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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 86 Documents
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Search results for , issue "JPS Volume 8 Nomor 4 (2025)" : 86 Documents clear
Validasi Metode Analisis KCKT untuk Penetapan Kadar Parasetamol dalam Sediaan Tablet Generik dan Bermerek Harfiansyah, M. Deddy; Purba, Gratia Apulina Cindylawsa; Fitria, Fitria; Rambe , Ummi Khairani; Amar , Ageng Azhar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1107

Abstract

Background: Paracetamol is one of the most widely used analgesic and antipyretic drugs, and quality control of its dosage forms is crucial to ensure therapeutic effectiveness. Objective: This study aimed to validate a simple, rapid, and reliable High-Performance Liquid Chromatography (HPLC) method for the determination of paracetamol content in generic and branded tablet formulations. Methods: The chromatographic analysis was performed on a C18 column using a mobile phase of distilled water and methanol (3:1, v/v) with a flow rate of 1.0 mL.min–1, injection volume of 20 µL, and detection wavelength at 243 nm. Validation parameters including system suitability, linearity, accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ) were evaluated according to pharmacopeial guidelines. Results: The method demonstrated excellent linearity over the range of 8–12 µg.mL–1 (r = 0.9998), with LOD and LOQ values of 0.13 µg.mL–1 and 0.40 µg.mL–1, respectively. Accuracy values were 99.00% for generic and 98.86% for branded tablets, while precision showed %RSD of 0.53% and 0.68%. The paracetamol content was 101.47% and 100.20% for generic and branded formulations, respectively, meeting pharmacopeial standards (90–110%). Conclusion: The validated HPLC method proved to be accurate, precise, and sensitive for the quantitative determination of paracetamol in tablet dosage forms. This method is suitable for routine quality control and can be extended for stability or pharmacokinetic studies.
Efektivitas Pemberdayaan peer group support terhadap Peningkatan Kepatuhan Pengobatan pada Klien Tuberkulosis: a systematic review Yanta , Hardi; Permatasari , Henny; Mulyono , Sigit; Nursasi , Astuti Yuni
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1122

Abstract

First The prevalence of tuberculosis shows a global increase, so a sustainable management strategy is needed. The peer group support approach provides a space for continuous interaction between peer educators and peer groups, which allows for more intensive information delivery to improve treatment adherence in tuberculosis patients. Purpose This systematic review aims to assess the effectiveness of peer group support interventions in improving treatment adherence in tuberculosis clients. Methods: A literature search was conducted using PRISMA guidelines, through several databases PubMed, Clinical Key, Science Direct, Proquest for articles published between 2020 and 2024. Results: Peer group support interventions have been shown to significantly improve treatment adherence in pulmonary tuberculosis clients. Social support from peer groups contributes significantly to strengthening client regularity in the therapy schedule. This approach is considered more effective because group members not only transfer knowledge gained from educators and personal experiences, but are also able to identify and resolve problems faced independently. Peer group support interventions have been proven effective in improving treatment adherence in tuberculosis clients.
Optimasi Konsentrasi BHT untuk Menjaga Stabilitas Pigmen Alami pada Sediaan Cream Blush Ekstrak Hemigraphis colorata Ratih, Hestiary; Sutarna, Titta Hartyana; Al-Hakim, Nur Achsan; Dwijayanti, Anisa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1139

Abstract

The use of natural dyes from Hemigraphis colorata Hall. extract as cosmetic dyes faces stability challenges due to oxidative degradation. This study aims to test the effect of Butylated Hydroxytoluene (BHT) antioxidant concentration on the physical stability and color of cream blush formulations. H. colorata leaves were extracted by maceration and lyophilization, then formulated into four cream blush preparations with varying concentrations of BHT: without BHT (F0), 0.0075% (F1), 0.05% (F2), and 0.1% (F3). Physical stability of the formulations was evaluated for 28 days through organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and color stability using UV-Visible spectrophotometry. The results showed that all formulations met the physical standards for topical preparations. However, F2 (0.05%) and F3 (0.1%) successfully maintained color stability with minimal shifts. This study concludes that BHT can effectively maintain the physical stability of cream blush formulations based on H. colorata extract, with 0.05% (F2) being the optimal BHT concentration (the lowest effective concentration), based on considerations of effectiveness, safety, and cost, proven to be optimal in protecting natural pigments from degradation. These results provide important information for the development of safe, high-quality natural cosmetic products with a longer shelf life.
An Studi Kepuasan Pengguna Layanan Farmasi di Klinik Kesehatan X di Jember Isnawati, Nafisah; Nuraini , April; Sholeh, Ayu Angger Putri M.; Cendekiawan, Khrisna Agung; Khairomatul L , Atmanita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1142

Abstract

User satisfaction with pharmaceutical services in healthcare facilities is a critical indicator of service quality and plays an essential role in improving the overall healthcare experience. High satisfaction levels reflect the appropriateness, efficiency, and responsiveness of pharmacy services. This study aimed to evaluate the level of satisfaction among users of pharmaceutical services at the Pharmacy Installation of Clinic X in Jember. This study employed a prospective observational design conducted in August 2025. The study population consisted of outpatients receiving pharmaceutical services, and the sample included patients who met the inclusion criteria and agreed to participate. A total of 160 respondents were selected using consecutive sampling, a non-probability sampling technique. Data were collected using a structured questionnaire and tables documenting respondent characteristics and patient satisfaction outcomes. Satisfaction was assessed across five dimensions of pharmaceutical service quality: reliability, responsiveness, empathy, tangibles, and assurance. Descriptive analysis was used to summarize respondent characteristics and satisfaction scores. Of the 160 respondents, the majority were female (71.25%) and within the age group of 25–44 years (53.75%). Most respondents had a senior high school education or equivalent (50.00%), were self-employed (64.38%), and had visited the clinic twice (38.75%). Satisfaction scores across service dimensions were as follows: reliability 97.1%, responsiveness 65.5%, empathy 68.1%, tangibles 82.1%, and assurance 66.7%. The overall Customer Satisfaction Index (IKM) was 82.2%, categorizing the service quality as good. The results indicate that users were generally satisfied with the pharmaceutical services provided at Clinic X. The high score in the reliability dimension suggests consistent service performance and accuracy. However, the lower scores in responsiveness, assurance, and empathy highlight areas requiring improvement, particularly regarding timely service delivery, confidence-inspiring interactions, and patient-centered communication. Although the overall satisfaction level was good, targeted improvements in these dimensions are essential for enhancing the overall quality of pharmaceutical care. Overall, the level of user satisfaction with pharmaceutical services at Clinic X was categorized as good, with an IKM score of 82.2%. All five dimensions of service quality were rated positively, although responsiveness, assurance, and empathy showed room for improvement. These results highlight the importance of strengthening service quality components beyond technical accuracy to ensure a more holistic and patient-centered pharmaceutical care experience.
Identifikasi Faktor-Faktor Yang Mempengaruhi Pemberian MP-ASI Dini Dan Susu Formula Pada Bayi Sebelum Usia 6 Bulan Di Klinik Pratama Evi Manullang , Lesdi Citra Lamtama Br; Putri , Aulivia; Fikry , Mei Waddah Ayunda; Giawa, Aniria; Zai, Lismawarni; Nababan, Tiarnida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1170

Abstract

Background: Infant health is greatly influenced by optimal nutritional intake, particularly through exclusive breastfeeding for the first six months of life. However, the rate of exclusive breastfeeding in Indonesia, especially in North Sumatra and Evi Primary Clinic, is still low. Many mothers provide early complementary feeding and formula milk before the baby is 6 months old, which can increase the risk of health issues in infants. Objective: To identify and analyze the factors affecting early complementary feeding and formula milk use in infants under 6 months of age at Evi Primary Clinic. Method: This study uses a qualitative descriptive design with a phenomenological approach. Sampling was conducted through purposive sampling until data saturation was reached, with a total of 10 informants (mothers of infants under 6 months who provided complementary feeding/formula). Data were collected through in-depth interviews. Data analysis followed the Miles, Huberman, and Saldana (2024) model. Results: The analysis revealed three main themes: (1) The perception of insufficient breast milk as the primary trigger for providing complementary food/formula, (2) Socio-cultural pressure and advice from the nuclear and extended family (especially in-laws) that encourage early provision, and (3) The inconsistent dual role of health workers, ranging from those who support exclusive breastfeeding to those who recommend formula milk from the start. Factors such as mothers' low knowledge about exclusive breastfeeding, economic conditions, and mothers returning to work also played a role. Conclusion: The practice of providing early complementary foods and formula milk to infants under six months of age is influenced by a complex interaction of internal and external factors, with maternal perception, culture, and family support as the dominant factors. The implications of this research highlight the need for ongoing education involving families, consistent training for health workers, and supportive policies to enhance breastfeeding practices.
Formulasi dan Karakterisasi Tablet Dispersibel Berbasis Nanopartikel untuk Meningkatkan Disolusi dan Stabilitas Formulasi Metformin Asmal , Adhitama; Nurvianthi , Riska Yuli
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1172

Abstract

Metformin therapy for type 2 diabetes mellitus is limited by its very low aqueous solubility and moderate oral bioavailability, factors that may reduce therapeutic effectiveness. Dispersible tablets also offer advantages for geriatric patients with swallowing difficulties. This study aimed to formulate and characterize nanoparticle-based dispersible tablets of metformin to enhance drug dissolution and early physicochemical stability. Metformin nanoparticles were produced via nanoprecipitation and characterized for particle size, polydispersity, zeta potential, and solid-state properties using XRD and DSC, while SEM imaging was used to assess morphology. The nanoparticles were subsequently compressed into dispersible tablets and evaluated according to pharmacopeial standards. The resulting metformin nanoparticles exhibited a mean particle size of 180 ± 20 nm (PDI 0.25, zeta potential −25 mV). XRD and DSC analyses indicated partial amorphization, which was further supported by SEM micrographs showing smooth, spherical particles with uniform distribution. The dispersible tablets complied with compendial specifications and demonstrated markedly improved dissolution compared with the conventional formulation, achieving 88% release at 30 minutes. Following accelerated stability testing at 40 °C/75% RH, assay values remained ≥95%, with no significant changes in dissolution performance (p > 0.05). In conclusion, the nanoparticle-based dispersible tablets successfully enhanced the in vitro dissolution of metformin while maintaining early physicochemical formulation stability, supporting further development toward improved patient acceptability and future bioavailability studies.
Analisis Faktor-Faktor yang Berhubungan dengan Pemilihan Tempat Persalinan Ibu di Wilayah Kerja Puskesmas Ambukha Kecamatan Lolofitu MOI Kabupaten Nias Barat Tahun 2024 Gulo, Mery Kristinawati; Ginting, Daniel; Sirait, Asima; Manurung, Kesaktian; Sinaga, Janno
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1202

Abstract

Background: Maternal mortality remains a significant public health concern in Indonesia, where 19.3% of deliveries are still conducted outside healthcare facilities or without skilled birth attendants. The working area of Ambukha Public Health Centre (Puskesmas) has the lowest proportion of facility-based deliveries in the West Nias District (67% in 2023), indicating the need to analyse factors associated with delivery place choice. Objective: To identify factors related to the selection of delivery place among mothers in the working area of Ambukha Public Health Centre, Lolofitu Moi Subdistrict, West Nias District. Methods: This study employed an observational analytic design with a cross-sectional approach. The population consisted of all mothers who delivered within the Ambukha Public Health Centre area in 2023 (N=78), and samples were obtained using a total sampling approach. Data were collected using structured questionnaires and analysed using Chi-square tests and logistic regression. Results: Significant associations were found between the choice of delivery place and maternal knowledge (p=0.000; OR=2.267), maternal attitude (p=0.000; OR=4.250), national health insurance (JKN) membership (p=0.000; OR=5.333), access to healthcare facilities (p=0.000; OR=6.038), husband’s support (p=0.000; OR=4.250), perceived need factors (p=0.000; OR=3.333), as well as cultural beliefs (p=0.004; OR=2.473). Multivariate logistic regression identified maternal knowledge as the most influential factor in delivery place selection, as indicated by the most significant coefficient value (B = –4.204) and statistical significance (p=0.005). Conclusion: Maternal knowledge, attitude, JKN membership, access to healthcare facilities, husband’s support, perceived need, and cultural beliefs are significantly associated with the selection of delivery place. Efforts to increase facility-based delivery coverage in this area should prioritise improving maternal knowledge, followed by strengthening other supporting factors.
Pengaruh Berbagai Bentuk Intervensi Apoteker terhadap Kepatuhan Pengobatan dan Kualitas Hidup Pasien Rawat Jalan Skizofrenia : Narrative Review Sambada, Annisa; Putri, Mukarromah Dita; Mulyati, Noviani Ayu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1204

Abstract

Schizophrenia is a global issue with a significant increase in recurrence, affecting approximately 23 million people or 1 in every 345 individuals worldwide, with recurrence rates increasing from 28% in 2019 to 54% in 2021[2]. This narrative review examined the literature from 2015–2024 from PubMed and Google Scholar with inclusion criteria of pharmacist interventions in outpatient schizophrenia patients, the use of assessment instruments such as MARS, PANSS, and WHOQOL-BREF, and the reporting of quantitative outcomes related to adherence and quality of life. Seven studies that met the criteria showed that pharmacist counseling can significantly improve medication adherence. In the Si-Care model, adherence rates increased from 77.38% to 97.57% (an increase of 20.19%; p = 0.000). Higher effectiveness was seen in longer-duration interventions, interactive methods such as home visits, and implementation involving collaboration with psychiatrists, which also supported improvements in quality of life. However, variations in study design resulted in diverse findings, and single-session interventions tended to be less optimal than ongoing support. Without counseling, adherence rates remained low, at around 65%. Overall, the available evidence confirms the benefits of pharmacist counseling, but further research is needed to standardize intervention models and evaluate the long-term impact on outpatients with schizophrenia.
Evaluasi Formulasi Teh Celup dari Kombinasi Kulit Jeruk Manis (Citrus sinensis L.) dan Buah Ara (Ficus carica L.) sebagai Antibakteri terhadap Staphylococcus aureus Husni, M. Irgisyach Aqilla; Simat, Marcelina Oktavia Mayang Sari; Suhartomi, Suhartomi; Hendrianto, Hendrianto; Syarifah, Siti; Putri, Maulinda; Widyawati, Tri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1205

Abstract

The development of natural-based antibacterial agents is essential to reduce dependency on antibiotics and the risk of resistance. Sweet orange peel and fig fruit contain bioactive compounds with potential antibacterial effects. This study aimed to develop tea bag formulations made from sweet orange peel with the addition of fig fruit as an additive and to evaluate their in vitro antibacterial activity against Staphylococcus aureus. This experimental study employed two approaches, including disc diffusion and microdilution on several combination formulations of sweet orange peel and fig tea bags. The formulations consisted of F1 (1 g sweet orange peel and 1 g fig), F2 (1.5 g sweet orange peel and 0.5 g fig), and F3 (1.75 g sweet orange peel and 0.25 g fig). The disc diffusion assay showed that all formulations exhibited weak antibacterial activity against Staphylococcus aureus, producing inhibition zones of approximately 6–7 mm, except for F3 infusion, which demonstrated the widest inhibition zone with a mean diameter of about 8.21 mm (P-Value = 0.688). In the microdilution test, the MIC of F3 infusion was found to be 40 mg/mL, while the MBC was not detected at the tested concentrations. Overall, it can be concluded that the infusion of the tea bag formulation containing 1.75 g sweet orange peel and 0.25 g fig was the most promising combination; however, its antibacterial activity remained weak and was bacteriostatic rather than bactericidal.
Determinan Kejadian Stunting di UPT Puskesmas Sumbul Kecamatan Sumbul Kabupaten Dairi Tahun 2024 Sihotang, Nola Winarta; Manurung, Kesaktian; Lia Rosa Veronika; Sembiring, Rinawati; Ginting, Daniel
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1206

Abstract

malnutrition so that the child is too short for his age. Stunting has an impact on children's cognitive decline and productivity in the future. So far, addressing malnutrition has focused on babies from birth to five years old. In fact, the golden period is when the child is still in the womb until the age of two years. Therefore, a paradigm shift in handling malnutrition is needed. Therefore, the government is implementing the Acceleration of Nutrition Improvement Program with the First 1000 Days of Life Movement. SKI data for 2023, Dairi district is in second place with a figure of 32.6% of stunted toddlers out of 439 toddlers and based on the entry of toddler data on the e-PPGBM application in December 2024, the prevalence of stunted toddlers in the Sumbul Community Health Center, Sumbul District is around 13.98% or 258 toddlers. The incidence of stunting is influenced by several factors, namely maternal height, maternal education, compliance with taking blood supplement tablets and smoking. The aim of this research is to determine the determinants of stunting incidents at the Sumbul Community Health Center UPT, Sumbul District, Dairi Regency in 2024. This type of research is cross sectional with research methods. The population in this study were all mothers with toddlers. The number of samples in this study was 70 mothers.  Based on the research results, it was found that there was a relationship between height and stunting (p-value=0.004), there was a relationship between maternal education and stunting (p-value=0.004), there was a relationship between adherence to taking blood supplement tablets and stunting (p-value=0.000) and there was a relationship between smoking and stunting (p-value=0.000). Increasing health promotion to the community about the importance of parenting patterns and fulfilling nutrition in the First 1000 Days of Life, starting from pregnant women until children are 2 years old, as well as outreach about the health of young women and prospective brides.

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