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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 27 Documents
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Search results for , issue "Vol 7 No 2 (2024)" : 27 Documents clear
Uji Aktivitas Enzim Fibrinolitik Dari Makanan Fermentasi Kacang Koro (Mucuna Pruriens) Metode Clot Lysis In Vitro Pamungkas, Bayu Aji; Indrayati, Ana; Pramukantoro, Ganet Eko
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p153-159

Abstract

Fibrinolytic enzymes are a group of serine proteases that can destroy blood clots (fibrin) in various thrombosis diseases. This study aims to determine the activity of fibrinolytic enzymes contained in jack bean tempeh using the in vitro clot lysis method. First, crude extraction of the jack bean tempeh enzyme was carried out by centrifugation to produce pellets and supernatants. Then purification using 70% ammonium sulfate salt, determination of enzyme protein levels using the Lowry method and fibrinolytic potential testing using the in vitro clot lysis method. The variations in extract concentrations used in the test were 12.5; 25; 50 and 100% with positive control Natokinase and negative control aquadest. This study showed the results of pellets after purification as much as 26.78 gr. Then it also showed an increase in protein level activity between before purification 22,515 µg / mL and after purification 27,215 µg / mL. In vitro clot lysis testing was carried out with several variations showing the most optimal variation in destroying blood clots was at 100% variation after purification with a lysis percentage of 61%. The most optimal results were also in the Two Way Anova test with a value of 63,592 samples after 100% concentration purification.
Eksplorasi Pengetahuan Suku Tolaki terhadap Penggunaan Tumbuhan sebagai Obat di Desa Iwoimendaa, Ladahai, Lambopini, Lawolia, Tamborasi, Ulukalo dan Watumelewe Kecamatan Iwoimendaa Kabupaten Kolaka Safaruddin, Safaruddin; Ariati, Widya; Sastrawati, Andi Nila; Amin, Rahmasinar
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p186-201

Abstract

Biodiversity has value in the health sector, one of which is in the use of plants as medicine. Medicinal plants are closely related to traditional medicine by local communities. Exploration of local knowledge regarding the use of natural materials as medicines is carried out in order to obtain information about data on traditional herbal medicines used by ethnic groups in Indonesia. The Tolaki tribe is one of the ethnic groups that are widely spread in the province of Southeast Sulawesi, including in the Iwoimendaa sub-district, Kolaka district. This study aims to explore local knowledge related to the types of medicinal plants, parts of plants used as medicine and how to process plants as medicine by the Tolaki tribe in the villages of Iwoimendaa, Ladahai, Lambopini, Lawolia, Tamborasi, Ulukalo and Watumelewe, Iwoimendaa sub-district, Kolaka district. The results of the study showed that the diversity of plant species based on the families used by the Tolaki tribe in the Iwoimendaa sub-district consisted of 68 species and 41 families, where the most widely used were from the Zingiberaceae family. The most widely used parts of the plant are the leaves, followed by the fruit, rhizome, herbs, tubers, roots, exudates/sap, stems and seeds. The most common way of processing plants is boiling. Other processing methods include brewing, grating, pounding, chewing, smearing, dripping, kneading, applying, sticking, squeezing and without mixing.
Uji Aktivitas Antioksidan Ekstrak Etanol dan Fraksi Etil Asetat Daun Renggak (Amomum dealbatum Roxb.) Dengan Metode ABTS Radiartini, Ni Nyoman; Andayani, Yayuk; Deccati, Rizqa Fersiyana
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p143-152

Abstract

Renggak leaves (Amomum dealbatum Roxb.) contain secondary metabolites such as flavonoids, terpenoids, and tannins, which act as antioxidants. Previous research has shown that ethanol extract of renggak leaves has moderate antioxidant activity using the DPPH method. However, research on the antioxidant activity of the extract is limited, thus further investigation at the fraction level is needed. This study aims to identify the secondary metabolite content and antioxidant activity using the ABTS method (2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) of the ethanol extract and ethyl acetate fraction of renggak leaves. The renggak leaf samples were extracted using maceration with 96% ethanol (1:10), followed by fractionation with water, n-hexane, and ethyl acetate using a separatory funnel (1:1). Secondary metabolite screening was conducted on the ethanol extract and ethyl acetate fraction. Antioxidant activity was measured based on the reduction in absorbance at the ABTS maximum wavelength, expressed as IC50 (inhibitory concentration 50%) values, with ascorbic acid as a comparison. The secondary metabolite screening results indicated that both the ethanol extract and ethyl acetate fraction of renggak leaves contain alkaloids, flavonoids, tannins, and steroids. The antioxidant activity of the ethanol extract was very weak with an IC50 value of 236.11 ppm, whereas the antioxidant activity of the ethyl acetate fraction was strong with an IC50 value of 86,95 ppm, compared to the antioxidant activity of ascorbic acid with an IC50 value of 10,00 ppm.
Tekanan Darah Pasien Hipertensi Dengan Diabetes Melitus Tipe II Di Puskesmas Ngemplak Simongan Kota Semarang Rukminingsih, Fef; Octasari, Paulina Maya; Dewi, Restu Anita Sukma
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p41-46

Abstract

Hypertension is often asymptomatic and if left untreated can cause complications. Hypertension is an increase in systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg. The blood pressure target for hypertensive patients with type II diabetes melitus (HT-DMTII) is <130/80 mmHg. The risk of complications increases if blood pressure does not reach the therapeutic target. Ngemplak Simongan Health Center, Semarang City has quite a lot of HT-DMTII patients, who undergo routine check-ups every month. This study aims to determine the achievement of blood pressure targets for HT-DMTII patients at Ngemplak Simongan Health Center, Semarang City. This study is an observational descriptive study using purposive sampling technique. The data used is retrospective data obtained from medical record data of HT-DMTII patients for the period August - October 2023. The inclusion criteria used were patients aged ≥36 years, receiving the same treatment for 2 consecutive months and having blood pressure data for 2 consecutive months. The data taken included medical record number, age, gender, blood pressure data for 2 consecutive months in the period August - October 2023, antihypertensives given and duration of use. From 62 patients, it was known that the majority were female patients 72.58%, aged >60 years as many as 58.06% and those who used antihypertensives for more than 5 years as many as 61.29%. A total of 59 people (95.16%) received single antihypertensive therapy. The most widely used antihypertensive was amlodipin (90.32%). There were 20 patients (32.26%) whose blood pressure reached the target.
Optimasi Carnauba Wax dan Paraffin Wax Pada Lipstik Ekstrak Umbi Bit (Beta vulgaris) Dengan Metode Simplex Lattice Design Sumule, Arsiaty
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p31-40

Abstract

Decorative preparations, such as lipstick, are women's dreams. The dyes used in lipstick formulas must comply with safety standards because this cosmetic product is applied to the mouth area, which can be swallowed through food, drinks, or saliva. Therefore, natural dyes appear to be a safe alternative with minimal side effects. The abundance of beetroot in Indonesia can make it a potential natural dye in cosmetic formulas. The physical form of lipstick also needs to be considered because it plays an important role in the characteristics and stability of the preparation. Therefore, a wax base is needed in the lipstick formula. Formula optimization can determine the optimal ingredient ratio without trial and error, thus saving time, costs, and materials. The purpose of this study was to determine the effect of the combination of carnauba wax and paraffin wax on the physical properties of beetroot extract lipstick and determine the optimum beetroot extract lipstick formula. This type of research is experimental by making eight lipstick formulas with variations of carnauba wax and paraffin wax and testing their physical properties, such as organoleptic, pH value, adhesion power, and melting point. The results were analyzed using Design Expert 11.1.2.0 software with the simplex lattice design method to obtain the optimum formula. The results showed the optimum formula of beetroot extract lipstick with a combination of 10% carnauba wax and 10% paraffin wax so that the pH value was 6.509, the adhesive power was 98.667 seconds, and the melting point was 67.931oC. The combination of carnauba wax and paraffin wax affects physical properties, such as pH value, adhesive power, and melting point in beetroot extract lipstick preparations.
EFEKTIVITAS TERAPI INSULIN TERHADAP GLUKOSA DARAH DAN HbA1c PASIEN DIABETES MELITUS DI RUMAH SAKIT UMUM X JAKARTA SELATAN Aulia, Gina; Azzahra, Aristi; Purwaningsih, Neneng Sri; Ismaya, Nurwulan Adi; Hasanah, Nur; Putri, Annisa Septyana; Kurniawati, Dewi Indah; Werawati, Ayu; Sayyidah, Sayyidah
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p167-172

Abstract

Diabetes mellitus is a serious and chronic condition. Diabetes mellitus patients often experience serious acute and chronic complications, even causing death. South Jakarta has the 4th highest prevalence of diabetes mellitus, namely 2.83%. The aim of this study was to analyze the effectiveness of insulin therapy by examining differences in blood glucose and HbA1c after 4 months and 8 months of therapy in diabetes mellitus patients. The research method in this research is quantitative descriptive analysis with a cohort retrospective approach. The sample in this study was 92 diabetes mellitus patients on insulin therapy who had their HbA1c checked with blood glucose routinely in 2023 taken using the purposive sampling method. The results showed that most patients were in the 56-65 years age group (45.7%), the most common gender was female (57.6%), and 76.1% of patients had comorbidities. The most widely used insulin therapy is a combination of Rapid acting and Long acting insulin (63%). The conclusion in this study was that there was no significant difference in either blood glucose levels after 4 months of therapy (P=0.442) or blood glucose levels after 8 months of therapy (P=0.148), compared with 1st month blood glucose, and there was a difference significant both HbA1c levels after 4 months of therapy (P=0.000) and HbA1c levels after 8 months of therapy (P=0.000), compared with HbA1c in the 1 month
FORMULASI DAN EVALUASI FISIK SEDIAAN SHOOTING EKSTRAK BUNGA KARAMUNTING (Melastoma malabathricum L.) Citrariana, Shesanthi; Febrianto, Yahya; Rahman, Sudarman; Fatiqin, Awalul; Suprayogi, Thatit; Alfanaar, Rokiy; Arsana, Mu’afa Purwa
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p86-91

Abstract

Soothing gel is a new cosmetic preparation in society with physical properties that increase the acceptability and effectiveness of therapy. Karamunting (Melastoma malabatricum L.) is a plant that is widely known in the Central Kalimantan region. Karamunting flowers contain flavonoid, alkaloid and saponin. The flavonoid in karamunting can be used as antioxidants. The aim of this research is to formulate karamunting flower extract (Melastoma malabathricum L.) as a soothing gel and evaluate the physical properties. The formulation method used variations of carbopol and HPMC with an extract concentration of 5%. Phytochemical testing of the extract was carried out using a tube test and total flavonoid using UV-Vis. The physical properties of the gel were tested in the form of organoleptic, homogeneity, viscosity and adhesion tests. The total flavonoid yield of karamunting flower extract was 21.22% w/w. Organoleptic properties: odorless aroma, brownish red color, and cool sensation on the skin. The preparation is homogeneous and has a viscosity of 200-300 dpa's and an adhesive force of 10.50-21.24 seconds. So it can be concluded that shooting gel karamunting flower extract has good physical properties.
Uji Efektivitas Krim Anti-Aging Ekstrak Etanol Akar Pasak Bumi (Eurycoma longifolia Jack) pada Kulit Punggung Kelinci Albino yang Terpapar Sinar UV-A Puspitasari, Ismi; Waty, Carolina Eka
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p202-212

Abstract

Eurycoma longifolia Jack (Tongkat Ali) root, rich in phenolic compounds with antioxidant and anti-aging properties, was formulated into an anti-aging cream. This study aimed to meet physical quality standards and evaluate in-vivo efficacy on rabbit dorsal skin exposed to UV-A radiation. The root extract, prepared through maceration, was formulated into creams at concentrations of 1.5%, 3%, and 6%, meeting physical quality criteria. Anti-aging effectiveness was assessed in five shaved rabbits exposed to 6 hours of daily UV-A radiation for 14 days. Each treated rabbit's dorsal skin, exposed to UV-A, was divided into five areas for cream application over 28 days: area I was applied with a negative control (ointment base), area II with a positive control, and areas III-V with a series concentrations of the extract cream of Eurycoma longifolia Jack. Anti-aging parameters, including collagen and elasticity percentages measured with a skin analyzer at pre-exposure (T0), after 14 days (T1), and after 28 days of cream application (T2). The result demonstrated that the 6% concentration yielded the most significant effects. The tested cream met high physical quality standards, showcasing potential as a promising anti-aging formulation.
VALIDASI METODE ANALISIS SIBUTRAMIN HCL PADA SEDIAAN JAMU PELANGSING DENGAN SPEKTROFOTOMETER UV-VISIBLE Febriani, Yuyun; Izati Savitri, Nurul; Azim, Muhlisun
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p20-30

Abstract

Sibutramine HCl was known as one of the anti-obesity drugs known for its appetite-suppressing properties. The aims of this research were to analyze pharmaceutical chemicals content in slimming herbal remedies available in the East Lombok district market and to analyze the value and validation parameters for analyzing method of sibutramine HCl in these remedies using UV-Visible spectrofotometry. The method used qualitative analysis using thin-layer chromatography (TLC) and quantitative method used spectrophotometry UV-Visible. The method was validated to meet the specified requirements, including linearity, Limit of Detection (LoD), Limit of Quantification (LoQ), precision, and accuracy. The results of this research were, in qualitative analysis, 2 out of 5 samples were identified to contain sibutramine HCl with a value of Rf of 0.78. The selected wavelength for sibutramine HCl analysis was 224.40 nm, and the respective parameters of linearity, LoD, LoQ, precision, and accuracy were (r) 0.9991, 2,406 ppm, 7,291 ppm, 0.446% RSD, and 98.92% recovery. Based on the results above, showed that using the spectrofotometry UV-Visible method in this research complies with the established parameters.
Aktivitas Antibakteri Ekstrak Etil Asetat Kulit Biji Lamtoro (Leucaena leucocephala) terhadap Bakteri Propionibacterium acnes: Aktivitas Antibakteri Ekstrak Etil Asetat Kulit Biji Lamtoro (Leucaena leucocephala) terhadap Bakteri Propionibacterium acnes Bulu, Atalia Tamo Ina; Shalsabilla, Lulu; Solichah, Ayu Ina
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p130-142

Abstract

Acne is an inflammation that is accompanied by blockage of the ducts of the skin’s oil glands (sebum) and hair (pilosebaceous ducts). Propionibacterium acnes is one of the bacteria that contribute to acne. Some natural ingredients such as lamtoro seed husk have flavonoids, alkaloids, saponins, and tannins which are antibacterial compounds that inhibit the growth of Propionibacterium acnes. This study aims to determine the antibacterial activity of ethyl acetate extract from lamtoro seed husk which is effective in inhibiting the growth of Propionibacterium acnes. Lamtoro seed husk (Leucaena leucocephala) was extracted by remaceration method using ethyl acetate solvent. Phytochemical identification is done qualitatively through color reaction with appropriate reagents confirmed by the TLC test. The results of the analysis showed that ethyl acetate extract of lamtoro seed husk had antibacterial activity against the growth of Propionibacterium acnes bacteria with the average diameter of the inhibition zone in the 15%, 20%, and 25% extract concentrations series of 1,454 mm, 3,313 mm, and 5,763 mm. Based on this study, it can be concluded that there is an influence of the concentration of ethyl acetate extract of lamtoro seed husk on the antibacterial activity of Propionibacterium acnes, the greater the concentration of the extract, the greater the diameter of the inhibition zone.

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