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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK BUAH MAHKOTA DEWA (Phaleria macrocarpa) DENGAN EKSTRAK HERBA MENIRAN HIJAU (Phyllantus niruri Linn.) TERHADAP PERTUMBUHAN Staphylococcus aureus Aulia Rahmah Triastanti; Putri Vidiasari Darsono; Siti Malahayati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1101

Abstract

S.aureus infection was found to be around 5%-35% and cases of S.aureus resistance increased by 22.8% due to people being less compliant in treatment. One of the preventions of resistance is to return to the use of natural materials, especially plants that have been scientifically and empirically proven, one of which is Mahkota Dewa Fruit (Phaleria macrocarpa) and Green Meniran Herb (Phyllanthus niruri L.). The study was conducted using the True Experimental method using S.aureus bacteria. 3 treatment groups were used, namely positive control (Amoxicillin), negative control (DMSO), as well as Mahkota Dewa extract (Phaleria macrocarpa) and Green Meniran Extract (Phyllanthus niruri L.). Using the disc diffusion method and the dilution method to determine the magnitude of the inhibition zone, the value of MIC, and MBC. The extract of the Crown of God Fruit, The Green Meniran Herb, as well as the combination of the two extracts have successive bacterial inhibitory power with an average of 18.02 mm; 15.95 mm; and 15.09 mm against S.aureus. Testing by the dilution method obtained a KHM value of 60% (0.06g/mL) in each extract. KBM is not obtained in each extract.
AKTIVITAS ANTIHIPERTENSI EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R.Forst. & G.Forst.) PADA MODEL HEWAN HIPERTENSI YANG DIINDUKSI PREDNISON DAN NaCl Kharina Septi Lestari; Elis Susilawati; Aulia Nurfazri Istiqomah; Silvi Nur Amalia; Widhya Aligita
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1103

Abstract

Hypertension is a disease without symptoms that is very dangerous (silent killer) because it is often not realized. Conditions that are not controlled and occur continuously will cause a disease factor related to cardiovascular disease. Empirically, matoa leaves are commonly used as antihypertensive drugs. This study aims to determine the activity of the ethanolic extract of matoa leaves as a diuretic and antihypertensive. Diuretic testing was carried out for 6 hours with urine volume measurement every hour. Each test animal was given warm water as a loading dose, using a comparison (Furosemide 3.6 mg/KgBW) and the matoa leaf ethanol extract test group with doses of 150, 300, and 500 mg/KgBW. Antihypertensive testing was carried out in a preventive manner using Prednisone 1.5 mg/KgBW and NaCl 2%, comparison (Hydrochlorothiazide 2.25 mg/KgBW) and the test group ethanol extract of matoa leaves with doses of 150, 300, and 500 mg/KgBW. given orally for 14 days. The test parameters were urine volume, systolic blood pressure and diastolic pressure. The data obtained were analyzed using One Way ANOVA and Kruskall Wallis. The results showed that the ethanol extract of matoa leaves could increase urine output, and decrease systolic and diastolic blood pressure because it had a comparable activity with the comparison group (p<0.05). A dose of 150 mg/kgBW has the most effective activity as an antihypertensive.
LETHAL CONCENTRATION OF Saussurea costus WITH BRINE SHRIMP LETHALITY TEST METHOD Dhigna Luthfiyani Citra Pradana; Hany Yusmaini; Erna Harfiani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The safety of using herbal plant extracts is essential for COVID-19 patients who consume herbal plants daily to increase immunity and overcome the symptoms of the disease. One of the herbal plants used by the community in COVID-19 therapy is Qusthul Hindi (Saussurea costus). The public needs to know the safety of these herbal remedies when consuming them. Therefore it is essential to conduct a toxicity test of Hindi Qusthul extract. Secondary metabolite compounds present in plant extracts can be tested for toxicity in vitro using the Brine shrimp lethality test (BSLT) method using Artemia salina Leach larvae to determine LC50 values. The BSLT method is used to determine biological activities in extract plants, such as cytotoxic activity, phototoxic, enzyme inhibition, and ion regulation, using Artemia salina Leach shrimp larvae as bioindicators. The BSLT method is carried out by observing the mortality rate in Artemia salina Leach shrimp larvae which are given extracts from plants and then incubated for 1x24 hours. The results obtained from this study as an LC50 (Lethal concentration) value of 532.78 ppm. LC50 (Lethal Concentration) value of 532.78 ppm indicates that the concentration of the compound can cause death in Artemia salina Leach by as much as 50%.
OPTIMASI SODIUM LAURIL SULFAT DAN NATRIUM CHLORIDA PADA SABUN CAIR EKSTRAK LIDAH BUAYA: SIMPLEX LATTICE DESIGN I Gusti Ngurah Agung Windra Wartana Putra; Ni Made Maharianingsih Maharianingsih; I Gusti Rai Widowati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1169

Abstract

This study aims to determine the concentration of SLS and NaCl which can produce the best formula of aloe vera extract liquid soap (Aloe vera L.). The method used in this study is the Simplex Lattice Design method. Eight formulas were made with different concentrations of SLS and NaCl, then the parameters of viscosity, specific gravity, foam resistance, and pH were determined. The data obtained was tested with one sample t-test to see the difference between the software's design expert predicted results from the optimization method and the results of laboratory tests. From the results of testing the 8th parameter of the formula, the formula that has the closest desire ability value to 1 was chosen as the optimum formula, namely at a concentration of 180 g of SLS and 65 g of NaCl. From this formula, a one sample t test was carried out between the software's predicted value and laboratory parameter values. The significant values ​​obtained for the parameters of viscosity, specific gravity, foam resistance and pH were 0.570; 0.245; 0.882; 0.069. which means there is no difference in parameter values ​​between the software and the laboratory. It can be concluded that the formula with a variation of SLS of 180 g and NaCl of 65 g is the best formula in the formulation of aloe vera extract liquid soap which produces values ​​that meet quality requirements such as viscosity of 3270 Cp, Specific Weight of 1.079 g/ml, foam resistance of 67%, and pH value 6.73.
PROFIL PENGETAHUAN DAN PERSPEKTIF HIPNOTERAPI DI KALANGAN MASYARAKAT WILAYAH SURABAYA Fauziyyah Syandria Afrisa; Amara Damayanti; Mutmainnah Mutmainnah; Shabrina Insan Nabil; Luthfia Andini Nathaneila; Febri Zalfa’ Pratama; Avif Muhammad Zaki Hidayat; Reza Fahlevy Firmansyah Putra; Alwiyah Alwiyah; Abdul Rahem
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1259

Abstract

Hypnotherapy is an alternative and complementary therapy or non-pharmacological therapy that uses hypnosis as a suggestion of the human unconscious. Many people are negative about hypnotherapy and do not know that it has many benefits. The purpose of this study is expected to increase knowledge and change people's perspectives on hypnotherapy treatment. This study is a cross sectional study with non-random sampling (accidental sampling) techniques with research instruments in the form of online questionnaires and spread leaflets. The study was 108 respondents, with 108 respondents meeting the inclusion criteria. The results of the knowledge study showed 38.0% with good knowledge, 46.3% of respondents with sufficient knowledge and 15.7% of respondents with low knowledge and results at perspective showed 18% of respondents were positive, and 82% were negative. Based on the results of the respondents' knowledge and perspective, there is a need for an introduction to hypnotherapy treatment to prevent misperception among the people of Surabaya.
EFEKTIVITAS PENYULUHAN PENGETAHUAN MENGENAI SKABIES PADA WALI SANTRI PONDOK PESANTREN DARUS SALAM TORJUN, SAMPANG Muhammad Za'im Munif; Garuda Nusantara Putra Utomo; Lynda Rossyanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1260

Abstract

Increased knowledge about scabies not only needed to be given to students at the schools, but also to the families for minimizing contact with their children whose suffering scabies when they return home. One way to increase knowledge about scabies among the students’ family is to provide them with counseling. The purpose of this study was to evaluate the effectiveness of counseling on scabies to the students’ family of the Pondok Pesantren Darus Salam Torjun, Sampang. This research is a quasi-experimental type with a one group pretest and posttest design which was carried out at Pondok Pesantren Darus Salam Torjun, Sampang on July 11, 2022 to August 1, 2022. 52 participants were obtained using purposive sampling. The research instrument used for this study was a questionnaire containing 15 valid and reliable questions about scabies. The statistical test used was the Wilcoxon test because the pretest and posttest data were not normally distributed. The results of statistical tests showed that there was a difference between the results of the pretest and posttest (p=0.000). The conclusion of this study is that counseling about scabies to the students’ family of the Pondok Pesantren Darus Salam Torjun, Sampang showed effective results.
FORMULASI GEL HAND SANITIZER EKSTRAK DAUN PALIASA (Kleinhovia hospita Linn) DENGAN GELLING AGENT HPMC Yetri Elisya; Wardiyah Wardiyah; Junaedi Junaedi; Farah Hamidah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1268

Abstract

Gel hand sanitizer is a novel product formula that can be utilized as a cost-effective and portable replacement for hand washing soap. One of the plants whose leaves can be used as a central component of hand sanitizer gel is the Paliasa plant (Kleinhovia hospita Linn). Staphylococcus and Escherichia coli resist the antimicrobial effects of alkaloids, tannins, and saponins. To create the hand sanitizer gel, three different concentrations of the HPMC gelling ingredient were used: 1%, 2%, and 3%. Variations in the amount of HPMC used in each formulation impact the gel's characteristics, particularly its viscosity, spreadability, and adherence. Following the cycle test, the three formulations' viscosity decreased, but their pH, spreadability, and stickiness increased. There was no significant difference between the stability test on day 0 and day 12 for pH, viscosity, spreadability, and gel adhesion, according to testing utilizing the paired sample T-test. > 0.05.
FORMULATION OF LIPS BALSAM FROM RED DRAGON FRUIT EXTRACT (Hylocereus polyrhizus) Amelia Sari; Meisya Raihan; Nurmalia Zakaria; Rima Hayati; Ernita Silviana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lip balm is a moisturizer used as a lip balm. Red dragon fruit skin has anthocyanin as an antioxidant and protects against free radicals. The aim is to formulate red dragon fruit extract on the skin in the form of lip balm which has physical and safety characteristics. Red dragon fruit extract on the skin used in lip balm preparations, namely 0%, 5%, 10% and 15%. Evaluation of the lip balm including organoleptic, homogeneity, smearability, pH got good results and irritation test showed that all lip balm concentrations were safe to use because there was no reaction. So that the red dragon fruit extract on the skin can be used as a lip balm preparation. The difference in the concentration of red dragon fruit extract on the skin does not affect the physical properties of the lip balm preparation.
OPTIMASI FORMULA DAN UJI AKTIVITAS SECARA IN VITRO LOTION O/W SENYAWA KALKON SEBAGAI TABIR SURYA Khansa Labibah; Abdul Karim Zulkarnain
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1272

Abstract

Chalcone is flavonoids class that have activity as sunscreen. The objective of this research is to find out the optimum formula of chalcone lotion, physical properties and stability of optimum formula lotion o/w, and sunscreen activity by spectrofotometry.          The optimum formula was obtained by Simplex Lattice Design (SLD) method using Design Expert® version 10. To determine the optimum formula used three responses, namely viscosity, spreading, and adhessiveness. The physical properties of the lotion o/w were carried out including spreading test, adhessiveness test, and viscosity. The physical stability test of lotion o/w was done by cycling test. The sunscreen lotion activity o/w is determined by spectrophotometry by determining SPF, %Erythema Transmission, and %Pigmentation Transmission. Data were analyzed by t-test and One Way ANOVA with 95% confidence level. The results showed that the optimum lotion formula was found in combination of 2.40% cetyl alcohol, 0.36% carbopol, and 5.74% glycerin. The optimum formula of chalcone lotion has a viscosity of 73.48 ± 6.18 dPas, adhesiveness of 7.14 ± 1.26 seconds, and a spreading power of 24.99 ± 1.11 cm2. The results of statistical analysis showed that the lotion has a pretty good stability. Lotion has activity as sunscreen at concentration of chalcone in lotion 0,05% with SPF 36,927 and can provide protection against erythema and pigmentation.
POTENSI ANTIINFLAMASI EKSTRAK DAUN KECAPI SENTUL (Sandoricum koetjape Merr) DENGAN METODE STABILISASI MEMBRAN SEL DARAH MERAH Yusrinie Wasiaturrahmah; Nida Amalia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i1.1277

Abstract

Tissues that experience detrimental disturbances caused by chemical, mechanical or infectious stimuli will respond in the form of inflammation. Inflammatory processes that cannot be controlled and last long can damage cells, causing pathological effects. Kecapi sentul (Sandoricum koetjape Merr) is a plant that can thrive in Indonesia. Kecapi sentul leaves contain saponins, flavonoids, tannins, alkaloids, steroids, phenolics, and triterpenoids. The content of bioactive compounds in kecapi sentul leaves can provide various pharmacological effects, including as an anti-inflammatory. This study aims to determine the anti-inflammatory potential of kecapi sentul leaf extract using the membrane stabilization of the red blood cell method. The results showed that the percentage value of hemolysis inhibition possessed by kecapi sentul leaf extract at concentrations of 50, 100, 200, and 400 ppm were 6.137%, 15.884%, 24.549%, and 40.433%. The percentage of hemolysis inhibition possessed by 100 ppm aspirin as a positive control was 60.650%. The IC50 value of Kecapi sentul leaf extract was 492.305 ppm. Kecapi Sentul leaf extract is known to have the potential as an anti-inflammatory.

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