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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Environmental Factors and Protective Effects of Epigallocatechin-3-Gallate to Systemic Lupus Eritematosus: A Review Study Herin Mawarti; Jusak Nugraha; Djoko Agus Purwanto; Joewono Soeroso
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14750

Abstract

SLE (Systemic Lupus Erythematosus) is one of autoimmune disease in which the immune system attacksits own tissues, causing widespread inflammation and tissue damage in the affected organs. Etiology andpathogenesis are not clearly mention until now by the scientist, but environmental factor is contribute todevelopment of Lupus and Flare disease. The objective of this study to explain the relationship betweenenvironmental factors and pathogenesis development of SLE, and how the Epigallocatechin-3-Gallate(EGCG) can protect or prevent of organs damage and environmental effects.Method: The research design of this study was used literature review. The data sources collected fromElectronic database in Pubmed, Sage, Google Scholar and website of science including reports, journals andmostly published in the last 10 years.Results: The pathomechanism of SLE was influenced by environmental factors and this was caused anincreasing of oxidative stress, chronic inflammation, dysregulation of immune system and decreased theclean of immune complex and apoptosis of cells. The production of autoantibodies and immune complex arerelated with target tissue with is it was caused chronic inflammation and the end it caused irreversible damagein glomerulus of the kidneys, arteries, lungs and other tissues. EGCG plays a protecting role in environmentalfactors as a trigger because it works as an antioxidant, anti-inflammatory and immunomudulator. So EGCGcan as a potential agent to protect SLE.Conclusion: Environmental factors plays an important role as a triger of SLE and flare. Moreover, EGCG asa potential agent to protect the presence of oxidative stress, inflammation and immune dysregulation.
A Prediction Model of Mortality in Patients Hospitalized with Diabetic Ketoacidosis in a Tertiary Referral Hospital in Surabaya, Indonesia Hermina Novida; Fajar Setiyawan; Soebagijo Adi Soelistijo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14751

Abstract

Background: The mortality rate of diabetic ketoacidosis (DKA) remains high in Indonesia. Differentpatterns were contributing to DKA mortality from previous studies. We aim to identify clinical and laboratoryfindings as mortality predictors of DKA.Methods: This retrospective study was conducted in a tertiary referral hospital in Surabaya. Medical recordsof DKA patients from January 2016 to December 2018 were analyzed. Clinical and laboratory data wereobtained from medical records for three years period. Clinical outcome was defined as either dischargedhome or death.Results: Fifty-six among 116 DKA patients did not survive during hospitalized. Age of 60 or older, thedepressed mental state with GCS below 13, potassium serum less than 3.5 mmol/L, and bicarbonate serumless than 15 mmol/L are found to be significant as independent factors of mortality in DKA patients.Conclusion: The mortality rate of DKA patients in this study is still high. It independently associatedwith the age of 60 years or older, depressed mental state, hypokalemia, and low bicarbonate level. Earlystratification of these predictors would help to treat patients accordingly.
In-Vitro Differentiation Adipose-Derived Mesenchymal Stem Cells into Pancreatic Progenitor Cells Hermina Novida; Agung Pranoto; Askandar Tjokroprawiro; Sony Wibisono; Purwati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14752

Abstract

Background: Adult stem cells are currently reliable sources of mesenchymal stem cells for regenerativetherapy, include diabetes mellitus. The aim of this study is to develop endocrine pancreatic progenitor cellscharacterized by Pdx1 and insulin expression from rat adipose-derived mesenchymal stem cells using twosteps in-vitro differentiation.Methods: In this experimental study, ADMSCs were isolated from rat adipose tissue and exposed toinsulinogenic differentiation medium containing nicotinamide, activin A and glucagon-like peptide-1 (GLP1). After induction, the existence of pancreatic progenitor cells (PPCs) was confirmed by immune-stainingassay of Pdx1 and insulin.Results: After three weeks of in-vitro differentiation, expression of Pdx1 and insulin proteins showed upas green in the immunofluorescence assay. Immunofluorescence intensity of Pdx1 was higher in PPCs thanin ADMSCs control (p<0.05). Immunofluorescence intensity of insulin was also higher in PPCs than inADMSCs control (p<0.05). Therefore, in-vitro differentiation was successful to develop PPCs from ratADMSCsConclusion: This study has demonstrated the in-vitro differentiation of ADMSCs into PPCs that expressedPdx1 and insulin
Estimation of Lepitn, Melatonin , and Adropin Hormones in Gestational Diabetes Mellitus (GDM) in Tikrit City Hiba Hazim Salih; Rasha Shamil hussin; Wasan Sarhan Oubeid
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14753

Abstract

The increased incidence of gestational diabetes (GDM), and its negative effect for the mother, and thefetus imposes the need to study the mechanisms which resulting in pregnancy complications development.This study was carried out to study the relationship between (GDM) and some hormones levels (liptin,melatonin, and adropin) in the three semester of pregnant women’s, also estimation of (glucose, and lipid)profil). the study included (90) pregnant women divided to three groups (1st semester, second semester, andtrimester) (30) women for each group. Also the study included (30) non infected women with (GDM). Theresults showed significant increase of leptin, and adropin(p?0.05) in first semester comparative with secondand third semester and control group. There was significant decrease of melatonin in GDM comparative tocontrol group. The level of lipid profile elevated in (GDM) comparative to non.
Study of Laparoscopic Cholecystectomy in case of Complicated Cholecystitis Honeypalsinh Maharaul; Param shah; Ohang Chaudhary
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14754

Abstract

Cholelithiasis is one of the commonest disorders of GIT. Cholecystectomy was done traditionally by openor conventional cholecystectomy. But now Laparoscopic approach is believed to be the gold standardin treatment of calculous cholecystitis. Common problems encountered during Laparoscopic approachare Difficult dissection due to distorted Anatomy, Infection at GB Fossa, Frozen Callot’s triangle [1],hypervascularity. In this study we included 30 patients having complicated calculous cholecystitis whowent under laparoscopic cholecystectomy. They were assessed to determine the feasibility and safety oflaparoscopic approach in complicated calculous cholecystitis. e.g. Gall bladder Mucocele, Gall bladderEmpyema [2], Gangrenous changes in Gall bladder, Gall bladder Perforation, Common Bile Duct stonesalong with Cholangitis /Pancreatitis. Early post-operative ambulation (within 1 to 2 days) along with alesser duration of post-operative hospitalisation, decrease chance of sepsis during post-operative period anddecrease in morbidity along with lesser complication rate can be achieved with laparoscopic cholecystectomyin complicated calculus cholecystitis.
Immunohistochemical Expression of Myeloid Differentiation Adaptor Protein-88(MYD-88 )and Toll like Receptor (TLR-4) in Human Leiomyomas Huda Saddon Jassim; Ali Yhea Salman; Sajid saad mohanned
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14755

Abstract

Leiomyomas are the most common benign tumor of the female reproductive tract. The aim of this study wasto explore the role of TLR4/ MYD-88signaling pathway in the pathogenesis of leiomyomas. Benign natureand smooth muscle origination of leiomyomas was easily documented via histological examination, in thiscross-sectional study of 20 conventional leiomyomas cases TLR4/ MYD-88 antibody status was positive in90% for TLR-4 and in 95% for MYD-88 of leiomyomas. Leiomyomas were stained with TLR4/ MYD-88marker more than those in normal myometrium cases (P<0.001). In conclusion leiomyomas growth may beassociated with TLR4 and MyD88 expression
Autopsy Death Profile Due to Railway Injury in Mangalore, A Coastal City of South Karnataka- A Retrospective Analysis Ibrahim Jibril; B Suresh Kumar Shetty; Pavanchand Shetty; Jagadish Rao Padubidri; Haneil Larson D’souza; Eshetu Sileshi; Miressa Belay
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14757

Abstract

Background: Accident deaths is one of the most common types of deaths in India. In India railway relateddeaths are reported throughout the year. Fatal trains impacts cause extensive musculoskeletal injuries due tothe nature of the object as well as the amount of force transmitted during impacts. The purpose of all accidentinvestigation to take a positive step in correction of causation and to prevent such incidents in the future.Objective: The aim of this study is to assess and learn demographic details, characteristics of the incident infatal train crashes and recognize the injury profile.Methods: This is a retrospective autopsy based study. We considered 59 cases of railway track relateddeaths in three years (2016-2018) conducted at Tertiary Care Hospital, mortuary, Mangalore and analyzedthem statistically.Results: The study showed most of the victims were men between 30-40 years of age. Most victims ofincidents were pedestrians (72.9%,). The circumstance of incident in the majority was while walking on sideof railway track (39%). The highest number of fatalities 42.4 % were observed between 6 Am to 12 pm.Analysis as to cause of death in accidental circumstances revealed that multiple injuries (35.9%) followedby blunt trauma of head (33.3%) and in suicidal circumstances, death due to blunt trauma to head (40%) anddecapitation (40%) were the most prevalent.Limitations: The study needs to be done for longer duration and more detailed parameters in the railwaytrack accidents.Conclusion: The study established that majority of railway related deaths are accidental. and there is arequirement of awareness and implementing strict traffic laws to strengthen their safety for such preventabledeaths especially among the commuters of train and among the pedestrians using railway level crossings
Access Rights to Health Services for Tolotang Believers as Minority Group, Sidrap District, Indonesia Iin Karita Sakharina; Aidir Amin Daud; Hamzah Halim; Muh. Hasrul; Wahyudi Pratama; Sukri Palutturi; Anif Laila Sahir
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14758

Abstract

The purpose of this paper was to analyze the forms of protection and fulfillment of human rights by localgovernments against the followers of the Tolotang faith in accessing their right to health service as minoritygroup in Sidenreng Rappang District, South Sulawesi Province. The type of research used was normativelegal research using a statutory approach. The results showed that The followers of the Tolotang faith havebeen recognized by the state, and weregiven space to worship based on their beliefs. Also Tolotang faithhave recognize by the local goverment as part of the community in Sidenreng Rappang who have the sameaccess in order to get health service from any medical stuff, doctor, clinic , hospital whenever they needit.The findings of this article can provide insights into the forms of protection and fulfillment of humanrights by local governments against the followers of the Tolotang faith inin in accessing their right to healthservice as minority group in Sidenreng Rappang District, South Sulawesi Province.The followers of theTolotang faith have been recognized by the state, and weregiven space to worship based on their beliefs.Also Tolotang faith have recognize by the local goverment as part of the community in Sidenreng Rappangwho have the same access in order to get health service from any medical stuff, doctor, clinic , hospitalwhenever they need it.
Cardiac Fibrosis Attenuation by Chlorogenic Acid and Epigallocatechin-Gallate Mediated by Suppression of Galectin-3 Gene Expression and Collagen Deposition in Rat Metabolic Syndrome Model Indah Nur Chomsy; M. Saifur Rohman; Mifetika Lukitasari; Dwi Adi Nugroho; Husnul Khotimah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14759

Abstract

Objective: Metabolic syndrome (MetS) is a set cluster of risk factors for metabolic abnormalities thatcan develop cardiovascular disease (CVD), one of that is remodeling or cardiac fibrosis. Cardiac fibrosisidentified from the high levels of the profibrotic molecule; one of them is galectin-3. Aim: This studyintended to determine the effect of combination therapy of green coffee (CGA) and green tea (EGCG) oncardiac fibrosis by raise of the galectin-3 gene expression and collagen deposition in rat cardiac tissue inthe rat metabolic syndrome model. Methods: Twenty-four male MetS rats (Sprague-Dawley) divided intotwo control groups and three groups therapy (n=5) administration of the CGA 200mg/kgbw (body weightin kilograms) and EGCG 300mg/kgbw orally. After eight weeks of treatment, rats euthanized, then mRNAexpression of galectin-3 was measured. Furthermore, collagen deposition of cardiac tissue carried out inhistology slides. Results: Research reveals that the expression of galectin-3 decreased in the metabolicsyndrome model group, which given combination therapy compared with metabolic syndrome model micethat did not receive any therapy (P=0.000). Collagen deposition in cardiac tissue also found less than inthe therapy group compared with the group not treated with both compounds (P=0.000). The correlationbetween the two parameters shows a positive association with low strength. Conclusion: This study showsthat the combination therapy of CGA and EGCG is an engaging therapeutic candidate. It expected to reducethe progression of cardiac fibrosis in metabolic syndrome
A Comparative Study to Evaluate the Effect of Blood Flow Restriction Therapy and Retro Walking on Pain, Strength of Muscles and WOMAC Score in Patients of Osteoarthritis of Knee Indrani Gurjalwar; Deepali Patil; Kiran Kumar; Pratik Phansopkar
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14760

Abstract

Background - Osteoarthritis of knee being of the major causes for disability in older population. Due tosedentary lifestyle this disease is becoming common in younger population as well. As prevalence of thedisease is increasing it is a need of the hour to come up with a highly reliable exercise protocol which will bebeneficial for the patients. This research aims to establish a beneficial and reliable exercise protocol whichcan be well tolerated by the patients suffering from osteoarthritis of knee.Methods – 150 subjects will be selected. Randomly they will be assigned to two groups that is Group A andGroup B using chit method. Group A will receive Blood Flow Restriction Training and Group B will receiveretro walking training. Training will continue for 15 days. After 15 days patient will be reassessed for pain,strength and WOMAC score.Result – Studies have proved that Blood Flow Restriction Therapy and retro walking both the interventionare beneficial in patients of osteoarthritis to reduce pain, improve strength and WOMAC score. This studywill provide us an intervention which is beneficial in treating osteoarthritis and is well tolerated by thepatients. We may get a result where blood flow restriction would have a better impact on few outcomemeasures while retro walking may fetch better impact on other outcome measures. We may also concludethat combination of both the interventions is a better option for the treatment of osteoarthritis patients.

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