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Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
Published by Pusat Riset dan Inovasi Nasional
ISSN : 2828934X     EISSN : 28289358     DOI : https://doi.org/10.55606/jurrike.v1i2
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Jurnal Riset Rumpun Ilmu Kedokteran adalah jurnal yang ditujukan untuk publikasi artikel ilmiah yang diterbitkan oleh Pusat riset dan Inovasi Nasional, Universitas Sains dan Teknologi Komputer. Jurnal ini adalah jurnal Riset Rumpun Ilmu Kedokteran yang bersifat peer-review dan terbuka. Bidang kajian dalam jurnal ini termasuk sub rumpun Ilmu Kedokteran Spesialis, Ilmu Kedokteran Akademik, Spesialis Kedokteran gigi dan mulut, Kedokteran Gigi Akademik. Jurnal Riset Rumpun Ilmu Kedokteran menerima artikel dalam bahasa Inggris dan bahasa Indonesia dan diterbitkan 2 kali setahun: April dan Oktober.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 235 Documents
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Optimasi Formula SEDDS (Self-Emulsifying Drug Delivery Systems) Ekstrak Etanol Daun Ketepeng Cina (Cassia alata, L.) Sebagai Anti Malaria Dzukharian Munandar; Rahayu Samalo; Pratiwi Soegiharti
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5908

Abstract

Flavonoid dalam ekstrak daun ketepeng cina (Cassia alata, L.) terbukti sebagai anti malaria. Ekstrak etanol daun ketepeng cina (EEDKC) dikembangkan menjadi Self-Emulsifying Drug Delivery Systems (SEDDS) karena kelarutannya yang rendah dalam air dan kurang stabil dalam kondisi penyimpanan. Penggunaan ekstrak dalam sediaan juga memiliki kekurangan dalam hal absorbsi dan bioavailabilitasnya yang rendah. Namun hal tersebut dapat diatasi dengan memformulasikan EEDKC menjadi sediaan SEDDS. Tujuan dari penelitian adalah untuk menentukan pengaruh dari fase minyak, surfaktan, dan kosurfaktan terhadap formulasi SEDDS EEDKC dan mengkarakterisasinya pada respon parameter waktu emulsifikasi dan % transmitan sehingga memperoleh komposisi yang optimum pada formula SEDDS EEDKC. Pembuatan SEDDS EEDKC dimulai dari uji kelarutan berupa uji pendahuluan kelarutan EEDKC pada minyak, surfaktan, dan kosurfaktan dengan pseudoternary diagram untuk mengidentifikasi area terbentuknya SEDDS yang isotropik. Optimasi formula SEDDS EEDKC menggunakan perangkat lunak Design Expert versi 12 dengan model desain D-Optimal Mixture Design. Dan parameter karakteristik yang diuji adalah waktu emulsifikasi, % transmitan, extract loading, dan stabilitasnya secara termodinamika. Hasil formulasi yang optimal untuk SEDDS EEDKC yaitu 10,00% minyak jagung sebagai fasa minyak; 59,82% Cremophor RH 80 sebagai surfaktan dan 30,18% Transcutol CG sebagai ko-surfaktan. Karakterisasi formula optimum SEDDS EEDKC memiliki waktu emulsifikasi 30,18 detik, nilai transmitan 66,00%.
Hubungan Kekuatan Otot Lengan, Kelentukan Otot Punggung, dan Keseimbangan terhadap Kemampuan Lempar Tangkap Anak Usia 9-10 Tahun di Vio Surabaya Krisna Pratama Syahlendra; Heri Wahyudi; Achmad Widodo; Noortje Anita Kumaat
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6186

Abstract

Age 9-10 years is a crucial stage of motor development, where physical abilities such as muscle strength, flexibility and balance significantly affect performance in sports activities, including throwing and catching skills.This study to analyze relationship between arm muscle strength, back muscle flexibility, and balance on the throwing and catching skills children aged 9–10 years at VIO Surabaya. This is quantitative research with correlational design and multiple regression analysis. The sample use 15 children (8 boys and 7 girls) who were athletes from the VIO Baseball Club Surabaya, all aged between 9-10 years. Instruments included a push-up test to measure arm muscle strength, a V-sit and reach test for back muscle flexibility, a one-leg balance test, and a throwing and catching test using a softball. The results is arm muscle strength had a significant relationship with throwing and catching skills (Pearson correlation value of r = 0.921 (p < 0.05)). In contrast, back muscle flexibility (r = 0.328) and balance (r = 0.131) did not show significant relationships. The conclution arm muscle strength is most influential factor in determining throwing and catching in children, therefore, training programs should prioritize arm strength development to support motor skill advancement in early age.
Asuhan Keperawatan Gangguan Pola Tidur pada Pasien GGK yang Menjalani Hemodialisa dengan Terapi Relaksasi Nafas dalam Combain Inhalasi Aromatherapy Lavender di Ruang Rawat Inap : (RSUP Dr. Kariadi Semarang) Siti Al Maroh; M Jamaluddin
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6189

Abstract

Chronic Kidney Failure (CKD) is a condition of permanent and progressive decline in kidney function. CKD patients undergoing hemodialysis often experience sleep disturbances, which impact their physical and psychological condition. Non-pharmacological interventions such as deep breathing relaxation and lavender aromatherapy can be alternative therapies to address these disorders. This study analyzes nursing care for sleep disturbances in CKD patients undergoing hemodialysis and evaluates the effectiveness of deep breathing relaxation therapy combined with lavender aromatherapy inhalation. This study used a case study approach with three CKD patients undergoing hemodialysis and experiencing sleep disturbances. The intervention was carried out for three days with a combination of deep breathing relaxation therapy and lavender aromatherapy inhalation. After three days of intervention, complaints of insomnia decreased in all three patients. The sleep pattern score increased to 5, indicating undisturbed sleep patterns. Deep breathing relaxation therapy combined with lavender aromatherapy inhalation is effective in addressing sleep disturbances in CKD patients undergoing hemodialysis. This therapy is recommended as an additional intervention in the hospital and should be carried out with family support to increase patient comfort.
Dampak Konsumsi Kopi terhadap Respons Cold Pressor Test pada Mahasiswa Kedokteran Universitas Tarumanagara: Studi Komparatif Nikita Tan; Susy Olivia Lontoh
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 3 No. 2 (2024): Oktober : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v3i2.5507

Abstract

Caffeine contained in coffee has a stimulating effect on the sympathetic nervous system, which can influence blood pressure. The Cold Pressor Test (CPT) is a method used to measure blood pressure response to cold-induced stress. This study aimed to compare the mean blood pressure between coffee-drinking and non-coffee-drinking medical students after undergoing the CPT. This research employed a quantitative experimental design with a cross-sectional approach, involving 89 students from the Faculty of Medicine at Universitas Tarumanagara. Subjects were divided into two groups: coffee drinkers and non-coffee drinkers. Blood pressure measurements were taken before and after the CPT intervention. The results showed that both systolic and diastolic blood pressure increased significantly in both groups after CPT. However, the increase in mean blood pressure, particularly diastolic pressure, was significantly higher in the coffee-drinking group compared to the non-coffee-drinking group (p < 0.05). These findings indicate that coffee consumption prior to CPT contributes to a greater blood pressure response. Therefore, it can be concluded that there is a significant difference in mean blood pressure between coffee drinkers and non-coffee drinkers following the Cold Pressor Test.
Komunikasi Orang Tua dan Remaja dalam Kesehatan Seksual dan Reproduksi: Literature Review Yusuf, Nurlathifah N.; Siswari, Baiq Disnalia; Supiani
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6139

Abstract

Komunikasi antara orang tua dan remaja mengenai kesehatan seksual dan reproduksi masih menghadapi berbagai hambatan, mulai dari norma budaya hingga keterbatasan pengetahuan orang tua. Ketidakterbukaan dalam komunikasi keluarga dapat berdampak negatif terhadap perkembangan kognitif dan perilaku seksual remaja. Penelitian ini bertujuan untuk menganalisis secara sistematis temuan-temuan empiris terbaru terkait pengaruh komunikasi orang tua–remaja terhadap keterampilan berpikir kritis, sikap terhadap seksualitas, pengambilan keputusan, dan akses informasi remaja. Metode yang digunakan adalah kajian literatur integratif terhadap 14 artikel jurnal internasional bereputasi yang diterbitkan pada rentang tahun 2020–2025. Hasil kajian menunjukkan bahwa komunikasi yang terbuka, empatik, dan berbasis nilai dalam keluarga berkontribusi positif terhadap kemampuan reflektif remaja serta sikap dan perilaku seksual yang sehat. Sebaliknya, komunikasi yang normatif dan satu arah cenderung memperkuat stigma dan membatasi kapasitas remaja dalam mengambil keputusan yang tepat. Kajian ini merekomendasikan pentingnya intervensi berbasis keluarga yang memperkuat kapasitas komunikasi orang tua, dengan dukungan pendekatan digital yang adaptif dan kolaborasi lintas sektor untuk menciptakan lingkungan yang mendukung kesehatan reproduksi remaja.
Modalitas Terbaru Pengobatan Luka Bakar Hafiz Khairun Marwan; Andi Irwansyah Achmad; Nurul Rumila Roem
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6184

Abstract

Burn injuries are complex tissue damage often accompanied by serious complications such as infection, systemic inflammation, and organ dysfunction. Effective burn management requires a comprehensive multidisciplinary approach, including infection control, local wound care, nutritional support, and regenerative therapy. Along with advances in science and technology, various novel treatment modalities have been developed to accelerate healing, reduce scarring, and improve patients’ quality of life. This study aims to evaluate the effectiveness and clinical prospects of the latest burn treatment modalities through a review of relevant literature from 2021 to 2025. This research employed a descriptive qualitative literature review method, analyzing 10 relevant scientific articles obtained from academic databases such as PubMed, ScienceDirect, and Google Scholar. The reviewed modalities include stem cell therapy, Platelet Rich Plasma (PRP), silver nanoparticles, nanofiber and hydrogel-based dressings, natural extracts such as aloe vera and binahong, as well as advanced technologies like smart dressings and low-level laser therapy. The results indicate that regenerative and smart technology-based approaches significantly enhance epithelialization, reduce infection, and improve tissue repair. Natural therapies also show promising potential as safe, affordable, and effective treatment alternatives. In conclusion, the integration of biological therapy, phytotherapy, and modern technology represents a promising direction in contemporary burn care. Further large-scale clinical research is needed to confirm the long-term safety and effectiveness of each modality.
Stab Wounds to The Chest that Penetrated The Heart Hendri Meirialdi Saputra; Abdul Gafar Perinduri
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6201

Abstract

Sharp trauma is an abnormality in the body caused by the contact of objects whose surface is able to slice so that tissue continuity disappears. It is usually caused by knives, swords, scissors, razors, axes and others. The types of wounds due to sharp violence that can be identified are stab wounds, iris wounds and also stab wounds. All of these types of injuries can endanger the victim's life and cause death for the victim. Every case of persecution or violence against life that causes death must be medically examined. This must be done to help the police as law enforcers in uncovering murder cases based on forensic medical science. This examination includes an examination of the outside of the victim's body and also an examination of the victim's internal organs. The results will be used as valid evidence used in the judicial process. Case description: A case was reported, a male corpse, known, with the initials DR, with the suspected death of elements of a criminal act.Conclusion From the results of the examination, the cause of death of the victim was a stab wound to the left chest that penetrated the heart and heart sac due to sharp violence that resulted in bleeding and tissue damage..
Pathological Review of Clinical Autopsy in The Perspective of Health Law in Indonesia Muhammad Yoga Dwi Anggara Sopiyan; Fahmi Irsan Nasution; Hendri meirialdi
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6223

Abstract

Clinical autopsy is an important procedure in the medical world to determine the exact cause of death and evaluate the quality of medical services. In Indonesia, its implementation is still limited due to various legal, social, and ethical obstacles. This article discusses the position of clinical autopsy from the perspective of pathology and medicolegal forensics and examines the relevant legal framework for health in Indonesia. This study aims to encourage the implementation of autopsy legally, professionally, and ethically through a multidisciplinary approach. In conclusion, regulatory reform and enhanced education are needed to support the implementation of clinical autopsies that are legally valid and beneficial for both the medical and legal fields.
Eccrine Poroma pada Kulit Kepala: Laporan Kasus dan Tinjauan Histopatologis Ekawaty Suryani Mastari; Bayu Irvia Satria; Fahmi Irsan Nasution
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6228

Abstract

Poromas are benign neoplasms composed of epithelial cells that show tubular differentiation, which arises from the intraepidermal part of the eccrine of the sweat glands. This lesion can resemble melanoma or non melanoma.1,2 Case description We reported a case of eccrine poroma in a man, Mr. ES, 50 years old, with complaints of a lump in the head of the temporal region of the region. On macroscopic examination, a blackish-brown scalp tissue size 2x1x0.5 was received, the surface was uneven, the consistency was springy. Microscopic examination of squamous epithelial coating with round, oval, monotone, smooth chromatin, eosinophilic cytoplasm appear. In the sub-epithelium, there is a mass of tumors consisting of proliferative eccrine glands, in groups forming islands, with cuboidal coatings, with round, oval, monotonous nuclei, fine chromatin, eosinophilic cytoplasm. The stroma consists of fibrous connective tissue and blood vessels. The sebaceous glands, hair follicles and infiltration of lymphocyte cells appear. Discussion and conclusions: Based on the results of histopathological examination, it can be concluded as eccrine poroma. In this case electrosurgery is performed, removal with the help of a carbon dioxide laser, or excision surgery can be performed.
High Grade Myxoid Round Cell Liposarcoma Fahmi Irsan Nasution; Lely Hartati; Muhammad Natsir Ilvira
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6230

Abstract

Background: Myxoid liposarcoma is a malignant tumor composed of uniform, partially round to oval cells with lipoblast, in the myxoid stroma with branching capillaries. Very rarely presents as a primary neoplasm of the subcutis or retroperitoneum. Myxoid liposarcoma in the retroperitoneum is the most common metastases. Case description: We reported a case of Mr M, male, 48 years old, came to the hospital. Private in the city of Medan on April 19 2021 with complaints of upper left abdominal pain, nausea (+), vomiting (-), fever. vital sign, general condition: compos mentis, temperature: 36 ℃, Pulse: 80 x/min. Breathing: 20x/min, Blood pressure: 120/80 mmHg. Previously, a gastric biopsy was performed on suspicion of gastric carcinoma and a histopathological examination was carried out with the results of a gastric adenoma. Subsequently, an exploratory laparotomy was performed with tumor debulking and the tissue was sent to the H. Adam Malik Hospital unit. On macroscopic examination, the tissue was split in a state of 16 cm x 12 cm x 7 cm, yellowish-gray in color, chewy consistency. The of cutting, a solid mass of white, yellow, and brown color appears, the consistency is chewy and brittle. With a tissue-weight of 800 grams then labeled O/1260/21. On microscopic examination of the tumor mass, it appears that the tumor mass is mostly arranged in solid sheets, consisting of round, relatively uniform cells, arranged back to back. Round and oval nuclei with increased N/C ratio, coarse chromatin, eosinophilic cytoplasm. Among them are lipoblast cells with spider web and small signet ring lipoblast. Atypical mitoses are relatively easy to find > 19 mitoses / 10 LPB. Proliferative and congested blood vessels, necrotic masses <50% are also seen. Immunohistochemical examination was carried out with S100 positive staining results on the nuclear membrane and cytoplasm of tumor cells with a proportion of more than 70% moderate to strong intensity. Conclusion: Based on macroscopic and microscopic examination this patient was diagnosed with High grade myxoid round cell liposarcoma grade III with ICD-O 8852/3.

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