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LPPM Universitas Sari Mulia Gedung D Lantai 1 JL. Pramuka No. 02 Banjarmasin Kelurahan Pemurus Luar Kecamatan Banjarmasin Timur Kota Banjarmasin Kalimantan Selatan Indonesia
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Journal of Pharmaceutical Care and Sciences
Published by Universitas Sari Mulia
ISSN : -     EISSN : 28284828     DOI : https://doi.org/10.33859/jpcs.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Journal of Pharmaceutical Care and Sciences published by the LPPM Sari Mulia UniversityPharmacy department of Sari Mulia University offers a forum for publishing the original research related to pharmaceutical science and clinical research. our focus and scope are Pharmaceutical Technology, Pharmacology & Toxicology, Drug Delivery Development, Pharmacokinetic & Biopharmaceutics, Pharmacoeconomy, Pharmacoepidemiology, Pharmacovigilance, Clinical Pharmacy, Community Pharmacy, Chemical Pharmacy, and Chemical Analysis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 177 Documents
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A Aktivitas Antibakteri Ekstrak Daun Kopi Aranio (Coffea canephora ) Terhadap Bakteri Propionibacterium Acnes: Aktivitas Antibakteri Ekstrak Daun Kopi Aranio (Coffea canephora ) Terhadap Bakteri Propionibacterium Acnes Rahmah, Aulia; Nastiti, Kunti; Mahdiyah, Dede; Darsono, Putri Vidiasari
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.417

Abstract

Background: Acne is a skin disease due to chronic inflammation with complex pathogenesis, excessive bacterial colonization, and inflammation. One of the causes of acne is due to excessive sebum gland activity and is exacerbated by bacterial infection, one of the bacteria that causes acne is Propionibacterium acnes. Coffee leaves are used by the community, especially in Babayau Village, Balangan Regency, South Kalimantan, to treat acne naturally and traditionally by mixing the cleaned coffee leaves with wet powder and then rubbing it evenly all over the face.         Objective: Knowing the effectiveness of coffee leaf extract (Coffea canephora) in inhibiting the growth of Propionibacterium acnes bacteria, and knowing the Minimum Inhibitory Concentration and Minimum Bactericidal Concentration against Propionibacterium acnes bacteria.                                              Methods: The type of research to test the antibacterial activity of aranio coffee leaf extract against Propionibacterium acnes bacteria was true expertimental with a post test only control group design, control group 100%, 75%, 50% and 25%, negative control using DMSO, positive control with clindamycin. Screening for antibacterial activity of aranio coffee leaf extract using the disc diffusion method and determining the Minimum Inhibitory Concentration and Minimum Bactericidal Concentration using the dilution method.                                                                Results: Coffee leaf extract (Coffea canphora) contains secondary metabolites, namely flavonoids, tannins, and saponins which have antibacterial activity. The antibacterial activity test of coffee leaf extract (Coffea canphora) in the disc diffusion method had an inhibition zone of 27.86 ± 2.14 while in the dilution method the Minimum Inhibitory Concentration (MIC) was at a concentration of 75% and did not have a Minimum Bactericidal Concentration (MBC).                                                Conclusion: Coffee leaf extract (Coffea canphora) can inhibit Propionibacterium acnes at a concentration of 75%, and cannot kill Propionibacterium acnes.                                               
F Formulasi Dan Uji Stabilitas Fisik Body Wash Ekstrak Etanol 70% Bunga Telang (Clitoria ternatea L.): Formulasi Dan Uji Stabilitas Fisik Body Wash Ekstrak Etanol 70% Bunga Telang (Clitoria ternatea L.) Haikal, Vikri; Audina, Mia; Hidayah, Nur; Budi, Setia
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.418

Abstract

ABSTRACT Background: Body wash is made by adding antibacterial active ingredients to suppress the growth of microorganisms. Antibacterial metabolite compounds owned by 70% ethanol extract of butterfly pea flowers are saponins, tannins, terpenoids, alkaloids and flavonoids Objective: Knowing the effect of differences in natrosol concentrations of 0.5%, 1% and 1.5% on the stability of body wash formulations of butterfly pea flowers Methods: The research method used is quasy-experimental with a one-group pretest-posttest design Results: The organoleptical stability of the three stable formulas is consistent and has a purplish-blue color, the characteristic smell of falcon flowers. All three stable formulas are homogeneous. The high stability of foam and viscosity of the three formulas are stable and qualified. The pH stability of all three formulas meets the qualifying range. Conclusion: Variations in natrosol concentration affect the stability test of pH evaluation and have no effect on organoleptis stability tests, homogeneity, foam height, viscosity and emulsion type. The most optimal formulation is formulation II (1%)
E Evaluasi dan Uji Aktivitas Formulasi Sediaan Peel-Off Mask Anti Jerawat Ekstrak Batang Brotowali (Tinospora crispa L.) : Evaluasi dan Uji Aktivitas Formulasi Sediaan Peel-Off Mask Anti Jerawat Ekstrak Batang Brotowali (Tinospora crispa L.) Amelia, Norrahmi; Malahayati, Siti; Melviani, Melviani; Noval, Noval
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.419

Abstract

Background: Facial skin care for acne treatment is better formulated in topical form, this is due to the duration of the active substances that interact with the skin. One dosage form is a peel-off mask with active substances brotowali stems which contain flavanoids, tannins, alkaloids as antibacterial causes acne. Objective: Analyzing the effect of variations in the concentration of brotowali stem extract (Tinospora crispa L.) on physicochemical evaluation and antibacterial activity of optimal anti-acne peel-off mask preparation formulations Methods: The research method used is True Experimental with a posttest only control group design research design. Make peel-off mask formulations with variations in extract concentrations of 20%, 30%, and 40%. The evaluation then includes organoleptis, homogeneity, dispersion, adhesion, dry time, pH, viscosity, and antibacterial activity tests, statistically analyzed using One Way ANOVA Results: Qualify in the organoleptis test is formula II (30%) and III (40%), the dispersion test is formula I (20%) and II (30%) with a p-value of 0.022, the adhesion test of all formulations with a p-value of 0.014, the dry time test of all formulations with a p-value of 0.000, the pH test is formula I (20%) with a p-value of 0.000, the viscosity test is formula II (30%) with a p-value of 0.000. The diameter of the formula's third inhibitory zone against propionibacterium acnes was 8.61mm ± 0.19 respectively; 14.31mm ± 3.88, and 15.54mm ± 4.80 with a p-value of 0.012 Conclusion: Variations on concentration of brotowali stem extract have an influence on physicochemical evaluation and antibacterial activity, the most optimal formulation is formulation II (30%)
U Uji Aktivitas Antibakteri Ekstrak Daun Pulutan (Urena lobata L) Terhadap Bakteri Streptococcus pyogenes Pusvita, Shela; Rohama, Rohama; Yuwindry, Iwan; Darsono, Putri Vidiasari
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.420

Abstract

Background: Pharyngitis or sore throat has a fairly high prevalence rate in Indonesia caused by Streptococcus pyogenes bacteria. Pulutan has experience as a medicine for sore throat, rheumatic fever, antipyretic, fracture, antifertility, and vaginal discharge. Based on research on ethanol extract that was done previously, pulutan leaf extract has antibacterial activity. Objective: To determine the antibacterial activity of pulutan leaf extract (Urena lobata L) which has the potential as an antibacterial against the growth of Streptococcus pyogenes and to determine the minimum inhibitory concentration and minimum killing concentration. Methods: This type of true experimental research design, namely research methods that look for causal relationships between independent and dependent variables. Antibacterial testing using disc diffusion and dilution methods. With concentrations of 100%, 75%, 50%, 25%, positive control amoxicillin and DMSO negative control. Results: The results of the disc diffusion test were able to inhibit the growth of the Streptococcus pyogenes bacteria which was indicated by the presence of a clear zone around the disc paper. The results of the dilution test obtained the MIC value at a concentration of 50% indicated by the media tube which looks clear. There was no KBM value at all the concentrations of the extracts tested, indicated by the growth of bacteria in the test medium. Conclusion: Pulutan leaf extract (Urena lobata L) has antibacterial activity which is indicated by the presence of an inhibition/clear zone around the disc paper. MIC results found at a concentration of 50%, KBM results on pulutan leaf extract (Urena lobata L) did not have killing power at all concentrations. Keywords: Antibacterial, Pulutan Leaf Extract (Urena lobata L), Streptococcus pyogenes.
A Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Daun Sirih Merah (Piper crocatum Ruiz & Pav) Dengan Variasi Ukuran Partikel Serbuk Simplisia Oktavia, Rissa; Rohama, Rohama; Saputri, Rina
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.422

Abstract

Background: Red betel (Piper crocatum Ruiz & Pav) is a medicinal plant that is used empirically by the people of Tehang, Central Kalimantan for wound healing. The ability of red betel leaves to heal wounds is associated with the anti-inflammatory properties of the secondary metabolites of the flavonoid class contained therein which also have a role as a source of antioxidants. Particle size will affect the amount of bioactive compounds in an extract. Objective: To determine the difference in antioxidant activity and flavonoid content ethanol extract of red betel leaf in a variation of particle size simplisia powder. Methods: True experimental quantitative research which divided into two experimental groups, namely red betel leaf extract with a mesh particle size of 40/60 and 60/80. Testing of antioxidant activity with the DPPH method and determining the levels of flavonoids with the UV-Vis Spectrophotometry method. Results: The results of antioxidant activity based on IC50 values at 40/60 and 60/80 mesh particle sizes is 5.96 ppm and 2.74 ppm. The results of flavonoid content determination at 40/60 and 60/80 mesh particle size is 1.448 mg QAE/g and 3.5 mg QAE/g. Statistical analysis with the Mann Whitney test showed a significant difference (p value 0.025 <0.05). Conclusion: There is a significant difference with the variation of particle size on the antioxidant activity and levels of flavonoids. The highest antioxidant activity and flavonoid levels were observed in extracts with a mesh particle size of 60/80. The smaller the particle size, the stronger the antioxidants and the higher the levels of flavonoids.
P Penentuan Nilai SPF (Sun Protection Factor) dan Evaluasi Fisik Sediaan Cream Ekstrak Etanol Bunga Rosella (Hibiscus sabdariffa L.) Sebagai Sun Protection Melitia, Ni Putu Nova; Audina, Mia; Mahdiyah, Dede
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.424

Abstract

Background: The skin has a very influential role in protecting the body from the external environment such as physical impact or exposure to free radicals. Skin problems often occur due to exposure to sunlight in the form of ultraviolet (UV) rays. So to maintain healthy skin, you can use sunscreen cream preparations or sun protection. rosella flower (Hibiscus sabdariffa L.) contains anthocyanin compounds which are efficacious as antioxidants which have potential as sunscreens thatare able to absorb UV-A and UV-B rays thereby reducing the intensity on the skin.Objective: To observe and analyze the differences in the results of physical evaluation and the SPF value of variations in the concentration of the active substance in sunscreen cream preparations of ethanol extract of rosella flowers (Hibiscus sabdariffa L.) as sun protection.Methods: This research is a pre-experimental study with a one-shot case study design. Sunscreen cream is formulated with different active substance concentrations of rosella flower ethanol extract, namely 9%, 10%, 11%. The evaluation included organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion, emulsion type and in vitro SPF activity test. Data were analyzed using one way ANOVA.Results: The results showed that the variation of the active substance affected the differences in the results of physical evaluation on pH, spreadability, adhesion and viscosity, as well as the SPF activity test. Based on one way ANOVA statistics, the results obtained were <0.05, meaning that there was an effect of variations in the concentration of the active substance of the ethanol extract of rosella flowers. SPF value activity gets (F1)29,12,(F2)29,97(F3)29,97 in the range of 30 SPFConclusion: The results of the physical evaluation and activity testing of the SPF value of the rosella flower ethanol extract sunscreen cream had a significant difference in the results from the influence of variations in the active substance.Keywords: Rosella flower, Sun cream
F Formulasi Dan Evaluasi Sediaan Essence Ekstrak Daun Sirih Hijau (Piper Betle L.) Sebagai Anti Jerawat: Formulasi Dan Evaluasi Sediaan Essence Ekstrak Daun Sirih Hijau (Piper Betle L.) Sebagai Anti Jerawat Dewi, Sinta; Malahayati, Siti; Darsono, Putri Vidiasari
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.425

Abstract

Background: Piper betel leaf extract has antibacterial activity against P.acnes because it contains tannins, flavonoids, alkaloids, and terpenoid compounds. Objective: The purpose of this study is to formulate piper betel leaf extract in the form  of essence that meets the requirements of physical quality and has antibacterial activity against P.acnes. Methods:  This study uses true experimental method  and well diffusion method for antibacterial test. The essence preparation was  made with 3 different extract concentrations (concentrations of 5%, 10%, and 20%), then a physical evaluation was carried out and then the formulation was tested for antibacterial activity against P.acnes. The data obtained were statistically analyzed ANOVA with a significance value of 0.05. Results: The results showed that  the essence preparation  had a yellowish-brown to dark brown color, liquid form and characteristic smell of betel leaves with a pH of 5.4-5.5, homogeneous preparation, viscosity 324-463, dispersion power 9.74 mm-11.62mm, and in antibacterial activity tests showed the ability to inhibit the growth of P.acnes bacteria  by having inhibitory power that was categorized as strong. Conclusion: The results of the physical evaluation and the results of the antibacterial activity test for essence preparations had a significant effect on variations in extract concentrations because the p-value was <0.05. Based on the evaluation results, all formulas met the specifications, and the most optimal was formula II
E Efektivitas Pemberian Edukasi Dengan Metode Focus Group Discussion (FGD) Menggunakan Media Audio-Visual Terhadap Rasionalitas Penggunaan Antibiotik Di Desa Kresik Bura Mursidah, Diana Aulia; Saputri, Rina; Aryzki, Saftia; Syamsu, Erlina
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.426

Abstract

Background: Irrational use of antibiotics can lead to therapy failure and the risk of resistance. One of the factors that influence the use of antibiotics is knowledge that can be increased by providing education. The FGD method aims to explore more specific issues related to the topics discussed. Education with audio-visual media facilitates the delivery of information and is more easily accepted by the public. Objective: To analyze the effectiveness of providing education using the Focus Group Discussion (FGD) method using audio-visual media on the rationality of using antibiotics in the people of Kresik Bura Village Method: True experimental with pretest posttest control group design. The sampling technique used was stratified random sampling with a total sample of 100 respondents. This research was conducted in Kersik Bura Village in June 2023-July 2023. Results: The results of the rationality of using antibiotics before education with a rational result of 40%, after being given education there was an increase to 72%. The results of the Wilcoxon test in the control group were 0.180 and in the experimental group 0.000. The results of the Mann-Whitney test obtained a p-value of 0.000. Conclusion: Providing education using the FGD method using audio-visual media is effective in increasing the rationality of using antibiotics.
U Uji Aktivitas Antibakteri Ekstrak Etanol Buah Jeruju (Achantus ilicifolius L.) Terhadap Bakteri Staphylococcus aureus Dan Salmonella thypi Marwah, Jannatul; Hakim, Ali Rakhman; Rohama , Rohama
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.431

Abstract

Background: According to WHO (2018), there are cases of antibiotic resistance in 500,000 people with suspected bacterial infections in 22 countries. Jeruju fruit extract (Achantus ilicifolius L.) has antibacterial activity because it contains secondary metabolite compounds such as alkoloids, phenols, flavonoids, tannins, saponins and steroids, which are expected to be an alternative choice in the treatment of bacterial infections. Objective: To identify the antibacterial activity of jeruju fruit extract (Achantus ilicifolius L.) against the bacteria Staphylococcus aureus and Salmonella typhi to determine the MIC and KBM values. Method: Type of research design True Experimental Research Posttest Only With Control Group research design. Antibacterial testing uses disc diffusion and dilution methods. With concentrations of 500mg/ml, 800mg/ml, 1000mg/ml, positive control ciproflaxacin and negative control DMSO. Results: The results of the diffusion test showed that jeruju fruit extract was able to inhibit the growth of bacteria, there was a clear zone around the paper disc at a concentration of 500 mg/ml (9.95 mm). The results of the dilution test have a minimum inhibition at a concentration of 500mg/ml seen in clear media and the ability to kill bacteria at a concentration of 1000mg/ml. It can be said that jeruju fruit extract has MIC and KBM concentration values. Conclusion: Jeruju fruit extract has antibacterial activity with an inhibitory zone at a concentration of 500mg/ml (9.95 mm) and has the power to kill Salmonella typhi bacteria at a concentration of 1000mg/ml.
H Hubungan Pendekatan Health Belief Model (HBM) Terhadap Minat Masyarakat Pada Vaksinasi Booster Covid-19 di Kelurahan Tumbang Miri Pebrianti, Pebrianti; Yuwindry, Iwan; Herawati, Anita
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.439

Abstract

Background: The Covid-19 pandemic has infected millions of people and caused up to 143,685 deaths in Indonesia. One of the most promising Covid-19 prevention strategies is vaccination. Although clinical investigations have proven the safety of Booster doses, public rejection or hesitation due to effectiveness and safety reasons is still a major problem in the Covid-19 Booster vaccination program. Objective: To determine the relationship of the Health Belief Model (HBM) approach to public interest in Covid-19 Booster vaccination in Tumbang Miri Village. Methods: Quantitative research with a cross-sectional approach. Sampling with purposive sampling technique. The number of samples obtained was 81 respondents. Univariate data analysis for respondent characteristics and bivariate analysis of Chi-square statistical tests to determine the relationship between the Health Belief Model and acceptance of Booster Covid-19 vaccination. Sampling was carried out for one month, starting from June 2023. Results: Perceived susceptibility had an association with vaccine acceptance (0.008 < 0.05), perceived severity had no association with vaccine acceptance (0.225, 0.137 and 0.913 > 0.05), perceived benefit had an association with vaccine acceptance (0.009 and 0.000 < 0.05), perceived barriers had no association with vaccine acceptance (0.272, 0.471 and 0.913 > 0.05), trigger to act had an association with vaccine acceptance (0.032 and 0.000 < 0.05). Conclusion: Perceived susceptibility, perceived benefits, and triggers to act have a relationship with the acceptance of Booster Covid-19 vaccination in the community of Tumbang Miri Village.  

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