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Jurnal Farmasi Indonesia

jfi
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Published by Ikatan Apoteker Indonesia

ISSN : 14121107 EISSN : 2355696X DOI : https://doi.org/10.35617/jfionline

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.

Arjuna Subject : Profesi Kesehatan - Farmasi

Articles 149 Documents

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Artikel Review: Kandungan Senyawa Aktif Tanaman Untuk Kesehatan Kulit Gunarti, Neni; Yuniarsih, Nia; Toni. S, Rifqi Maulana; Khoerunnisa, Rita; Allahuddin, Allahuddin; Anggraeni, Fera; Ruhdiana, Tita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Background: Skin is the outermost organ of the body that coats the human body that needs to be treated to prevent skin damage from free radicals or infection. The way to maintain and care for the skin is using synthetic compounds that can help maintain healthy skin. Another alternative in skin care is to use plants that have active compounds that are beneficial for skin health and have relatively low side effects compared to synthetic chemicals. Objective: This study aimed to determine the active compounds of plants that can improve skin health. Method: Article review using Google Schoolar database with keywords related to the research topic, namely "Active Compounds, Plants, Health, Skin". Journals used in the last 10 years (2012-2022). Results: The results of a literature review show that there are 10 plants that can improve skin health, namely yam (Pachyrhizus erosus), liquorice (Glycyrrhiza glabra), arceola cherry (Malpighia emarginata), aloe vera (Aloe vera), guava (Psidium guajava L.), tomato (Solanum lycopersicum L.), Moringa leaf (Moringa oleifera), papaya (Carica papaya L), avocado (Persea americana M.) and sweet orange (Citrus x aurantium L) The active compounds in these plants that are beneficial for skin health are alkaloids, terpenoids, phenolics, flavonoids, carotenoids, polyphenols, tannins, steroids, triterpenoids, vitamin-C, vitamin-B, niacinamide, lycopene, glabridin, saponins and antraquinones. Conclusion: Active plant compounds that are beneficial for skin health are alkaloids, terpenoids, phenolics, flavonoids, carotenoids, polyphenols, tannins, steroids, triterpenoids, vitamin-C, vitamin-B, niacinamide, lycopene, glabridin, saponins and antraquinones.

H. Aktivitas Antiinflamasi Daging Buah Pala (Myristica fragrans Houtt.) Pada Tikus Putih Yang Diinduksi Karageenan Nur, Amran; Fiskia, Ermalyanti; Rahman, Ismail
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Inflammation is a defence reaction of the body to eliminate factors that can damage and then rebuild the body's homeostasis. Synthetic anti-inflammatory drugs are known to cause many side effects. Therefore, the research for new drugs from nature is carried out, generally sourced from natural ingredients. One of the natural ingredients that has potential as an anti-inflammatory is nutmeg flesh (Myristica fragrans Houtt.). This study aimed to determine the anti-inflammatory activity of nutmeg flesh ethanol extract (EDBP) in carrageenan-induced paw edema models in Wistar albino rats. This study is an experimental study using 30 Wistar albino rats that were randomly divided into six treatment groups which included a negative control group (Sodium CMC), a positive control group (diclofenac sodium 0.9mg/200gBW of rats), and three levels of ethanol extract of nutmeg flesh: 2.5mg/200gBW, 5mg/200gBW and 7.5mg/200gBW administered orally. One hour after the treatment, the rats were injected with 0.1 ml Carrageenan 1% sub plantar. The edema volume was measured with a plethysmometer every 30 minutes for 3 hours. Anti-inflammatory activity was measured by comparing the percentage of inflammatory protection. The data were then analysed using one-way ANOVA to compare the anti-inflammatory activity between the treatment and the control groups. The results showed that EDBP 2.5mg, 5mg, and 7.5mg gave significantly different effects compared to the control group (p<0.05), where EDBP 7.5 mg showed the highest anti-inflammatory activity.

Formulasi Granul Sarang Walet Putih (Aerodramus fuciphagus) dengan Variasi Kombinasi Maltodextrin dan Povidon Suena, Ni Made Dharma Shantini; Adrianta, Ketut Agus; Wardani, I Gusti Agung Ayu Kusuma; Antari, Ni Putu Udayana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: White swallow nest (SWP) contains Epidermal Growth Factor, which can increase immunity, and glutathione, which functions as an antioxidant. SWP has a high potential to become an antioxidant-rich immunomodulatory drink. Combining maltodextrin and povidone in a granule formula can protect the active substance from heat and maintain the flavor components. However, the wrong concentration can reduce the quality of the resulting granules. This study aims to obtain a combination of maltodextrin and povidone concentrations in SWP granule formulations that produce granules with the best quality and physical stability. The wet granulation method prepared the ten SWP formulas with combined concentrations of maltodextrin-povidone (code: F1 to F10). Evaluation of the physical quality of the granules (organoleptic, pH, soluble time, moisture content, compressibility index, and flow properties) was evaluated on the first, seventh, fourteenth, and twenty-first days. Linear regression is used to create an equation model of the effect of formulation on granule quality parameters. Formula F6 has the lowest compressibility index and the highest flow rate. There was no significant difference for all physical quality parameters of all formulas during storage (p>0.05). The effect of varying concentrations of maltodextrin is inversely proportional to the effect of varying concentrations of povidone on the physical quality of SWP granules. From the research results, it can be concluded that the combination of maltodextrin (5%) and povidone (1%) in F6 produces granules with the best physical quality. All formulas are stable during storage.

PENGARUH PENGGUNAAN MEDICATION AIDS TERHADAP TINGKAT KETAATAN PASIEN PEPTIK ULKUS DI RUMAH SAKIT UMUM DAERAH ARIFIN ACHMAD PROVINSI RIAU Fina Aryani; Septi Muharni; Yudina Awaliyah Harahap
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Peptik ulkus merupakan penyakit yang ditandai dengan adanya luka yang terdapat pada saluran gastrointestinal akibat banyaknya produksi asam dan pepsin yang disebabkan oleh infeksi Helicobacter pylori, NSAIDs dan stres, sehingga terapi yang di rekomendasikan tergantung pada penyebab dari tukak tersebut. Terapi peptik ulkus minimal selama delapan minggu dan pasien dituntut untuk taat dalam mengkonsumsi obat. Salah satu upaya untuk meningkatkan ketaatan pasien adalah penggunaan medication aids. Tujuan dari penelitian ini untuk mengetahui pengaruh pemberian medication aids terhadap tingkat ketaatan pasien peptik ulkus di Riau. Medication aids yang digunakan adalah wadah pengingat pil dan kemasan sekali pakai. Penelitian ini menggunakan metode eksperimen semu (quasi experiment), dengan rancangan NonRandomized Control Group Pretest dan Posttest Design yang dilakukan terhadap 60 pasien yang dikelompokkan menjadi 30 pasien kelompok kontrol dan 30 pasien kelompok perlakuan selama bulan Mei - Juli 2017. Metode pengambilan sampel secara accidental sampling yang memenuhi kriteria inklusi yakni pasien peptik ulkus yang disebabkan oleh NSAIDs, berusia lebih dari 18 tahun dan bersedia menjadi responden. Pengumpulan data ketaatan menggunakan kuesioner standar yakni Morisky Medication Adherence Scale 8 (MMAS-8). Data dianalisis menggunakan uji statistik Mann-Whitney. Hasil penelitian menunjukkan nilai p=0,000 (p<0,05) yang artinya terdapat pengaruh pemberian medication aids terhadap tingkat ketaatan pasien peptik ulkus.

Pengetahuan, Sikap dan Perilaku Penggunaan Obat pada Mahasiswa di Jember Rachmawati, Ema; Astutik, Amelia Windi; Pratama , Antonius Nugraha Widhi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: The ease of accessing information about medicines has an impact on increasing the practice of self-medication in the community. However, there are still many irrational self-medication practices, including inappropriate drug selection, not being aware of side effects, or the use of antibiotics for self-medication. Students are a group of people with a higher education level who cannot be separated from the use of medicines for self-medication of the disease they are experiencing. This study aimed to determine the knowledge, attitudes, and behavior of drug use among students in Jember and the factors that influence it. This study was a cross-sectional survey using a questionnaire conducted online in April-May 2020. The research respondents were undergraduate students (diploma and strata-1 students) at several universities in Jember. A total of 544 students became respondents in this study. The majority of respondents (344; 63.2%) had "enough" knowledge with an average knowledge value of 5.02 ± 1.71. The attitude of the majority of respondents (353; 64.9%) towards the use of drugs is included in the "enough" category with an average attitude value of 12.74 ± 1.19. The results of the Chi-square test show that the majors taken in university studies are related to knowledge but do not affect attitudes toward the use of medicines. Education about the medication use needs to be improved to increase the correct use of medicines in the practice of self-medication in the community.

Aktivitas Antioksidan Ekstrak Daun, Bunga, dan Tangkai Sirih Hutan (Piper aduncum L.) Mariani, Ria; Perdana, Farid; Widiana, Revi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Forest Betel (Piper aduncum L.) belongs to the genus Piper. Many researches on antioxidants of various genera of Piper have been carried out such as Piper crocatum and Piper betle, but research on antioxidants in forest betel is still very limited. Natural antioxidants can be used to reduce free radicals in an effort to prevent degenerative diseases. This study aims to determine the antioxidant activity of flowers, leaves and stalks of forest betel and the group of compounds responsible for the antioxidant activity. Antioxidant activity was tested using the DPPH method (2,2 diphenyl-1-picrylhydrazyl) with UV-Vis spectrophotometry and thin layer chromatography (TLC). The antioxidant activity test results using UV-Vis spectrophotometry showed that forest betel leaf extract had 47.252 µg/ml as an IC50 value, forest betel flower extract had 49,756 µg /ml as an IC50 value and forest betel stalk extract had 48.674 µg/ml as an IC50 value.. While vitamin C as a comparison has 5.223 µg/ml as an IC50 value. From the TLC results showed that the compounds suspected of providing antioxidant activity in the flower and stalk extracts were flavonoid compounds because they had the same Rf values, which 0.35; 0.53; 0.66 on the plates that had been sprayed with DPPH and sitroborate. Extracts of leaves, flowers and stalks of forest betel have antioxidant activity with IC50 of 47.252; 49.756 and 48.674 µg/ml respectively and suspected the presence of flavonoid compounds that are responsible for the antioxidant activities of flower and stalk extract.

Hubungan Tingkat Pengetahuan Masyarakat Terhadap Kesediaan Diri Vaksinasi COVID-19 RW 01 Kecamatan Cineam Anggriani, Ani; Sutrisno, Entris; Saskia, Puti Bela
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: The spread of the COVID-19 virus is rapidly expanding so that it becomes a big problem due to the increasing number of positive patient cases and cases of patients dying. Various efforts have been made, one of which is implementing a vaccination program with the aim of being able to work effectively by producing specific antibodies in the body so that it can reduce the incidence and break the chain of transmission. The attitude of the community towards their willingness to carry out the vaccination program still raises pros and cons. On November 4, 2021, it was recorded that Tasikmalaya Regency was ranked first as the region with the lowest vaccination rate in West Java. This study aims to analyze whether there is a significant relationship between the level of public knowledge on self- availability for the COVID-19 vaccine in the RW 01 area, Cineam District, Tasikmalaya Regency. This research is included in the type of quantitative research with analytical observational method with a cross sectional approach. Data were collected by distributing questionnaires and obtained a sample of 338 respondents. Data were analyzed using SPSS for frequency test and correlation test with Spearman Rank. The results obtained for the level of community knowledge of 88.9% and self-willingness of 67.8%, and the correlation test obtained is a significance value of 0.000 (0.000 <0.05) indicating a significant relationship between the level of knowledge and the presence of the community for implement a vaccination program.

Profil Penyimpanan Obat LASA (Look Alike Sound Alike) Pada Beberapa Apotek di Kota Medan Dasopang, Eva Sartika; Utami, Adinda; Hasanah, Fenny; Siahaan, Desy Natalia; Harefa, Niken Septriani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Drug production in the current era is quite rapid so that many drugs have similar names and pronunciation and almost the same packaging known as LASA (Look Alike Sound Alike). The number of LASA drugs on the market must be considered, especially their storage. Improper storage of LASA drugs can cause drug administration errors to patients Objective: to see how LASA drug storage and LASA drug items are in several pharmacies in Medan city. The research was conducted by direct observation at the sampled pharmacies using an observation form table through a check list system, then calculated the percentage of LASA storage standards based on pharmaceutical service standards in pharmacies. This study involved 14 pharmacies that were willing to be involved in this study from the many pharmacies in Medan city, data were taken from December 2021 to March 2022. This study shows that only 50% of the 14 pharmacies sampled have implemented LASA (Look Alike Sound Alike) drug storage, while the other 50% have not implemented the LASA (Look Alike Sound Alike) drug storage system in accordance with statutory regulations, namely Permenkes number 58 of 2014. The implementation of LASA drug storage according to Permenkes No. 58 of 2014 is still quite low in Medan city.

Profil Penggunaan Antibiotik pada Balita Penderita ISPA di Puskesmas Koya Barat Periode Januari-Desember 2020 Gunawan, Elsye; Rusnaeni, Rusnaeni; Febrianty, Silva Dewi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Acute Respiratory Tract Infection (ARTI) is the most common infection in humans at all ages. Children and toddlers are the most susceptible to ARTI. Prevalence of ARTI among toddler in Papua is 11.91%, in Jayapura district (10.23%) and Jayapura City (10.95%). This study aimed to determine the profile of antibiotics usage that given to toddler patients with ARTI on January-December 2020 at Koya Barat Public Health Center. The study design was retrospective of 155 prescriptions for toddler patients with ARTI that qualified the inclusion criteria. Data were analyzed using Microsoft excel software and presented in percentages (%) based on patient characteristics, and the level of antibiotic use was calculated. The results showed that male toddler was dominantly affected by ARTI, namely 87 patients (56,13%), age 0-30 months were 87 patients (56,13%), the type of antibiotic amoxicillin syrup used were 57 patients (74,03%). Overall used of antibiotics in toddler with ARTI at Koya Barat Public Health Center during January-December 2020 was 49,68%. Toddler with ARTI without comorbidities were 86,59%, and with comorbidities such as diarrhea, malaria, blepharitis, and pyoderma were 13.41%.

Aktivitas Antidislipidemia Rebusan Daun Mangga Kultivar Manalagi (Mangifera indica L. Var. Manalagi) Sulaeman, Agus; Susilawati, Elis; Aolina, Shelin
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Dyslipidemia is characterized by changes in lipid levels in plasma, a common indicator that is prone to the risk of cardiovascular disease. Plants that are suspected to have antidislipidemia activity, one of which is mango leaves. This study aimed to determine the effective dose in a decoction of mango manalagi leaves (Mangifera indica L. var. Manalagi) in decreasing levels of total cholesterol, triglycerides, LDL, and increasing HDL levels in high-fat feed-induced rats and propylthiouracil for 28 days. This research method was carried out preventively using 30 Wistar strain male rats which were grouped into 6 groups, namely negative control, positive control, comparison control (simvastatin 1.8mg/Kg BW), and a decoction test of manalagi mango leaves at a dose of 200, 400, 800 mg/kg BW. The parameters of the observed lipid profile are determined enzymatically using the micro lab. The results of the study on total cholesterol levels, showed the largest decreasing in the 200mg/kg BW dose group by 31.29%, in triglyceride levels the largest decreasing was found in the 400mg/kg BW dose group by 40.59%, in LDL levels the largest decreasing was found in the 200 mg/kg BW dose group by 48.03%, and in HDL levels there was the largest increasing in dose 800mg /kg BW of 97.40%. This study concludes that manalagi mango leaf decoction can be an antidyslipidemia in decreasing total cholesterol, triglyceride, and LDL levels as well as increasing HDL levels, with an effective dose of 200mg/ kg BW.

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Home Page

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Contact Name Hilwan Yuda Teruna

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Editorial Address Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

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Contact Name
Hilwan Yuda Teruna

Contact Email
hilwan@iai.id

Phone
+6221-56962581

Journal Mail Official
info@jfi-online.org

Editorial Address
Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA