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Jurnal Aisyah : Jurnal Ilmu Kesehatan
Published by Universitas Aisyah Pringsewu
ISSN : 25024825     EISSN : 25029495     DOI : 10.30604/jika
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Jurnal Aisyah: Jurnal Ilmu Kesehatan (JIKA), with registered number ISSN 2502-4825 (Print) and ISSN 2502-9495 (Online), is an international peer-reviewed journal published two times a year (June and December) by Universitas Aisyah Pringsewu (UAP) Lampung. JIKA is intended to be the journal for publishing articles reporting the results of research on Health Science field especially Nursing and Midwifery, as well as with their development through interdisciplinary and multidisciplinary approach. The submission process of the manuscript is open throughout the year. All submitted manuscripts will go through the blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : Keperawatan - Keperawatan (Lain-Lain)
Articles 1,302 Documents
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Effectiveness of the Covid-19 Module in Preventing and Reducing the Positive Rate of Covid-19 during the New Normal Period in the City of Padang. Asep Irfan; Darwel Darwel; Suksmerri Suksmerri; Delima Delima; Sari Arlinda
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (599.141 KB) | DOI: 10.30604/jika.v8i2.1851

Abstract

Although the number of people exposed to COVID-19 in Indonesia is currently under control, efforts to prevent COVID-19 must still be carried out properly to avoid the dangers of COVID-19 which are always threatening. The study aimed to determine community participation in the Prevention and Reduction of the Positive Rate of Covid 19 during the New Adaptation Period. This type of research is quantitative with a cross-sectional study design. The research was conducted in the city of Padang. The intervention was implemented by implementing the Corona Virus Disease 19 (Covid-19) module on the Prevention of Covid 19 Disease Behavior in the City of Padang. The sampling technique used was purposive sampling, with as many as 123 people. Data were analyzed by univariate and bivariate, with statistical test dependent t / paired t. The results of the study: the average score of Covid prevention measures before being given an intervention was 47.6098 and after receiving an intervention it increased to 52.6992. The analysis showed that with the value of p = 0.000 (p less than 0.05), there was a significant difference in community participation in efforts to prevent copying. To prevent Covid 19, it is necessary always to carry out promotive and preventive efforts, one method of providing education can be used, one of which is through interactive media in the form of educational videos and educational modules. Abstrak: Meski jumlah orang yang terpapar COVID-19 di Indonesia saat ini sudah terkendali, namun upaya pencegahan COVID-19 tetap harus dilakukan dengan baik untuk menghindari bahaya COVID-19 yang selalu mengancam. Tujuan penelitian adalah mengetahui partisipasi masyarakat dalam Pencegahan Dan Penurunan Angka Positif Rate Covid 19 Pada Masa Adaptasi Baru.  Jenis penelitian ini kuantitatif dengan desain crossectional studi. Penelitian dilakukan di Kota Padang. Intervensi yang dilakukan penerapan modul Corona Virus Desease 19 (Covid-19) Terhadap Perilaku Pencegahan Penyakit Covid 19 di Kota Padang Teknik sampling yang digunakan purposive sampling, sebanyak 123 orang. Data dianalisis dengan univariat dan bivariat, dengan uji statistik t dependen/ paired t. Hasil penelitian: rata rata skort tindakan pencehgehan Covid sebelum diberi intervensi 47.6098 dan setelah mendapat intervensi meningkat menjadi 52.6992. Hasil analisis didapatka nilai p=0,000 (p kurang dari 0,05) terdapat perbedaan yang signifikan partisipasi masyarakat dalam upaya pencegahan copid. Untuk mencegah Covid 19, perlu upaya promotif dan preventif yang selalu dilakukan, salah satu metode penyelenggaraan pendidikan dapat digunakan, salah satunya melalui media interaktif berupa video edukasi maupun modul edukasi.
Bibliometric and visual analysis of global research: Enhanced Recovery After Caesarean Surgery (ERACS) Fithriani Sri Utami; Elsye Maria Rosa
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2529.083 KB) | DOI: 10.30604/jika.v8i2.1811

Abstract

Background: ERACS (Enhanced Recovery after Caesarean Surgery) is a method developed in obstetric services. Its global popularity has grown in recent years. The purpose of this article is to find out the extent to which ERACS has been researched and published in the world over the past ten years. Researchers also want to know an overview of the scope of research related to ERACS. Methods: This research is a quantitative study by analyzing bibliographic data using the VOS viewer program. Bibliographic data on ERACS was searched through Scopus (www.scopus.com) and processed with the VOS viewer program. Results: 123 publications with ERACS-related papers over the previous 10 years were found in the search results. The most is in the United States. Nelson, G is the researcher who has the greatest productivity. In the analysis of terms in the research abstract, there are 5 clusters. The most widely used term in the article is “caesarean section” with 109 occurrences. Based on the keyword analysis used, cluster 1 theme is about "Postoperative care", cluster 2 theme is about "obstetric anesthesia", cluster 3 theme is about "preoperative and perioperative care", cluster 4 theme is about "postoperative pain" and cluster 5 theme is about "enhanced recovery after surgery". Conclusion: This bibliometric analysis presents the current state of ERACS programs from a variety of angles and serves as a resource and pointer for scholars conducting additional research. Postoperative care, obstetric anesthesia, preoperative and perioperative care, postoperative pain, and enhanced recovery after surgery are the themes that appear in this bibliometric analysis.
The Role of CVA Gymnastics Against Increase Functional Ability of Post Cerebro Vascular Accident Patients Grido Handoko Sriyono; Alwin Widhiyanto; Mariani Mariani
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (654.559 KB) | DOI: 10.30604/jika.v8i2.1760

Abstract

Background Cerebrovascular accident (CVA) has a sudden and severe impact on the blood vessels of the brain. In Indonesia alone, 28.5% of CVA sufferers die and the rest experience paralysis or disability, only 15% can make a full recovery. Cerebrovascular accident (CVA) exercise aims to improve the functional abilities of post-CVA patients. The study aims to determine the difference in the effectiveness of CVA exercise therapy 3 x a week and 4x a week for 12 weeks. Methods The research design used a quasi-experimental approach with a non-random pretest-posttest. The study sample was 44 people who experienced ischemia CVA. data collection using the Barthel Index scale. Results Analysis of data normality with the Shapiro-Wilk test and then paired t-test and Mann-Whitney test. The results of CVA exercise research can improve the functional ability of post-CVA patients with an average increase in CVA exercise 4x and 4x a week is 9.636 (p=0.000) and 10.909 (p=0.000). However, the difference in functional ability improvement between the two groups of participants was not statistically significant (p-value = 0.198). Conclusion CVA exercise can improve the functional abilities of post-CVA patients. Abstrak: Latar belakang Cerebro vascular accident (CVA) memberikan dampak cedera yang berat dan mendadak pada pembuluh-pembuluh darah otak di Indonesia sendiri, 28,5% penderita CVA  meninggal dunia dan sisanya mengalami kelumpuhan atau kecacatan, hanya 15 % saja yang dapat sembuh total. Senam cerebro vascular accident (CVA) bertujuan meningkatkan kemampuan fungsional pasien paska CVA. Penelitian bertujuan untuk mengetahui perbedaan efektifitas terapi senam CVA 3 x seminggu dan 4x seminggu selama 12 minggu. Metode Rancangan penelitian menggunakan quasi eksperimen dengan pendekatan non random pretest-posttest. Sampel penelitian 44 orang yang mengalami CVA iskemia. pengumpulan data menggunakan skala Indeks Barthel. Hasil Analisa normalitas data dengan  uji Shapiro-wilk, selanjutnya uji t berpasangan dan uji mann whitney. Hasil penelitian senam CVA dapat meningkatkan kemampuan fungsional pasien paska CVA dengan rerata peningkatan pada senam CVA 4x dan 4x seminggu adalah 9,636 (p=0,000) dan 10,909 (p=0,000). Akan tetapi, perbedaan peningkatan kemampuan fungsional antara kedua kelompok partisipan tersebut secara statistik tidak signifikan (p value= 0,198). Kesimpulan Senam CVA dapat meningkatkan kemampuan fungsional pasien paska CVA.
Mask-Wearing Behavior towards COVID-19 Prevention Erni Yetti Riman; Zadrak Tombeg; Anto J Hadi; Haslinah Ahmad; Fahrizal Alwi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (633.388 KB) | DOI: 10.30604/jika.v8i2.1788

Abstract

COVID-19 is an infectious disease caused by a coronavirus that occurs in the digitalization era and has become a global pandemic that can attack various age groups and hinder various types of activities. This study was to analyze the relationship between the behavior of wearing masks and the prevention of COVID-19. This study was a quantitative correlation with a cross-sectional design approach. 58 were applied and selected using accidental sampling. Data were collected using a questionnaire and analyzed using the chi-square and logistic regression. The results showed that knowledge (p=0.003), attitude (p=0.and 001), duration of eating at food stalls (p=0.021), personal protective equipment (p=0.041), health checks (p=0.041), behavior using masks (p=0.003) associated with the prevention of COVID-19, and of the four variables the most related is knowledge with a value of Exp (B)=11.466, p=0.033. The conclusion was obtained that the behavior of using masks is related to the prevention of COVID-19. It is hoped that the use of masks by health workers and the public in a disciplined manner during activities in public facilities or crowded places must be followed by other actions such as maintaining distance in crowded places and diligently washing hands with antiseptic soap to reduce the rate of spread and prevent transmission of the deadly virus. Abstrak: COVID-19 merupakan penyakit menular yang disebabkan oleh virus corona yang terjadi di era digitalisasi dan telah menjadi pandemi global yang dapat menyerang berbagai kelompok umur dan menghambat berbagai jenis aktivitas. Penelitian ini untuk menganalisis hubungan antara perilaku memakai masker dengan pencegahan COVID-19. Penelitian ini bersifat kuantitatif korelasional dengan pendekatan desain cross sectional. 58 diterapkan dan dipilih menggunakan sampling aksidental. Data dikumpulkan dengan menggunakan kuesioner dan dianalisis menggunakan chi-square dan regresi logistik. Hasil penelitian menunjukkan pengetahuan (p=0.003), sikap (p=0.dan 001), lama makan di warung makan (p=0.021), alat pelindung diri (p=0.041), pemeriksaan kesehatan (p=0.041), perilaku menggunakan masker (p=0,003) berhubungan dengan pencegahan COVID-19, dan dari keempat variabel yang paling berhubungan adalah pengetahuan dengan nilai Exp (B) = 11,466, p = 0,033. Didapatkan kesimpulan bahwa perilaku penggunaan masker berhubungan dengan pencegahan COVID-19. Diharapkan penggunaan masker oleh tenaga kesehatan dan masyarakat secara disiplin saat beraktivitas di fasilitas umum atau tempat keramaian harus diikuti dengan tindakan lain seperti menjaga jarak di tempat keramaian dan rajin mencuci tangan dengan sabun antiseptik sehingga dapat mengurangi laju penyebaran dan mencegah penularan virus mematikan tersebut.
Peer Group Education Effective on Students' Anxiety Levels Facing Premenstrual Syndrome Anastasya Febiyani Bari; Regina Vidya Trias Novita; Ainum J Hidayah
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.158 KB) | DOI: 10.30604/jika.v8i2.1933

Abstract

Adolescence in teenage girls, sexual maturity is marked by menstruation. Disorders accompanying menstruation are called Premenstrual Syndrome (PMS). The most common symptoms are crying easily, irritability, difficulty concentrating, and anxiety. The purpose of this research is to analyze the effect of peer group education on the level of PMS anxiety in female students at BHK Grogol High School, West Jakarta. The design of this research is pre-experimental with one group pre-post test design. The population is all students of grades X and XI at SMA BHK Grogol, who are already menstruating with sample 77 students. The technique used is the proportional random. Peer education and independent variables PMS anxiety dependent variable. Data collection using a questionnaire, and statistical test. The paired t-test is used to see the effect of peer group education on the level of students' anxiety about PMS. There was a lot of respondents' anxiety before pre-education categories of no stress, mild anxiety, moderate, severe, and very severe, as many as 29 each (37.7%) 23 (29.9%),16 (20.8%), 8 (10.4%), and 1 (1.3%). Respondents' anxiety after the intervention 56 (72.7%) had no anxiety, 15 (19.5%) had moderate anxiety and 6 (7.8) had anxiety currently. The results of the paired t-test showed a significant value of 0.000 less than 0.05. It can be concluded that there is an effect of peer group education on PMS anxiety in class X and XI students at BHK Grogol High School, West Jakarta.
Parents' oral care practices and oral health profiles of pediatric cancer patients receiving chemotherapy Dera Alfiyanti; Nury Sukraeny; Yuni Sufyanti Arief
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (637.17 KB) | DOI: 10.30604/jika.v8i2.1971

Abstract

Chemotherapy in chilhood cancer increases the toxic effects that impact the child's oral health. Appropriate oral care is the main intervention in children receiving chemotherapy. Oral care can reduce the colonization of oral cavity microorganisms, reduce pain, and prevent oral soft tissue infections that are at risk of becoming systemic infections. Children need parents to maintain oral health. This study aims to determine the oral care behavior of parents and the oral health profile of children who receive chemotherapy. The research design used a quantitative descriptive method. The sample in this study were parents and children with cancer who received chemotherapy. The results showed that the oral care behavior of most parents was in the less category, namely 76%. The oral health profile of children with cancer who received chemotherapy based on Oral Assessment Guide (OAG) was mostly in the unhealthy category, which was 52%. Nurses need to provide health education about oral health care to children and parents and provide written guidelines regarding appropriate oral care protocols. Future research is expected to be able to develop research on appropriate educational methods to improve parental behavior or oral care practices in children with cancer who are receiving chemotherapy. Abstrak: Kemoterapi pada anak kanker meningkatkan efek toksik yang berdampak pada kesehatan mulut anak. Perawatan mulut yang tepat adalah intervensi utama pada anak yang menerima kemoterapi. Perawatan gigi dan mulut dapat mengurangi kolonisasi mikroorganisme rongga mulut, mengurangi nyeri, dan mencegah infeksi jaringan lunak mulut yang berisiko menjadi infeksi sistemik. Anak membutuhkan orang tua untuk menjaga kesehatan gigi dan mulut. Penelitian ini bertujuan untuk mengetahui perilaku perawatan gigi dan mulut orang tua dan profil kesehatan gigi dan mulut anak yang menjalani kemoterapi. Desain penelitian menggunakan metode deskriptif kuantitatif. Sampel dalam penelitian ini adalah orang tua dan anak penderita kanker yang menjalani kemoterapi. Hasil penelitian menunjukkan bahwa perilaku perawatan gigi dan mulut sebagian besar orang tua berada pada kategori kurang yaitu 76%. Profil kesehatan gigi dan mulut anak penderita kanker yang menjalani kemoterapi berdasarkan Oral Assessment Guide (OAG) sebagian besar berada pada kategori tidak sehat yaitu sebesar 52%. Perawat perlu memberikan pendidikan kesehatan tentang perawatan kesehatan gigi dan mulut kepada anak dan orang tua serta memberikan pedoman tertulis mengenai protokol perawatan gigi dan mulut yang tepat. Penelitian selanjutnya diharapkan dapat mengembangkan penelitian tentang metode pendidikan yang tepat untuk meningkatkan perilaku orang tua atau praktek perawatan gigi dan mulut pada anak penderita kanker yang sedang menjalani kemoterapi.
Best Trauma Assessment System for Trauma Patients in Papua, Indonesia Kristiyani Herda Rophi; Sri Andarini; Suryanto Suryanto
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (650.547 KB) | DOI: 10.30604/jika.v8i2.1975

Abstract

Indonesia's economic growth increases work and transportation accidents. In 2018, Riskesdas reported 10.1% injury prevalence in Papua Province, compared to 9.2% nationally. To reduce trauma-related disability and death, an ideal trauma assessment system needs to assess trauma severity, predict patient prognosis, and improve reaction time and decision-making. The combined trauma scoring system was established to solve the shortcomings of the anatomical and physiological scoring systems This study aims compared TRISS and ASCOT's trauma patient mortality prediction accuracy. The study's design is an observational, retrospective, analytic investigation. Systematic sampling yielded 269 trauma patient reports. Statistical evaluation utilizing the Receiver Operating Characteristics (ROC) and Area Under the Curve (AUC) diagnostic tests. The results indicated that the accuracy of TRISS in predicting mortality in trauma patients had an AUC value of 0.90 (strong), p=0.000, 92% sensitivity and 76% specificity, with a sensitivity of 92% and a specificity of 76%. The AUC value for ASCOT's ability to predict mortality in trauma patients is 0.93 (very strong), p=0.000, with 96% sensitivity and 82% specificity. ASCOT predicts mortality in trauma patients more accurately than TRISS.Abstrak: Perkembangan industri dan perekonomian yang terus meningkat di Indonesia berbanding lurus dengan peningkatan kasus kecelakaan kerja dan transportasi. Riskesdas melaporkan prevalensi cedera pada tahun 2018 di Provinsi Papua cukup tinggi yakni 10,1% dari rerata nasional 9,2%. Sangat penting untuk membangun sistem penilaian trauma yang ideal, yang dapat dimanfaatkan untuk mengukur keparahan trauma, memprediksi prognosis pasien, peningkatan respon time dan pengambilan keputusan agar dapat meminimalisir kecacatan bahkan kematian akibat trauma. Sistem penilaian trauma kombinasi merupakan kombinasi sistem penilaian anatomis dan fisiologis, yang disusun untuk mengatasi kekurangan kedua sistem penilaian trauma yang sudah ada sebelumnya. Tujuan penelitian ini untuk mengetahui perbandingan efektivitas sistem penilaian kombinasi yakni TRISS dan ASCOT dalam memprediksi mortalitas pada pasien trauma. Desain penelitian secara observasional analitik dengan pendekatan retrospektif study. Jumlah sampel 269 rekam medis pasien trauma yang diambil secara purposive sampling. Analisis statistik dengan uji diagnostik Receiver Operating Characteristics (ROC) dan Area Under the Curve (AUC). Hasil penelitian menunjukkan akurasi TRISS dalam prediksi mortalitas pasien trauma memiliki nilai AUC 0.90 (kuat), p=0.000, sensitivitas 92% dan spesifisitas 76%. Akurasi ASCOT dalam prediksi mortalitas pasien trauma memiliki nilai AUC 0.93 (sangat kuat), p=0.000, sensitivitas 96% dan spesifisitas 82%. ASCOT lebih baik memprediksi mortalitas pada pasien trauma dibandingkan TRISS
Developing Sharing Breastmilk Program : Survey Communities toward Intention in Breastmilk Donor Practice Krisdiana Wijayanti; Murti Ani; Novita Ika Wardani
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (676.754 KB) | DOI: 10.30604/jika.v8i2.1341

Abstract

Not all mothers can breastfeed directly or provide sufficient breast milk to their babies. This condition makes  a sharing breastmilk become one of solution to fullfill the baby need in breastmilk. The purpose of this study was to survey the public's knowledge and intention to donate breast milk or receive breast milk donors. The research design used an analytical survey with the general population being man and women of productive age (less than 20 years). The sampling technique used survey sampling, with a sample of 140 respondent’s. Measurement of knowledge and intension using pre and post-questionnaires after the respondents participated in the mini-workshop sharing breast milk milk in persective of religion, humanism and health. Data was analized using paired t-test. The result of the knowledge test was p=0.003 (p less than 0.05), the intention test were p = 0.043 (p less than 0.05), which means that there was a difference between pre and post mother's knowledge and intention after attending a mini-workshop. The survey results showed that there is an increase in interest when respondents are given knowledge become the basis for doing second phase of research, which is Study Management in Breastmilk Bank di Dr. Jose Fabella Memorial Hospital Philippines dan Lactashare Malang Indonesia. Abstrak: Tidak semua ibu dapat memberikan ASI secara langsung atau memberikan cukup ASI kepada bayinya. Kondisi ini membuat program berbagi ASI menjadi salah satu solusi untuk memnuhi kebutuhan bayi akan ASI melalui penyediaan ASI donor. Tujuan penelitian ini adalah mengetahui pengetahuan dan minat masyarakat untuk mendonorkan ASI atau menerima ASI donor. Desain penelitian menggunakan survey analitik dengan populasi adalah masyarakat umum laki laki maupun perempuan usia produktif (kurang dari 20 tahun). Teknik sampling menggunakan survey sampling, dengan jumlah sampel 140 respondent. Pengukuran pengetahuan dan minat menggunakan kuisioner pre dan post setelah responden mengikuti kegiatan mini woskhop tentang berbagi ASI dalam perspektif agama, humanisme dan kesehatan. Analisis data penelitian menggunakan uji paired t-test. Hasil uji pengetahuan p=0,003 (p kurang dari 0,05), minat p=0,043 (p kurang dari 0,05), yang berarti ada beda pre dan post pengetahuan dan minat setelah mengikuti mini workshop berbagi ASI. Hasil survei yang menunjukkan ada peningkatan minat ketika responden diberikan pengetahuan menjadi dasar peneliti melanjutkan penelitian tahap kedua, yaitu  Studi Manajemen di Breastmilk Bank di Dr. Jose Fabella Memorial Hospital Philippines dan Lactashare Malang Indonesia
Correlation between Blood and Cerebrospinal Fluid (CSF) Neutrophil-Lymphocyte Ratio With Bacterial Meningitis Prognosis Patient Paulus Sugianto; Abdulloh Machin; Devi Ariani Sudibyo; Muhammad Hamdan
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.743 KB) | DOI: 10.30604/jika.v8i2.1993

Abstract

Bacterial Meningitis is a bacterial infection of the central nervous system’s protective membranes called the meninges. Bacterial Meningitis has a high disability and case fatality rate. This inflammatory process not only manifests in CSF but also systemically. The neutrophil-lymphocyte ratio(NLR) can be a predicting factor of severity and prognosis in systemic inflammation. Only a few studies in Indonesia evaluate the neutrophil-lymphocyte ratio as a predictor of mortality in adult bacterial meningitis. This study also aimed to compare neutrophil-lymphocyte ratio in LCS and systemic as a predictor of mortality in patients with adult bacterial meningitis. This is an analytic cross-sectional study in Dr. Soetomo's general hospital—a total sample of 44 bacterial meningitis patients from the inpatient ward of Dr. Soetomo General Hospital Surabaya. The blood Neutrophil- Lymphocyte ratio, Glasgow Coma Scale upon admission, and  Absolute lymphocyte count were significant with bacterial meningitis outcome with p-value less than 0.05. Early detection of bacterial meningitis patient prognosis could alert the healthcare provider to give careful monitoring and aggressive treatment. Abstrak: Meningitis bacterial adalah inflamasi akibat bakteri di selaput otak dan sumsum tulang belakang bernama meningen. Meningitis merupakan penyakit dengan angka kematian dan angka kecacatan yang cukup tinggi walaupun sudah memberikan pengobatan yang tepat. Proses inflamasi ini terjadi tidak hanya pada system saraf pusat namun juga terjadi di seluruh tubuh. Rasio neutrophil-limfosit pada darah selama ini dapat menjadi tanda derajat keparahan dan prognosis pada kasus inflamasi sistemik. Hanya beberapa penelitian yang mencari tentang hubungan rasio limfosit dan neutrophil pada cairan serebrospinal apakah dapat menunjukan derajat keparahan pada infeksi meningitis bakteri. Dalam penelitian ini juga ingin mencari rasio limfosit dan neutrophil darah apakah selaras dengan rasio di dalam cairan serebro spinalis. Penelitian ini merupakan studi reptrospektif kroseksional analitik. Total sampel dari populasi ini adalah 44 yang memenuhi kriteria inklusi dan ekslusi. Secara Statistik didapatkan rasio neutrophil-limfosit darah, tingkat Glassgow Coma Scale saat masuk, dan nilai limfosit absolut signifikan dalam menentukan prognosis pasien dengan meningitis bakteri dewasa (P kurang dari 0.05 ).
In Vitro Study of Antibacterial Activity of Snake Fruit Extract against Extended Spectrum Beta Lactamase (ESBL) Escherichia coli Linda Chiuman; Sherlyn Sherlyn; Natasya Sabaria Aritonang; Rudy Rudy; Suhartomi Suhartomi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2182.841 KB) | DOI: 10.30604/jika.v8i2.1962

Abstract

Snake fruit is a tropical fruit that is currently in great interest by the public. The This fruit is known to have high antioxidants so it can prevent an increase in cholesterol and other plasma lipids. Moreover, it can also prevent diarrhea. This study investigated the effective which one of the effective doses (25%, 50%, and 100%) from snake fruit extract against the ESBL-Escherichia coli (E. coli). This study was an experimental study with a post-test-only control group design in Microbiology Laboratory, Universitas Prima Indonesia. To investigate the antibacterial activity of snake fruit extract, this study was used disc diffusion methods which used five different groups including positive control (meropenem), negative control (DMSO), 100%, 50%, and 25% of snake fruit extract. The antibacterial assay showed that it required 100% snake fruit extract to inhibit the growth of ESBL-E. coli with average inhibition zone diameter of 7.33 ± 0.58 mm. The lower concentration extract did not show any antibacterial activity like the negative control group. The positive control group showed the most potent antibacterial activity with an average inhibition zone diameter of 36.33 ± 0.58 mm. Thus, it can be concluded that the snake fruit has antibacterial activity against ESBL-E. coli, but it was not as good as the meropenem. Abstrak: Buah salak merupakan buah tropis yang saat ini banyak diminati oleh masyarakat. Buah ini dikenal memiliki antioksidan yang tinggi sehingga dapat mencegah peningkatan kolesterol dan berbagai lipid plasma. Selain itu, juga dapat mencegah diare. Penelitian ini menyelidiki dosis mana yang efektif (25%, 50%, dan 100%) dari ekstrak salak terhadap ESBL-Escherichia coli (E. coli). Penelitian ini merupakan penelitian eksperimen dengan desain post test only control group di Laboratorium Mikrobiologi Universitas Prima Indonesia. Untuk mengetahui aktivitas antibakteri ekstrak buah salak, penelitian ini menggunakan metode difusi cakram yang menggunakan lima kelompok berbeda yaitu kontrol positif (meropenem), kontrol negatif (DMSO), ekstrak buah salak 100%, 50%, dan 25%. Uji antibakteri menunjukkan bahwa diperlukan 100% ekstrak salak untuk menghambat pertumbuhan ESBL-E. coli dengan diameter zona hambat rata-rata 7.33 ± 0.58 mm. Ekstrak konsentrasi rendah tidak menunjukkan aktivitas antibakteri seperti pada kelompok kontrol negatif. Aktivitas antibakteri paling kuat ditunjukkan oleh kelompok kontrol positif dengan rata-rata diameter zona hambat 36.33 ± 0.58 mm. Dengan demikian dapat disimpulkan bahwa salak memiliki aktivitas antibakteri terhadap ESBL-E. coli, tetapi tidak sebaik meropenem.

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