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Jurnal Farmasi Indonesia

jfi
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Published by Ikatan Apoteker Indonesia

ISSN : 14121107 EISSN : 2355696X DOI : https://doi.org/10.35617/jfionline

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.

Arjuna Subject : Profesi Kesehatan - Farmasi

Articles 149 Documents

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Hubungan Sosiodemografi dan Penyakit Penyerta Terhadap Nilai D-Dimer Pasien Covid-19 Michael, Michael; Ramatillah, Diana Laila; Hartuti, Silvy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

D-dimer is a degradation of soluble fibrin which is the result of systematic degradation of vascular thrombus through a fibrinolytic mechanism. The purpose of this study was to look at sociodemographic factors and other diseases that affect the d-dimer value of COVID-19 patients. This study uses a retrospective cohort method with the collection of sampling is convenience sampling. There were 137 patients who met the study criteria. Age, BMI, blood pressure and respiration rate are sociodemographics that affect the D-dimer lab value. For comorbidities that affect the D-dimer lab value, there are CKD, anemia, hypertension and heart disease. A high D-dimer value also has a significant relationship with the severity of the COVID-19 infection. In addition, patients who died were found to have high D-dimer values. By this research, patients with high age, BMI, blood pressure and respiration rate can increase patient mortality and for comorbidities that have an important role in increasing mortality in Covid-19 patients are CKD, anemia, hypertension and heart disease.

Pengaruh Antioksidan dan Kombinasi Pengawet terhadap Stabilitas Ekstrak Cair NADES Biji Kopi Hijau Ramadon, Delly; Septiani, Rosalina Mesusi; Putri, Salsabila Nursyifa; Mun'im, Abdul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Green coffee beans (Coffea canephora Pierre ex A. Froehner) contain caffeine and chlorogenic acid which are beneficial for health. These two main ingredients can be extracted using Natural Deep Eutectic Solvents (NADES) in combination with the Ultrasound-Assisted Extraction (UAE) method which is environmentally friendly. NADES can be used for extracting green coffee beans, but the solvent cannot be evaporated, thus the result is a liquid extract. During storage, liquid extracts are susceptible to oxidation and bacterial growth so that they can disrupt physical, chemical, and microbiological stabilities. In this study, butylated hydroxytoluene (BHT) was added as a synthetic antioxidant and a combination of methylparaben-propylparaben as preservative to determine its effect on the physical, chemical, and microbiological stability of the NADES liquid extract of green coffee beans, as well as to determine the best storage temperature. The concentrations of BHT added in this study were 10, 20, and 30 ppm. The concentration of the methyl paraben:propyl paraben combination added was 110:55 ppm, 100:50 ppm, and 90:45 ppm. Each extract was stored at storage temperatures of -20°C ± 5°C, 5°C ± 3°C, and 30°C ± 2°C for 54 days. The results showed that the liquid extract added with 30 ppm BHT concentration and a combination of preservatives with a concentration of 110:55 ppm and stored at a storage with the temperature of -20°C ± 5°C which had the best physical, chemical, and microbiological stability. This shows that the addition of BHT and a combination of preservatives can increase the stability of the green coffee bean NADES extract.

UJI DAYA HAMBAT EKSTRAK ETANOL DAUN RAMBAI (Sonneratia Caseolaris (L) Engl) TERHADAP BAKTERI Propionibacterium acnes DAN Staphylococcus epidermidis Fitriani, Tiya; Nashihah, Siti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Currently there are many anti-acne preparations on the market but not a few of these drugs give side effects to the user. The need for alternatives from nature that can act as antibacterial in the treatment of acne that has a smaller risk of side effects. This study aims to determine the inhibition of ethanol extract of rambai leaves (Sonneratia caseolaris (L) Engl) against acne-causing bacteria Propionibacterium acnes and Staphylococcus epidermidis. Extraction was carried out by the UAE method and a yield of 9.21% was obtained. Phytochemical screening obtained positive results containing flavonoids, triterpenoids, tannins, saponins and phenol compounds. Antibacterial activity test was conducted using the well diffusion method with 4 different concentrations of 15%, 25%, 50% and 75% with positive control of clindamycin 0.03% and negative control of DMSO 1%. The results of antibacterial activity testing on Propionibacterium acnes bacteria obtained inhibition zone diameters of 3.3 mm; 4.43 mm; 6.48 mm; and 8.45 mm, respectively, while on Staphylococcus epidermidis bacteria 11.08 mm; 12.27 mm; 15.38 mm; and 16.78 mm, respectively. The results of the One Way ANOVA statistical test obtained a significance value of 0.000 (p<0.05) which indicates that the treatment of each group is significantly different.

PENETAPAN KADAR FENOLIK EKSTRAK METANOL RUMPUT POLYGALA (POLYGALA PANICULATA L.) DENGAN METODE KLT-DENSITOMETRI Aktsar Roskiana ahmad; Dwiyanti Puspitasari; Virsa Handayani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Polygala grass (Polygala paniculata L.) is a plant that grows a lot in the Enrekang area, South Sulawesi. Polygala grass (Polygala paniculata L.) belongs to the Polygalaceae family which is widely used by the community as a medicine to treat wound. This study aims to determine the phenolic content in the methanol extract of polygala grass (Polygala paniculata L.). Methanol extract of polygala grass (Polygala paniculata L.) was obtained by maceration method with methanol P as solvent. Chemical component analysis used thin layer chromatography (TLC) method which was marked by the appearance of stains. The determination of phenolic content of methanol extract of polygala grass (Polygala paniculata L.) using the TLC-Densitometry method. The results showed that the phytochemical test on the methanol extract of polygala grass (Polygala paniculata L.) was positive for 35.280 µg of phenolic compounds.

Studi molecular docking senyawa diterpen abieten terhadapenzim protease utama (mpro) virus corona Hilwan Yuda Teruna; Kamal Rullah; Fajri Khatami
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Coronavirus disease atau Covid-19 merupakan suatu penyakit yang disebabkan oleh virus corona jenis baru yaitu SARS-CoV-2. Penyakit ini pertama kali ditemukan di Wuhan, China dan saat ini telah menjadi pandemi yang sudah menyebar hampir ke seluruh negara di dunia. Salah satu enzim yang berperan penting dalam memediasi replikasi dan transkripsi pada virus SARS-CoV-2 adalah enzim protease utama (Mpro). Penelitian ini bertujuan untuk menemukan senyawa yang berpotensial menginhibisi enzim protease utama (Mpro) virus corona (PDB ID: 6LU7 dan 2GTB) melalui studi molecular docking pada senyawa turunan diterpen abieten. Studi molecular docking dilakukan menggunakan perangkat lunak Autodock4 dan divisualisasi menggunakan PyMOL dan Discovery studio. Validasi metode atau redocking menunjukkan akurasi yang baik dengan nilai Root Mean Square Deviation (RMSD) sebesar 1,85 Å pada enzim 6LU7 dan 1,92 Å pada enzim 2GTB. Studi molecular docking enzim 6LU7 pada 3 senyawa turunan diterpen abieten (6-asetil7-hidroksiroileanon, 7-hidroksiroileanon dan diterpenoid glukosida (CH-6)) menunjukkan nilai energi ikatan masing-masing sebesar -9,07; -8,22 dan 7,94 kcal/mol, pada enzim 2GTB menunjukkan nilai -9,54; -9,14; -8,26 kcal/mol. Hasil ini menunjukkan senyawa 6-asetil7-hidroksiroileanon dan 7-hidroksiroileanon memiliki afinitas lebih kuat terhadap enzim protease utama (Mpro) dan enzim peptidase utama dibandingkan dengan kontrol positif yang mempunyai energi ikatan sebesar -7.38 dan -7,97 kcal/mol. Selain itu, senyawa yang memiliki afinitas paling kuat yaitu 6-asetil7-hidroksiroileanon memiliki 6 ikatan hidrogen yang sama dengan ligan asli dalam situs aktif enzim protease utama (Mpro). Sehingga, diprediksi senyawa 6-asetil7-hidroksiroileanon mampu dijadikan sebagai inhibitor pada enzim protease utama (Mpro) Covid-19 maupun pada enzim peptidase utama SARS-CoV dari strain sebelumnya.

Analisis komponen minyak atsiri daun nilam (Pogostemon cablin) lokal Pekanbaru menggunakan GC-MS Teruna, Hilwan Yuda; Rahayu, Wiwit Nur
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Pogostemon cablin or nilam Aceh is a patchouli oil producer plant that is widely cultivated in Indonesia because the quality of the essential oil produced is better than other types of Pogostemon. The purpose of this study was to extract the local patchouli oil of Pekanbaru and compare its chemical components with standard patchouli oil. The quality of the patchouli essential oil of local Pekanbaru was also analyzed based on the chemical components. The extraction method used in this research was hydrodistillation using Clevenger apparatus. Volatile oil vapor evaporated together with water vapor and passed through the condenser. The oil was characterized by its components by GC-MS. The results found that the concentration of patchouli alcohol was 31.13%, along with other compounds such as α-patchoulene, β-patchoulene, seychellene, α-bulnensene, and cyclosativene. The difference of patchouli oil of P. cablin grown in Pekanbaru with the standard patchouli oil was that the concentration of patchouli alcohol in the local patchouli oil of Pekanbaru was high with no α-guaiene, there was a cyclosativene instead. Based on this, the local patchouli oil of Pekanbaru has a fairly good quality and has the potential to be developed further.

Evaluasi Hasil Klinis Pada Tim Medis yang Mendapat Vaksinasi Booster di Rumah Sakit Bengkayang Kalimantan Barat Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri; Paulina, Ida; Gloria, Fransisca; Michael, Michael
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: In reducing the risk of transmission to health workers, the Government has given the 3rd Booster Covid-19 Vaccination since August 2021. This study uses the Astra Zeneca Vaccine, Moderna Vaccine and Pfizer Vaccine. The purpose of this study was to evaluate the effectiveness of the 3rd Booster vaccine and the clinical outcomes of post-vaccination health workers at West Kalimantan Hospital. Research method Observational Cross-sectional Prospective by conducting questionnaires and interviewing health workers. Samples were taken by convenience sampling and statistical analysis of chis-square. The research instrument used a questionnaire distributed in the hospital. In the study, it was found that as many as 12.60% (14 out of 118 health workers) were infected with Covid-19. The habit that influenced the effectiveness of the 3rd booster vaccination was sunbathing (p <0.05). The low severity of health workers infected with Covid-19 after the 3rd booster vaccine can be seen from the place of treatment, namely 97% independent isolation, 60% without using antivirals and 77% without using antibiotics. The type of vitamin that is most widely used is vitamin C. Hence with this booster vaccination aims to prevent and reduce the severity of patients who contract Covid-19 after vaccination.

Brine Shrimp Lethality, Aktivitas Antioksidan dan Kadar Total Fitokimia dari Ekstrak Etanol Kasumba Turate (Carthamus tinctorius) Tahar, Nurshalati; Satrianegara, Fais; Rukmana, Rusmadi; Hamzah, Nursalam; Rukmana, Sitti; Alwi, Fitria; Roni, Abdul; Mukhriani, Mukhriani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

bstract: Kasumba turate had been used extensively in the treatment of varicella, but studies of safety, efficacy, and quality are incomplete. The objectives of these studies were to determine brine shrimp lethality, antioxidant activities and phytochemical contents of safflower ethanolic extract. The studies began with extraction, which soaked simplicia in 70% ethanol. Dried extract was determined for toxicity used brine shrimp lethality method. Although, antioxidant activities were measured by three methods, i.e., free radical scavenging (1,1-diphenyl-2-picrylhydrazil), cupric reducing antioxidant capacity, and ferric reducing antioxidant power. The phytochemicals total contents that measured were phenols, flavonoids and carotenoids. Based on studies result, rendemen extraction was 14.7%. The lethality level for brine shrimp was 109.64 ± 5.29 mg/L. The free radical scavenging, cupric reducing, and ferric reducing antioxidant activities were 35.40 ± 1.62 mg/L, 12.42 ± 0.95 mg/L and 36.47 ± 2.79 mg/L. Although, the phenol, flavonoid and carotenoid contents per gram were 135.40 ± 0.12 g gallic acid equivalent, 124.54 ± 3.38 mg quercetin equivalent and 27.25 ± 0.83 mg β-carotene equivalent. Based on these data, the ethanol extract of kasumba turate has high phytochemical and antioxidant potential and low toxicity.

EVALUASI INTERAKSI OBAT-OBAT PADA PASIEN DEWASA DI APOTEK PESISIR SURABAYA Faizah, Ana Khusnul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The pharmacist's responsibility is to prevent, find, and give solutions to drug interactions received by patients. Drug interactions could increase the effectiveness of therapy but can also have undesirable effects on toxicity. This study aimed to examine the potential drug-drug interactions in the prescriptions of adult patients at the Surabaya coastal pharmacy. This study was conducted with a retrospective method for three months at five pharmacies in the coastal area of Surabaya. We obtained 249 prescriptions and identified 85 (34%) that have potential drug-drug interactions. Among the 153 identified pDDIs, 0.7%, 18.3% and 35.5% were contraindicated, major and moderate severity types, respectively. Based on the mechanical action of drug interactions, 130 (84.9%) are identified by pharmacokinetics, 21 (13.7%) pharmacodynamics, and 2 (1.3%) unknowns. The pharmacist's role in providing safe, effective, and rational drug therapy can be done by either identifying drug interactions or preventing and minimizing the negative effect of drug interactions

Analisis Pengaruh Kualitas Layanan Informasi Swamedikasi Online Berbasis Whatsapp Bot Terhadap Kepuasan Masyarakat Widyaningrum, Esti Ambar; Yestari, Farah Eka Julia; Sari, Erni Anika; Srihartini, Indah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Abstract: The innovation of online self-medication information services, one of which is based on WhatsApp Bot, is needed to make it easier for people to find self-medication information for the community. This innovation needs to be continuously developed so that it can provide adequate information services, can increase knowledge and provide satisfaction to users. The purpose of this study was to determine the level of community satisfaction with online self-medication services based on WhatsApp Bot and the effect of expectations on satisfaction using the RATER dimension (Reliability, Assurance, Tangible, Empathy, Responsiveness) in the community of Talun Village, Blitar Regency. The method used in this study is an analytical survey using a cross sectional design. Sampling was done by purposive sampling technique and obtained 264 respondents from the residents of Talun Village, Blitar Regency. Gap analysis was obtained at -0.10 with a level of satisfaction that was not satisfied with the services that had been provided with detailed attributes including: layout, absence of constraints, valid and reliable information, complete information, attention to user needs and the speed of customer service responding, needs to be improved to increase user satisfaction. Spearman rank correlation test obtained P value 0.05 and correlation coefficient value of 0.644. The community is not satisfied with this information service and there is an influence between the quality of information source services and satisfaction in the community of Talun Village, Blitar Regency with a positive correlation and strong correlation strength so it is necessary to develop this Whatsapp Bot-based self- medication information service.

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Home Page

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Journal Mail Official info@jfi-online.org

Editorial Address Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

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Contact Name
Hilwan Yuda Teruna

Contact Email
hilwan@iai.id

Phone
+6221-56962581

Journal Mail Official
info@jfi-online.org

Editorial Address
Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA