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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 10 Documents
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Search results for , issue "vol. 9, no. 2" : 10 Documents clear
The profile of skin cancer patients at Dr Pirngadi Hospital Medan: A retrospective study Lingga, Febrina Dewi Pratiwi; Indira, Aisya; Siregar, Remenda
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Skin cancer is among the most common malignancies, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma. In Indonesia, it ranks third after cervical and breast cancer. This study aimed to analyze the demographic, clinical, and treatment patterns of skin cancer cases at Dr. Pirngadi General Hospital, Medan, Indonesia from 2019 to 2023. Methods: A retrospective descriptive study was conducted using medical record data of all skin cancer patients treated from 2019 to 2023. Variables analyzed included age, sex, occupation, lesion site, skin cancer type, and treatment modality. Data were analyzed using univariate statistics and presented as frequency distributions. Results: A total of 106 patients were included, most aged >50 years (73.6%) and male (60.4%). Outdoor occupations, such as farming (23.6%) and entrepreneurship (23.6%), were the most common. Lesions were predominantly located on the face (93.4%). BCC was the most frequent type (90.6%), followed by SCC (7.5%) and melanoma (1.9%). Excisional surgery was the main treatment (51.9%), followed by excision with skin flap reconstruction (48.1%). Conclusion: Skin cancer in this study was most prevalent among older males with outdoor occupations, with the face being the most frequent lesion site. BCC was the predominant type, and excisional surgery remained the primary treatment. These findings provide an updated epidemiological overview to support prevention and early detection efforts in Indonesia.
Video education on the knowledge of cosmetics and skin care contact dermatitis: A cross-sectional study Prasetyo, Muhammad Rizkinanda; Damayanti, Damayanti; Herawati, Lilik; Anggraeni, Sylvia
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Contact dermatitis is an immunologic reaction to irritants, allergens, and is commonly associated with cosmetics and skin-care products. Limited knowledge of this condition increases the risk of improper product use and delays preventive measures. Therefore, education plays a crucial role in fostering a comprehensive understanding of its etiology and prevention. This study aimed to evaluate the effectiveness of a video-based educational intervention in enhancing women’s knowledge regarding contact dermatitis related to cosmetics and skin-care products. Methods: This cross-sectional study collected primary data from 100 female academics aged 17–45 at Airlangga University, Surabaya, East Java, Indonesia. Knowledge of contact dermatitis was assessed using questionnaires administered before and after a video-based educational intervention. Knowledge levels were categorized as low (X < 16/20), medium (16/20 ≤ X ≤ 17/20), and high (X > 17/20). Data were analyzed using the Wilcoxon Signed Rank test (SPSS version 25) and summarized in tables. Results: The medium category (16 ≤ X ≤ 17) was the most common in the pretest (61 respondents) and increased in the post-test (88 respondents). The Wilcoxon Signed Rank Test showed a significant increase in post-test scores following the video-based intervention, with a p-value of 0.008 (p < 0.05). Conclusion: Video-based education significantly improved knowledge regarding contact dermatitis related to cosmetics and skin-care products among women.
Extensive superficial dermatomycosis caused by Cladophialophora sp., a deep mycosis pathogen: A case report Limantara, Nikko Vanda; Siswati, Agnes Sri; Yogianti, Flandiana
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Superficial dermatomycosis, predominantly caused by dermatophytes, affects approximately 20–25% of the global population. However, non-dermatophytic fungi, such as Cladophialophora species (sp.), can also cause similar cutaneous infections. Although less common, these organisms are particularly concerning in immunocompromised individuals. Case Illustration: A 66-year-old immunocompromised male presented with widespread pruritic and erythematous patches, initially misdiagnosed as tinea corporis. Despite receiving standard antifungal therapy, his condition persisted. Further investigation through fungal culture identified Cladophialophora sp., which was resistant to common antifungal agents such as fluconazole, itraconazole, and ketoconazole. However, the fungus was sensitive to terbinafine, which has been successfully used to treat extensive superficial dermatomycosis. Discussion: This case highlights the ability of non-dermatophytic fungi, especially Cladophialophora sp., to cause extensive superficial dermatomycosis, especially in immunocompromised patients. The patient’s compromised immune system likely contributed to the extensive nature of the lesions. In this case, antifungal resistance may have been exacerbated by prior unsupervised self-medication and environmental exposure. Conclusion: We report an immunocompromised patient with inadequate prior antifungal treatment who developed extensive superficial dermatomycosis caused by Cladophialophora sp., a deep mycosis pathogen resistant to multiple azoles, highlighting the role of host immunity and inappropriate unsupervised therapy in disease severity and antifungal resistance.
Effectiveness and safety of moisturizing wash and cream in the treatment of elderly xerosis cutis Legiawati, Lili; Yusharyahya, Shannaz Nadia; Astriningrum, Rinadewi; Puteri, Fathirah Rahmatiah; Ilyas, Nabila Chalisya
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: The skin undergoes degenerative and metabolic changes with aging, increasing susceptibility to dermatological conditions. Xerosis cutis, characterized by rough, scaly skin on the lower legs, is the most common cause of pruritus in elderly patients, with a prevalence of 38–85%. Treating xerosis cutis is challenging due to its multifactorial causes, especially in the elderly. Moisturizers remain the primary and most effective treatment, providing convenience and efficacy. This study aimed to evaluate the effects of QV Intensive Moisturizing Cleanser™️ and QV Intensive Cream™️ (Ego Pharmaceuticals, Australia), which contain humectants, emollients, and occlusives. Case Illustration: This observational case series involved six elderly subjects (>60 years) with xerosis cutis. Exclusion criteria included medications that cause dry skin, use of topical moisturizers within 2 weeks, or oral supplements (hyaluronic acid, vitamin C, and ceramide) within 4 weeks before the study. Over four weeks, subjects used only the specified cleanser and moisturizer on affected skin. Improvement was assessed subjectively using the Smoothness, Redness, Roughness, Cracking (SRRC) score, the Dermatology Life Quality Index (DLQI), and the 5D Pruritus Scale. Objective measures included transepidermal water loss (TEWL) via Tewameter® TM300 and skin capacitance (SCap) via Corneometer® CM825 (Courage+Khazaka Electronic GmbH, Germany). Discussion: All subjects showed improvement in SRRC, 5D Pruritus Scale, DLQI, TEWL, and SCap after four weeks of cleanser and moisturizer use, with no side effects or irritation observed. Conclusion: Cleansers and moisturizers containing humectants, emollients, and occlusives were found to be safe and effective for treating xerosis cutis in geriatric patients.
Successful management of generalized pustular psoriasis with cyclosporine in HIV-infected patient Deltania, Rasinta Ayudya; Yuniaswan, Anggun Putri
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Generalized pustular psoriasis (GPP) can be associated with human immunodeficiency virus (HIV) infection, making its management more challenging and complex. This case report aims to evaluate the effectiveness and safety of cyclosporine in HIV-associated GPP. Case illustration: A 31-year-old male with a six-year history of HIV on antiretroviral therapy presented with rapidly spreading erythematous plaques with scaling and patches, along with “lakes of pus”, involving 50% of the body surface area (BSA). He reported oral burning, dysgeusia, and odynophagia; tongue Gram stain showed budding yeast and pseudohyphae. The patient was diagnosed with GPP and oral candidiasis in the setting of HIV. Cyclosporine was started at 2.5 mg/kg/day and escalated to 5 mg/kg/day; supportive care included nystatin 4x400,000 IU (swish-and-retain), paracetamol 3x500 mg, 0.9% NaCl wet compresses to pustular areas, emollients for xerosis, and intravenous 0.9% NaCl for hydration. By day 9, BSA improved from 50% to 12% with no severe adverse effects, only fatigue and loss of appetite. Discussion: GPP, a rare severe psoriasis variant, may be exacerbated in HIV patients due to immune dysregulation and CD4+ T-cell decline. In this case, cyclosporine treatment and supportive care improved symptoms without severe adverse effects. Cyclosporine appeared effective with minimal infection risk compared to methotrexate. This case highlights the importance of tailored, cautious immune suppression to manage GPP in HIV and balancing efficacy with infection risk. Conclusion: Cyclosporine may be an effective option for managing GPP in HIV-infected patients with CD4+ decline when used cautiously with close monitoring for opportunistic infections.
The efficacy of tranexamic acid in melasma: A review Sari, Ninda; Putri, Rachmah Diana; Syahrir, Syahriani; Agustina, Agustina; Bulqiah, Mikyal
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Melasma is a common acquired pigmentary condition presenting as dark macules or patches on sun-exposed areas of the face. Conventional treatments rely on topical bleaching agents and sun protection, while additional adjuvant options such as chemical peels, dermabrasion, and laser procedures are often applied. However, recurrence is frequent, and overall therapeutic success remains modest, significantly affecting patient quality of life. Recently, tranexamic acid (TXA) has gained attention as a novel therapeutic approach. This review provides an overview of the available evidence on the efficacy of TXA, used as monotherapy or in combination regimens, for the management of melasma. Discussion: TXA has been investigated for administration via several routes, including oral, intradermal, and topical. The pathophysiology of melasma involves not only abnormal melanogenesis but also enhanced dermal vascularity and angiogenic activity. TXA acts by interfering with the plasminogen–plasmin system, thereby altering keratinocyte–melanocyte signaling and reducing melanogenesis. In addition, it demonstrates anti-angiogenic effects, leading to reduced vessel density and erythema. Clinical data suggest oral TXA generally yields superior outcomes compared to intradermal or topical approaches, although study results remain heterogeneous, particularly in trials combining multiple therapies. Conclusion: TXA appears to be a promising therapeutic option for melasma, with potential use as a stand-alone intervention or in combination with other modalities. Combination regimens often produce better clinical improvement than monotherapy. Nonetheless, standardized guidelines for the optimal use of TXA in melasma treatment remain lacking.
Laser and light-based therapy for hair growth and hair removal Wiryadana, Michelle; Jusuf, Nelva Karmila
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Recent advances in laser and light-based technologies have introduced new options for both the stimulation of hair growth for alopecia and the reduction of unwanted hair growth. However, the clinical evidence remains varied, and treatment outcomes are influenced by factors such as device type, wavelength, and individual response. Ongoing evaluation of safety, efficacy, and standardization of treatment parameters is therefore essential. Discussion: This review provides an in-depth discussion of the principles, mechanisms, safety, and efficacy of lasers in promoting hair growth, as well as on lasers and light-based therapies used for hair removal. The mechanisms of laser-induced hair growth stimulation include the acceleration of vellus hair transformation into terminal hair. In contrast, lasers and light-based devices utilize melanin as a target chromophore for hair removal. Conclusion: Appropriate devices and techniques of lasers and light-based devices, whether used alone or in combination with other therapies, are beneficial for both hair growth and hair removal.
Difficulties in diagnosing primary cutaneous mucormycosis: Excluding mycobacterium other than tuberculosis Indah, Chinda Liaska; Menaldi, Sri Linuwih Susetyo Wardhani; Sirait, Sondang Pandjaitan; Widaty, Sandra
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Mucormycosis is a rare fungal infection caused by a group of opportunistic fungi from the class Zygomycetes. Primary cutaneous mucormycosis is the most common type of mucormycosis in immunocompetent patients. This study reported a case of primary cutaneous mucormycosis with nonspecific clinical characteristics and various supporting examinations. The patient was successfully treated with in toto excision and oral ketoconazole. Case Illustration: A 40-year-old female presented with purplish-red spots and painless lumps on the second finger of her right hand, which had been present for a year. She had a history of frequent fish tank cleaning and gardening but denied any known injury. Physical examination revealed multiple well-circumscribed and confluent erythematous-violaceous plaques and nodules. An in toto excisional biopsy was performed for histopathological examination, culture, and a rapid molecular test (RMT) using the Xpert MTB/RIF® test (Cepheid, USA). Histopathological examination revealed granulomatous suppurative inflammation, and fungal culture revealed growth of Mucor species. Discussion: Clinical findings in cutaneous mucormycosis are nonspecific. The diagnosis is confirmed by identifying the organism through biopsy and histopathological examination, as well as culture. Histopathology will reveal granulomas in the dermis and subcutis containing numerous macrophages and Langhans giant cells, often with phagocytosed fungal elements. Fungal culture yields positive results in 72–89% of cases of skin mucormycosis conducted on Sabouraud and potato dextrose agar media. Conclusion: This case emphasizes the need for broad differential consideration and thorough diagnostic workup in nonspecific cutaneous mucormycosis and supports surgical excision with systemic antifungal therapy for chronic, localized primary disease.
The recurrence of Bowen’s disease after topical 5% 5-fluorouracil cream application: A systematic review Antoniman, Mohammad Agassi; Anggraini, Ika
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Bowen’s disease (BD) may develop into cutaneous squamous cell carcinoma (CSCC), which can spread to other parts of the body. 5% 5-fluorouracil (5-FU) cream is commonly used for topical therapy on BD; however, the frequency and duration of treatment per cycle have not been standardized. This systematic review aimed to identify the most effective frequency and duration of 5% 5-FU treatment for achieving complete clearance or minimal recurrence. Methods: A literature search was conducted using three electronic databases (PROSPERO ID: CRD42024607488): MEDLINE, Cochrane, and Scopus. The articles were selected based on their relevance to the clinical question. Appraisals were conducted using the Newcastle-Ottawa Scale and the revised Cochrane risk-of-bias tool for randomized trials. Results: Five selected studies with 550 participants were critically reviewed; two were cohort studies and three were randomized trials. Some patients in total studies used more than one therapy cycle. Four of the five studies showed a recurrence rate in 12 months after the end of treatment. In cohort studies, the recurrence rate was 0–8.3% with twice-daily application for 9–16 weeks, whereas in randomized trials, the recurrence rate was 14.3–27.3% with various application frequencies for 4 weeks. Conclusion: The most suitable duration and frequency of 5% 5-FU cream application per cycle to minimize the recurrence rate of BD is twice daily for four weeks per cycle. However, other factors may affect the recurrence rate.
Association between vitamin D and cholesterol in post-acne hypertrophic scars and keloids: A cross-sectional study Kurniawati, Yuli; Yahya, Yulia Farida; Diba, Sarah; Novriani, Rina; Yusuf, Hasbiallah; Martgaredta, Ekta
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
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Background: Post-acne hypertrophic scars and keloids result from abnormal wound healing within the pilosebaceous unit. Ruptured microcomedones create wounds that can lead to prolonged inflammation, increased collagen synthesis, and fibrinolysis inhibition, resulting in elevated scar tissue in acne lesions. Vitamin D deficiency can lead to prolonged inflammation and damage to dermal collagen. High total cholesterol levels can lead to excessive sebum production, exacerbating inflammation and fibrosis. This study aimed to determine the association between serum vitamin D and total cholesterol levels with scar severity in patients with post-acne hypertrophic scars and keloids. Methods: This analytical cross-sectional study was conducted at Dr. Mohammad Hoesin General Hospital, Palembang, South Sumatera, Indonesia, among patients who met the inclusion and exclusion criteria. Scar severity was assessed using the Vancouver Scar Scale (VSS). Blood samples were collected for examination of serum vitamin D and total cholesterol. The data were analyzed statistically. Results: Chi-square test of serum vitamin D with VSS scores showed a significant association (p-value = 0.007), while total cholesterol with VSS showed no association (p-value = 1.000). Odd-ratio (OR) for serum vitamin D and VSS was 60, concluding that vitamin D deficiency increased the risk of high VSS by 60-fold in study patients. Conclusion: There was a significant association between serum vitamin D levels and VSS score, while there was no association between total cholesterol and VSS score. Deficiency of serum vitamin D is associated with a higher risk of developing a higher VSS score in patients with post-acne hypertrophic scars and keloids.

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