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Medical and Health Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 28073541     DOI : https://doi.org/10.20884/1.mhj.2023.2.2.8053
Core Subject : Health,
Medicine & Pharmacology
Medical and Health Journal (EISSN. 2807-3541) is containing various articles/ manuscripts in the forms of research article, systematic reviews, case reports in the field of medicine focusing on basic medicine, clinical medicine, biomedical sciences, medical biotechnology, and public health. This journal is published by Universitas Jenderal Soedirman, Purwokerto, Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 28 Documents
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Search results for , issue "Vol 5 No 2 (2026): February" : 28 Documents clear
Synthesizing The Evidence: TP53 Mutations as a Prognostic and Predictive Biomarker in Breast Cancer Chuvita, Laila; Wibowo, Syifa Sofia
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19146

Abstract

The journey to personalize breast cancer therapy increasingly navigates the complex landscape of somatic TP53 mutations, the most frequent genetic drivers of this disease. Moving beyond a simple prognostic badge, we now understand these mutations create a spectrum of clinical behaviors, deeply influenced by their specific functional impact and, critically, by their genetic companions. A systematic literature review was conducted across three major electronic databases: ScienceDirect, ProQuest, and Scopus. The search was restricted to peer-reviewed journal articles published in English between 2021 and 2024 to ensure the inclusion of recent evidence. The confluence of TP53 and PIK3CA mutations stands out as a devastating synergy that heralds a tumor phenotype with profound resistance to common chemotherapy regimens, especially taxanes, and the direst survival outcomes. This genetic context also subtly reshapes responses to HER2-targeted drugs, revealing that TP53's influence is both powerful and context-dependent. A more nuanced profiling, one that accounts for these critical genetic interactions, is no longer a future aspiration but a present necessity. These findings collectively advocate for the integration of comprehensive molecular profiling, including nuanced TP53 and PIK3CA assessment, into clinical decision-making.
Association Between Lumbar Vertebral MRI Findings and Neuropathic Pain in Patients With Low Back Pain at Prof. Dr. Margono Soekarjo General Hospital Rizki Adiputri, Hening Yanita; Kuncoro, Prasetyo Tri; Gunarto, Untung; Pratama, Tisna Sendy; Permatasari, Octavia; Wijayana, Kamal Agung; Setyanto, Muhamad Rifqy
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19165

Abstract

Background: Low back pain (LBP) is a common musculoskeletal condition that may be accompanied by neuropathic pain due to irritation or compression of lumbar neural structures, often associated with structural abnormalities detected on MRI. Objective: This study aimed to assess the association between lumbar MRI findings and neuropathic pain in patients with LBP at Prof. Dr. Margono Soekarjo General Hospital. Methods: An analytical observational study with a cross-sectional design was conducted involving 68 patients, using lumbar MRI data and neuropathic pain screening with the ID Pain questionnaire. Associations were analyzed using Chi-square tests and multivariate logistic regression with a significance level of p < 0.05. Results: The most frequent MRI findings are herniated nucleus pulposus (85.3%), spinal stenosis (57.4%), spondylosis (38.2%), and spondylolisthesis (19.1%), while neuropathic pain is identified in 66.2% of patients. Significant associations are observed between neuropathic pain and all MRI findings, with lumbar spinal stenosis identified as the strongest predictor. Conclusion: Lumbar MRI abnormalities are significantly associated with neuropathic pain in patients with LBP, and spinal stenosis represents the most influential factor, emphasizing the importance of radiological evaluation in the management of LBP with neuropathic components.
Basic Immunization Status and Incidence of Measles Among Toddlers in Working Area of Limboto Public Health Center, Gorontalo Regency Katili, Asra wati; Ibrahim, Sri Andriani; Mohamad, Rini Wahyuni
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19301

Abstract

Measles (campak) is a contagious disease that remains a health problem among toddlers and contributes to high morbidity and mortality rates in children. Globally, measles cases increased from 170,000 cases in 2022 to over 320,000 cases in 2023, with deaths occurring mainly in children who did not receive complete immunization. This condition indicates that basic immunization plays an important role in measles prevention. In Gorontalo Province, measles and rubella cases are still found in several districts/cities, with Gorontalo Regency having the highest number of cases. One of the preventive efforts is the provision of complete basic immunization to enhance immunity against the disease. This study aimed to determine the relationship between basic immunization status and the incidence of measles in toddlers in the working area of Limboto Health Center, Gorontalo Regency.This study was a quantitative study with an analytic observational design using a cross-sectional approach. The study population consisted of all toddlers in the working area of Limboto Health Center, Gorontalo Regency, with a total sample of 60 toddlers taken using a total sampling technique. The research instrument used a checklist sheet. Data analysis was conducted univariately and bivariately using the Chi-Square test. The study results showed that there was a relationship between basic immunization status and the incidence of measles in toddlers (p-value < 0.05). The conclusion of this study is that there is a relationship between basic immunization status and the incidence of measles in toddlers. Therefore, it is recommended that healthcare workers increase education for parents and improve complete basic immunization coverage as a preventive measure against measles in toddlers.
Phytochemical Characterization of the Chloroform Extract of Foeniculum vulgare Mill. Leaves with Implications for Antiparasitic Agent Development Ihtiaringtyas, Suci; Sari, Octavia Permata; Susiawan, Lieza Dwianasari; Firinda, Rizma Haidif; Amalia, Ary Nahdiyani; Fuady, Rhovee Ilmiawan
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19358

Abstract

The development of antiparasitic agents derived from natural products continues to receive considerable attention due to increasing resistance and limitations of conventional therapies. This study aimed to examine the phytochemical profile of the chloroform extract of fennel leaves (F. vulgare Mill.) as a basis for antiparasitic agent development. The extract was obtained using a maceration method and analyzed using thin layer chromatography. Qualitative analysis was conducted based on the observation of visible spots after spraying with appropriate visualization reagents, while supporting analysis was performed based on the calculation of retention factor values for the detected spots. The results revealed the presence of several major groups of secondary metabolites, including flavonoids, terpenoids, alkaloids, and phenolic compounds, as indicated by specific color changes and retention factor values. The diversity of these metabolites suggests the possible involvement of multiple biochemical pathways related to antiparasitic mechanisms. Overall, the phytochemical profile of the chloroform extract of fennel leaves provides important preliminary data to support further research on natural product–based antiparasitic agents.
Effect of Level 1 Progressive Mobilization Therapy on Oxygen Saturation in Patients Diagnosed with Respiratory Failure in ICU of Prof. Dr. H. Aloei Saboe Hospital, Gorontalo City Patilima, Roni Mohammad A. R.; Yusuf, Zuhriana K.; Yusuf, Nur Ayun R.
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19371

Abstract

Level 1 progressive mobilization therapy is a non-pharmacological therapy using a complementary approach that can affect oxygen saturation. The purpose of this study was to determine the effect of level 1 progressive mobilization therapy on oxygen saturation in patients diagnosed with respiratory failure in the ICU of Prof. Dr. H. Aloei Saboe Regional Hospital, Gorontalo City. This study is a quantitative study with a quasi-experimental design using a one-group pre-post test design approach . which only involved one treatment group, namely the group of patients diagnosed with respiratory failure who were given level 1 progressive mobilization therapy intervention. The study population was 51 patients with an accidental sampling technique with a sample size of 45 patients. This research instrument used the SOP for level 1 progressive mobilization and an oxygen saturation observation sheet. Data analysis used the Wilcoxont-test. The results of the study obtained a p-value of 0.000 (α <0.05) meaning that there was an effect of level 1 progressive mobilization therapy on oxygen saturation in patients with respiratory failure at Prof. Dr. H. Aloei Saboe Regional Hospital, Gorontalo City. Level 1 progressive mobilization plays a crucial role in improving respiratory function, accelerating recovery, and maintaining the body's overall physiological balance. This research is expected to serve as a reference for providing nursing care, particularly level 1 progressive mobilization exercises for patients diagnosed with respiratory failure, as an effort to prevent decreased oxygen saturation.
The Relationship Between Peer Group Support and Snack Choosing Behavior Among School-Aged Children at Limboto 1 Public Elementary School H. Djafar, Stevilia Marcella; Hafid, Ridha; Mohamad, Rini Wahyuni
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19372

Abstract

School-age children, aged 6 to 12, are at a crucial developmental stage, where school experiences are a key aspect of their lives. Children's snack selection behavior is influenced by two factors: personal factors such as knowledge and habits, and environmental factors such as the role of family, peers (peer group), and school conditions. Peer group support is a form of social support provided by individuals within friendships to help and strengthen each other. This study aims to determine the relationship between peer group support and snack choice behavior among school-aged children at Limboto 1 Public Elementary School. This study used probability sampling, a technique that provides an equal opportunity for each member of the population to be selected as a sample. The method used in this study was proportionate stratified random sampling, a sampling technique used when the population has non-homogeneous members and is divided into strata with varying numbers. The results above indicate a relationship between peer group support and snack choice behavior among school-aged children. This was confirmed by statistical testing using Chi Square, which yielded a p-value of 0.009 <α = 0.05.
The Relationship Between Stress Levels and Disease Perception in DM-TB Comorbid Patients in Gorontalo City Husain, Siti Rahma; Zainuddin, Zainuddin; Sartika, Sartika
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19376

Abstract

Diabetes mellitus (DM) and tuberculosis (TB) are chronic diseases that remain major public health problems and frequently occur concurrently as DM–TB comorbidity. This condition not only worsens patients’ physical status but also affects psychological aspects, particularly stress levels and illness perception. Patients living with two chronic diseases simultaneously tend to experience stress due to long-term treatment burdens, complications, and demands for therapeutic adherence. High stress levels may influence how patients perceive their illness, reduce motivation, and shape negative illness perceptions, which can ultimately hinder optimal disease management. This study aims to analyze the relationship between stress level and illness perception among patients with DM–TB comorbidity in Gorontalo City. This study employed a quantitative, cross-sectional design. The sample consisted of patients with DM–TB comorbidity undergoing treatment at several community health centers in Gorontalo City. Stress level was measured using the Perceived Stress Scale (PSS), while illness perception was assessed using the Brief Illness Perception Questionnaire (BIPQ). Data were analyzed using statistical tests to determine the relationship between stress level and illness perception. The results showed that most patients experienced moderate to high stress levels and tended to have negative illness perceptions. Statistical analysis indicated a significant relationship between stress level and illness perception among patients with DM–TB comorbidity. The higher the patients’ stress levels, the more negative their perception of the illness. It can be concluded that psychological aspects play an essential role in the management of patients with DM–TB comorbidity; therefore, health interventions should integrate clinical and psychosocial approaches to improve treatment adherence and patients' quality of life.
Description of Uremic Pruritus in Chronic Kidney Failure Patients Undergoing Hemodialysis at Prof. Dr. Aloei Saboe Regional General Hospital Lahabu, Moh Ikbal; A. Kasim, Vivien Novarina; Maryadi, Maryadi; Djamaluddin, Nurdiana; Purwanto, Erwin
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19379

Abstract

Chronic kidney disease (CKD) is a global health problem with a steadily increasing prevalence, particularly among patients undergoing hemodialysis. One of the most frequently reported complaints is uremic pruritus, defined as a chronic itching sensation that significantly affects patients' quality of life. This study aimed to describe the characteristics of uremic pruritus in patients with chronic kidney disease undergoing hemodialysis at RSUD (Regional General Hospital) Prof. Dr. Aloei Saboe, Gorontalo City. This study employed a descriptive quantitative design using a total sampling technique involving 42 CKD patients undergoing hemodialysis who presented with uremic pruritus. Data were collected using a demographic questionnaire and the 5D Itch Scale instrument. The results showed that 3 respondents (7%) experienced mild pruritus, 24 respondents (57%) experienced moderate pruritus, and 15 respondents (36%) experienced severe pruritus. The findings indicate that uremic pruritus remains a predominant clinical problem among CKD patients undergoing hemodialysis. Consequently, increased attention to assessment and management is necessary to improve patients' quality of life
Acute Toxicity Test of Tamarillo Fruit Ethanol Extract (Solanum betaceum Cav.) on the Levels of Liver Transaminase Enzymes in Male Wistar Rats Amalia, Ary Nahdiyani; Yulianti, Rini Dwi; Khumaeni, Eko Hidayaturrohman; Hardiningsih, Denok Tri
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19413

Abstract

Indonesians traditionally utilize tamarillo for its various health benefits. However, the lipophilic compounds it contains have the potential to cause hepatotoxicity and increase transaminase enzymes, namely SGPT and SGOT enzymes. The study aimed to test the toxicity of tamarillo ethanol extract acutely on SGPT and SGOT levels in male Wistar white rats. The study used a post-test only experimental design with a control group design. Fifteen rats were randomly divided into five treatment groups. Group K1 as a control was given distilled water, group K2 was given paracetamol 2.5 g/kgBW, while groups K3, K4, and K5 were each given tamarillo ethanol extract in single doses of 200, 400, and 600 mg/kgBW. After 24 hours, rat blood serum samples were taken through the orbital sinus to measure SGPT and SGOT levels using the UV test method. The results showed that the average SGPT levels increased in the K2 group by 295.34±13.31 U/L and K5 by 93.67±19.03 U/L. Meanwhile, the average SGOT levels increased in the K2 group by 874±25.06 U/L, K4 by 164.67±7.57 U/L and K5 by 213.34±13.50 U/L. The One-Way ANOVA test showed a significance value of p=0.000 in the K2 and K5 groups for SGPT, while SGOT in the K2, K4 and K5 groups. Administration of tamarillo ethanol extract can cause liver damage at doses of 400 mg/kgBW and 600 mg/kgBW.
Management of Unilateral Hyperlactation in a Mother Exclusively Breastfeeding 7-Month-Old Infant: A Case Report Hasnawati, Zumrotin; Hafiidhaturrahmah, Hafiidhaturrahmah
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19447

Abstract

Background: Hyperlactation is a condition characterized by excessive breast milk production beyond the infant’s nutritional needs, which may lead to feeding difficulties and maternal discomfort. Unilateral hyperlactation is a rare condition and may result from idiopathic mechanisms, iatrogenic factors, or a combination of both. This case report describes the mechanism and successful management of unilateral hyperlactation occurring after contralateral breast abscess surgery. Case Report: A 24-year-old lactating mother presented with excessive milk production, breast pain, and recurrent ductal obstruction in the right breast. One month prior, she had undergone surgical drainage of a left breast abscess. Her 7-month-old infant experienced breastfeeding difficulties, green frothy stools, and excessive weight gain. The condition was diagnosed as a unilateral hyperlactation of idiopathic–iatrogenic hybrid, whereby reduced stimulation of the surgically treated left breast triggered compensatory overproduction in the right breast. A comprehensive management using Academy of Breastfeeding Medicine (ABM) protocol was implemented, including laid-back breastfeeding positioning, block feeding for 14 days, and oral pseudoephedrine 60 mg twice daily. Significant clinical improvement was observed, with reduced milk production to levels appropriate for the infant’s needs, resolution of maternal symptoms, and successful continuation of breastfeeding. Conclusion: Unilateral hyperlactation following breast surgery can be effectively managed using an ABM Protocol–based approach combining block feeding and pharmacological therapy, enabling successful continuation of breastfeeding.

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