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Jurnal Farmasi Indonesia

jfi
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Published by Ikatan Apoteker Indonesia

ISSN : 14121107 EISSN : 2355696X DOI : https://doi.org/10.35617/jfionline

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.

Arjuna Subject : Profesi Kesehatan - Farmasi

Articles 149 Documents

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Uji Resistensi Nyamuk Aedes aegypty Terhadap Cypermethrin 0,05% di Bandara Sultan Syarif Kasim II Pekanbaru Tahun 2020 Handayani, Dedes
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Dengue Hemorrhagic Fever (DHF) is one vector-borne disease caused by the Aedes aegypti mosquito vector. One way to control the Aedes aegypti mosquito vector is to use insecticides. The insecticide used must be known for its efficacy, safety and resistance status. The use of cypermethrin as an insecticide in controlling the Aedes aegypti mosquito at Sultan Syarif Kasim II Airport Pekanbaru needs to know its resistance status. This study aims to determine the resistance status of the Aedes aegypti mosquito to the insecticide cypermethrin at Sultan Syarif Kasim II Airport, Pekanbaru. The method in this research is descriptive with a cross sectional study design. The independent variable was the Aedes aegypti mosquito exposed to insecticide at Sultan Syarif Kasim II Airport Pekanbaru, while the dependent variable was the Aedes aegypti mosquito susceptibility status. The resistance test method refers to The World Health Organization Susceptibility Test criteria. The resistance test using WHO standard impregnated paper showed that the percentage of mosquito that died after being exposed to impregnated paper containing 0.05% Cypermethrin for 24 hours at Sultan Syarif Kasim II Airport Pekanbaru was 81.5% (Tolerant Phase). There has been a tolerance for the use of 0.05% Cypermethrin against the population of Aedes aegypti mosquitoes in Sultan Syarif Kasim II Airport, Pekanbaru.

ANALISIS EFEKTIVITAS BIAYA PASIEN COVID-19 MENGGUNAKAN TERAPI OKSIGEN DAN REMDESIVIR DI RSUD KABUPATEN TANGERANG Yusransyah, Yusransyah; Udin, Baha; Abdillah , Mursyid; Murdianto, Yudi; Soraya Uli, Elisabeth; Suryana, Nana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

COVID-19 is a contagious disease, so there is a potential for an increase in the number of COVID-19 cases. If there is an increase in incidence or prevalence, it will cause problems related to the costs and outcomes of an intervention. Therefore, a cost-effectiveness analysis is needed. This study aims to determine the cost-effectiveness of COVID-19 patients who use oxygen therapy with and without being given remdesivir. This study uses a cost-effectiveness analysis method that takes into account the ACER (Average Cost-Effectiveness Ratio) and ICER (Incremental Cost-Effectiveness Ratio) values. The data used is retrospective data and sampling is done by purposive sampling, the sample obtained in this study amounted to 34 cases. The results of this study showed that the total average direct medical costs of the remdesivir group were Rp. 32,399,532 with an effectiveness of 47%, while in the non-remdesivir group the total average direct medical costs were Rp. 26,853,729 with an effectiveness of 41%. The ACER value obtained in this study was Rp. 688,490 in the remdesivir group and Rp. 654,969 in the non-remdesivir group. The results of the ICER calculation in this study were Rp. 924,301 per day of hospitalization. In this study, it can be concluded that the therapy group of COVID-19 patients who use oxygen therapy without being given remdesivir is more cost-effective than the therapy group of COVID-19 patients who use oxygen therapy with remdesivir.

Optimasi Sodium Croscarmellose dan Pati Jagung Pregelatinasi dalam Orally Disintegrating Tablet Setirizin Dihidroklorida Irawan, Eka Deddy; Sari, Lusia Oktora Ruma Kumala; Cahyaningrum, Nitta
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Cetirizine dihydrochloride (Cetirizine diHCL) is an effective antihistamine to treat allergies. Cetirizin diHCL tablets are a dosage form that is commonly on the market. However, people who experience allergies will have symptoms of difficulty swallowing which make it difficult to take cetirizine diHCl tablets. Therefore, it is necessary to make cetirizine diHCl in the form of orally disintegrating tablets (ODT) which can dissolve in saliva in a few seconds without chewing tablets or drink water. The proportion of binder and super disintegran was used in ODT preparations must be taken into calculation because it will greatly affect the physical characteristics of the tablets. This study aims to optimize the super disintegran Croscarmelose Sodium and pregelatinasi corn starch binders using factorial design methods. The responses studied were flow rate, hardness, brittleness, wetting time, and disintegration time. The increased Croscarmelose Sodium factor reduces the flow rate and hardness, increases brittleness, and decreases wetting and disintegration times. The increased factor of pregelatinasi corn starch will increase the flow rate and hardness, reduce friability and increase wetting time and disintegration time. The optimum formula was obtained from the concentration of Croscarmelose Sodium 6.613 mg and pregelatinasi corn starch 20 mg which resulted in a flow rate response of 13.438 g/second, hardness 4.646 kg, friability 0.815%, wetting time 63.667 seconds, and disintegration time 18.641seconds.

Uji Aktivitas Analgesik Tablet Asam 4-(Klorometil)Salisilat pada Mencit Putih dengan Metode Writhing Test dan Hotplate Tiffany, Angela; Ribka Abiati, Meidelin; Foe, Kuncoro; Tjahjono, Yudy; Caroline; Esar, Senny Yesery; Hadinugroho, Wuryanto
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Acetylsalicylic acid is an analgesic drug that still popularly used. However, acetylsalicylic acid may result undesirable side effect of gastrointestinal as it can cause gastric ulcer to bleeding. Previous research has succeeded synthesizing new compound derived from salicylic acid, namely 4-(chloromethyl)salicylic acid which has the potential to reduce its side effects with a better pharmacological effects than acetylsalicylic acid. In its development, the formulation of the compound in tablet dosage form has been carried out. However, until now there has not been a pharmacological test to determine whether it still provides a greater effect than acetylsalicylic acid after being formulated. This study is to test the analgesic activity of 4-(chloromethyl)salicylic acid tablets in albino mice using writhing test and hotplate methods. Analgesic activity test using the hotplate method was carried out on albino mice which given the suspension of the tablet sample and the observations were made in a periodic of time. Analgesic activity test using writhing test method was carried out in 0.6% acetic acid-induced albino mice, where the suspension of the tablet was administered 30 minutes before administration of acetic acid. Analgesic activity was assessed by counting the number of writhings, and the results were statistically compared with one-way ANOVA. Tests were also performed on acetylsalicylic acid as a positive control and suspension as a negative control group. There were significant differences (P<0.05) of the analgesic activity observed among groups. Both methods show that 4-(chloromethyl)salicylic acid tablets provide stronger analgesic activity than acetylsalicylic acid.

Variasi Konsentrasi Maltodekstrin Terhadap Karakteristik Fisik dan Aktivitas Antibakteri Orally Disintegrating Film Ekstrak Daun Pecut Kuda (Stachytarpheta jamaicencis L.) Putri, Yola Desnera; Ledianasari, Ledianasari; Aziza, Farradiba Nur
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Orally dissolving film (ODF) preparations are a new invention that allows drugs to be used more conveniently than other oral solid preparations without the need for drinking water. Porterweed (Stachytarpheta jamaicencis L) is one of herbal medicine that can be developed into an Orally Disintegrating Film (ODF) preparation with providing fast disintegration time and convenience comsumption especially for patients who have difficulty swallowing tablets. Main component in ODF preparations is polymer. Combination of HPMC K100M and maltodextrin produce good physical characteristics. The research was aimed to determine the influence of variations concentration 3.5 grams, 4.5 grams and 5.5 grams of maltodextrin on the physical characteristic of ODF containing porterweed extract. Stages of research carried out the formulation of basis and preparations continued with physical evaluated and antibacterical activity. To ensure that the resulting ODF preparations are ideal, evaluation tests need to be carried out including organoleptic, pH of the preparations, average weight, thickness, swelling index, disintegration time, tensile strength, percent elongation, and antibacterial activity. The best physical characterictis evaluation is formula 2 of ODF porterweed extract (Stachytarpheta jamaicencis L) containing 4.5 grams of maltodextrin with pH surface 6.75 ± 0.025, average weight 0.0499 ± 0.0001 g, thickness 0.0997 ± 0.002 mm, swelling index in 15;30; and 45 sec. are 257.49 ± 0.244%; 322.46 ± 0.202%; and 403.21 ± 0.197%, disintegration time in 54 sec., tensile strength 12.67± 0.374 MPa, percent elongation 20% and have strong category of antibacterial ability against Staphylococcus aureus in 11.43 ± 1.401 mm.

Pengaruh Home Visit terhadap Kepuasan Konsumen Apotek Palasari Sumedang Zuniarto, Ahmad Azrul; Subagja, Subagja; Nurhasanah, Sarah; Sundari, Retno T; Pandanwangi, Siti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: In the context of service of pharmaceutical at pharmacy, patients satisfaction is a pleasure feeling appearing in someone’s body after getting service taken directly. The analysis of customer’s satisfaction is based on five dimensions of service quality, which are among others responsiveness, reliability, assurance, empathy, and tangible. The purpose of the research was to find out the influence of home visit activity toward the customer’s satisfaction at Palasari pharmacy Sumedang and the satisfaction level of customer’s satisfaction before and after the home visit activity. This research was a quantitative one where the independent variable was home visit whereas the dependent variable was the customer’s satisfaction at Palasari pharmacy Sumedang. The technic of sample taking was total sampling. The samples used in the research were 34 respondents, they were the PRB patients from Palasari pharmacy at Ganeas district who never take the medicine regularly. The research instruments used in the research was questionnaire of customer’s satisfaction. The results of the study with a questionnaire on the level of consumer satisfaction at Palasari Sumedang Pharmacy before the home visit and after the home visit experienced an increase in percentage results from 75.4% to 81.5% and a simple linear regression test showed that there was an effect of home visits on satisfaction consumer Pharmacy Palasari Sumedang with a value sig. 0.000. Results study show that Home visits are influential to satisfaction consumer Pharmacy Palasari Sumedang with level satisfaction consumers 75.4 % increase to 81.5%.

The Kombinasi Ekstrak Kulit Buah Nanas Dan Mangga Yang memiliki Aktivitas Antioksidan Dan Inhibisi Tirosinase Krismayadi, Krismayadi; Taurhesia, Shelly; Noor, Siti Umrah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The peel of pineapple (Ananas comosus (L.) Merr.) and mango (Mangifera indica L.) contain polyphenolics that have antioxidant activity and tyrosinase inhibitor. Both of these activities are useful for skin lightening treatments. The purpose of this study was to determine the value of the antioxidant and tyrosinase inhibitor activity of each pineapple peel extract (EKBN) and mango peel extract (EKBM), and their combination with a ratio of 2:1; 1:1; 1:2. The combination that gives the best value for antioxidant activity and tyrosinase inhibitor may be made for cosmetic preparations. The antioxidant activity of each extract and its combination was determined by the DPPH method, after the antioxidant IC50 value was obtained, then the tyrosinase enzyme inhibitory activity was tested. The results showed that EKBN; EKBM; the combination of EKBN and EKBM with a ratio of 2:1, 1:1, 1:2 has antioxidant activity with IC50 values: 618.42 ppm, 10.29 ppm, 30.73 ppm, 20.20 ppm and 18.04 ppm, has tyroinase inhibitory activity with IC50 of 5,019.98 ppm, 930.85 ppm, 1.992.31 ppm, 2.070.89 ppm and 2.839.75 ppm, respectively. There is a correlation between the IC50 of the combined extract and its weight. the combination of EKBN and EKBM, 1:2 gave the best antioxidant activity results with an IC50 value of 18.04 ppm (very strong) and the combination of EKBN and EKBM, 2:1 gave tyrosinase inhibitory activity with an IC50 value of tyrosinase 1.992.31 ppm. The combination of EKBN and EKBM, 1:2 may be developed further as cosmetic preparations such as serum, liquid spray, and others.

Korelasi antara Keyakinan Masyarakat terhadap Vaksinasi Covid-19 dengan Tingkat Kepuasan Pelayanan Vaksinasi Covid-19 Mardiana, Lina Aliyani; Julianto, Rasiman; Lutfah, Ika Oktaviyanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: Vaccination is a way of preventing various kinds of diseases caused by bacteria, viruses or other germs, where people who have been vaccinated become good, protected, not exposed or only experience mild illness when the disease outbreak occurs, as was the case some time ago when there was an outbreak the Covid-19 pandemic, the world community and also the Indonesian people carry out the Covid-19 vaccination simultaneously. Confidence in the success of vaccination encourages people to voluntarily do it and the quality of vaccination services should be in accordance with community expectations. This study aims to determine the correlation between public belief in the Covid-19 vaccination and the level of satisfaction with the Covid-19 vaccination service. This research is a quantitative research using cross sectional method. A sample of 360 people was obtained by distributing online and offline questionnaires. Shows that there is no correlation between public confidence in the Covid-19 vaccination and the level of satisfaction with the Covid-19 vaccination service, the p-value > 0.05 which means Ho is accepted or there is no significant relationship between public belief and service quality. There is no correlation between public confidence in the Covid-19 vaccination and the quality of the Covid-19 vaccination service.

Evaluasi Rasionalitas Terapi Antibiotik Pada Faringitis Akut di Puskesmas Kota Denpasar Manik Partha Sutema, Ida Ayu; Sukmantari, Pande Ni Nuhung; Windidaca Brata Putri, Dhiancinantyan
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Pharyngitis is an inflammatory disease of the throat caused by viruses (70-90%) and bacteria (10-30%), and one of the diseases that is ranked third in the pattern of the 10 most common diseases in Puskesmas 2017. Appropriate therapy in pharyngitis is still lacking, where antibiotic therapy is still very high in children. This study was conducted to determine the rationality of antibiotic therapy in acute pharyngitis based on the centor score and to see the description of the suitability of the dose, indication, time of administration, frequency of administration and the presence of drug side effects. The design of this study used descriptive analysis with a cross-sectional retrospective method. Data collection was carried out by collecting samples derived from secondary data by observing pharyngitis patient medical record data at the Denpasar City Health Center in February - April 2022. The inclusion criteria of this study were complete and readable medical records in children aged 3-14 years. Results showed that giving antibiotics based on suitability for centor criteria showed that 70.22% of cases in this study were still not giving antibiotics correctly based on the score obtained. Based on the appropriateness of the use of antibiotics seen from the criteria for dosage, indication, time of administration, frequency of administration and warning of drug side effects, the results obtained were as many as (39.40%) doses that were inappropriate because the dose received was lower than the dose stated in the literature, the duration of antibiotic administration 86.36% of patients who did not use the right antibiotic, and all patients had the right frequency of using antibiotics and none experienced drug side effects. The rationality of giving antibiotics for pharyngitis is still not in accordance with the Puskesmas guidelines using centor criteria. Suggestions need to be evaluated against the use of antibiotics in pharyngitis in an effort to reduce the use of antibiotics in accordance with centor criteria.

Eksplorasi efek etanol terhadap survival dan status imunitas Drosophila melanogaster Rosa, Reski Amalia; Latada, Nadila Pratiwi; Asbah, Asbah; Mu'arif, Ahmad; Yulianty, Risfah; Nainu, Firzan
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

: High doses of ethanol in the body can elicit damage to organs including the brain, liver and kidneys. In addition, ethanol can trigger the formation of reactive oxygen species (ROS), where excess levels of ROS in the body can promote cell death through the apoptotic pathway. Apoptotic cells that are not phagocytosed will undergo necrosis. In the process of necrosis, cells release DAMPs, endogenous pro-inflammatory molecules and induce the core immune system in Drosophila that are homologues to humans, namely Toll, IMD (Immune Deficiency), and JAK-STAT (Janus Tyrosine Kinase-Signal Transducer and Activator of Transcription). The aim of this research is to investigate how ethanol exposure influences gene expression in the Toll, Imd, and JAK-STAT pathways. The results showed that ethanol could affect the survival rate of male and female Drosophila melanogaster w1118. Exposure to ethanol at high concentrations (85%) caused a decrease in the expression of Drs, but not the expression of the Dpt. In addition, TotA expression, but not Upd3, was amplified significantly as the ethanol concentration increased. In conclusion, Drosophila experienced a decrease in the survival rate due to ethanol exposure which might be related to the stress response and the immune system which is mediated by certain pathways.

Page 7 of 15 | Total Record : 149

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Editorial Address Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

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Contact Name
Hilwan Yuda Teruna

Contact Email
hilwan@iai.id

Phone
+6221-56962581

Journal Mail Official
info@jfi-online.org

Editorial Address
Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA