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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
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TINJAUAN ARTIKEL: MACAM-MACAM METODE PENGUJIAN AKTIVITAS ANTIOKSIDAN Silvi Nugraheni, Tarisa; Setiawan, Iwan; Ardila Putri, Annisa; Wahyu Sukmawati, Aprillia; Nur Khasanah, Latifah; Khoirun Nisa, Logaritma; Nufus Hanyokro Putri, Lu'luin; Kisma Wulandari, Sindy; Amelia Riswana, Syifa
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 1 (2024): Jurnal Farmasi (Journal of Pharmacy), April 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/s54s8018

Abstract

Antioxidants are substances that fight and prevent the production of free radicals that can damage the body. The chemical structure, free radical sources, and physicochemical properties of preparations obtained from different samples can lead to different test results of antioxidant activity. Therefore, selective methods for analyzing antioxidant activity are needed for certain types of samples. Test methods for antioxidant activity include CUPRAC, DPPH, FRAP, HPLC, ORACFL, CAA, amperometric, voltammetric, and ABTS methods. The result from review are Antioxidant testing using the DPPH method is the most widely used method for measuring antioxidant activity as it is a quick, easy, and inexpensive assay. The DPPH method is based on the principle that a hydrogen atom of the DPPH radical is donated by an antioxidant compound, ultimately transferring DPPH to its reduced, non- radical form. Antioxidant testing uses his DPPH method in the field of cosmetic analysis to prevent free radicals that form in layers of the skin. Subsequently, in plant antioxidant tests, especially free radical measurements, the DPPH method is used to determine whether plant extracts have antioxidant activity.
PENGARUH VARIASI LAMA WAKTU EKSTRAKSI TERHADAP FLAVONOID TOTAL DAUN TAPAK LIMAN (Elephantopus scaber L.) SECARA SPEKTROFOTOMETRI UV-Vis Feronica, Donna; Susilowati; Saad, Muhammad
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 1 (2024): Jurnal Farmasi (Journal of Pharmacy), April 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/3a14k719

Abstract

Elephantopus scaber L. is used as a traditional medicine with flavonoid content. This study aims to determine the total flavonoid content of Elephantopus scaber leaves with varying extraction times of 5 minutes, 10 minutes and 15 minutes. Dried Elephantopus scaber leaves were extracted using water by heating at 95oC for 5, 10 and 15 minutes. Method: Identification of flavonoid compounds in the boiled Elephantopus scaber leaves used the Wilstater method and alkaline reagent test. Total flavonoids were measured using the UV - Vis Spectrophotometry method as quercetin. The research results showed that all test samples contained flavonoids. The highest total flavonoid content of Elephantopus scaber leaves was obtained at the 5th minute, amounting to 94.59 ± 0.1424 mgQE/ 100 ml and the lowest at the 15th minute, amounting to 85.55 ± 0.2376 mgQE/ 100ml. In the "One Way Anova" test, the significance value for flavonoid levels was 0.006 < 0.05, so it can be concluded that the length of heating time had a significant effect on the total flavonoids in Elephantopus scaber leaves. The recommended boiling time for tapak Liman leaves is 5 minutes at 95oC.
Aktivitas Antioksidan Ekstrak Batang Tanaman Wungu (Graptophyllum pictum (Linn) Griff) Menggunakan Metode FRAP Harwati, Wiwik; Mahfur
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/cwsm1p39

Abstract

The wungu plant is a type of ornamental plant originating from Papua New Guinea and Polynesia which contains flavonoid compounds. This study aims to determine the antioxidant activity of wungu plant stem extract (Graptophyllum pictum (Linn) Griff) using the FRAP method. Identification of flavonoids using color reagents and antioxidant testing using the FRAP method. Wungu plant stem extract was made into a series of solutions with concentrations of 50, 75, 100, 125 and 150 ppm, while quercetin as a comparison was made with concentrations of 2, 4, 6, 8 and 10 ppm. The results of flavonoid identification showed that the sample contained flavonoids. The results of antioxidant activity in the comparison standard quercetin had an IC50 value of 1,62 ppm, while the wungu plant stem extract had an IC50 value of 13.13 ppm. From these results it can be concluded that the wungu plant stem extract using the FRAP method has very strong antioxidant activity with an IC50 value of 13,13 ppm.
Analisis Drug Related Problems (DRPs) Pada Pasien Angina Pektoris RS X Kota Cirebon Tahun 2023 Efriani, Like; Irawan, Ade; Anwar, Mahfud
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/yfqmgz67

Abstract

Angina pectoris is one symptoms of heart disease that is a problem and a major trigger of death in Indonesia characterized by chest pain. The prevalence of angina increases every year due to various risk factors such as age, lifestyle and history diseases such as diabetes, cholesterol, and hypertension. Use of drugs in large is at risk of drug-related problems. Drug Related Problems (DRPs) are medication problems that directly or indirectly affect the results of prescribed therapy. The purpose of this study was to analyze the incidence of actual or potential DRPs in patients angina pectoris. This research is observational non-experimental. Data collection was taken from 66 medical records of angina pectoris patients from January to December 2023 who met the inclusion criteria. The incidence of DRPs was analyzed by qualitative descriptive method based on the literature. The results of the analysis showed DRPs occurred in 61 (92%) hospitalized angina pectoris patients. The presence of DRPs in the category of drug interactions (60.77%), duplication of drug groups (20.26%), underdose (12.05%), overdose (5.13%), and inappropriate drugs (1.79%). The results of the analysis did not show a significant relationship between comorbidities and polyphamidation to DRPs. It can be concluded that the incidence of DRPs in hospitalized angina pectoris patients is quite large (92%), requiring the role of pharmacists in preventing and overcoming DRPs.
Analisis Kadar Flavonoid, Fenolik, dan Aktivitas Antioksidan Ekstrak Tangkai Buah Cabe Rawit (Capsicum frutescens L.) Fadhli, Haiyul; Yuswidia Putra, Diova; Trihardiyanto, Agus; Ulfa Frasesa, Roscha
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/xgepzm57

Abstract

Cayenne pepper (Capsicum frutescens L.) is known to have many medicinal properties, especially its fruit. However, cayenne pepper fruit stalks have not been studied in depth and are only considered waste. This study aimed to ascertain the total flavonoid concentration, phenolic content, and antioxidant activity of the extract derived from cayenne pepper fruit. Sample extraction using multistage maceration with the help of sonication. Using 3 different solvents, namely n-hexane, ethyl acetate, and ethanol in a ratio of 1:4 (b/v), and then sonicated (30 minutes, 20-25 °C, 42 kHz). The spectrophotometric technique using a microplate reader was employed to determine the total flavonoid content (TFC). The Folin-Ciocalteu method was used to determine the total phenolic content (TPC). And the DPPH method with a microplate reader was used to determine the antioxidant activity of ethanol extract. Total flavonoid content of 30.333 ± 1.327 mgQE/g extract, total phenolic content of 16.333 ± 0.890 mgGAE/g extract, and IC50 of 544.82 ± 0.01 µg/mL showed that ethanol extract of chili fruit stalk had weak antioxidant activity.
Formulasi dan Uji Stabilitas Fisik Masker Gel Peel Off Ekstrak Metanol Alga Merah (Eucheuma cottonii) Variasi Konsentrasi Polivinil Alkohol (Film Forming) Arifin , Arfiani; Ida , Nur; Sureda
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/awpryp22

Abstract

Red algae is a type of seaweed that has many biological activities, including its role as an antioxidant. The purpose of this study was to formulate a peel off gel mask preparation of methanol extract of red algae (Eucheuma cottonii) that meets the requirements of the physical stability test. The extraction method used was maceration using methanol solvent. Formulations were made using variations in Polivinil Alkohol (PVA) concentration FI (8%), FII (9%) and FIII (10%). Physical stability testing included organoleptic test, homogeneity test, pH test, spreadability test, adhesion test and dry time test conducted before and after storage at 15OC and 40˚C for 6 cycles (24 hours) using a climatic chamber. Based on the results of the study, it was found that the peel off gel mask preparations with PVA concentrations FI (8%), FII (9%), and FIII (10%) met the requirements of the physical stability test before and after storage.
Analisis Gambaran Terapi dan Interaksi Obat pada Pasien Mixed Anxiety and Depressive Disorder di Rumah Sakit Islam Arafah Kota Jambi Tahun 2021-2023 Andriani, Medi; Sanuddin, Mukhlis; Umairoh, Sarah
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/1b1wxd70

Abstract

Mixed Anxiety and Depressive Disorder (MADD) is a condition in which individuals experience symptoms of anxiety and depression simultaneously, but do not meet all the diagnostic criteria for anxiety disorders and depressive disorders. When symptoms of anxiety and depression appear together, it will cause a significant decline in function for the sufferer. In 2015, it was estimated that more than 300 million people worldwide suffered from depression and anxiety. Based on data from Kementerian Kesehatan Repbulik Indonesia, the prevalence of depression in Jambi Province is 1.8%. During the COVID-19 pandemic, the prevalence of anxiety was found to be 32.2%. This study aims to analyze the therapeutic features and potential drug interactions in MADD patients at the Rumah Sakit Islam Arafah, Jambi City. The research sample consisted of 153 patients diagnosed with MADD in 2021-2023. Data collection in the study used a retrospective method, namely searching secondary data from medical records. Research results show that concoction prescriptions are widely prescribed in 2021-2023, namely 52%, 52% and 50% respectively. The classes of drugs prescribed for MADD sufferers in 2021-2023 are antidepressants and benzodiazepines. The most frequently prescribed drug classes for patients with comorbidities are antipsychotics at 16%, 17% and 18% respectively and antihypertensives at 3% in 2021-2023. The drugs most commonly prescribed in 2021-2023 are sertraline at 14%, 14%, 11% and alprazolam at 13%, 13% and 15%. The prescribed dose of sertraline is 50 mg and alprazolam 0.25 mg, 0.5 mg and 1 mg. The frequency of sertraline prescribed is 1x per day and 2x per day. The frequency of alprazolam prescribed is 1x per day and 2x per day. The most cases of drug interactions are at the moderate level (aripiprazole-sertraline) at 7% and 8% in 2021 and 2022, while in 2023 it will be 9% (alprazolam-aripiprazole).
Identifikasi Kualitatif Ekstrak, Fraksi n-Heksan, Fraksi Etil Asetat, Fraksi Air Herba Bandotan (Ageratum conyzoides L.) Ayu Palupi, Dwi; Pratimasari, Diah; C.E. Dhurhania
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/kk6rmd70

Abstract

Bandotan (Ageratum conyzoides L.) is a plant that grows in subtropical and tropical regions and has high growth and adaptability. Some studies have shown that Bandotan herb has good activity as an antibacterial, anti-inflammatory, antioxidant, and antidiabetic agent. Existing research is limited to the content and activity of Bandotan herb extracts. However, some extracts that undergo fractionation are known to enhance their activity. Therefore, this study aims to identify the flavonoid and phenolic compounds in the polar, semi-polar, and non-polar fractions of Bandotan herb. The research started with macerating the Bandotan herb using ethanol as a solvent and concentrating it to obtain a thick extract. This thick extract was then suspended in warm water and fractionated successively using n-hexane and ethyl acetate solvents. The extracts and fractions obtained were analyzed for their content using tube tests and Thin Layer Chromatography (TLC). The tube test results indicated that the extract, ethyl acetate fraction, and water fraction were positive for flavonoids, while the n-hexane fraction was negative for flavonoids. TLC results showed variations in the compound profiles among the extract and its different fractions.
Tingkat Kepuasan Konsumen Terhadap Pelayanan Kefarmasian di Apotek Armada Kabupaten Wonogiri Geffi Audystivirani, Keysha; Mursiany, Anita
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/0hh59e61

Abstract

Service quality is an essential element in the utilization of healthcare services. Evaluating good service quality not only focuses on the physical healing of diseases but also involves the attitude, knowledge, and skills of the staff in providing services. Moreover, effective communication, accurate information, politeness, punctuality, responsiveness, and the availability of adequate facilities and physical environment are equally important. This study employs a descriptive approach with a survey method, examining five dimensions of service quality: reliability, responsiveness, assurance, empathy, and tangible aspects. The population of this study includes all patients who redeem medications and healthcare products at Apotek Armada. Samples were selected using purposive sampling, with the sample size calculated using Cochran's formula, resulting in 385 samples collected in February 2024. The results showed that patient satisfaction levels at Apotek Armada for the reliability dimension were 85.17% (very satisfied), responsiveness 86.97% (very satisfied), assurance 87.39% (very satisfied), empathy 89.27% (very satisfied), and tangible aspects 84.75% (very satisfied). The average satisfaction across all dimensions was 86.71%, categorized as very satisfied. In conclusion, the level of patient satisfaction with pharmaceutical services at Apotek Armada is classified as very high.

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