cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Farhamzah
Contact Email
farhamzah@ubpkarawang.ac.id
Phone
+6281380007942
Journal Mail Official
buanafarma@ubpkarawang.ac.id
Editorial Address
JL. H.S. Ronggowaluyo Telukjambe Timur Karawang 41361
Location
Kab. karawang,
Jawa barat
INDONESIA
Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 16 Documents
 1   2 
Search results for , issue "Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi" : 16 Documents clear
SENYAWA ALAMI DAUN BAWANG UNTUK DIABETES: PENDEKATAN IN SILICO TERHADAP PPAR-γ Hidayah, Himyatul; Ruswanto; Mindawati , Erisa; Amal, Surya; Farhamzah
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1466

Abstract

Leek leaves (Allium fistulosum L.) are plants that contain flavonoid compounds with diverse biological activity potential. This study aims to examine the stable interaction of the docking results between the PPAR-γ receptor complex structure and the best candidate flavonoid compounds in leek leaves as antidiabetic candidates. The method used in this study is quantitative and designed using molecular docking techniques based on computational molecular dynamics (MD), which simulates the dynamic behaviour of a molecular system as a function of time, treating each entity in the simulation box (protein, ligand, or water, if present) as flexible. The results of molecular docking on 16 onion leaf flavonoid compounds showed that hesperidin had the smallest Gibbs free energy (ΔG) of -10.0 kcal/mol, which is close to that of natural ligands. The RMSD and RMSF values are sufficiently stable. Hesperidin also has good pharmacokinetic properties and is non-toxic, thus meeting the criteria for drug-likeness as a potential oral drug candidate. These findings indicate the potential for developing flavonoid compounds, particularly hesperidin from onion leaves, as a candidate for an antidiabetic drug by inhibiting the PPARγ receptor. This study provides a foundation for further in vitro and in vivo studies to validate its biological activity.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN FACE MIST FRAKSI DAUN LIDAH MERTUA (Sansevieria trifasciata Prain) Yuniarsih, Nia; farhamzah, Farhamzah; Wulansari, Nur Intan
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1475

Abstract

Face mist is a cosmetic that is often used as a skin freshener, serves to refresh facial skin by removing residual oil, as a mild disinfectant, while closing pores again and can have activity as an antioxidant. The Sansevieria trifasciata Prain contains flavonoids, alkaloids and tannins that have the potential to be a source of natural antioxidants. This study aims to examine the potential of n-hexane, ethyl acetate and water fractions of Sansevieria trifasciata Prain as active substances in face mist formulations. This study used the Fractionation and DPPH methods to determine the effectiveness of antioxidant activity of various formulations with F1 (n-hexane fraction); F2 (ethyl acetate fraction) and F3 (water fraction), which were compared with commercial products.. The results showed that F1 and F2 had strong antioxidant activity, while F3 had moderate antioxidant activity. The results of physical evaluation and stability tests using the accelerated stability method (cycling test) showed that the resulting face mist preparation met SNI standards, had good stability and did not cause irritation. From these results, it can be concluded that the n-hexane, ethyl acetate and Sansevieria trifasciata Prain leaf water fractions have the potential to be effective natural antioxidants in the formulation of face mist preparations.
PENGEMBANGAN DAN UJI AKSEPTABILITAS FORMULA “BELIWUH” PLESTER DEMAM HIDROGEL GUNA ULANG BERBAHAN TANAMAN BELIMBING WULUH (Averrhoa Bilimbi L.) Sugiharta, Sudrajat; Mudrikah, Siti; Mursal, Iin Lidia Putama; Rahma, Suci; Nisa, Shabrina Zahratun; Zahro, Putri Latifah Nur; Hermawan, Ghifari Hanif
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1522

Abstract

Fever is commonly managed using conventional oral medications, however, compresses remain a widely preferred adjunctive therapy. Most commercially available compresses are single-use, making them economically inefficient. Averrhoa bilimbi L. (bilimbi) possesses known antipyretic activity and contains bioactive compounds such as alkaloids, flavonoids, and saponins, which have potential as natural antipyretic agents. This study aimed to develop an optimal formulation based on varying concentrations of PVP K-30 and potassium chloride (KCl), and to evaluate the quality of bilimbi-based hydrogel and hydrogel plaster formulations that are reusable, stable, comfortable to use, and have minimal side effects. An experimental design was employed to prepare three hydrogel plaster formulations using different concentrations of PVP K-30 and KCl. The formulations were evaluated for organoleptic properties, homogeneity, adhesiveness, pH, gel fraction, swelling index, viscosity, thickness, moisture absorption, folding endurance, weight uniformity, and acceptability. All formulations met established quality standards for hydrogel and hydrogel plasters. The resulting plasters exhibited a solid gel consistency, green coloration, and a distinctive green tea scent, with safe pH values ranging from 4.2 to 6.5. The P4K2.5 formulation demonstrated the most stable viscosity (16,575.3 cP), while P4.5K3.5 was identified as the most optimal overall. P3.5K1 was most preferred in terms of color; P4K2.5 and P4.5K3.5 in aroma; and P3.5K1 and P4.5K3.5 in texture. After five hours of use, participants strongly favored P4K2.5 and P4.5K3.5. Notably, P4.5K3.5 also provided the highest cooling sensation after refrigeration and is recommended as a promising candidate for a reusable hydrogel plaster formulation for fever therapy.
PENGARUH PEMBERIAN ANTIBIOTIK PROFILAKSIS TERHADAP LUARAN BEDAH PADA PASIEN GERIATRI: SISTEMATIK REVIEW Syam, Ricky Aditya
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1351

Abstract

This systematic review examined the effectiveness of prophylactic antibiotic administration in reducing the risk of surgical wound infection in geriatric patients. This topic is of particular importance globally given the rapid increase in the elderly population susceptible to postoperative complications, as well as the variability of the existing evidence regarding the effectiveness and optimal duration of prophylactic antibiotics. Although many studies have been conducted, there has not been a comprehensive synthesis of recent evidence to fill the gap. This study, which is a systematic review based on the PRISMA 2020 guidelines, analyzes articles from the Scopus, PubMed, and Google Scholar databases (2020-2025). The study involved 31 articles that met the inclusion criteria, including retrospective observational studies and randomized clinical trials, with the primary outcomes of postoperative infections and antibiotic-related side effects. The analysis method includes evaluation of the quality of the study as well as narrative and quantitative synthesis. The results showed that the administration of prophylactic antibiotics appropriately significantly reduced the risk of infection, especially in high-risk surgeries such as colorectal, orthopedic, and cardiothoracic, with an optimal duration of about 24 hours postoperatively. The risk of antibiotic resistance and opportunistic infections remains a major concern. The practical implications demand the development of evidence-based guidelines with adjustments to the duration of administration and the strengthening of alternative prevention strategies. Advanced research with a multicenter randomized clinical trial design is essential to optimize prophylactic regimens in diverse and complex elderly populations.
ANALISIS RASIONALITAS OBAT DIABETES MELITUS TIPE II DI UPT PUSKESMAS SAKETI PERIODE JULI-DESEMBER 2023 Santi, Santi Endrawati; Maimunah, Sariyati; Cahyadi, Andi
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1374

Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia, the treatment process must be carried out rationally, including correct diagnosis, correct patient, correct drug, correct dose, correct indication and correct time interval. This study aims to determine the rationality of the use of antidiabetic drugs at the Saketi Health Center UPT in the period July-December 2023. Retrospective data collection based on medical records using the Total sampling method was carried out on 138 samples that had met the inclusion and exclusion criteria. Data analysis using univariate analysis using the Microsoft Office Excel 2010 program, data was analyzed using the 2021 Perkeni literature and the Indonesian Ministry of Health 2019 for the rationality of 138 Diabetes Mellitus (DM) patients. Patient characteristics in the form of gender, there is a percentage of women 99 (72%) and men 39 (28%), Diabetes Mellitus (DM) which often occurs in the age range of 46-65 years with 110 cases (80%) The percentage of rationality of the use of diabetes mellitus drugs in patients with the right diagnosis is 138 patients 100%, right patients 138 100%, right drug selection 26 (19%) patients, wrong drug selection 112 (81%), right indication 138 patients 100%, right dose patients 138 100% and interval time of administration 138 patients.
STUDI PELAPORAN KEJADIAN NYARIS CEDERA (KNC) DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT DI KARAWANG TAHUN 2017 Agustini, Dewi Darwati; Safitri, Maida; Mariam, Iyam
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1379

Abstract

Pelaporan keselamatan pasien pada pelayanan kefarmasian dititikberatkan pada KNC yang menjadi aspek penting dalam menunjang keselamatan pasiend engan mengurangi terjadinya medication error. Penelitian ini bertujuan untuk mengetahui banyaknya angka kejadian nyaris cedera yang dilaporkan selama tahun 2017 dan pada bagian mana paling sering terjadinya KNC di unit rawat jalan RSUD Karawang. Penelitian dilakukan bersifat deskriptif cross sectional. Penelitian dilakukan pada lembar rekapitulasi laporan KNC selama tahun 2017. Hasil penelitian menunjukkan selama tahun 2017 terjadinya KNC pada penginputan resep sebanyak 316 kali, penulisan etiket 47 kali, peracikan 122 kali, dan penyerahan obat sebanyak 4 kali. Total keseluruhan terjadi KNC sebanyak 489 kali atau sekitar 0,5% terhadap lembar resep. Dapat disimpulkan bahwa selama tahun 2017 bagian yang paling sering mengalami KNC adalah pada penginputan resep sebanyak 316 kali terjadinya KNC.
EKSPLORASI AKTIVITAS HEPATOPROTEKTIF EKSTRAK ETANOL TEMU KUNCI (Boesenbergia rotunda) MELALUI PARAMETER MAKROPATOLOGI ORGAN HATI DAN INDEKS ORGAN PADA MODEL HEPATOTOKSISITAS TIKUS Harahap, Mawandha Sari; Jayanti, Heppy Nova; Silitonga, Desni Rinanda; Candrika
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1380

Abstract

Hati merupakan organ paling berperan dalam mayoritas sistem metabolisme pada tubuh. Metabolisme N-acetyl-p-aminophenol (APAP) memiliki metabolit reaktif N-acetyl-p-benzoquinone imine (NAPQI) yang dapat menyebabkan berkurangnya antioksidan glutation hati serta disfungsi mitokondria dan mengakibatkan meningkatnya jumlah radikal bebas dihati, yang pada akhirnya akan merusakkan hati. Antioksidan dibutuhkan guna meminimalisir radikal bebas. Rimpang temu kunci (Boesenbergia rotunda (L.) Mansf) mengandung metabolit sekunder berupa flavonoid yang diketahui memiliki sifat antioksidan sehingga rimpang temu kunci memiliki potensi untuk melindungi hati dari kerusakkan. Penelitian ini bertujuan untuk menganalisis aktivitas hepatoprotektif ekstrak etanol rimpang temu kunci terhadap tikus putih jantan yang diinduksi dengan APAP. Tikus putih jantan sebanyak 24 ekor digunakan pada penelitian ini, tikus dibagi dalam 6 kelompok perlakuan yakni kelompok kontrol normal, kontrol negatif diberi CMC-Na 0,5%, kelompok uji diberi ekstrak etanol rimpang temu kunci (EERTK) dosis 250, 500 serta 750 mg/kgBB dan kelompok kontrol positif diberi asetilsistein 200 mg. Selama 10 hari berturut-turut. Pada hari kesepuluh diinduksi dengan APAP 800 mg/kgBB secara oral. Setelah 16 jam, dilakukan pembedahan dan pengambilan organ hati. Organ hati untuk pengukuran indeks relatif organ dan makropatologi organ hati. Data dianalisis menggunakan one way-ANOVA lalu dilanjutkan Post Hoc Turkey HSD. Hasil analisis menjelaskan bahwa pretreatmen dengan EERTK secara signifikan menyebabkan indeks relatif organ hati menurun akibat dari pemberian EERTK, disisi lain EERTK juga memperbaiki makropatologi organ hati.
LITERATURE REVIEW: POTENSI OBAT BAHAN ALAM DARI TANAMAN SEMANGGI AIR (Marsilea crenata) Chandra, Pra Panca Bayu; Laksmitawati, Dian Ratih
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1383

Abstract

The use of plants as natural medicine is used because Indonesia has a wealth of natural resources. One of the plants used is water clover (Marsilea crenata). This plant is used as food and medicine. This study aims to identify the potential of natural medicine from water clover (Marsilea crenata). The research method in the literature study is to apply journal searches to the Google Scholar, Science Direct, and Pubmed databases with the keywords water clover (Marsilea crenata) and pharmacological activity. The journals used are national and international journals published from 2012 to 2025. The journals used are research on the potential of water clover as a natural medicine in silico, in vitro and in vivo. From the results of the literature study, 9 journals were obtained. After obtaining research data from journals, they were then combined and studied, then explained and explained systematically. The results of the study showed that water clover leaves in both extract and fraction forms have pharmacological activities including anticholesterolemia, antihyperglycemia, antioxidant, anti-inflammatory, HMG-CoA reductase enzyme inhibitory activity, sperm quality improvement activity in hyperglycemic mice, anti-neuroinflammatory serum. The content of secondary metabolites found in Marsilea crenata is a bioactive compound that is responsible for providing pharmacological activity.
SURVEI ETNOFARMAKOGNOSI DAN PROFIL KIMIA DARI 33 TUMBUHAN OBAT DI PURWAKARTA, INDONESIA Fikayuniar, Lia; Abriyani, Ermi; Yunita, Dewi
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1384

Abstract

Traditional medicine practices in Indonesia have long utilised medicinal plants as the main foundation for public health resilience. This research aims to document local knowledge of medicinal plant usage and analyse its chemical profile to strengthen the scientific validity of traditional utilisation by the Purwakarta community. The methods used include ethnopharmacognosy surveys through semi-structured interviews with snowball sampling technique, specimen collection and identification, phytochemical screening of six groups of bioactive compounds, and qualitative-quantitative data analysis (UV, FUV, RFC, FL). The results show that there are 33 species of medicinal plants used by the communities of Taringgul Tonggoh and Wanasari villages, with leaves being the most utilised part (91% of oral usage). The Zingiberaceae family dominates the utilisation, while flavonoids and tannins were detected in the highest amounts in the phytochemical screening, supporting empirical claims as antioxidants, anti-inflammatory, and antimicrobial agents. These findings demonstrate the consistency between traditional practices and pharmacological potential, while also filling the gap in ethnopharmacognosy documentation in Purwakarta. The implications of this study strengthen the scientific basis for integrating local knowledge into modern pharmacy and open up opportunities for the development of phytopharmaceuticals based on local biodiversity.
STUDI KANDUNGAN SENYAWA KIMIA TUMBUHAN OBAT DI DESA LEGOKHUNI DAN SUKADAMI KABUPATEN PURWAKARTA Abriyani, Ermi; Fikayuniar, Lia; Zulfa, Amanda Auliya
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1393

Abstract

A study on the chemical compound content of medicinal palnts was conducted in Legokhunimand Sukadami Villagesa, Purwakarta Region. The aim of this study was to examine the chemical compound found in various plants used as traditional medicine in Legokhuni and sukadami Villages in Purwakarta Region. The method used involved interviewing several residents from both villages regarding the traditional medicines they used, and performing phytochemical screening assay using specific reagents. The results of this study showed there 33 types of medicinal plants identified through interviews. The phytochemical screening revealedthat the most commonly found secondary metabolites in these palnt were alkaloids and flavonoids, each present in all33 palnt species. Quinoneswere found in 24 plant species, phenolics and tannins in 26 species, and saponins in 30 species. These plant types are therefore considered promising candidates for further in-dept research.

Page 1 of 2 | Total Record : 16

 1   2 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 1 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 4 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 3 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 2 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 4 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 3 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 4 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 3 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi More Issue