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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 11 Documents
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Search results for , issue "Vol 5 No 3 (2024): October 2024" : 11 Documents clear
Perbandingan Metode Ekstraksi terhadap Kadar Flavonoid Total Ekstrak Etanol Daun Kersen (Muntingia Calabura L.) Alfiraza, Ery Nourika; Nurhidayati, Lailiana Garna; Fahamsya, Arifina; Wahyuningtias, Arum
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5136

Abstract

Flavonoid compounds, triterpenes, tannins, polyphenols, and saponins can be found in cherry leaves (Muntingia calabura L.). Flavonoids are proven to be able to reduce free radicals, and thus can act as an antioxidant. The use of extraction methods can affect the content of flavonoid compounds contained in the extract . Thus, to extract flavonoids from plant leaves, it is necessary to optimize the right extraction method. Objective of this study was to compare the effect of using three different extraction methods, namely maceration, reflux, and sonication, on the total flavonoid content of cherry leaf ethanol extract. Cherry leaves were extracted with ethanol (1:10), using three different extraction methods, namely maceration, reflux, and sonication. The viscous extract obtained was then measured for total flavonoid content using UV-VIS spectrophotometry at 431 nm, using a standard solution of quercetin as a comparison. Total flavonoid content of ethanol extract of cherry leaf extracted by maceration, reflux, and sonication method respectively were 73.98 ± 0.06 mgQE/g; 60.55 ± 0.05 mgQE/g; and 92.53 ± 0.12 mgQE/g. Conclusion of this study was The extraction process influences the overall flavonoid concentration of cherry leaf ethanol extract.
Hubungan Kemampuan Aktivitas Antioksidan dengan Pelarut Ekstraksi Daun Pecut Kuda (Stachytarpheta jamaicensis L.) Amin, Asni; Waris, Risda; Aminah, Aminah; Yuliana, Dewi; Fitri, Nurul
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5221

Abstract

The increasing prevalence of degenerative diseases, cancer and other non-communicable diseases is due to exposure to free radicals, so that currently research on antioxidants is increasingly being carried out. This research aims to prove the relationship between antioxidant activity and extraction solvents of different polarities in reducing DPPH radicals ((1,1-Diphenyl-2-picryl hydrazyl) from horse whip (DPK) leaves (Stachytarpheta jamaicensis L.) from North Kolaka district. The research was carried out using a post test only control experiment. Samples were extracted by maceration with 96% ethanol solvent and n-hexane solvent, then each extract was evaporated using a rotary evaporator, the thick extract was screened for phytochemicals with a second color reagent. The extract was tested for antioxidants against DPPH and measured absorbance using a UV-Vis spectrophotometer at a wavelength of 515 nm, and compared with the quercetin standard. The results of the phytochemical screening showed the content of anthraquinone glycosides, phenols, and flavonoids for the DPK ethanol extract, while the hexane extract contained alkaloids, phenols, flavonoids, tannins and steroids. The antioxidant activity of DPK extract can capture DPPH free radicals with the IC50 value of 96% ethanol extract being 12.17 μg/mL and hexane extract being 5.904 μg/mL. Both extracts are classified as very strong antioxidants like quercetin. There is a relationship between the extraction solvent and the antioxidant ability of HWL extract which is significant at p < 0.05, while the relationship between quercetin, ethanol extract and hexane extract significantly influences the antioxidant ability. Abstrak Meningkatnya prevalensi penyakit degeneratif, kanker, dan penyakit tidak menular lainnya diakibatkan adanya paparan radikal bebas, sehingga saat ini penelitian antioksidan semakin banyak dilakukan. Penelitian ini bertujuan untuk membuktikan adanya hubungan aktivitas antioksidan dengan pelarut ekstraksi yang berbeda kepolaran dalam meredam radikal DPPH ((1,1-Diphenyl-2-picryl hydrazyl) dari ekstrak etanol 96% dan ekstrak heksan daun pecut kuda (DPK) (Stachytarpheta jamaicensis L.) asal kabupaten Kolaka Utara. Penelitian dilaksanakan menggunakan post test only control eksperiment. Sampel diekstraksi secara maserasi dengan pelarut etanol 96%, dan pelarut n-heksan, kemudian tiap-tiap ekstrak dievaporasi menggunakan rotavapor, ekstrak kental diskrining fitokimia dengan pereaksi warna. Uji peredaman radikal bebas ekstrak dengan konsentrasi 1; 2; 3; 4 dan 5 μg/mL diukur absorbansinya dengan spektrofometer UV-Vis pada panjang gelombang 515 nm, dan dibandingkan dengan standar kuersetin. Hasil skrining fitokimia didapatkan kandungan glikosida antrakinon, fenol, flavonoid untuk ekstrak etanol DPK, sedangkan ekstrak heksan mengandung alkaloid, fenol, flavonoid, tanin, dan steroid. Aktivitas antioksidan ekstrak DPK dapat meredam radikal bebas DPPH dengan nilai IC50 ekstrak etanol 96% adalah 12,17 μg/mL dan ekstrak heksan adalah 5,904 μg/mL. Kedua ekstrak tergolong antioksidan sangat kuat seperti kuersetin. Terdapat hubungan antara pelarut ekstraksi dengan kemampuan antioksidan ekstrak DPK yang signifikan pada p < 0,05, sedangkan hubungan antara kuersetin, ekstrak etanol dan ekstrak heksan secara signifikan berpengaruh dengan kemampuan antioksidan.
Analisis Minimalisasi Biaya (AMiB) Antihipertensi Irbesartan dengan Candesartan pada Pasien Hipertensi Rawat Jalan Nurlaela, Nurlaela; Fauziah, Fauziah; K, Khamdiyah Indah; Kusuma, Ikhwan Yuda
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5599

Abstract

Cost minimization of antihypertensive therapy is very essential to optimize patient care and allocation of hospital resources. This study aimed to compare the most cost-minimized cost of irbesartan and candesartan therapy treatment in hypertensive patients at Goeteng Taroenadibrata Purbalingga in the periods January to December 2023. The research method used quantitative with a retrospective approach. Data were analyzed using normality kormogorov smirnov test and continued by mann whitney test. population in this were hypertensive patients at Goeteng Taroenadibrata Purbalingga with a sample of 100 hypertensive patients.The results showed that out of 100 samples, 37 samples used irbesartan and 63 candesartan samples with an average total direct medical cost of antihypertensive treatment, laboratory costs and consultation costs required by patients using irbesartan therapy Rp. 158,665, and candesartan Rp. 116,874. Statistical analysis has a p-value that shows a significant difference between irbesartan treatment and candesartan treatment. the conclusion in this study is that the most cost-minimizing antihypertensive therapy is the candesartan group compared to the irbesartan group. Further research is needed to analyze a broader CMA of blood pressure control and comorbid diseases.
Analisis Pengaruh Vaksin Covid-19 Terhadap Nilai HbA1c Pasien DM Tipe-2 Di Puskesmas: Studi Retrospektive Setyaningsih, Intan Wiji; Kurniasih, Khamdiyah Indah; Setianingsih, Siti
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5666

Abstract

Coronavirus Disease 2019 (Covid-19) is a dangerous type of infection that causes death and is at risk in DM patients, so the selection of vaccines is very selective, especially moderna or pfizer vaccines that will know the increase in blood glucose. The purpose of this study was to determine the description and relationship of HbA1c values in type 2 DM patients after the 2nd dose of moderna or pfizer Covid-19 vaccine at Mrebet Health Center. The method used was analytical research with a retrospective observational approach conducted by conducting interviews with DM patients in the form of compliance with drug use, remaining drug use in 1 month, and sugar diet. Measurement of HbA1c values obtained from 3 months before and 3 months after the 2nd dose of moderna or pfizer vaccine. The results of the study obtained 32 DM prolanis patients, where the most patients were aged 45 - 65 years as many as 28 (87.5%), and female gender 27 (84.4%). The type of vaccine obtained was 25 (78.1%) moderna vaccine and 7 (21.9%) pfizer vaccine. The average pre-vaccine and post-vaccine HbA1c values increased by 0.3% from 8.0% to 8.3% and a standard deviation of 0.10. Based on the analysis, the p-value of 0.000 <0.050 was obtained, so statistically there was a slight increase with almost the same value between HbA1c values in type 2 DM patients after the Covid-19 moderna vaccine or the 2nd dose of pfizer. Conclusion There is an increase between pre-vaccine and post-vaccine HbA1c values and there is a relationship between HbA1c values in patients with type 2 DM after the Covid-19 moderna or pfizer 2nd dose vaccine.
Penentuan Nilai SPF (Sun Protection Factor) Sediaan Serum Anti-Aging Ekstrak Rimpang Galoba (Horstedtia Alliacceae) Safaruddin, Safaruddin; Suleman, Abdul Wahid; Zahira, Saliza
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5760

Abstract

The rhizome of Galoba (Horstedtia alliacceae) contains flavonoids, alkaloids, saponins, tannins, and triterpenoids which are secondary metabolite compounds that have antioxidant activity. The most antioxidants are flavonoids where antioxidants are used as anti-aging agents because free radicals are involved in the aging process of the skin. Objectives of the study to determine whether ethanol extract of galoba rhizome (Horstedtia alliacceae) can be formulated into a physically and chemically stable serum preparation, as well as to determine the SPF (Sun Protection Factor) value in serum preparations. The research method used an experimental method in vitro using a UV-Vis spectrophotometer, extraction by maceration method using 96% ethanol solvent, and then an anti-aging serum preparation formulation was made with concentrations of F1 (5%), F2 (10%), F3 (15%), F3 (20%). Then the SPF (Sun Protection Factor) value is determined. The results of the serum formula research showed that it was physically and chemically stable, which was marked by no difference before and after the cycling test, both in organoleptic, homogeneity, pH, viscosity, and humidity tests. The results of the SPF value of serum preparations at F1 (5%) were 4.51, F2 (10%) was 5.66, F3 (15%) was 8.67, and F4 (20%) was 13.06. The conclusion of this study is to show that Galoba rhizome extract (Hornstedtia alliacea) can be formulated into a physically and chemically stable anti-aging serum preparation, and the best SPF value obtained from the F4 formula (20%) is 13.06 with the maximum protection category.
Body Scrub Kombinasi Cangkang Telur Ayam Horn dan Ekstrak Daun Kenikir Sebagai Brightening Skin Yunitasari, Risky; Natasya, Leanasta Ina; Poppy, Leony Rayvina; Agustin, Nanda Nelly; Fatika, Diva Aulia Nur; Isnawati, Nafisah
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5870

Abstract

Maintaining beauty is an important aspect for every woman, including appearance and cleanliness of the entire body. One product that supports healthy skin is a body scrub, which can be made using egg shell waste as a scrub and kenikir leaf extract as the active ingredient for a body scrub. Egg shells contain calcium carbonate which is abrasive for exfoliation. Meanwhile, kenikir leaves are rich in antioxidants, vitamins C, A and E which play a role in brightening the skin. The method used is a qualitative and quantitative experimental research method which includes physical evaluation and antioxidant activity testing of body scrub preparations. The aim of this research is to determine the formulation, characteristics and antioxidant activity of a combination of horn chicken (Gallus gallus domesticus) egg shell waste and kenikir (Cosmos caudatus) leaf extract using the DPPH method and to evaluate the physical preparation. The research results showed that the physical evaluation of the body scrub preparation met the requirements and the best antioxidant activity was found in F3 with an IC50 value in the medium category of 111.121.
Pemanfaatan Limbah Ekstrak Metanol Dari Kulit Buah Kakao (Theobroma Cacao L.) Sebagai Antimikroba Mierza, Vriezka; Razali, Mariany; Hanafi, Muhammad; Pandiangan, Martina
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6137

Abstract

Microorganisms, which include bacteria, fungi, viruses, and parasites, are a large class of microscopic organisms with one or more cells. Among them are Staphylococcus epidermidis, Bacillus subtilis, Proteus mirabilis, and Streptococcus pyognes. One type of plant that has health benefits is the cocoa plant (Theobroma cacao L.) which belongs to the Malvaceae tribe. In this study, methanol extract of cocoa fruit peel (Theobroma cacao L.) was made as an inhibition test against Streptococcus pyognes, Bacillus subtilis, Proteus mirabilis, and Staphylococcus epidermidis bacteria. Cocoa pod peel (Theobroma cacao L.) was the test material used in the experimental methodology of this study. Simplisia preparation, ethanol solvent maceration extraction, agar diffusion method antibacterial activity testing, and phytochemical screening for chemical compound component analysis are part of the stages of this research. Drying of cocoa fruit peels produced 26.5 kg of simplisia, and maceration with ethanol produced 14.41 g of thick extract. Antibacterial activity of ethanol macerated extract of cocoa fruit peel was shown by inhibition against Streptococcus pyognes bacteria by 21 mm, Bacillus subtilis bacteria by 68 mm, Bacillus subtilis bacteria by 14.06 mm, Proteus mirabilis bacteria by 14.4 mm, and Staphylococcus epidermidis bacteria at a concentration of 100 mg/ml. The results of phytochemical screening of ethanol extract of cocoa pod skin showed the presence of anthraquinone glycosides, flavonoid chemical compounds, triterpenoids, tannins, and saponins.
Efektivitas Senyawa Bioaktif Biji Kopi Arabika (Coffea arabica L.) Sebagai Antibakteri Sari, Nurmala; Razali, Mariany; Kusuma, Ariyanti; Simanjuntak, Labora; Damanik, Mia; Silvany, Rika
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6138

Abstract

Arabica coffee has a myriad of benefits for the health of the human body, Arabica coffee contains secondary metabolites including flavonoids, tannins and saponins which have good antibacterial properties in leaves, seeds, and even coffee fruit skin, where Arabica coffee is taken in a mature state to see how much antibacterial is contained in coffee beans. The purpose of this study was to identify the chemical content of secondary metabolites contained in the ethanol extract of Arabica coffee beans and the antibacterial activity of the extract in terms of preventing the growth of Staphylococcus aureus and Escherichia coli bacteria. This research method is experimental, plant material is taken identified then made simplisia, Arabica coffee beans are extracted using ethanol p.a. solvent, phytochemical screening and antibacterial activity tests are carried out using the agar well diffusion method (Agar Well Plate Diffusion Assay Method). The diameter of the growth inhibition of microorganisms is one of the factors observed in the ethanol extract of Arabica coffee beans undergoing phytochemical screening which shows the presence of terpenoids / steroids, alkaloids, flavonoids, tannins and saponins. The concentrations used start from 100 mg / ml, 50 mg / ml, 25 mg / ml, 12.5 mg / ml, 6.25 mg / ml and 3.12 mg / ml in the ethanol extract of Arabica coffee beans (Coffea arabica L.). The ethanol extract of Arabica coffee beans showed antibacterial activity against Escherichia coli bacteria with the largest inhibition zone of 9.5 mm in diameter observed at a concentration of 100 mg/ml, while the smallest inhibition zone of 0.73 mm in diameter was observed at a concentration of 6.25 mg/ml, in contrast to Staphylococcus aureus bacteria which had the smallest inhibition zone at a concentration of 100 mg/ml and the largest inhibition zone at a concentration of 8.48 mm at 12.5 mg/ml with an inhibition zone diameter of 1.73 mm.
Uji Efektivitas Ekstrak Etanol Daun Ketapang (Terminalia cattapa L.) Terhadap Bakteri Patogen Saputri, Muharni; Mierza, Vriezka; Zebua, Nilsya Febrika; Panjaitan, M Ridho Pangestu
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6139

Abstract

Antiba Antibacterials work by preventing and managing the growth of pathogenic bacteria. The goal of controlling bacterial growth is to stop the spread of infection. Basically, people use synthetic drugs in antibacterial prevention but often there is a lot of resistance in the human body that can cause adverse effects. The active ingredients in ketapang leaves have the potential to act as natural antibiotics and antibacterials to combat antibiotic resistance. To determine the antibacterial effectiveness of these chemical compounds against bacteria Pseudomonas aeruginosa, Demacoccus nishinomiyaensi, Stapylococcus epidermidis and Micrococcus luteus, a study was conducted with the aim of knowing the content of chemical compounds contained in ketapang leaves based on maceration results. This study uses an experimental descriptive method with Ketapang leaf test material (Terminalia cattapa L.) This research stage includes making simplisia, maceration extraction using ethanol solvent, antibacterial activity test agar well diffusion method and analysis of chemical compound components by phytochemical screening.The results of drying fresh ketapang leaves produce as much as 1.6 kg of simplisia, and when 300 grams of ketapang leaf simplisia is macerated using ethanol pro analysis, 1.5 kg of simplisia is obtained. The ethanol extract from the maceration of ketapang leaves has antibacterial activity as shown by the inhibition of Pseudomonas aeruginosa bacteria by 18.38 mm, Dermacoccus nishinomiyaensis bacteria by 23.05 mm, Staphylococcus epidermidis bacteria by 18.71 mm, and Micrococcus luteus bacteria by 20.71 mm. After screening the ethanol extract of ketapang leaves, triterpenoid components, anthraquinone glycosides, saponins, and tannins were found. Flavonoid compounds were also found.
Uji Most Probable Number (MPN) Bakteri Coliform Pada Jamu Yang Beredar di Pasaran Kusumastuti, Yulia; Tanjung, Siti Aisyah; Fatimah, Cut; Ayi, Alicia
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6140

Abstract

Herbal Medicine is one of the traditional medicines used since the time of the ancestors until now with ingredients that have not been standardized. jamu has a myriad of benefits for the human body, one of which can maintain body health, prevent disease, maintain fitness and beauty. jamu has two types circulating in the market, namely jamu gendong and jamu kemasan. Processing of jamu gendong which is still done in a simple way with makeshift tools is very likely to cause bacterial contamination. Rich biological resources, especially medicinal plants, can be found in Indonesia. According to research, 90% of Asia's medicinal plants are estimated to be found in Indonesia, with 25% of them-about 7,500 plant species-having been proven effective. In the process of making herbal medicine, it is very important to look at its hygienity, this is because herbal medicine is very easily contaminated by bacteria such as Coliform bacteria, which are indicators of bacterial contamination in general. in this test carried out by the MPN method, the authors are interested in examining the Coliform bacteria mpn test on herbal medicine circulating in the sudirejo village, Medan city. This test sample was carried out using a simple random method on jamu gendong and jamu packaging located in sudirejo Medan. in testing bacterial contamination using Most Probable Number (MPN) with a 3:3:3 tube series with Lactose Broth (BGLB) media and a complete test using Eosin Methylen Blue Agar (EMBA) media, performing gram dye painting and observing microscopic colonies. The results in this study showed that all samples of jamu gendong and packaged jamu (K3) found in the Sudirejo Medan area were contaminated with Coliform bacteria, while the sample of packaged jamu (K6) was not contaminated with Coliform bacteria.

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