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Jurnal Farmasi Indonesia

jfi
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Published by Ikatan Apoteker Indonesia

ISSN : 14121107 EISSN : 2355696X DOI : https://doi.org/10.35617/jfionline

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.

Arjuna Subject : Profesi Kesehatan - Farmasi

Articles 149 Documents

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Cytotoxic Activity Test Of Ethanolic Extract Of Berenuk Fruit (Crescentia Cujete L.) On Artemia Salina Leach Shrimp Larva Using Brine Shrimp Lethality Test (BSLT) Method Suzana, Dona; Handayanti, Isnani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy, which has cytotoxic effects. One of the plants that has the same effect is berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae. This plant contains napthoquinone as one of its cytotoxic chemical compounds and other secondary metabolites such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. The objective of this study is to determine the cytotoxic activity of an ethanolic extract of the fruit of berenuk on Artemia salina Leach larvae. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larvae that had been prepared and the value of mortality was observed. The result of a cytotoxic activity test of an ethanolic extract of berenuk fruit on A. salina larvae had a LC50 value of 529.386 ppm, which is categorized as toxic.

Effect of Flyers on Knowledge and Adherence to Medication of Hypertensive Patients Husnawati; Reni Zulfitri; Fina Aryani; Septi Muharni; Fitra Ramadhan
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Knowledge and adherence to taking medication in patients with hypertension is very important because knowing and adhering in taking antihypertensive drugs can control the blood pressure of people with hypertension. The purpose of this study was to determine the effect of giving flyers on knowledge and adherence to taking medication for hypertensive patients. The method used in this research is a quasi-experimental method, with a non-randomized control group pretest and posttest design which was carried out on 96 respondents with purposive sampling technique. Collecting data for knowledge using the knowledge questionnaire, and adherence using the MMAS-8 scale. Data were analyzed using Wilcoxon test and Mann-Whitney test. The results of the study on hypertensive patients showed that giving flyers had a significant effect on knowledge with a p value = 0.000 and on patient adherence with a p value = 0.000.

Uji Aktivitas Antibakteri Ekstrak Daun Karamuntin (Rhodomyrtus tomentosa (Aiton) Hassk.) terhadap Bakteri Streptococcus mutans Ramadhanty, Dewi Alfisyah; Lestari, Yulianita Pratiwi Indah; Nashihah, Siti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Indonesia has many medicinal plants that can used to treat various diseases. One of the plants is the leaves of karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.). Traditionally, karamunting leaves are used as a treatment in dental caries, wound care, and scabies. This study was aimed to determine the antibacterial effect of karamunting leaves ethanol extract against Streptococcus mutans by the well method. The design of this study was experimental laboratory research. The sample was karamunting leaves ethanol extract. The extracts were evaluated for antibacterial activity against Streptococcus mutans using the well method with a concentration of 6,25%; 12,5%; 25%; and 50% w/v. The result showed karamunting leaves ethanol extract provided an antibacterial activity against Streptococcus mutans with an inhibition zone diameters of 17,7±0,0577; 22,6±0,2516; 25,3±0,1527; and 28,3±0,0577 mm. at the concentration of 6,25% w/v, 12,5% w/v, 25% w/v, and 50% w/v, respectively. karamunting leaves ethanol extract had significant antibacterial activity against Streptococcus mutans at the concentration 50% w/v with inhibition zone diameters of 28,3 mm.

Formulasi Sabun Cair Perak Nanopartikel dengan Penstabil Polyvinil Alcohol : Sabun Cair Perak Nanopartikel Sutriyo; Hanandi, Sharon; Putri, Kurnia Sari Setio; Poetri, Okti Nadia; Annisa, Syifa; Rahmasari, Ratika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

According to Global Burden of Disease reported on 2019, about 1.53 million deaths caused by infectious diseases such as pneumonia and diarrhea. Triclosan is one of the active ingredient commonly used in antibacterial soap as one way to prevent the spread of infectious disease.. However, bacteria resistance against triclosan has been reported. Silver nanoparticles (AgNP) is an alternative antibacterial that potential to be used in liquid hand wash. However AgNp tend to aggregate during storage, thus stabilizer is needed This study aims to synthesize AgNP, formulate the liquid hand wash contain AgNP with polyvinil alcohol as stabilizer, and evaluate its effectiveness against Escherichia coli, Staphylococcus aureus, and Salmonella thypi. AgNP was prepared using the chemical reduction method between silver nitrate and sodium borohydride, followed by its characterization using UV-Vis spectrophotometer, TEM, PSA, and AAS. The physical characteristic of AgNp-liquid hand wash were also evaluated. Further, the antibacterial activity of AgNP-handwash was evaluated by phenol coefficient method. The peak of UV absorption spectrum of colloidal was found at 404.2 nm indicated the presence of AgNP. Ag content in AgNP colloidal was 38.405 mg/Kg ± 0,008. The spherical shape of AgNP was observed. The AgNP size was 65.1 nm with polydispersity index value of 0.543, and zeta potential value was -22.25 mV. The obtained AgNP-hand wash met the Indonesian standard criteria and was stable for 28 days. The best phenol coefficient value was obtained at formulation with addition of 30% AgNP (0.1 for S. typhi, 0.4 for E. coli, and 0.01 for S. aureus).

Potensi Kurma Sebagai Sumber Nutrasetikal dan Pangan Fungsional Gondokesumo, Marisca Evalina; Susilowati, Retno Wilujeng
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Dates are cultivate as a staple food in many countries, especially in the Arabian Peninsula, North Africa, and the Middle East. Dates fruits and date seeds as their by-products have nutritional and health values. It is an abundant source of carbohydrates, dietary fiber, and protein. They are high-source minerals and B complex vitamins, such as thiamine (B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), and folate (B9). Based on literature studies, the fruit and seeds of dates are also rich in phytochemicals, such as phenolics, anthocyanins, carotenoids, tocopherols, tocotrienols, and phytosterols. However, date fruits and seeds have not been fully utilized as functional food ingredients with numerous potential to be developed into foods that promote health benefits. Several studies have reported the health benefits of dates in in-vitro and in-vivo conditions. Further research will provide valuable information for the potential utilization of date fruit and seeds as nutritional and functional food ingredients. This review article provides comprehensive information on the bioactive compounds and nutraceutical properties of date fruits and seeds, as well as their potential for use as functional food ingredients.

Kadar Flavonoid Total dan Uji In Vitro Aktivitas Tabir Surya Ekstrak Kulit Batang Tuntun Angin (Elaeocarpus floribundus Blume) Utami, Rahayu; Alpasiri, Ikhsan Mauludi; Fadhli, Haiyul; Ikhtiarudin, Ihsan; Mora, Enda; Furi, Mustika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The stembark of tuntun angin (Elaeocarpus floribundus Blume) has been traditionally using to treat various diseases, including fever, gingivitis and rheumatism. Our previous study has shown that stembark extract of this plant contains significant levels of total phenolics. The aim of this recent study was to determine total flavonoid content and providing an initial determination of sunscreen activity of n-hexane, ethyl acetate and methanol extracts of its stembark. Extraction was carried out by maceration method using three different solvents successively. The quantitative evaluation of total flavonoid content was expressed as mg Quercetin Equivalent (QE)/gram extract at a wavelength of 430 nm using a microplate reader. Evaluation of sunscreen activity was performed by determining value of Sun Protection Factor (SPF) using a UV-Vis spectrophotometer. The results showed that the n-hexane, ethyl acetate and methanol extracts contained total flavonoid levels of 9; 15.81 and 15.56 mgQE/g extract, respectively. Ethyl acetate extract showed the most potential sunscreen activity (ultraprotection category) among other extracts with SPF values of 44.626; 40,687; 33.710 and 23.607 for the tested concentrations of 1000; 800; 600 and 400 µg/mL, respectively. However, this activity is not as good as benzophenone-3 as positive control at a concentration of 50 μg/mL with an SPF value of 22.646 demonstrated an ultraprotection category of sunscreen activity.

Cytotoxicity Assay of Dètente Instantanée Côntrolée Pre-Dried Pandanus conoideus Lam. Extracts Yunita, Oeke; Kohar, Indrajati; Allaf, Karim; Anggara, Aris Sri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Red fruit (Pandanus conoideus Lam.) contains antioxidant compounds in high levels, including beta-carotene and tocopherol, which neutralize free radical compounds which can cause cancer. Red fruit contains 46% water so red fruit can only last 5 days in this condition. To maintain its stability, it is necessary to dry it with various methods, for example détente instantanée contrôlée (DIC) is a revolutionary pressure drop drying procedure. Every procedure for drying raw material can affect its quality and activity, for example the anticancer activity of red fruit. In-vitro cytotoxicity of DIC pre-dried red fruit extracts on HeLa cells has never been tested, so it is important to study. Red fruit which was obtained from Klamono, Sorong, a highland in Papua was extracted with ethanol or hexane which previously dried by DIC pre-drying or conventional drying methods were weighed then dissolved in DMSO. Cytotoxicity assays was conducted using method the MTT with five levels of extract concentration. Result of this research showed that cytotoxicity assay of red fruit extracts on HeLa cells showed that red fruit extract can inhibit cell viability. The conventionally dried red fruit extract shows stronger cytotoxicity against HeLa cells than the DIC pre-dried extract. Red fruit extract cytotoxicity against HeLa cells: ethanolic extract of red fruit previously dried by conventional drying technique > ethanolic extract of red fruit previously dried by DIC pre-drying process > hexane extract of red fruit previously dried by conventional drying method > hexane extract of red fruit previously dried by DIC pre-drying process.

Karakterisasi Morfologis dan Molekuler Varietas Kedelai (Glycine max) untuk Identifikasi Bahan Baku Obat Tradisional Indonesia Wiradjaja, Fuad Soegibudiono; Yunita, Oeke
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Many nutrients and active medicinal compounds in soybean (Glycine max) reduce the risk of cancer, cardiovascular disease, postmenopausal issues, diabetes, and some neurodegenerative disorders. Soybean protein causes several allergic reactions, which necessitates quality control for traditional medicines and herbal products. Morphological and molecular characterization using Random Amplified Polymorphic DNA (RAPD) method were used to control soybean quality. Morphological characterization of 35 soybean varieties from the Research Institute for Various Beans and Tubers (BALITKABI), Malang, East Java, included photos of each variety and seed size, color, hilum color, weight, and special characteristics. RAPD with OPF-3 and OPF-16 primers characterized 35 soybean seed varieties. This study found that morphological characteristics like seed color, hilum color, seed shape, and seed weight are difficult to use to distinguish between varieties, especially if there are no specific features that predominate in these varieties. However, molecular authentication with RAPD can distinguish 35 soybean varieties by the presence of specific polymorphic bands that can only be found in certain varieties.

Formulasi Nasal Spray Anti-Influenza yang Mengandung Nanopartikel Perak : Nasal Spray Anti-Influenza Nanopartikel Perak Sutriyo; Wilbert Wylie; Kurnia Sari Setio Putri; Okti Nadia Poetri; Rahmasari, Ratika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Influenza A virus is one of the most common causes of respiratory disease in the world. Even though, vaccines and anti-influenza virus are become the first line for therapy, but the mutation ability of influenza virus is able to cause several outbreaks in the world. Silver nanoparticles (AgNP) have been proven to exhibit antiviral activity; however, the use of AgNP in pharmaceutical products is still limited. In this study, we aimed to formulate nasal spray containing AgNP, to evaluate its physicochemical properties, and its antiviral activity toward H5N1 influenza A virus. AgNP were synthesized using chemical reduction method with polyvinyl alcohol as stabilizer, and further prepared into nasal spray product. Physicochemical properties and anti-hemagglutination activity of nasal spray were further evaluated. The nasal spray contained different size of AgNP (less and more than 50 nm) showed physical stability after 28 days storage. However, Anti-influenza evaluation of nasal spray contained AgNP less than 50 nm exhibited better anti-hemagglutination activity against influenza A virus.

Pengaruh Variasi Bahan: Pelarut dan Lama Ekstraksi Ultrasonik dari Ekstrak Daun Kelor terhadap Rendemen dan Kadar Total Fenol Rifkia, Via; Revina, Rika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Moringa (Moringa oleifera L.) is a plant that has a wide range of health benefits. The benefits of Moringa can be obtained from the leaf part. One of the compounds that are in Moringa leaves and have benefits is phenol compounds. Phenol compounds were tested from Moringa leaf extract obtained using the ultrasonic method. The ultrasonic method is an extraction method that can produce extracts effectively and efficiently. The purpose of this study was to determine the effect of variations in material concentration: solvent (1:10, 1:15, and 1:20) and extraction duration (10, 20, and 30 minutes) on the yield value and total phenol content of Moringa leaf extract. The extract obtained is then weighed and calculated the yield value. After that, Moringa leaf extract was tested for phytochemical screening and total phenol level test. Based on the results of the study, it showed that the highest amendment value of Moringa leaf extract was obtained from the ratio of ingredients: solvent 1:20 b / v with an extraction time of 30 minutes, which was 35.89%. Then the highest total phenol content results were obtained from moringa leaf ethanol extract at the ratio of ingredients: solvent 1:20 b / v with an extraction time of 30 minutes, which was 25,9 GAE/g.

Page 9 of 15 | Total Record : 149

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Editorial Address Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

Location Kota adm. jakarta barat, Dki jakarta INDONESIA

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Contact Name
Hilwan Yuda Teruna

Contact Email
hilwan@iai.id

Phone
+6221-56962581

Journal Mail Official
info@jfi-online.org

Editorial Address
Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA