluble fractions of Zingiber zerumbet rhizome. Identify secondary metabolites for the alkaloids, saponins, flavonoids, polyphenols, tannins, and steroids/triterpenoids using the chemical reaction method in test tubes. Antioxidant activity was determined based on DPPH absorbance measurements using UV-Vis Spectrophotometry. The methanolic extract contained alkaloids, flavonoids, polyphenols/tannins, steroids, and triterpenoids. The ethyl acetate soluble fraction contained flavonoids and polyphenols/tannins, and the n-hexane soluble fraction contained alkaloids and flavonoids. The free radical scavenging activities of ascorbic acid, methanol extract, ethyl acetate, and the n-hexane soluble fraction were 7.79; 100,956; 69,476, and 77,780 ppm, respectively. The findings indicated that the methanolic extract, ethyl acetate, and n-hexane soluble fraction were suitable sources of natural antioxidants.
Analysis of Borax Contaminants in Sempol Snacks in Gonilan Village Kartasura Nuzulia Sari Asyifa'; Reni Ariastuti; Fadilah Qonitah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37435

Abstract

Sempol is a snack made from processed meat that is quite popular among the public. In its manufacture, there is still a lot of misuse of prohibited additives, one of which is borax, in order to obtain a more supple shape and a longer shelf life. This study aims to determine the content and levels of borax in sempol snacks circulating in Gonilan Kartasura Village. The methods used in this study were qualitative using turmeric paper and quantitative using UV-Vis spectrophotometry. The results of the qualitative study showed that of the 7 samples of sempol snacks, there were 2 that positively contained borax, namely samples F and G. The quantitative results showed that the level of borax in sample F was 101,55±0,75 mg/g and in sample G was 166,69±0,67 mg/g. KEYWORDS: Borax; Sempol; UV-Vis Spectrophotometry

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