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AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh
Published by Universitas Malikussaleh
ISSN : 24775231     EISSN : 25028715     DOI : https://doi.org/10.29103/averrous
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Averrous: Jurnal Kedokteran dan Kesehatan Malikussaleh (Averrous: Malikussaleh Journal of Medicine and Health - Averrous: MJMH*) is a peer-reviewed and open-access journal. Publishes by the Faculty of Medicine Universitas Malikussaleh in collaboration with the Institute for Research and Community Service (LPPM) Universitas Malikussaleh, which focuses on disseminating research findings that cover a wide range of subjects in medicine and health from basic medical and health sciences, applied sciences, and public health research. Original research papers, case studies, reviewed-articles are acceptable. Averrous: MJMH journals are published twice a year May and November. All research articles published in website Averrous: MJMH is free-downloaded according to the open access policy.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 10 Documents
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Search results for , issue "Averrous, Volume 11 No.1 Mei 2025" : 10 Documents clear
Effects of Black Garlic Extract Against Monosodium Glutamate-Induced Liver Damage in Rats: Macroscopic Studies Maulina, Nora; Zachreini, Indra; Gholib, Gholib; Akmal, Muslim
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v11i1.18815

Abstract

Monosodium glutamate (MSG) enhances flavor during food processing by providing an umami taste, but its metabolic by-products can cause liver injury. The liver is crucial for the metabolism of xenobiotics including glutamate. Black garlic, derived from fresh garlic (Allium sativum L.) through chemical reactions and heat treatment, may have hepatoprotective properties; however, studies are limited. This study assessed the hepatoprotective effects of black garlic extract (BGE) on MSG-induced liver damage. Twenty-five Wistar rats (Rattus norvegicus) were divided into five groups (n = 5): P0 (negative control); P1 (MSG group), 8 mg/kg MSG for 21 days; and P2, P3, and P4, receiving the same MSG protocol as P1 plus BGE doses of 200, 400, and 600 mg/kg body weight, respectively, for 16 days. After the experiment, rats were euthanized for liver tissue extraction. Although liver weights in the BGE-treated groups were lower than those in the MSG group, the difference was not statistically significant. These results indicated that a BGE dose of 200 mg/kg body weight mitigated MSG-induced hepatic damage. Further biochemical and histological studies are required to elucidate the mechanism of BGE's hepatoprotective action of BGE against MSG-induced hepatotoxicity.
Risk Factors Of Type 2 Diabetes Mellitus In The Working Area Of The Kalumata Public Health Center Lamasila, Ismy Hanifa; Permana, Dini Rahmawati; Marsaoly, Ryan Rinaldy
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, insulin function, or both. In Indonesia, the number of people with DM reaches 8.5 million, making it the 7th in the world. According to the 2018 Riskesdas report, the prevalence of DM in North Maluku was recorded at 15,381 cases and was the second highest DM case, of which 2,822 cases were found in Ternate City. This study aims to determine the risk factors for type 2 diabetes mellitus in Kalumata Health Center. This study uses a type of quantitative research using case control observational research design, data collection tools in the form of medical records at Kalumata Health Center and primary data using questionnaires, the population of this study were DM and non-DM patients, the sample size of this study was 100 samples, the sampling technique used simple random sampling, this research was conducted in September-December 2024 and the analysis used was chi-square analysis and logistic regression. Of the total 100 samples obtained, the risk factor associated with the incidence of type 2 DM is age with a risk of 0.202 times (p=0.025; 95% CI 0.053-0.768). With this study, it is hoped that it can provide insight into the risk factors for Type 2 Diabetes Mellitus. Thus, the results can be utilized to organize routine counseling.
An Overview of Antibiotic Use, Length of Stay, and Amputation Incidents in Diabetic Foot Patients at Cut Meutia Regional Hospital Debbyousha, Maulina; Bayu Rizaldy, Muhammad; Syifa, Siti
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Diabetic foot ulcer is a condition of ulceration on the skin surface associated with neuropathy and angiopathy in the lower extremities. Improperly treatment for diabetic foot resulting significant functional and financial consequences for the patient. The purpose of study was to determine and assess an Overview of Antibiotic Use, Length of Stay and Amputation Incidents in Diabetic Foot Patients at Cut Meutia Regional Hospital. This type of research is descriptive research using a purposive sampling method with a cross-sectional approach with a sample size of 55 people using the Slovin formula. Data were processed using the univariate method with the results in the form of characteristics of patients are middle age 45-59 years (42.5%), the most patients were male (57.5%) and the majority of patients were housewives (36.3%). The most common description of antibiotic usage is combination antibiotics (71.3%) with the majority is a combination of cephalosporin and metronidazole (48.8%). The most commonly prescribed single antibiotics are cephalosporins (25%). Meanwhile, the length of stay was <7 days (55%) and the majority of patients did not experience amputation (76.3%). The conclusion of this study was the majority of patients were men, middle age 45-59 years, the majority of occupations were housewives, The use of antibiotics was dominated by a combination of cephalosporins with metronidazole and the single antibiotic used was a cephalosporin, the length of stay was <7 days, and the patients did not experience amputation. Keywords: diabetic ulcer, antibiotics, combination therapy, complication
Tracing Mumps in Rural Area: A Clinical Profile of Infected Children and Adolescents in Bulu, Tuban Dion, Aldy; Pribadi, Florence; Dewi, Karina
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Mumps, also known as epidemic parotitis, is a viral infection that affects the salivary glands. This disease commonly occurs among school-aged children and adolescents. According to data from the World Health Organization (WHO), the incidence of mumps in Southeast Asia (excluding Indonesia) reached 8,985 cases in 2022. In Indonesia, the Ministry of Health reported 6,593 cases in 2024. Given these challenges and the high number of cases found in the community, researchers aimed to study the clinical profile of mumps in school-aged children and adolescents in Bulu, Tuban. This research was observational in nature, using a descriptive cross-sectional study design. The findings revealed that male children are at higher risk of contracting mumps, with the highest infection rate observed in the 8-10 year age group. Areas characterized by close-knit living conditions and low immunization coverage reported a higher incidence of mumps. The most common complaint that led patients to seek medical care was cheek pain. Additionally, a significant number of mumps patients were found to be underweight. The most frequently administered treatment involved a combination of analgesic and vitamin.
Investigating the Effects of Combined Pegagan and Snakehead Fish Extracts on BDNF Levels in Rats: Implications for Neuroprotective Therapy Siregar, Sarah Rahmayani; Surura, Hedya Nadhrati; Lubis, Ilfan Adi Putra; Bukhari, Al
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v11i1.21507

Abstract

One of the most common health problems in the elderly is dementia. People living with dementia were found to have smaller hippocampal volumes and low serum BDNF levels. BDNF increases synaptogenesis, and plays a role in neurogenesis.  It is believed that the decrease in BDNF levels can be prevented by the dietary intake of plants, including gotu kola (Centella asiatica) and snakehead fish (Channa striata). Gotu kola contains  terpenoids and flavonoids, while snakehead fish contains arginine and glutathione. This study aims to examine the combination of water extracts of gotu kola and snakehead fish  as neuroprotector agent. This research was truly experimental; experimental animals (n=35) were divided into seven groups, five animals each with the following treatment: K0: normal control; K-: distilled water 10 mg/kgBW/day; P1: snakehead fish extract 300 mg/kgbb/day; P2: gotu kola extract 300 mg/kgbb/day; P3-P5: combination of gotu kola and snakehead fish at doses of 100/300, 300/300 and 600/300 mg/kgbb/day. The extract is given orally once a day along with induction at K-, P1-P5 with D-galactose (150 mg/kgbb/day) subcutaneously for six weeks. Then, BDNF gene expression was examined in brain tissue using the Real-Time PCR method. Data were analyzed using the One Way Anova test. The results of this study showed that the greatest BDNF gene expression was found in P3 (2.8). This study concluded that a neuroprotective effect based on BDNF gene expression was found in the combination of gotu kola and snakehead fish extracts at a dose of 100/300 mg/kg bb/day
Characteristic of Adenocarcinoma Lung Patients With Ros-1 Mutation Among North Sumatra Population Ritonga, Adewita; Soeroso, Noni Novisari; Tarigan, Setia Putra
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Lung cancer is expected to be the most frequent cancer by 2020, accounting for over 2 million diagnoses and approximately 1.8 million deaths globally. Lung cancer, the most prevalent cancer, is identified by histopathological characteristics such as ROS-1 mutations, which impact 0.9% to 2.6% of adenocarcinomas worldwide with no data from Indonesia. The aim of this study is to examine the clinical characteristics of patients with ROS-1-mutant adenocarcinomas. A study with a cross-sectional design. Clinical characteristics of patients include their gender, history of smoking, family history of cancer, clinical stage, and the histological grading of their adenocarcinoma in hospitals. ROS-1 using RT-PCR in conjunction with paraffin blocks. A total of 90 adenocarcinoma patients were included in the study. The majority of patients were male (66.7%), aged 41–60 years (55.6%), former smokers (67.8%), and had no family history of cancer (97.8%). The highest malignancy level was at stage IVA (82.2%), with poorly differentiated histopathological grading being the most common (53.3%). The detection of ROS-1 fusion in 2% of patients emphasizes the need for molecular analysis in assessing individual genetic risk. ROS-1 fusion detection was obtained in 2% of female patients who were younger (average age 50 years) and never smoked. Only 2% of patients in the North Sumatra region met the criteria for ROS-1 fusion, including being female, being younger than the average patient age of 50, and not smoking.
Characteristics of Diabetes Mellitus with Diabetic Neuropathy at Cut Meutia Hospital Khairunnisa, Khairunnisa; Maulina, Nora; Ramadhansyah, Fitriana
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Diabetic neuropathy is a complication in the form of nerve damage that often occurs in patients with diabetes mellitus, which is 50% of sufferers. Nerve complications can cause a decrease in quality of life and other complications. This study aims to determine the characteristics of nerve damage that occurs in diabetes mellitus patients at Cut Meutia Hospital. The type of research used in this study was a non-experimental quantitative descriptive study taken through medical records and patient status from 43 people. Respondents were selected using a total sampling technique. Analysis of data was performed by univariate analysis. The results showed that the most age who experienced DM neuropathy was the middle age category, 46-59 years old and there were 20 people (46.51%). The gender that experienced DM neuropathy most in this study was male with 22 people (51.16%). Peripheral neuropathy is the most common type of neuropathy in this study which was experienced by 24 people (55.81%).
The Effect of Sunkist Orange (Citrus Sinensis (L.) Osbeck) Granule Extract on Ovarian Follicle Histomorphology in Female Rats (Rattus Norvegicus) with Obesity Mutia, Maya Sari; Faridahanum, Faridahanum; Silitonga, Impola Dinita Felicia; Ramadhini, Amelya Putri; Sari, Ajeng Mestika; Lubis, Yolanda Eliza Putri; Sihotang, Widya Yanti
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Obesity is a medical condition in which a person experiences abnormal fat accumulation that exceeds normal limits, which can have a negative impact on health. Obesity sufferers are increasing, especially in developed and developing countries. The prevalence of obesity is estimated to be 42% in 2030. Risk factors that can cause obesity include unhealthy lifestyles and lack of physical activity. When there is excess fat accumulation in the body, there will be an increase in leptin levels in the body resulting in oxidative stress that triggers the emergence of free radicals that can inhibit the growth of follicles in the ovaries. To neutralize free radicals in the body, antioxidants are needed. One type of fruit that is rich in antioxidants is sunkist oranges (Citrus sinensis (L) Osbeck), this study discusses the effect of giving sunkist orange granule extract (Citrus sinensis (L) Osbeck) on the morphology of ovarian follicles in obese female wistar rats (Ratus norvegicus). Using a laboratory experimental research design with a post-test only control group design, using 25 female rats divided into 5 groups, namely the Negative Control Group, the Positive Control Group (Alloxan and High Fat), and the Treatment Group given alloxan and Sunkist orange granule extract at a dose of 50 mg / kgBW / day, 100 mg / kgBW / day, 150 mg / kgBW / day. Results: Sunkist Orange Granule Extract (Citrus sinensis (L.) Osbeck) has a significant effect on the histomorphology of ovarian follicles with obesity induction in female rats (Rattus norvegicus).
The Effect of Sunkist Orange (Citrus Sinensis (L.) Osbeck) Peel Granule Extract on Testicular Histophatology in Male Rats (Rattus Norvegicus) with Obesity Mutia, Maya Sari; Br Sitepu, Rachel Maria Cruz Jovanca; Putri, Shafyra Mahdyah; Gurusinga, Fransisco Bastanta; Lubis, Yolanda Eliza Putri
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Obesity is a body condition where there is excessive weight gain due to an imbalance between calories consumed and energy expended so that calories accumulate in fat tissue. In Indonesia, there are 14.8% of the population aged > 18 years who are obese. The basic principle of obesity is that there is an imbalance between three aspects, namely food intake (intake), energy expenditure (output), and energy storage. The result of the imbalance in energy intake and output, where energy intake is greater than energy expenditure, will cause the accumulation of fat tissue in the body and will be stored as energy reserves. Obesity is a predisposing factor for various health problems. One of them is the quality of a person's reproduction which results in infertility. To find out that the extract of sunkist orange peel granules can affect the histopathology of testis in male mice with obesity, this study used an in vivo laboratory experimental method with a research design of Post Test Only Control Group Design. In this study, there were 25 male rats divided into 5 groups, with a negative control group (normal rats without treatment), a positive control group (rats induced with high-fat feed), a treatment group of rats induced with high-fat feed with Sunkist orange peel extract granules (Citrus Sinensis (L.) Osbeck) at a dose of 50 mg/KgBW, 100 mg/KgBW, and 150 mg/KgBW. Conclusion: Sunkist orange peel granule extract (Citrus Sinensis (L.) Osbeck) had an effect on blood glucose levels, total cholesterol, and body weight, but did not show a significant effect on the histopathological results of the testes in male rats.
The Fragmented Landscape of Stroke Epidemiology in Indonesia Ikhsan, Maulana; Wahyuni, Hendra
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Indonesia encounters substantial obstacles in stroke surveillance, as indicated by Riskesdas, BPJS, and hospital registries. The disconnected and inconsistent data that is gathered from these sources is the root cause of these challenges. When there are inconsistencies in case definitions, reporting, and geographical biases, it is challenging to conduct an accurate burden assessment and develop appropriate policies. The analysis of stroke epidemiology data from 2007 to 2023 in this study reveals significant deficiencies. These deficiencies encompass discrepancies in diagnostic accessibility, underrepresentation in hospital registries, and methodological inconsistencies in national surveys. One of the recommendations is the integration of a National Stroke Registry with BPJS to facilitate real-time data transmission. Additionally, the standardization of reporting through the application of WHO standards and ICD-11 classification, as well as the enhancement of rural documentation through the application of professional development and digital technologies, are additional recommendations. The resolution of these issues would enhance the precision of data, facilitate the application of evidence-based decision-making, and enhance the equity of stroke care in all of Indonesia's numerous regions.

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