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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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ANALISIS KINERJA APOTEK AVICENA MENGGUNAKAN PENDEKATAN BALANCED SCORECARD DENGAN ANALISIS SWOT Eka Hayati Rhomah; Titik Sunarni; Ika Purwidyaningrum
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.997

Abstract

The concept of BSC can be used as performance evaluation tool . The purpose of this study is to analyze the performance of Pharmacy in BSC perspectives and determine the strategic map using SWOT method. This research is non-experimental research with a descriptive design. Performance on the BSC. The results of performance measurements are combined with SWOT analysis to determine the strategy map. The results showed the value of TOR, ROI and Nett Profit Margin have not met the standard. Dispensing time meets the standards; Based on the SWOT analysis, the strategy map prepared prioritizes strengthening perspective of learning and growth to improve the quality of pharmaceutical services so can increase customer and revenue growth.
UJI AKTIVITAS OBAT HERBAL GEL EKSTRAK DAUN GAHARU (Gyrinops versteegii (Gilg.) Domke) TERHADAP LUKA DIABETES PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Silvi Nurafni; Antonius Padua Ratu; Tia Marliana; Ega Rahmawati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.1002

Abstract

A study to test the activity of gel extract of gaharu (Gyrinops versteegii (Gilg.) Domke) leaf extract against diabetic wounds in male white rats (Rattus norvegicus). The research was conducted experimentally with the method of pre-test and post-test with group design. Gaharu leaf extract gel was formulated with concentrations of 4%, 6% and 8% and then tested for its activity on non-diabetic male white rats and diabetic male rats with alloxan induction. The negative control was given gel base and the positive control was given bioplacenton gel. The gel was administered once a day and the wound length was measured every day for 14 days. The results showed that all gel formulas of gaharu leaf extract had wound healing activity in non-diabetic rats and diabetic rats, the higher the concentration of the extract, the faster the wound healing and the greater the percentage reduction in wound length. The group of non-diabetic rats treated with gaharu extract gel with a concentration of 8% showed a wound length of 0,00 ± 0,00 mm (wound healed) on day 6 with an average percentage reduction in wound length of 100,00 ± 0,00 %. The results of statistical testing with Kruskal Wallis obtained p-value > 0.05 (p-value = 0.315) so it can be concluded that there was no significant difference between the treatment groups.
PENGENDALIAN PERSEDIAAN VAKSIN PADA DINAS KESEHATAN KABUPATEN HULU SUNGAI SELATAN Marliza Noor Hayatie; Muhammad Aditya Aitama
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.1015

Abstract

In the case of vaccination in Indonesia, the problem that often occurs is the shortage of vaccine supplies in one area while in other areas there is a problem of excess vaccine supply which results in the accumulation of goods in warehouses. The purpose of this study is to determine which type of vaccine is more widely used in the community so that there is no excess or shortage of supplies. This study uses the Activity Based Costing (ABC) inventory control analysis method to determine which vaccine is more priority and which is more widely used in Hulu Sungai Selatan Regency. The type of data used in this study is quantitative data, namely data on entry and expenditure of vaccine supplies in 2021 at the Hulu Sungai Selatan District Health Office. The data source used is secondary data with documentation collection techniques. Based on the results of research using the ABC method, the stock of vaccine types that are more prioritized for use by the community is the type of group A vaccine, namely with 2 types of vaccines, namely Sinovac 1 ml and Sinovac 5 ml.
UJI TOKSISITAS KITOSAN CANGKANG KERANG BULU (Anadara antiquata) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Nadila Indra Sepvina; Ridwanto Ridwanto; Zulmai Rani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.1023

Abstract

Shellfish is one of Indonesia's fishery commodities which is increasing every year, one of which is blood clams and feather shells, which are easily found in Southeast Asia and East Asia. Shellfish also have great potential so that it has an impact on the increasing waste that is allowed to accumulate without any handling of the pollution that exists in the environment and society. One alternative to the use of waste from feather shells to have a high use value is to isolate it into chitosan. The purpose of this study was to investigate the utilization of shellfish waste into chitosan and to determine the LC50 value of the chitosan produced. The analysis carried out was the toxicity test of chitosan from shellfish shell waste on Artemia salina Leach shrimp larvae using the Brine Shrimp Lethalitiy Test (BSLT) method with various concentrations of 100; 250; 500; 750; and 1000 µg/mL, and determining the value of LC50 by probit analysis. Based on the results of the toxicity test of chitosan from shellfish waste, the LC50 value was µg/mL. These results indicate that chitosan from shellfish waste has no toxic effect on Artemia salina Leach shrimp larvae.
AKTIVITAS ANTIOBESITAS DAN ANTIINFLAMASI EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus (L.) Merr) PADA TIKUS WISTAR JANTAN OBESITAS Aulia Nurfazri Istiqomah; Hendra Mahakam Putra; Widhya Aligita; Betti Risa O
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.1059

Abstract

Obesity is currently a disease with a prevalence that continues to increase every year and is a significant risk factor for cardiovascular disease. The relationship between obesity and inflammation is characterized by increased levels of TNF- which triggers inflammation. This study was conducted to determine the activity of katuk (Sauropus androgynus (L.) Merr) leaves as anti-obesity and anti-inflammatory properties. The study was conducted with a preventive method on white male wistar rats aged 2-3 months and body weight of 180-200 g. The test animals were divided into 6 groups that were induced by high-fat and carbohydrate diets except the normal group and were measured for anti-obesity and anti-inflammatory parameters. The results showed that katuk (Sauropus androgynus (L.) Merr) leaves can maintain activity as an anti-obesity and anti-inflammatory in test rats. Katuk leaf ethanol extract at a dose of 300 mg/kgBW has an effective activity as an anti-obesity, while at a dose of 150 mg/kgBW it has an anti-inflammatory activity.
PENGARUH EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUZ) DALAM MENGHAMBAT DEGRANULASI SEL MAST DAN MENCIT PUTIH JANTAN YANG TERSENSITISASI AKTIF Relin Yesika; Meiridha Mutiara A.
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type I hypersensitivity reactions, also known as allergic reactions or anaphylactic reactions. The mechanism of anaphylaxis involves the release of mediators from mediator cells. The degranulation of mast cells and basophils causes an exaggerated immune response and causes the signs and symptoms of anaphylaxis. Red dragon fruit peel contains secondary metabolites such as triterpenoid flavonoids and steroids. This study was an in vitro study of the ethanol extract of red dragon fruit peel (Hylocereus polyrhizuz) on the mast cells of male white mice induced by antigen. Five variations of the concentration used are 25; 50; 100; 200; 400 µg/mL. The percentage of mast cell degranulation by red dragon fruit peel extract at concentrations of 25; 50; 100; 200 dan 400 µg/mL is 75.27; 69.05; 64.04, 56.61; 45.17; dan 27.88%. There Red dragon fruit peel extract had a significant effect in inhibiting mast cell degranulation (p<0.05).
FORMULASI & EVALUASI FISIK GRANUL EFFERVESCENT KOMBINASI EKSTRAK ETANOL 70% BUNGA ROSELLA (Hibiscus sabdariffa L.) & BUNGA TELANG (Clitoria ternatea L.) SEBAGAI ANTIOKSIDAN Wahyudin Bin Jamaludin; Nadia Masytoh; Eka Fitri Susiani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1065

Abstract

Rosella (Hibiscus sabdariffa L.) and telang flower (Clitoria ternatea L.) contain anthocyanins which have antioxidant, so the researchers combined to use as effervescent granules. This study aims to determine the characteristics, and the antioxidant activity of effervescent granule combination of rosella and telang flower extract. Antioxidant activity testing using DPPH. The antioxidant activity of the combined thick extract was obtained ???????? 50 7.5 ppm, after that it was made into an effervescent granule preparation in 4 formulas. The resut show that all formulas had a characteristic taste of almost uniform color, dark turquoise. In all test formulas for water content, the results obtained are 1.68%-2.82%, compressibility index 11.641%-16%, angle of repose 31.2º-34.43º, flow time 6.25-6.83 seconds, dissolving time 208 -257 seconds and pH 6.2-6.6. The results of the antioxidant activity of effervescent granules revealed ???????? 50 of 62,628 ppm (strong).
OPTIMASI FORMULA HAIR TONIC MIKROEMULSI BIOTIN (VITAMIN B7) DENGAN METODE FACTORIAL DESIGN Fauziyyah Al Hasanah; Gunawan Pamudji Widodo; Endang Dyah Ikasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1071

Abstract

Loss becomes a problem in the hair that causes baldness. Biotin is a vitamin that nourishes hair and prevents hair loss. Biotin which is formulated in microemulsion tends to be transparent, has low viscosity and high solubility. Formula optimization was carried out to determine the concentration of span 80, tween 80, and PEG 400 in biotin microemulsion hair tonic. The research was conducted on an experimental basis using a factorial design method with 3 factors, namely span 80, tween 80, and PEG 400. The optimum microemulsion formula was determined using Design Expert 13 software using the Factorial Design method. Testing the physical quality of the preparation is carried out at the optimum formula. Optimization of biotin microemulsion hair tonic showed results of span 80 (20%), tween 80 (9.466%) and PEG 400 (5%) with a predicted viscosity of 46.75 cPs and globule size of 2.98 µm. Prediction testing and test results compared to the One Sample T-test showed results that were not significantly different with a significance value of >0.05. The optimum formula has a viscosity value of 47.67 cPs and a globule size of 2.4 µm. The results obtained concluded that the optimal composition composition of the biotin microemulsion formula from the combination of span 80, tween 80 and PEG 400 which produces hair tonic with good effects and physical quality is span 80 20%, tween 80 9.47% and PEG 400 5%.
KARATERISTIK ENKAPSULASI LIPOSOM EKSTRAK SUPEROKSIDA DISMUTASE (SOD) Bacillus altitudinis Nurfitriyawatie Nurfitriyawatie; Ana Indrayati; Rizal Maarif R.
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Photoaging causes the dermis and collagen fibers to decrease which results in skin aging. Genus Bacillus has SOD activity as an anti-photoaging agent that can neutralize ROS (Reactive Oxygen Species) due to exposure to UV-A rays. This study aimed to examine the activity of crude extract and the encapsulation characteristics of liposomes from B. altitudinis. The study began with the isolation of the SOD enzyme, determination of the total protein content of the crude extract of the SOD enzyme and liposome encapsulation, then characterization liposome tes including particle size analysis, sorption efficiency and zeta potential. The results of the crude extract activity test were 85.09% ± 1.24%. The characteristic test was produced with a size of 112.96 ± 17.3 ; the adsorption efficiency was 81.1% and the zeta potential was 7.0 ±5.1 mV. The results showed that the SOD B. altitudinis liposomes were in the nanoparticle range.
STUDI IN SILICO PEMBENTUKAN KOKRISTAL MELOXICAM DENGAN BERBAGAI KOFORMER PERBANDINGAN (1 : 1) Yuli Ainun Najih; Farizah Izazi; Siswandono Siswandono; Bella Anggraini Putri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cocrystal is one form of modification in increasing the solubility of meloxicam which is included in Biopharmaceutics Classifications System (BCS) II. Cocrystal is a multicomponent system with a stoichiometric ratio between the active ingredient and the coformer which are bound in the crystals lattice to form hydrogen bonds. Design of new drugs can be done through an in silico program to optimize the parent compound before the synthesis of derivative compounds. This study aims to predict which coformers are most stable in the formation of crystals. Cocrystal formation is done by drawing a two-dimensional structure from meloxicam and coformer using ChemBioDraw Professional 16.0 software from CambridgeSoft®. The prediction will result in the amount of bond energy formed between meloxicam with coformer. The smaller the bond energy, the more stable the meaning of the bond. The smaller the bond energy formed, the more stable the bond is. Stable bonds have a high probability of forming cocrystals meloxicam. Hydrogen bonds occur between hydrogen atoms and other atoms that have high electronegativities such as O and N atoms which have lone pairs of electrons. This electronegativity difference makes H atoms tightly bound to O and N atoms so that the hydrogen bonds in the meloxicam cocrystal are tightly bound and stable. From the results of the study showed that the most stable coformer can form cocrystals with a small bond energy that can produce bonds with meloxicam, namely urea.

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