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Adhar Arifuddin
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Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Published by Universitas Tadulako
ISSN : 24078441     EISSN : 25020749     DOI : https://doi.org/10.22487
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) merupakan media komunikasi dan publikasi ilmiah di bidang ilmu kesehatan yang diterbitkan oleh Unit Penjaminan Mutu Fakultas Kedokteran Universitas Tadulako yang. Jurnal ini terbit secara berkala 4 kali dalam setahun (Januari, April, Juli dan Oktober). Jurnal Tadulako Sehat diterbitkan pertama kali pada tahun 2015. Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) menerima dan menerbitkan artikel penelitian, tinjauan pustaka dan laporan kasus di bidang kedokteran dan kesehatan.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 20 Documents
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Search results for , issue "Vol. 11 No. 3 (2025)" : 20 Documents clear
Characteristics of Hypertension Patients at Lanto Dg Pasewang Jeneponto Regional General Hospital 2022-2023 Saputra, Muh Farhan; Royani, Ida; Hamzah, Pratiwi Nasir; Harahap, Muhammad Wirawan; Tahir, Akina Maulidhany
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1718

Abstract

Background: Cardiovascular diseases, including hypertension (blood pressure >/140/90 mmHg), contribute to heart and vascular damage. Risk factors include non-modifiable factors (age, gender, family history) and modifiable factors (smoking, behavior, alcohol). Objective: This study aimed to identify the characteristics and risk factors of hypertensive patients at RSUD Lanto DG Pasewang Jeneponto. Methods: A descriptive study using secondary data from medical records of hypertensive patients at RSUD Lanto DG Pasewang Jeneponto was conducted in September 2024. Data were analyzed descriptively by age, gender, hypertension grade, body mass index (BMI), and comorbidities. Results: A total of 93 patients were included. Most patients were aged 61–70 years (31.2%), followed by 51–60 years (26.9%). Females (59.1%) were more affected than males (40.9%). The majority (92.5%) had grade 2 hypertension. Based on BMI, 63.4% were normal, 21.5% overweight, and the rest underweight, obese, or grade 2 obese. Comorbidities included heart disease (76.3%), diabetes (14%), and kidney failure (9.7%). Conclusion: Most hypertensive patients at RSUD Lanto DG Pasewang Jeneponto were aged 60–70 years, female, had normal nutritional status, grade 2 hypertension, and a history of heart disease.
Risk Factors for the Incidence of Cholelithiasis at Ibnu Sina Makassar Hospital for the 2021-2023 Period Yusuf, Awalia Rezeki S; Bamahry, Aryanti R; Yanti, Andi Kartini Eka; Gani, Aziz Beru; Kanang, Indah Lestari Daeng
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1721

Abstract

Background: Cholelithiasis is an important health problem with severity and septic complications related to the type of gallstone. Several risk factors also influence the incidence of cholelithiasis. Objective: This study aims to determine the distribution of cholelithiasis patients based on gender, Body Mass Index (BMI), age, childbearing age in women, triglyceride levels, and total cholesterol levels at Ibnu Sina Hospital Makassar in the period 2021 to 2023. Method: This type of research is descriptive using a Cross Sectional Study approach, namely explaining the risk factors for the incidence of cholelithiasis at Ibnu Sina Hospital Makassar. Results: The distribution of cholelithiasis patients at Ibnu Sina Hospital Makassar in 2021-2023 shows that the risk factors are mostly female, overweight/obesity, age >40 years, hypertriglyceridemia, and hypercholesterolemia. However, women of childbearing age suffer less from cholelithiasis than older women. Conclusion: Cholelithiasis at Ibnu Sina Hospital Makassar in 2021-2023 is more common in women, >40 years of age, overweight/obesity, hypertriglyceridemia, and hypercholesterolemia, with a lower incidence in women of childbearing age compared to old age.
Literature Review: The Effect of Extra Virgin Olive Oil (Olea europaea L.) on Pseudomonas aeruginosa Bacteria Domu, Anugrah Julistiar Aksan; Syamsu, Rachmat Faisal; Karim, Marzelina; Hadi, Santriani; Arfah, Arni Isnaini
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1722

Abstract

Background: Olive oil, especially Extra Virgin Olive Oil (EVOO), which contains polyphenols and phytochemical compounds such as flavonoids and oleuropein, has long been utilized to enhance human health and exhibits potential antibacterial activity against Pseudomonas aeruginosa, an opportunistic pathogenic bacterium often responsible for severe infections and resistance to various antibiotics. Objective: To investigate the antibacterial properties of extra virgin olive oil (Olea europaea L.) against Pseudomonas aeruginosa. Method: A literature review study obtained from the internet, including theses, journals, textbooks, and e-books. The databases used were Google Scholar, Elsevier, ScienceDirect, and PubMed NCBI. Results: Extra Virgin Olive Oil (EVOO) demonstrates antibacterial activity against Pseudomonas aeruginosa based on findings from 10 journals. Bioactive compounds such as polyphenols, oleuropein, and hydroxytyrosol are effective against Pseudomonas aeruginosa through mechanisms that include inhibiting quorum sensing, damaging the cell wall, increasing membrane permeability, and inhibiting biofilm formation and virulence factors. Olive leaf extract and combinations with nanoparticles further enhance antibacterial effectiveness against resistant strains, making EVOO a potential natural antibacterial agent. Conclusion: Olive oil, particularly Extra Virgin Olive Oil (EVOO), contains bioactive compounds such as oleacein, oleocanthal, polyphenols, flavonoids, oleuropein, and hydroxytyrosol, which exhibit significant antibacterial activity against Pseudomonas aeruginosa.
PD-1 and PDL-1 Immune Checkpoint Inhibitors: Emerging Hope for the Future of Lung Cancer Immunotherapy Ilyasa, Muhammad Riza; Ramadhani, Muhammad Zulmi; Santoso, Rex Jeremy; Hutasoit, Gina Andyka; Miskad, Upik Anderiani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1723

Abstract

Background: Lung cancer is the leading cause of cancer-related deaths worldwide, with Non-Small Cell Lung Cancer (NSCLC) being the most common type. Despite advances in treatment, the prognosis remains poor. Immune checkpoint inhibitors targeting PD-1 and PD-L1 have emerged as a promising first-line treatment approach in combating cancer. Objectives: This literature review aims to evaluate the effectiveness of PD-1 and PD-L1 immune checkpoint inhibitors in the treatment of NSCLC. It also explores the potential of these inhibitors to improve patient survival rates compared to conventional therapies. Methods: A systematic literature search was conducted using databases such as PubMed, Google Scholar, ScienceDirect, and NCBI, with keywords including "PD-1," "PD-L1," "NSCLC," "lung cancer," and "immunotherapy." Results: All four inhibitors significantly improve survival rates compared to traditional chemotherapy. Atezolizumab and pembrolizumab show high effectiveness in patients with high PD-L1 expression. Durvalumab, when combined with chemotherapy, overcomes resistance mechanisms. Nivolumab, enhancing survival rates. Conclusion: PD-1 and PD-L1 inhibitors provide substantial benefits in the treatment of NSCLC, including increased survival rates and reduced need for aggressive therapies. Further research should focus on optimizing combination therapies to expand the therapeutic benefits of these inhibitors.
Description of Appendicitis Patients Post-Appendectomy at Prof. Dr. H. Aloei Saboe Hospital Gorontalo in 2023 Aryaputra, fadhil; Abdul, Romy; Antu, Yuniarty; Siregar, Muchtar Nora Ismail; Kasim, Vivien Novarina A
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1731

Abstract

Background: Appendicitis is an acute or chronic inflammation of the appendix caused by obstruction of the lumen. According to the World Health Organization (WHO), appendicitis ranked eighth as a global cause of death in 2014. Objective: To describe the characteristics of post-appendectomy appendicitis patients at Aloei Saboe Hospital, Gorontalo, in 2023. Methods: A retrospective descriptive study was conducted in June–August 2024 at Aloei Saboe Hospital, Gorontalo. The population included appendicitis patients who underwent appendectomy between January–December 2023. Using purposive sampling, 98 patient medical records were analyzed. Data were described based on gender, age, and surgical procedure. Results: Most patients were female (64.3%). The highest age distribution was late adolescence (17–25 years) at 39.8%. The most frequent surgical technique performed was open appendectomy (53.1%), followed by other procedures. Conclusion: At Aloei Saboe Hospital, the majority of post-appendectomy appendicitis patients were female, predominantly in late adolescence, with open appendectomy being the most common surgical method. These findings are expected to provide useful information and education for individuals with high-risk factors for appendicitis.
Different Sepsis Patient Outcomes Due to Multidrug-Resistant Organisms (MDRO): A Study of Empirical Antibiotic Sensitivity Test Results Fadrian, Fadrian; Ahmad, Armen; Harvindra, Astrid; Putri, Vidola Yasena
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1740

Abstract

Background: Sepsis, a severe immune response to infection, has a concerning global mortality rate of 85%, predominantly due to Gram-negative bacteria. The rise of antibiotic resistance in these organisms complicates treatment, leading to higher mortality and prolonged hospital stays. Effective empirical antibiotics can mitigate these outcomes. Objective: This study compares outcomes of sepsis patients infected with multidrug-resistant organisms (MDRO) based on empirical antibiotic sensitivity testing, focusing on mortality and length of stay (LOS) within 14 days of sepsis onset. Methods: A prospective cohort observational study at Dr. M. Djamil General Hospital included 94 participants. Patients who died within 14 days were excluded from the LOS analysis to prevent bias. Initial assessments included culture sampling and organ dysfunction. Results: The study revealed no significant difference in mortality based on antibiotic sensitivity (p=0.283), but the LOS was significantly shorter in those treated with sensitive antibiotics (p<0.016). Conclusion: LOS was significantly affected by antibiotic sensitivity, with patients receiving effective antibiotics experiencing shorter stays, though mortality differences were not statistically significant in the 14-day window
Characteristics of Osteoarthritis Genu Patients at Ibnu Sina Hospital Makassar Based on Clinical Manifestations, Body Mass Index, and Radiological Imaging Aisyah, A Aidha Nurul; Nurmadilla, Nesyana; Syahruddin, Febie Irsandy; Putra, Fadil Mula; Rahmawati, Rahmawati
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1748

Abstract

Background: Knee osteoarthritis is a major cause of chronic pain and disability in the elderly. Obesity is a key risk factor, as excess body weight increases pressure on knee joints. Clinical and radiological assessments are essential to determine disease severity. Objective: To describe the characteristics of knee osteoarthritis patients at Ibnu Sina Hospital Makassar during 2023–2024 based on clinical manifestations, body mass index (BMI), and radiological imaging. Methods: A descriptive cross-sectional study was conducted using medical records of 63 patients with knee osteoarthritis. Variables analyzed included clinical manifestations, BMI, and radiological grading. Results: Of 63 patients, most (50.8%) presented with bilateral knee pain as the main complaint, while 25.4% experienced knee swelling. BMI analysis showed that the largest proportion of patients were in obesity class I (30.2%). Radiological imaging revealed that 41.3% were classified as grade II according to the Kellgren and Lawrence criteria. Conclusion: Knee osteoarthritis patients at Ibnu Sina Hospital Makassar were predominantly characterized by bilateral knee pain, obesity class I, and grade II radiological severity. Interventions such as weight management, physiotherapy, and public education on joint health are important to reduce risk and slow disease progression
The Correlation Between Knowledge of Pregnant Women and the Incidence of Anemia in Pregnancy in the Working Area of Puskesmas Nagrak Susanti, Elsa; Novryanthi, Dhinny; Andriani, Ria
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1750

Abstract

Background: Anemia in pregnancy is a global health issue with a prevalence of 48.9% in Indonesia (Riskesdas, 2018). This condition is influenced by iron deficiency (50% of cases), dietary patterns, and socioeconomic factors. Previous studies indicate a correlation between maternal knowledge and anemia incidence, yet research in the Puskesmas Nagrak area remains limited. Objective: To identify the relationship between pregnant women's knowledge and anemia incidence in the working area of Puskesmas Nagrak. Methods: A quantitative cross-sectional study involving 70 pregnant women in trimesters 1-3. Data were collected using Guttman-scale questionnaires and secondary data from maternal health records. Chi-Square test (a=0.05) was used for analysis. Results: 52.9% of respondents had anemia (Hb<11 g/dL). Women with low knowledge (38.6%) showed the highest anemia risk (p<0.000). Education level (57.1% junior high graduates) and occupation (92.9% housewives) significantly contributed. Conclusion: Knowledge level significantly affects anemia incidence. Community-based health education interventions are recommended to improve immunization coverage and Fe tablet consumption.
The Relationship Between Knowledge, Attitude, and Behavior Factors With the Implementation of Smoke-Free Areas in the Campus Environment: Literature Review Putri, Hanan Aliya; Umaroh, Ayu Khoirotul
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1751

Abstract

Background: The prevalence of smoking among Indonesians aged >/ 15 years was 36.3% in 2013 and decreased to 33.8% in 2018 (Riskesdas). The Smoke-Free Area (SFA) policy aims to minimize the adverse health impacts of smoking. Compliance in campus settings requires the academic community to follow regulations, such as refraining from smoking in designated SFA zones. Objective: To identify significant factors knowledge, attitudes, and behaviors associated with compliance to the SFA policy in the campus environment. Methods: A literature review was conducted following the PRISMA approach, using databases including Google Scholar, PubMed, and ScienceDirect. Inclusion criteria were full-text articles, quantitative cross-sectional studies with bivariate analysis, published in Indonesian or English between 2013–2023. Results: Four eligible articles were reviewed. Two focused on knowledge as a factor, two on attitudes, and one on behaviors influencing compliance. Findings indicate that higher knowledge levels, positive attitudes, and supportive behaviors contribute to improved adherence to SFA implementation in campuses. Conclusion: Knowledge, attitudes, and behaviors are significant factors in enhancing compliance with SFA policies. Promoting awareness and cultivating positive behavioral changes among the academic community can strengthen the success of smoke-free campus initiatives
Spatial Pattern Analysis and Determinants of Stunting Prevalence in Central Sulawesi, Indonesia: Using Linear Regression, Local Moran’s I, and Random Forest Approaches Arifuddin, Adhar; Fauzan, Achmad; Hakim, Raden Bagus Fajriya; Nur, A Fahira
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1863

Abstract

Background: Stunting remains a significant public health issue in Indonesia, particularly in Central Sulawesi, where socio-economic and environmental factors contribute to its prevalence. Understanding these determinants is crucial for effective intervention strategies. Objective: This study aims to analyze the spatial distribution and predictors of stunting prevalence in Central Sulawesi, focusing on socio-economic and environmental factors. Methods: An observational design was employed, utilizing secondary data from the Central Sulawesi Provincial Health Department. Spatial analysis, including Moran’s I and Local Moran’s I, assessed spatial autocorrelation and identified outliers. Regression analysis and Random Forest modeling examined predictors of stunting prevalence. Results: The study found significant spatial clustering in stunting prevalence. Key socio-economic factors identified were maternal education and household income, with poverty being the most influential predictor. Random Forest analysis highlighted sanitation and access to health facilities as important, although access to clean water did not show a significant effect. Conclusion: The findings provide valuable insights into the socio-economic determinants of stunting and emphasize the need for targeted, comprehensive intervention strategies focusing on improving maternal education and addressing poverty, along with enhancing healthcare access in Central Sulawesi

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