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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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EFEKTIVITAS ANTIVIRUS OSELTAMIVIR PADA SUBJEK COVID-19 DENGAN ATAU TANPA PENYAKIT PENYERTA DI PUSKESMAS ARUT SELATAN – PANGKALAN BUN Soufia Ardiani; Abdul Rahem; Anita Purnamayanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.879

Abstract

South Arut occupies the highest position with 51.55% of the total COVID-19 cases in Kota Waringin Barat, Central Borneo. The purpose of the study was to determine patient characteristics and analyze the effectiveness of oseltamivir in COVID-19 patients. The research design was an observational study and data collected retrospectively. Inclusion criteria were COVID-19 subjects with or without comorbidities and outpatient treatment at the Arut Selatan, Pangkalan-Bun Health Center who were given Oseltamivir. Parameters of therapeutic effectiveness were measured by the WHO Clinical Progression Scale consisting of 5 levels of clinical condition of patients with a score range of 0 (uninfected) – 10 (died). Data analysis was descriptively grouped according to clinical progression scale scores. The results of the study of 107 subjects were mostly male (56.1%) and aged 26-45 years (34.6%). The clinical results of therapy were 0.9% of subjects recovered with negative swab results (score 0), 98.2% improved (score 1), and 0.9% died (score 10). There were no subjects who needed to be referred to the hospital, Self-quarantine of 8-15 days showed 96 (89.7%) subjects experienced clinical improvement, symptoms free, and swab results were negative. It could be concluded that oseltamivir was effective for mild Covid-19 subjects in South Arut, Pangkalan Bun, Kota Waringin, Central Borneo.
TERAPI FAVIPIRAVIR PADA SUBYEK COVID-19 DERAJAT SEDANG TANPA GANGGUAN LIVER DI RS PUSAT INFEKSI PROF DR SULIANTI SAROSO Hastutik Cairn Brisbane; Abdul Rahem; Anita Purnamayanti; Rosamarlina Rosamarlina; Memy Aviatin; Adria Rusli
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.880

Abstract

The outbreak of the corona virus which first contracted in December 2019 in Wuhan, China; Currently it has been designated by the World Health Organization (WHO) as a pandemic and is known as Corona Virus Infection Disease 2019 (Covid-19). This study aimed to describe the profile of favipiravir therapy in moderate COVID-19 inpatients without liver impairment at Prof. dr. Sulianti Saroso Infection Center Hospital. The design of this study was an observational study conducted retrospectively. All the patients in this research were received favipiravir loading dose of 1600 mg bid on the first day, and 600 mg bid starting on the day-2 of therapy. The results of the research were 81 moderate Covid-19 inpatients without history or recent liver impairment who were hospitalized in the period October 2020 - July 2021 dominating by female gender (56%). Mode of hospital admission were self-referral to Prof. dr. Sulianti Saroso Infection Center Hospital (83%), primary care (Puskesmas) referral (12%), and other hospital referral (5%). There were no comorbidity in 74,1% of the subjects. Among 25,9% subjects with comorbidity, most of the patients suffered from hypertension (29%); hypertension, and cardiovascular disease (17%). diabetes (12%); diabetes and hypertension (12%); Asthma (12). None of the subjects experienced increased in liver transaminases (ALT, AST), nor ALP and total bilirubin. Eighty-one patients were either cured (12%) with negative PCR test results or improved (88%) at the end of the therapy.
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL, METANOL, DAN AQUADES DARI KULIT BUAH MUNDAR (Garcinia forbesii) Muhammad Ikhwan Rizki; Liling Triyasmono; Khoerul Anwar; Anna Khumaira Sari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.882

Abstract

Mundar (Garcinia forbesii) is a typical plant from South Kalimantan. Mundar pericaps can be used as a natural antioxidant. The use of solvents in the extraction process can affect the antioxidant activity. The purpose of this study was to determine of phytochemical compounds and antioxidant activity of the ethanol, methanol, and aquades extracts from pericaps of mundar (Garcinia forbesii). Mundar pericaps is dried, then made into powder. Mundar pericaps powder was extracted with three different solvents, ethanol 70%, methanol, and aquades. Phytochemical screening and analysis by thin layer chromatography were performed on the three extracts. The three extracts were tested for antioxidant activity by DPPH method. The results showed that ethanol and methanol extracts contained phytochemical compounds of phenolic, flavonoids, tannins, alkaloids, steroids, and terpenoids. Aquades extract contains phenolic, flavonoids, tannins, and alkaloids. The chromatographic profile showed that the ethanol and methanol extracts had an Rf value of 0.307. The antioxidant activity from highest to lowest was ethanol extract (192.64 ppm), methanol extract (236.64 ppm), and aquades extract (443.13 ppm) from mundar pericaps
FORMULASI DAN UJI STABILITAS FISIK GEL ANTIJERAWAT EKSTRAK ETANOL DAUN SURUHAN (Peperomia pellucida L.) Arfiani Arifin; Intan Intan; Nur Ida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.908

Abstract

Suruhan leaves (Peperomia pellucida L.) are known to be rich in secondary metabolites including alkaloids, flavonoids, saponins, tannins and triterpenoid compounds that have potential as anti-acne so that they can be applied as active ingredients in gel preparations. The purpose of this study was to determine the best base for the formulation of an anti-acne gel preparation of suruhan leaf extract that was physically stable. The research method includes the extraction of suruhan leaves by maceration using 96% ethanol. The gel formulation was designed with variations of carbopol base, HPMC, and Na CMC with a concentration of 2%. Physical stability tests include organoleptic, homogeneity, pH, dispersion, viscosity and adhesion which were carried out before and after accelerated storage using a climatic chamber. The results of this study showed that the gel preparation of the ethanol extract of suruhan leaves using carbopol and HPMC bases produced a physically stable gel based on the results of organoleptic tests, homogeneity, pH, dispersibility, adhesion and viscosity, before and after accelerated storage.
ANALISIS BIAYA DAN INDEKS UTILITAS YANG DIUKUR MENGGUNAKAN SF-6D PADA PASIEN GAGAL GINJAL KRONIS DENGAN HEMODIALISIS DI RSUD ADJI BATARA AGUNG DEWA SAKTI KUTAI KARTANEGARA Abdul Mahmud Yumassik; Gunawan Pamudji Widodo; Tri Murti Andayani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.942

Abstract

Hemodialysis (HD) patients with chronic kidney disease takes a long time and requires patient compliance. This will give the patient a psychological stressor which will then affect the quality of life. Apart from having an effect on quality of life, therapy hemodialysis also used a high cost, especially if the patient has complications. The purpose of this study was to determine the amount of hemodialysis costs, utility index, and the effect of complications on costs and utility index in hemodialysis patients. This study was a cross-sectional analytical research with the perspective of hospital. The research subjects were outpatient CKD who underwent hemodialysis at the HD Unit of Adji Batara Agung Dewa Sakti Hospital in September-Oktober 2020. Data were obtained use the SF-6D instrument, medical records, and financial financing. Data analysis used independent sample t-test and Kruskal-Wallis.The results showed that the average real cost of therapy in hemodialysis patients for a month was Rp. 12,014,488±0, while the real cost per hemodialysis episode is Rp. 1,316,722±273,989. The mean value of patient utility index as measured by the SF-6D was 0.717±0.143. The statistical test results show a significant value of 0.049 <0.05 on the utility index, which means that there is a relationship between complications on the utility index and a significant value of 0.125> 0.05 on costs, which means that there is no relationship between complications and costs in CKD patients with hemodialysis Keywords: Hemodialysis, Cost analysis, Index utility, SF-6D
MODEL RLB TURUNAN NAFTAKUINON INHIBITOR SEL LINE HELA Samsul Hadi; Uripto Trisno Santoso; Muhammad Luthfi Firdaus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.966

Abstract

Cervical cancer is a disease that is dangerous for life. Naphtaquinone is an anticancer agent whose derivatives have been successfully synthesized, so it is necessary to study QSAR to evaluate its potency. The purpose of this study was to determine the molecular descriptors of naphtoquinone-derived compounds that have a significant effect on the anticancer activity of HeLa cells and compile them into a valid QSAR model. A total of 15 compounds from naphtoquinone derivatives were used for modeling. The descriptors that were tried included 1,863 topological descriptors and physico-chemical properties descriptors. Results of correlation analysis obtained 17 descriptors that are feasible to be tested in modeling. Results of backward method obtained 3 descriptors that have a significant effect, namely AATSC6Z, AATSC7m, and MAXaaCH. The MLR model based on 3 descriptors fulfills the goodness of fit requirements with R=0.873, R2=0.763, R 2 Adjusted=0.698, F value=0.0009 (Ftable=11.778). The results of the validation test using the CV-LOO method obtained a value of Q2=0.572 and CV-LMO obtained a value of Q2=0.518 so that this HKSA model can be stated as a valid HKSA model.
FORMULASI ANTI-AGING CREAM POTASSIUM AZELOYL DIGLYCINATE TERHADAP STABILITAS FISIKA-KIMIA KRIM DENGAN VARIASI KONSENTRASI TRIETANOLAMIN SEBAGAI EMULGATOR Sholichah Rohmani; Tyas Rahmadian Putri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.974

Abstract

Potassium-azeloyl-diglycinate is an active ingredient as a sebum normalizer and skin lightening-agent to moisturize and treat hyperpigmentation. Anti-aging (AA) cream is a cosmetic used to prevent premature aging. The use of an emulsifying agent is necessary to produce a stable cream. One of the commonly used emulsifying-agents is triethanolamine. This study aims to formulate the AA-cream potassium-azeloyl-diglycinate preparation varied with the concentration of triethanolamine. Potassium-azeloyl-diglycinate AA-cream is formulated in 3 formula variants using TEA, namely 1.5%,2%, and 2.5%. Physical-chemical stability testing was carried out before and after 6 storage cycles of cycling-test, including organoleptic-test, homogeneity, adhesion, spreadability, stability, emulsion-type, viscosity, pH, antioxidant activity, and hydration on the respondents’ skin. The test results show that formula 3 is the best formula for AA-cream. Meanwhile, the antioxidant activity tested using the DPPH-method showed that the three formulas had a very weak activity with values in Formula 1, 2, and 3 of 63,856 ppm, 57,508 ppm, and 45,640 ppm, respectively. The antioxidant-activity of the cream decreased after the storage of the cycling-test. The hydration-test on the skin on the back of the respondents’ palms showed an increase in moisture on the skin after applying it for 10 days.
KEPATUHAN PENGAMBILAN ULANG OBAT ANTI HIPERTENSI PASIEN HIPERTENSI RUJUK BALIK DI APOTEK APPO FARMA BANJARMASIN Erna Prihandiwati; Yugo Susanto; Riza Alfian; Maya Sari; Leonov Rianto
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.980

Abstract

Complications of hypertension in the body's organs cause a high mortality rate. Hypertension requires long-term drug therapy so that patients must adhere to treatment. One type of adherence in the treatment of hypertension is adherence to taking drugs from health care facilities so that patients always have the availability of drugs to drink. The purpose of this study was to examine the adherence to taking antihypertensive drugs in patients with hypertension who were referred back at the Appo Farma Pharmacy Banjarmasin. The study used an observational design. Data collection was carried out retrospectively. Data were collected from patient prescriptions for referrals at the Appo Farma Pharmacy Banjarmasin in the period May-June 2022. A total of 123 samples were used in this study. The sampling method used simple random sampling technique. Data on adherence to drug taking was analyzed using the Medication Possession Ratio (MPR) method. The parameters of the MPR calculation results are divided into compliant categories if 80% and non-compliant if less than 80%. The research data is displayed descriptively. The results showed that the measurement of adherence to repeated drug taking with a period of 3 months and 6 months were both dominated by samples with the category of adherence to taking medication again with a total of 103 samples (83.74%). Based on these data, it can be concluded that the samples of hypertensive patients in this study were not all adherence in taking their antihypertensive drugs.
FORMULASI KRIM EKSTRAK BIJI KUPA (Syzygium polycephalum) DAN PENENTUAN NILAI SPF (Sun Protection Factor) SECARA IN VITRO Wulan Novian Dewi; Ira Rahmiyani; Anindita Tri Kusuma Pratita; Resha Resmawati Shaleha
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.984

Abstract

The high intensity of ultraviolet rays and exposure to the sun too often can have harmful effects on the skin, so sunscreen can be used to prevent interference from UV rays. The purpose of this study was to determine the activity of sunscreen and determine the SPF value of the extract and cream preparation of Kupa (Syzygium polycephalum) seeds. In this study, the seeds of Kupa fruit were extracted by the graded maceration method using 96% ethanol, ethyl acetate, and n-hexane as solvents. The ethyl acetate extract was formulated in the form of a cream dosage form with the added concentration of Kupa seed extract, namely 0.1% (F1), 0.2% (F2), and 0.5% (F3). Furthermore, the determination of the value of sunscreen on the extract and cream preparation using UV-Vis spectrophotometry and evaluation of the physical properties of the cream preparation include organoleptic tests, homogeneity, pH tests, spreadability, adhesion, and viscosity. The results showed that the SPF values ??of ethanol, ethyl acetate, and n-hexane extracts at a concentration of 200 ppm were 14.29; 19.32, and 14.02. While the SPF value of ethyl acetate extract cream preparations of Kupa fruit seeds F1, F2, and F3 respectively was 1.97; 2.96, and 4.96. Kupa seed extract has activity as a sunscreen with maximum and ultra protection levels. While the preparation of 0.5% ethyl acetate extract of Kupa seed had sunscreen activity with moderate protection. The physical properties of the cream preparations gave good results during the test.
FORMULASI DAN EVALUASI NANO HIDROGEL EKSTRAK DAUN SERUNAI (Chromolaena odorata L.) DENGAN VARIASI KONSENTRASI POLIMER CARBOPOL 980 Syafira Nabillah; Noval Noval; Nur Hidayah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.995

Abstract

Hydrogel is an ideal preparation as a wound dressing because it can provide a cold sensation that can reduce swelling in the wound area. Nanoparticles are particles that have a size of 1-1000 nm. Nanoparticles have the advantage of reducing the particle size and delivering the active substance to the target site. In the manufacture of nanohydrogels it is necessary to have a gelling agent in order to obtain a preparation that meets the requirements. In this study, nanohydrogels were made using Chrysanthemum leaf extract (Chromolaena odorata L.) as the active substance and made with various concentrations of carbopol 980 as a gelling agent. The purpose of this study was to determine the effect of variations in the concentration of carbopol 980 on nanohydrogel preparations of chrysanthemum leaf extract. The method used is Quasi Experimental Design. Simplicia was made into extracts and then made into nano preparations and evaluated. Data were analyzed using One Way Anova and Kruskal-Wallis. The particle size of Formula I nanohydrogel preparation was obtained at 412.9 nm. The results of the evaluation of the preparation showed that the nanohydrogel of chrysanthemum leaf extract with variations in the concentration of carbopol 980 had no effect on homogeneity, but it did affect the pH, viscosity, dispersibility, and adhesion test as shown in the One Way Anova statistical test (p<0.05). From the evaluation results, the ideal formula for nano hydrogel preparations was found in formula I with a carbopol 980 concentration of 0.5%.

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