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Proceeding of Mulawarman Pharmaceuticals Conferences

mpc
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Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

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Uji Aktivitas Antioksidan dan Formulasi Gel Ekstrak Etanol Daun Jeruk Nipis (Citrus aurantifolia): Antioxidant Activity Test and Gel Formulation of Lime Leaf Ethanol Extract (Citrus aurantifolia) Bayu Tri Andika; Dewi Rahmawati; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Citrus aurantifolia leaves have several pharmacological properties such as antibacterial and antioxidant activity. The main objective of this study was to determine the antioxidant activity and obtain the best gel formula from the lime leaves ethanolic extracts. Five different concentrations of Citrus aurantifolia leaves extract namely FI, FII, FIII, FIV, and FV were tested for its antioxidant activity using the DPPH method. Furthermore, the lime leaves extract gel were formulated using carbopol 940. The gels were then evaluated for various parameters including organoleptic, homogeneity, pH, spreadability and viscosity to select best formulation. The extraction process was conducted using maceration method. The results of the DPPH radical scavenging activity showed that lime leaves extract with concentration 60,84 ppm has the preeminent IC50 value. The preparation of lime leaf ethanol extract gel obtained was clear white, clear green, green, brownish green, dark green, homogeneous, and had a characteristic smell of lime leaf. Evaluation of dispersion of 5-5.4 cm, pH of 5.1-5.8, and viscosity of 4.44-6.39 Pa.s. From the evaluation results, it can be concluded that formula 2 is the best formula.

Pengaruh Waktu Fermentasi Bakteri Asam Laktat Dari Sari Kulit Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Aktivitas Bakteri Propionibacterium acne: Effect of Lactic Acid Bacteria Fermentation Time from Red Dragon Fruit Peel Juice (Hylocereus Polyrhizus) on the Activity of Propionibacterium acne Cindy Puspita Perdana; M. Arifuddin; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Fermentation of lactic acid bacteria from Red Dragon Fruit peel extract (Hylocereus polyrhizus) produces bacteriocins that can inhibit the growth of pathogenic bacteria. The purpose of this research is to the Red Dragon Fruit peel extract that has been fermented using lactic acid bacteria has the potential to inhibit the growth of Propionibacterium acne bacteria. The method includes the process of extracting samples and pasteurizing the juice and then proceeding with the fermentation process with variations in time of 3 days, 7 days, 12 days, and 14 days at 37?C. Antibacterial testing was carried out using the good method. The results showed that there was an effect of fermentation time on a low pH value of 3.98. As well as antibacterial testing can inhibit the growth of propionibacterium acne bacteria with the largest inhibition zone shown in the 7th day fermented extract at a concentration of 50% at 22.72 mm, a concentration of 75% is 22.99 mm, and a concentration of 100% is 25.97 mm.

Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Propolis Lebah Kelulut (Heterotrigona itama): Phytochemical Screening and Antioxidant Activity Test of Kelulut Bee Propolis (Heterotrigona itama) Ethanol Extract Debby Putri Mutiara Yusuf; Andi Tenri Kawareng; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Kelulut bee propolis (Heterotrigona itama) is one of the products produced by bees in the form of sap as a protective bee hive from predators and is commonly used by the community for treatment. This species also produces propolis more than stinging bees, but its potential has not been explored much. Purpose of this study was to determine the secondary metabolites and antioxidant activity of the ethanolic extract of kelulut bee propolis from Kutai Kartanegara. Propolis was extracted by maceration method using 96% ethanol solvent and evaporated and then carried out phytochemical screening and antioxidant activity test using the DPPH method (2,2-diphenyl-1-picrylhydrazil), ethanol extract of propolis was made in concentrations of 25 ppm, 50 ppm, 100 ppm, 500 ppm, 1000 ppm. The yield value of the propolis ethanol extract was 36% and the phytochemical test showed the presence of flavonoid, alkaloid and phenolic compounds and the IC50 value of the propolis extract was 282.92 ppm. This indicates that kelulut bee propolis containing these secondary metabolites has weak antioxidant activity.

Formulasi Sediaan Mouthwash Ekstrak Daun Sirih Hitam (Piper sp.) Terhadap Streptococcus mutans dan Candida albicans: Mouthwash Preparation Formulation of Black Betel Leaf Extract (Piper sp.) Against Streptococcus mutans and Candida albicans Deschania Noor Qhorina; Fajar Prasetya; Mirhansyah Ardana
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black betel (Piper sp.) contains compounds that function as antimicrobials, namely tannins, phenolic compounds, saponins, flavonoids, alkaloids, and steroids that can be used as active ingredients for making mouthwash. The purpose of this study was to determine the effective mouthwash formulation used as an antimicrobial. Antimicrobial testing method using well diffusion method with a reserve of 6 mm. Black betel leaf extract was dissolved with a variation of the concentration of glycerin 1:4; 1:8 and 1:12 and tested on Streptococcus mutans and Candida albicans bacteria, then tested for stability of the preparations, including organoleptic, pH and viscosity. The results obtained from various solvents were glycerin as the most stable solvent compared to 96% ethanol, tween 80 and aquades. The results obtained from the antimicrobial test with ANOVA analysis were for Streptococcus mutans bacteria p=0.004 (p<0.05) which means the p-value was significant between concentration variations and bacteria and for the fungus Candida albicans p=0.295 (p>0.05) which meant the p-value was not significant difference between concentration variations and fungi. The results of the evaluation test for the stability of the preparation, namely the organoleptic data, pH and viscosity at a temperature of 25ºC were relatively stable.

Evaluasi Penggunaan Obat Antiemetik pada Penderita Kanker Payudara Pasca Kemoterapi: Evaluation of Antiemetic Drugs Use in Breast Cancer Patients After Chemotherapy Dhea Amanda Sabilla Fauzi; Hajrah Hajrah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Data from the Ministry of Health Republic Indonesia in 2018 showed 42,100 women had breast cancer. Chemotherapy is the main choice of treatment for treating cancer, but it has several side effects, such as nausea and vomiting. The aims of this research, to identify characteristics breast cancer patient, classification risk of chemotherapy induce of nausea and vomiting also appropriate use of antiemetic to prevent chemotherapy side effect. Observational research had been use for this study with retrospective data collection based on patient medical records in January-December 2020. The results showed that breast cancer patients were women with age range of 46-55 years with percentage 38.1% and 33.33% had Body Mass Index (BMI) Obesity I. Combination of Antibiotics and Taxanes is the most widely used by 71.45% and has the most common risk classification of moderate nausea and vomiting. The most widely used antiemetic is a combination of 5-Hydroxitryptamine-3, Antagonists Histamine 2, and Dexamethasone. 96.2% compliance with antiemetic use was achieved and 3.8% was not achieved.

Evaluasi Penggunaan Antibiotik Secara Kuantitatif dan Kualitatif Pada Pasien Bedah Digestif di RSUD Abdul Wahab Sjahranie Samarinda: Quantitative and Qualitative Evaluation of Antibiotic Use in Digestive Surgery Patients at Abdul Wahab Sjahranie Hospital Samarinda Enjelina Natasya Sihite; Adam M. Ramadhan; Erwin Samsul
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antibiotics are drugs that are the most widely prescribed to treat bacterial infections. Prescription of high and not wise antibiotics has a detrimental impact: increasing antibiotic resistance. This study aimed to determine patient characteristics, quantity, and quality of antibiotic use in digestive surgery patients at Abdul Wahab Sjahranie Hospital Samarinda from January-December 2020. This study is a retrospective observational study with data collection techniques using the purposive sampling method. The results obtained 75 medical records, with the majority of the adults (26-45 years old) were 35 patients (48%), men were 45 patients (60%), length of stay 4-5 days were 30 patients (40%), private workers were 23 patients (30.7%), and type of disease appendicitis were 27 patients (36%). The most used antibiotic is ceftriaxone, which is 64.41 DDD/100 patient days, and antibiotics included in segment 90% were ceftriaxone and metronidazole. The quality of antibiotic use was 54.91% included in category 0 including ceftriaxone, metronidazole, cefpirom, and levofloxacin, category IIIB as 35.26% including ceftriaxone, metronidazole, cefpirom, and cefixime, category IIIA as 4.05% including ceftriaxone and metronidazole, the IVC category as 4.62% including ceftriaxone and cefixime, and IVA as 1.16% including metronidazole.

Pengujian Maksimal Penggunaan Ulang Masker Kain dengan Berbagai Jenis Bahan Baku Masker: Maximum Testing of Cloth Mask Reuse with Different Types of Mask Materials Eni Ayu Putri; Hajrah Hajrah; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Cloth masks are used as personal protective equipment from exposure to foreign particles in the air, the use of cloth masks while can reduce the number of medical mask waste number. Cloth masks in use need to be washed repeatedly, so it is necessary to know the effect of washing on the effectiveness and maximum duration of use. The purpose of this study was to determine the effectiveness of the use of cloth masks after going through a repeated washing process by looking at their characteristics and filtration ability in filtering bacteria. The experimental research method was carried out by making 3 types of cloth masks from different masks raw materials, cloth masks were washed 10, 20, 30, 40, and 50 times. Then it is characterized by looking at water absorption, steam filtration, translucency, and ability to filter Streptococcus aureus bacteria. The results showed that the average absorption capacity of the mask in the 10th wash was >60 seconds, while in the 50th washing it was <60 seconds. The results of the steam filtration test are only 4.5% of the masks that have changed characteristics. The results of the translucency test in the 10th wash were 7.4 ±1.67 lux while in the 50th washing the average was 11.4 ±1, 94 lux. The results of the bacterial mask filtering test in the 10th washing were 5.3±5.57 colonies, while in the 50th washing the average was 1.9±2.2 colonies. Based on the characteristic test and bacterial filtering test, there was no significant change in the three types of cloth masks in each wash so that the three types of cloth masks were still effective until the 50th washing. The conclusion is that the cloth masks made have the potential to be used by the public as an effort to prevent the transmission of infectious diseases.

Identifikasi Drug Related Problems Pada Pasien Congestive Heart Failure di Rumah Sakit “X” Balikpapan: Identification of Drug-Related Problems in Patients with Congestive Heart Failure at “X” Hospital Balikpapan Esa Wi Fatma; Nur Masyithah Zamruddin; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Heart failure is a condition where the heart fails to pump blood to meet the needs of the tissues. CHF patients are generally given at least 4 types of drugs, namely ACEIs, beta blockers, diuretics and digoxin. As a result, if it is not considered properly, it will be detrimental to the patient. This study is a non-experimental observational study with retrospective data collection on medical record data of patients who meet the inclusion criteria with the aim of knowing patient characteristics, knowing the description of drug use and knowing the incidence of DRPs in CHF patients at Hospital "X" Balikpapan. The results obtained from 106 patients, male patients were taller than female by 68 patients (64.15%), the highest age was in the late elderly category (56-65 years) as many as 40 patients (37.73%), the highest comorbid namely HHD 31 patients (29.24%), VES 16 patients (15.10%), renal insufficiency 13 patients (12.26%) and hypokalemia 13 patients (12.26%). The description of drug use in CHF patients included aspirin in 77 patients (72.64%), furosemide 62 patients (58.49%) and bisoprolol 49 patients (46.22%). The incidence of DRPs in the drug interaction category was 88 patients (83.01%), indicated without drugs 10 patients (9.43%), drugs without indications 4 patients (3.77%), inaccuracy of drug selection 2 patients (1.88%) , and failure to receive medication in 1 patient (0.94%), no incidence was found in the low dose, over dose and ADR categories.

Uji Toksisitas Ekstrak Berbasis Nades dari Daun Kadamba (Mitragyna Speciosa Korth) terhadap Mencit (Mus Musculus): Toxicity of Nades-Based Extract From Kadamba Leaf (Mitragyna Speciosa Korth) on Mice (Mus Musculus) Fauzan Afandi; Vita Olivia Siregar; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Traditionally, kadamba leaves have benefits for treating diarrhea, diabetes, pain, rheumatism, gout and have been scientifically proven to be antinociceptive and inhibit T47D breast cancer cells. This study aims to determine the toxicity of NADES-based extract from kadamba leaves by looking at the LD50 value and its effect on body weight and behavior of mice. The 15 mice used were divided into 5 groups with 3 mice in each group. The NADES-based extract from kadamba leaves was given orally with various doses of 4000 mg/KgBB, 8000 mg/KgBB, 16000 mg/KgBB, and 32000 mg/KgBB and one group was given a solvent. Each group was observed for 30, 60, 120, 180, and 240 minutes after administration of the extract and the observations were continued for 14 days to observe toxic symptoms, changes in body weight and death. Based on the results of the study, no deaths were found in the solvent group, 4000 mg/KgBB, and 8000 mg/KgBB. For the group with a dose of 16000 mg/KgBW, 2 mice died and the group with a dose of 32000 mg/KgBW found the death of 3 mice, so the LD50 value obtained was 14.256 g/KgBW which was included in the practically non-toxic category.

Optimasi Basis Formulasi Sediaan Handsanitizer Gel Ekstrak Daun Sirih Hitam (Piper betle var nigra) Sebagai Antibakteri: Optimization of the Hand Sanitizer Gel Preparation Base for Black Betel Leaf Extract (Piper betle var nigra) as an antibacterial Felina Alfiany; Novita Eka Kartab Putri; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black betel leaf (Piper betle var. nigra) is one of the plants that has the potential as an antibacterial. This research is a laboratory experiment and aims to determine the optimum concentration of hand sanitizer gel base which will then be used in the formulation of hand sanitizer gel preparations with the active ingredient of black betel leaf. Optimization was carried out for 7 days by looking at the physical properties of the gel preparation, namely organoleptic, homogeneity, pH test, viscosity, and spreadability test. Handsanitizer gel was made in three formulas with three different concentrations of Carbopol 940, namely A, B, and C. The results obtained in the evaluation of the organoleptic test were observed in clear color, semisolid dosage form and smelled of Carbopol 940. Homogeneity test was indicated by the absence of granules. rough on the preparation. The pH test is the pH of the gel preparation which is stable at pH 7. The dispersion test of 5-7 cm shows a semisolid consistency which is very comfortable to use. The viscosity test showed that the gel viscosity was in the range of 1,206 cps - 1,820 cps. The results of the evaluation of the optimum hand sanitizer gel base are obtained if it has good physical quality and meets the criteria for gel preparation. Based on the evaluation results on the optimization of the hand sanitizer gel base, it was obtained that the Carbopol 940 gel base with a concentration of A had met the criteria for making gel preparations.

Page 47 of 62 | Total Record : 612

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Home Page

OAI Link

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Contact Name Rolan Rusli

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Phone +6285222221907

Journal Mail Official admin@farmasi.unmul.ac.id

Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location Kota samarinda, Kalimantan timur INDONESIA

Abstract

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Abstract

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Abstract

Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA