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LPPM Universitas Sari Mulia Gedung D Lantai 1 JL. Pramuka No. 02 Banjarmasin Kelurahan Pemurus Luar Kecamatan Banjarmasin Timur Kota Banjarmasin Kalimantan Selatan Indonesia
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Journal of Pharmaceutical Care and Sciences
Published by Universitas Sari Mulia
ISSN : -     EISSN : 28284828     DOI : https://doi.org/10.33859/jpcs.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Journal of Pharmaceutical Care and Sciences published by the LPPM Sari Mulia UniversityPharmacy department of Sari Mulia University offers a forum for publishing the original research related to pharmaceutical science and clinical research. our focus and scope are Pharmaceutical Technology, Pharmacology & Toxicology, Drug Delivery Development, Pharmacokinetic & Biopharmaceutics, Pharmacoeconomy, Pharmacoepidemiology, Pharmacovigilance, Clinical Pharmacy, Community Pharmacy, Chemical Pharmacy, and Chemical Analysis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 177 Documents
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A Analisis Sifat Fisikokimia, Farmakokinetik, Dan Toksisitas Senyawa Aktif Dalam Jahe Merah (Zingiber Officinale Var Rubrum Rhizoma) Maulida, Masita Zumna; Ummahati, Daril; Muna, Laili Nailul
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.454

Abstract

Background:  Red ginger (Zingiber Officinale Var Rubrum Rhizoma) contains secondary metabolites that show pharmacological activity. However, not many know that Red ginger rhizome includes a compound produced as an anti-inflammatory. Objective:  This research aims to provide an initial screening by looking at the potential of the compounds produced by red ginger rhizomes Method: This research was carried out descriptively using ChemDraw software and then analyzed the physicochemical properties of the compounds. Next, the predictor servers, namely Lipinski and PreADMET, are used to see the pharmacokinetic characteristics. Meanwhile, to analyze the toxicity using Toxtree software. Result:  Based on the analysis, distinct physicochemical compounds are best: zingerone (period boil, period melted, a period critical temperature, and point necessary pressure) and zingiberene (Log P and gibs energy). Analysis results in Lipinski show geraniol, zingiberene, zingerone, and 1.8 cineol compounds criteria Lipinski. Besides That, pharmacokinetic data show the fourth compound has its solubility in high water. The intestinal absorption values of geraniol, zingiberene, zingerone, and 1.8 cineol are excellent. The compounds geraniol, zingiberene, zingerone, and 1.8 cineol all have good permeability to the blood-brain barrier, but of the four compounds, the compound with the best permeability is zingiberene. Conclusion: All compounds show a level of low toxicity for using skin and no toxicity for the heart.
F Formulasi Dan Evaluasi Serum Gel Ekstrak Daun Sengkubak (Pycnarrhena Cauliflora Diels) Rini, Ilma Widya; Budi, Setia; Tumanggor, Agustina Hotma Uli
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.459

Abstract

Background: Serum has a high concentration but a low viscosity. a facial serum that has a fairly good ability to absorb into the skin, releases the active substance of the serum well and is easy to apply to the face. Sengkubak (Pycnarrhena cauliflora Diels) is a type of plant in the Menispermaceae family which can be found in West Kalimantan. Sengkubak also has good potential to be developed as a source of antioxidant compounds Objectives: Knowing the optimal formulation of sengkubak leaf extract serum gel (Pycnarrhena Cauliflora Diels) and knowing the evaluation of the physical properties of Sengkubak leaf extract serum gel (Pycnarrhena Cauliflora Diels) Method: The study used a quasi-experimental design method with varying concentrations of 1 gram, 1.5 grams and 2 grams of natrosol. Serum gel was evaluated for physical organoleptic, homogeneity, spreadability, dry time, adhesion, pH, and viscosity. Results:  The results of the observations on the viscous liquid organoleptic test and on the homogeneity test of homogeneous preparations. the most optimal spreadability test results were formulation 1, the most optimal drying time was formulation 1. the most optimal adhesion test results were formulation 1, the most optimal ph test results were formula 1, and the most optimal viscosity test were formulation 2. Conclusion:  The most optimal serum gel of sengkubak leaf extract (Pycnarrhena Cauliflora Diels) is formulation 1, with a concentration of 1 gram.  
P Penetapan Kadar Metilparaben Pada Krim Pemutih Wajah Yang Beredar Di Kecamatan Mentaya Hilir Utara Menggunakan HPLC (High Performance Liquid Chromatography) Sa'diyah, Halimatus; Rahmadani, Rahmadani; Malahayati, Siti
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.475

Abstract

Background: Based on the results of direct observations made by researchers in North Mentaya Hilir District, there are still many traditional markets or cosmetic shops that sell cosmetic products, especially whitening creams that have not been registered with BPOM and do not meet the requirements that have been set, and are indicated to contain methylparabens exceeding the maximum limit set by BPOM. Objective: To analyze the difference in methylparaben levels contained in BPOM registered and non-BPOM registered whitening cream preparations. Methods: Qualitative analysis was carried out by observing retention time, quantitative analysis using HPLC, and making comparisons to see the differences in levels contained in BPOM registered and non-BPOM registered face whitening cream preparations with parametric statistical tests Paired Sample T-Test. Results: The results of the study of BPOM registered and non-BPOM registered whitening creams were positive for containing methylparabens with the average levels contained in BPOM registered whitening cream samples A 0.19 ± 0.003% and samples B 0.79 ± 0.008%. While the levels contained in whitening creams are not registered with BPOM in sample A 0.18 ± 0.0005% and sample B 1.16 ± 0.066%. From the results of determining these levels, there is no difference in methylparaben levels contained. Conclusion: Whitening creams registered with BPOM and not registered with BPOM circulating in North Mentaya Hilir district contain methylparaben.
P Profil Senyawa Alkaloid Dengan Metode Spektroskopi Inframerah (FTIR) Dan Penetapan Kadar Total Alkaloid Dari Ekstrak Daun Jarak Pagar (Jatropha curcas .L) Gamah, Gamah; Nastiti, Kunti; Aryzki, Saftia
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.476

Abstract

Background: Jatropha curcas leaves (Jarropha Curcas L.) is a plant that has potential medicinal properties. Empirically, Jatropha leaves (Jarropha Curcas L.) are used by the people of South Kalimantan to expedite the delivery process. One of the compounds that have pharmacological properties in Jatropha curcas leaves is alkaloids. Objective: Knowing the alkaloid compounds using infrared spectroscopy (FTIR) and determining the total alkaloid content of jatropha leaf extract (Jatropha Curcas L) leaf extract. Methods: This study used descriptive qualitative analysis to identify alkaloid functional groups from FTIR results and quantitative analysis to determine total alkaloid content. Results: Preliminary test results using thin layer chromatography on Jatropha curcas leaves (Jatropha Curcas.L) were positive for containing alkaloid compounds. The FTIR results showed that there was an alkaloid compound content in the presence of functional groups which were obtained C-H, C=O, C-O, N-H and aromatic C-H which are characteristics of alkaloid compounds and the total alkaloid content was obtained 5,645 % (g/5g). Conclusion: Jatropha curcas leaf extract (Jatropha curcas L) using FTIR analysis showed the content of alkaloid compounds and the total alkaloid content obtained was 5,645 % (g/5g).    
E Efektivitas Metode Focus Group Discussion (FGD) Menggunakan Media Reminder Medication Card Terhadap Kepatuhan Ibu Hamil Dalam Mengkonsumsi Tablet Tambah Darah di Puskesmas Pelambuan Wardhani, Yuliana; Saputri, Rina; Hateriah, Siti
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.477

Abstract

Background: Unadheence to taking blood supplements in pregnancy was still high. Health education with focus group discussion (FGD) method and reminder medication card media expected to increasing the adherence of consuming blood supplements regularly. Objective: To analyze the effectiveness of focus group discussion (FGD) using reminder medication card to pregnant women adherence on comsuming blood supplement tablet in Pelambuan Health Care Center. Methods: This true experimental pretest-posttest control group research conducted to 64 pregnant women on intervension and control group with simple random sampling technique on June at Pelambuan Health Care Center and analyzed with Wilcoxon and Mann Whitney U Test. Results: About 65,6% of intervension group were unadherence and 81,3% on control group were unadherence in pretest. About 90,6% of intervension group were adherence and 75% on control group were unadherence in posttest. There is a difference of pretest and posttest result on intervension group (p value = 0,000) and no difference on control group (p value = 0,317). There is a difference between intervension and control group (p value = 0,000). Conclusion: Focus group discussion (FGD) using reminder medication card effective to increasing pregnant women’s adherence on comsuming blood supplement tablet in Pelambuan Health Care Center.
F Formulasi Dan Evaluasi Fast Disintegrating Tablet (FDT) Dari Ekstrak Daun Pepaya (Carica Papaya L.) Dengan Variasi Konsentrasi AC-DI-SOL Sebagai Superdisintegran Kamalia, Hasna; Noval, Noval; Darsono, Putri Vidiasari
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.483

Abstract

Background: One of the risk factors that can cause an increase in the incidence of morbidity and mortality in patients with hypertension is patient non-adherence in taking antihypertensive drugs. As we get older, there is a decrease in the function of the tongue in achieving muscle pressure to make effective movements, which can cause difficulty swallowing drugs in solid dosage forms. This can be overcome with FDT preparations which can be disintegrated in the mouth without having to use water. Objectives: To compare the evaluation results of fast disengtengrating papaya leaf tablet formulation (Carica papaya L.) and to determine the effect of Ac-Di-sol concentration from fast desingtengriting tablet (Carica papaya L.) preparation Method: The method used is a quasi-experimental design with a non-equivalent control group design by comparing the results of the intervention with a control group from the formulation evaluation. Results: The tablet hardness test (hardness tester) obtained a significance result of 0.17 <0.05, which means that there is a difference in tablet hardness in all formulas. In the friability tester, the significance results were obtained for formula I, namely in formula III with a significance value (sig) of 0.000 <0.05, which means that the fragility data did not spread normally in all formulas. At the time of disintegration, a significant result of 0.027 < 0.05 was obtained, which means that there was a difference in the disintegration time of the tablets in each formulation. In the disintegration time test, a significance result of 0.139 <0.05 was obtained, which means that there is a difference in each disintegration result in all formulas. In the wetting time test, the significance result was 1.7 < 0.05, namely the wetting test aimed to determine the time required for the tablet to be wetted by water. So it can be said that there are significant differences in each formulation. Conclusion: Based on the results of the organoleptic test, all of the tablet formulations produced had a brown color, with a bitter taste, smelled of mint and papaya extract and were round in shape. The combination of the concentration ratio of Ac-Di-Sol and Mannitol has the effect of evaluating friability, hardness, disintegration time and wetting time on Fast Disintegrating Tablets Papaya leaf extract (Carica papaya L.) Formulation III with 5 mg Ac-Di-Sol is the most effective formulation. optimal for Fast Disintegrating Tablets Papaya leaf extract (Carica papaya L.).  
E Efektivitas Rosuvastatin Dan Pravastatin Sebagai Anti-Dislipidemia Pada Tikus JANTAN Furqan, Rizqi Nur; Nugraha, Dyan Fitri; Hakim, Ali Rakhman; Saputri, Rina; Komaliya, Risyda
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 2 (2024): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i2.485

Abstract

Background: Dyslipidemia is a disease that can have a negative impact on human health. Dyslipidemia treatment has 3 levels based on intensity, namely disease with high intensity, medium intensity, and low intensity. In this study, the drugs used were Pravastatin and Rosuvastatin, both of which were of medium intensity. Objective: Knowing the comparison of the effectiveness of the drugs Rosuvastatin and Pravastatin as anti-dyslipidemia in rats. Methods: The research method used in this study is True Experimental. The research design used in this study was the posttest only control group, namely by taking samples after being given the drugs Rosuvastatin and Pravastatin, so that it would be seen the effectiveness of the treatment given to the group of rats tested. Results: Rosuvastatin can lower LDL cholesterol better than Pravastatin because rosuvastatin has the highest binding interaction with HMG-CoA reductase, resulting in the strongest inhibition of cholesterol synthesis of all other statin groups. Pravastatin has the ability to lower LDL. From the results of the average values of the two statin class drugs, Rosuvastatin has a better average value than Pravastatin, but the statistical results can be concluded that there is no significant difference from the 0.5% Na CMC control to Rosuvastatin compared to Pravastatin. Conclusion: The statin class drug Rosuvastatin has better effectiveness than Pravastatin.
P Pengaruh Kombinasi Basis Karbopol 940 dan HPMC Terhadap Evaluasi Dan Stabilitas Sediaan Spray Gel Ekstrak Daun Sembung (Blume balsamifera (L.)) Uzma, Nor Syafa'atul; Budi, Setia; Rahmadani, Rahmadani
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 2 (2024): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i2.496

Abstract

Background: Sembung leaf extract was made into spray gel preparations, with various concentrations of carbopol 940 and HPMC. Spray gel was chosen because it has the advantage of being practical to use, relatively low contamination of microorganisms, easier to dry and easy to wash. Objective: To determine the effect of varying concentrations of Carbopol 940 and HPMC on the physical evaluation and stability of Sembung leaf extract spray gel (Blumea Balsamifera (L.)). Methods: The method used is laboratory experimental with one shot case study. Sembung extract was formulated into 4 spray gel formulations with various concentrations of carbopol 940 and HPMC respectively (0.2:0.5);(0.4:0.6);(0.6:0.7) and (0 ,8:0,4). Then a stability test was carried out using the cycling test method for 12 days for 6 cycles by evaluating before and after the cycling test, the evaluation included organoleptic tests, homogeneity, pH, viscosity, spreadability and spraying pattern, dry time and adherence resistance. Results: Organoleptic test results showed differences in color and consistency, homogeneity test obtained homogeneous preparations, pH test and viscosity of the formula decreased, spreadability test and good spraying pattern were formula III and IV, dry time test of all preparations was good, good adhesion resistance test are formulas III and IV. Conclusion: Variations in the concentration of Carbopol 940 and HPMC have an effect on the preparation before and after the stability test. Good preparations were found in formulas III and IV with concentrations of carbopol 940 and HPMC (0.6:0.7) and (0.8:0.4).
E Etnomedicine Tumbuhan Obat di Masyarakat Desa Belangian, Kalimantan Selatan: Syahfitri, Laili Shinta Ayu; Nastiti, Kunti; Kurniawati, Darini; Rohama, Rohama
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 2 (2024): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i2.549

Abstract

Background: The diversity of tribes and cultures in Indonesia makes culturaldifferences and traditional knowledge, one of which is in utilizing plants for thetreatment of a disease. One of the widespread tribes on the island of Kalimantanthat is thick with traditional medicine is the Banjar Tribe located in BelangianVillage, South Kalimantan. Ethnomedisin is a treatment by certain ethnicities basedon hereditary traditions in traditional medicine, in this case the use of medicinalplants.Objective: The purpose of this study was to determine the ethnomedicine ofmedicinal plants used by the Banjar Tribe of Belangian Village, Aranio District,South Kalimantan Province.Methods: This research is descriptive using qualitative and quantitative methods.Quantitative analysis with Fidelity Level (FL) calculations for each type ofmedicinal plant.Result: Based on the results of research from 38 informants, 58 species with 36families were obtained. There are 50 diseases that can be treated from 58 types ofmedicinal plants. The most popular method of processing is boiled 56.89 then drunk72.41%. The most widely used part of medicinal plants is the leaf part of 41.73%.Five types of plants with the highest FL values that stated effectiveness for treatmentwere Cymbopogon citratus 86.84%, Zingiber officinale 78.94%, Jatropha multifidaL 73.64%, Peronema canescens jack 68.42%, Syzygium polyanthum 65.78%. Thetradition of treatment with medicinal plants by the Banjar Tribe has been passeddown for generations with the value of local wisdom in its use.Conclusion: There are 58 types of medicinal plants that can be used as medicineor relief for certain diseases by the people of the Banjar Tribe, Belangian Village.With the highest FL value of five is found in Cymbopogon citratus plants 86.84%,Zingiber officinale 78.94%, Jatropha multifida L 73.64%, Peronema canescensjack 68.42%, Syzygium polyanthum 65.78%.
I Identifikasi Zat Pewarna Rhodamin B pada Liptint yang Beredar Via-Online Shop Menggunakan Kromatografi Lapis Tipis (KLT) dan Spektrofotometri Uv-Vis Raihanah, Raihanah; fitriani, Siska Fitriani; Laili, Rofiatul Laili; Fatimah, Siti Fatimah; Sinta, Sinta Pratiwi; Siti Monica Anjani
Jurnal Pelayanan Kefarmasian dan Sains Vol 5 No 2 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v5i2.568

Abstract

  Background: Rhodamine B (Color K10) is a synthetic dye. This dye is a dye that is generally used in the textile industry as a clothing dye. Meanwhile, use is prohibited or not permitted by BPOM. However, the majority of people in Indonesia still do not know about the health risks of using Liptint in circulation, so the use of rhodamine B is still widespread due to being tempted by its cheap price. Objective: This study aims to determine the presence of Rhodamine B in Via-olshap liptint cosmetics which are in demand by most female consumers. Method:   The research method uses laboratory experimental research using descriptive analysis. So the data used is qualitative data (KLT) and quantitative data (UV-Vis spectrophotometry) Results:  He results of testing using KLT showed that the O brand liptint sample showed an Rf value of 0.08, indicating a discrepancy with the theory of a good Rf value. Meanwhile, the results of determining Rhodamine B levels in Liptint brand O were 28,644 mg/L Conclusion: The O brand liptint sold Via-Online Shop contains rhodamine B dye

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