Molekul: Jurnal Ilmiah Kimia
The MOLEKUL is dedicated to fostering advancements in all branches of chemistry and its diverse sub-disciplines. It aims to publish high-quality research encompassing a wide range of topics, including but not limited to Pharmaceutical Chemistry, Biological Activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry. By providing a platform for rigorous scientific inquiry and dissemination of knowledge, the journal strives to contribute to the understanding, innovation, and practical applications of chemistry in various fields. We encourage submissions that explore new methodologies, elucidate fundamental principles, address pressing challenges, and demonstrate the potential for real-world impact. Our journal welcomes original research articles, reviews, and perspectives from researchers, scholars, and professionals across the global scientific community, promoting interdisciplinary collaboration and the advancement of chemical sciences. The scope of this journal encompasses a wide range of topics within the field of chemistry, with a particular focus on advancing knowledge and innovation in the following areas: 1. Theoretical Chemistry and Environmental Chemistry: This includes theoretical studies, computational modeling, and experimental investigations related to chemical reactivity, molecular structures, spectroscopy, and the environmental fate and impact of chemicals. 2. Materials Synthesis for Energy and Environmental Applications: The journal welcomes research on the synthesis, characterization, and application of materials for energy storage, catalysis, solar energy conversion, pollution mitigation, and sustainable environmental technologies. 3. Isolation, Purification, and Modification of Biomolecules: Manuscripts addressing the isolation, purification, and modification of biomolecules, such as proteins, nucleic acids, carbohydrates, and lipids, along with their applications in areas such as biotechnology, drug discovery, and diagnostics, are of particular interest. 4. Fabrication, Development, and Validation of Analytical Methods: The journal encourages submissions focusing on the development and optimization of analytical techniques, including chromatography, spectroscopy, electrochemistry, and mass spectrometry. Topics may include method validation, sample preparation, quality control, and applications in diverse fields.
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<![CDATA[Soil Toxicity Around the Textile Industry in Bantul using Spinach Seeds (Amaranthus gangeticus) and Bean Sprouts (Phaseolus aureus) ]]>
<![CDATA[Astari, Siti Alysha]]>;
<![CDATA[Suherman, Suherman]]>;
<![CDATA[Mudasir, Mudasir]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.5172
<![CDATA[The toxicity test of zinc metal in soil samples around the textile industry in Bantul on the growth of spinach (Amaranthus gangeticus) and bean sprouts (Phaseolus aureus) has been investigated in relation with the environmental assesment for the impact of industrial activities. This research was conducted to study physicochemical properties, adsorption-desorption, and zinc metal toxicity in the soil around the textile industry on the growth of spinach and bean sprouts. The study of physicochemical properties were water content, pH, electrical conductivity, ash content, total organic carbon, cation exchange capacity, metal content, and characterization using FTIR (Fourier transform infrared) spectrophotometry. Various zinc concentrations were studied for the adsorption capacity, whereas citric acid concentrations were used for the desorption. Atomic absorption spectrophotometry (AAS) was applied to measure metal concentrations for all samples. A toxicity tests were conducted on the growth of spinach and bean sprouts. The maximum zinc concentration was measured in point I, at 532.03 mg kg-1. Adsorption of zinc followed the Langmuir and Freundlich isotherms, and desorption process occurred at optimum concentration 0.7 mol L-1 citric acid and a pH of 3. In the zinc metal toxicity test, large concentration of zinc metal revealed inhibition effect on spinach and bean sprouts growth. Keywords: Adsorption, desorption, toxicity test, zinc.]]>
<![CDATA[Immobilization of Urease from Psophocarpus tetragonolobus L. DC. using Natrium Alginate Supporting Matrix ]]>
<![CDATA[Zusfahair, Zusfahair]]>;
<![CDATA[Ningsih, Dian Riana]]>;
<![CDATA[Lestari, Puji]]>;
<![CDATA[Bilalodin, Bilalodin]]>;
<![CDATA[Aryanti, Eva]]>;
<![CDATA[Muslihah, Niken Istikhari]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.7335
<![CDATA[Urease is an enzyme that has the role to hydrolyzes urea into ammonia and carbon dioxide. Immobilization is one of the most efficient strategies to improve its activity recovery and properties of urease. This research started with the germination of winged beans for 8 days. The winged bean was extracted by grinding using a mortar and pestle and then added with phosphate buffer at pH 7. The solution was homogenized using a stirrer and then centrifuged in cold conditions so that an extract of urease was obtained. Urease extracts were immobilized using a chitosan-supporting matrix. Optimization of the immobilization process of urease extract includes the concentration of chitosan and sodium tripolyphosphate (TPP) and contact time. The obtained was free and immobilized urease activities then tested using the Nessler method and measured using a UV-Vis spectrophotometer with a wavelength of 500 nm. The obtained data were then statistically tested using ANOVA. Urease-chitosan beads were further tested in repeated use and analyzed with SEM-EDX (Scanning Electron Microscopy-Energy Dispersive X-ray). The results showed that the optimum conditions for making urease-chitosan beads were a concentration of 4% (w/v), 2.5% (w/v) TPP, and 60 minutes of contact time, resulting in an activity value of 15.076 U/mL, which can be used 5 times with 46% activity from the initial activity. The EDX analysis results after the addition of the enzyme showed atom composition changes leading to increasing carbon and nitrogen contents. The existence of phosphor showed that TPP was a chitosan cross-link compound. Keywords: Chitosan, immobilization, TPP, urease, winged bean]]>
<![CDATA[Physicochemical Properties and Biodegradability of Biofilm Based on Taro Starch and Duck Bone Gelatin ]]>
<![CDATA[Laksanawati, Trias Ayu]]>;
<![CDATA[Khirzin, Muhammad Habbib]]>;
<![CDATA[Amaniyah, Maghfirotul]]>;
<![CDATA[Meidayanti, Karina]]>;
<![CDATA[Deva, Bella Diah]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.7628
<![CDATA[Biofilm is an environmentally friendly plastic that is easily biodegradable. However, not all biodegradable plastics have the desired properties for packaging because they are made from renewable natural materials. The biofilm in this study was made from renewable natural raw materials that had never been used before, namely taro starch and duck bone gelatin. Mixing the two materials improve their physical properties and biodegradabilily This study was to to investigate the effect of adding duck bone gelatin 0%, 5%, 15%, 25% and 35% on physicochemical properties, namely color, oxygen permeability, and metal content (Pb and Cd) as well as biodegradability of biofilms. The method used in this research was solution casting. The results obtained from the color parameter with the highest lightness (L) value were produced in the addition of 15% of 85.26, for the highest value of color a was produced in the addition of 0%, namely 0.94, and the value of color b with the addition of 35% resulted in the highest color value of 1.67. The highest percentage of biodegradability was produced on day 14 with the addition of 35% duck bone gelatin in compost soil to produce a percentage of 100%, while for barren soil the yield was 54.54%-66.66%. The content of Cd and Pb in the biofilm is below the SNI limit. Biofilm is impermeable which can be used as food packaging. Keywords: Biodegradability, biofilm, gelatin, physicochemical, starch]]>
<![CDATA[Synthesis of Some New Amino Carbonyl Compounds by Mannich Reaction ]]>
<![CDATA[Dawood, Nagham]]>;
<![CDATA[Saeed, Banan]]>;
<![CDATA[Saeed, Zainab]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.7799
<![CDATA[Beta-aminocarbonyl compounds are important intermediates produced from Mannich condensation. In this research, benzaldehyde, para-hydroxy acetophenone or para-nitro acetophenone were reacted with a various of primary aromatic amines to give compounds (1-7) and (8-14), respectively. The chemical formulas of the synthesized compounds were confirmed by conducting some physical and spectroscopic measurements, such as, melting points, IR and H1-NMR spectrum. After testing the biological activity of some of the synthesized compounds (8,10,11,13) using Gram-positive (Streptococcus, and Staphylococcus aureus), Gram-negative (Klebsiella spp., and Escherichia coli) bacteria, as well as yeast strains, were chosen for this investigation (candidan albicans). Isolated bacteria were identified using standard methods of isolation and identification, including direct assays and culture on various media. Some theoretical tests have also been carried out such as SwissADME and cardioToxCSM prediction on all prepared compounds to predict their activity in terms of pharmacokinetic properties (ADME) and also predict their cardiotoxicity on some heart functions such as arrhythmia, cardiac failure, heart block, hERG toxicity, Hypertension (HT), and Myocardial Infarction (MI). Keywords: Secondary amines, aldehyde, Mannich condensation, antimicrobial activity.]]>
<![CDATA[Sustainable Bioplastics Made from Cassava Peel Waste Starch and Carrageenan Formulations: Synthesis and Characterization ]]>
<![CDATA[Fadhallah, Esa Ghanim]]>;
<![CDATA[Assa'diyah, Indah Nurul]]>;
<![CDATA[Juwita, Nana]]>;
<![CDATA[Tullaila, Sholeha]]>;
<![CDATA[Yudistiro, Muhammad Kahfi Kharisma]]>;
<![CDATA[Zuidar, Ahmad Sapta]]>;
<![CDATA[Dameswary, Amarilia Harsanti]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.8394
<![CDATA[Plastic waste has become a global environmental problem as it is difficult to decompose and harms the environment. The alternative solution to overcome this problem is to produce biodegradable plastics made from renewable materials. Cassava peel waste contains starch that can form a thin film but has poor mechanical properties. Therefore, it is necessary to include additional substances to enhance its strength. Carrageenan is a substance that can improve bioplastic mechanical properties. This study aims to determine the characteristics of bioplastic made from cassava peel waste starch and carrageenan formulation. Nine formulations were tested in this study using the randomized complete block design factorial with the two factors of cassava peel starch (S) and carrageenan (C) concentrations, both at three levels and carried out under three replications. Bioplastics characteristics are observed in thickness, swelling, biodegradation, tensile strength, elongation, and elasticity. The formulation S2C1 (starch 20%; carrageenan 5%) produced the bioplastic with the best mechanical properties, including a tensile strength of 1.1 MPa, elongation of 1.33%, and elasticity of 0.87. Meanwhile, the formulation S3C1 (starch 30%; carrageenan 5%) had the best results for swelling, thickness, and biodegradability, with a swelling value of 57.79%, thickness of 0.36mm, and 11-day biodegradability.]]>
<![CDATA[Enhancement of TiO2 Photocatalyst Using Rare Earth Oxide (La2O3) via a Simple Preparation Method for Degradation of Methylene Blue under Visible Light ]]>
<![CDATA[Natsir, Taufik Abdillah]]>;
<![CDATA[Pamungkas, Alam Reformasi Putra]]>;
<![CDATA[Aprilita, Nurul Hidayat]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.8467
<![CDATA[The modification of TiO2 using rare earth oxide (La2O3) to increase the photodegradation activity of TiO2 under visible light has been conducted. The goal of this research is to identify the influence of La2O3 on the TiO2 to the photocatalytic activity of TiO2. The mixed oxide of TiO2/La2O3 was prepared using the precipitation method. The as-prepared catalyst was then calcined at 923 K. The photocatalyst was characterized using SRUV, XRD, FTIR, and SEM-EDX. The results showed that the photocatalyst activity of TiO2/La2O3-923 under visible light in the degradation of methylene blue was higher than pristine TiO2. The decrease in bandgap energy of TiO2/La2O3-923 from 3.2 eV to 3.01 eV was not the main factor in the increase of photocatalytic activity of TiO2/La2O3-923. The optimum condition of photodegradation of MB was obtained when the ratio of TiO2/La2O3 was 5, the concentration of MB was 10 ppm, the reaction time was 300 min, and the mass of the photocatalyst was 0.25 g. The reusability of TiO2/La2O3-923 was stable up to 3 sequent runs with the MB photodegradation of more than 90%. The mechanistic study of the mixed oxide TiO2/La2O3 showed that the hydroxyl radical played an important role in its high photocatalytic. Keywords: TiO2-La2O3, photocatalyst, visible light, methylene blue]]>
<![CDATA[Synergistic Antibacterial Activity of Curcuma domestica Val. Extract with Tetracycline Against Multidrug-resistant Acinetobacter baumannii ]]>
<![CDATA[Nasution, Halimah Raina]]>;
<![CDATA[Yuandani, Yuandani]]>;
<![CDATA[Septama, Abdi Wira]]>;
<![CDATA[Nugraha, Sony Eka]]>;
<![CDATA[Sufitni, Sufitni]]>;
<![CDATA[Khairunnisa, Nur Aini]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.8593
<![CDATA[Infections caused by multidrug-resistant (MDR) bacteria are on the rise globally. MDR is facilitated by overexpression of efflux pump and permeability changes of membrane. Acinetobacter baumannii is a pathogenic germ that causes a major problem in infection, also, there has been an increase in the incidence of resistance to various antibiotics. The present study highlights the synergistic of ethanolic extract of Curcuma domestica (EECD) rhizome with tetracycline against multidrug-resistant A. baumannii (MDR-Ab). Assessment of Minimum Inhibitory Concentration (MIC) was determined by microdilution using 96-well plates. The synergistic effect of EECD and tetracycline was determined by checkerboard method. The effect of EECD and tetracycline combination was investigated by bacteriolytic activity and inhibition of efflux pump by Ethidium Bromide (EtBr) accumulation assay. EECD presented the MIC value 250 µg/mL against MDR-Ab. Fractional Inhibitory Concentration Index (FICI) value of EECD and tetracycline combination was 0.4, which showed their synergistic effect. Additionally, the combination of EECD and tetracycline could inhibit the efflux pump in MDR-Ab. This combination can also compromise cell integrity by altering membrane permeability thus lysing the bacteria cells. According to these results, EECD and tetracycline combination has synergistic effects at some sites of action, and thus could be used as a breakthrough to overcome infection problems due to MDR-Ab. Keywords: Acinetobacter baumannii, antibacterial, Curcuma domestica, multidrug-resistant, tetracycline]]>
<![CDATA[Metabolite Profiles of Sukabumi Arabica Green Coffee Beans Evaluated by 1H NMR-Based Metabolomics ]]>
<![CDATA[Hamdani, Ahmad]]>;
<![CDATA[Happyana, Nizar]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.8950
<![CDATA[Although Sukabumi arabica coffee is one of the famous coffees in Indonesia, however its chemical information is still limited in the literature. In this work, the metabolite profiles of arabica green coffee beans obtained from various plantations in Sukabumi, including Ciayunan, Pondok Halimun, and Selabintana were evaluated by 1H NMR-based metabolomics. In total, 19 metabolites were successfully identified, including the major and minor metabolites of the coffee. The score plot of the OPLS-DA (Orthogonal Partial Least Square Discriminant Analysis) model was successful in classifying the metabolite profiles of the coffees based on their origins. The loading plot analysis showed that the signals belonging to fatty acids, sucrose, trigonelline, chlorogenic acid, lactic acid, and quinic acid, contributed to the classification. S-plot analysis revealed that Selabintana coffee was characterized with higher concentrations of trigonelline and sucrose, whereas Ciayunan sample had higher levels of fatty acids. Meanwhile, the metabolite profile of Pondok Halimun coffee demonstrated an intermediate characteristic between the Ciayunan and Selabintana samples. This work provided valuable scientific information for coffee development especially in West Java and generally in Indonesia. Keywords: metabolomics, multivariate data analysis, NMR, Sukabumi arabica green coffee beans.]]>
<![CDATA[Molecular Docking Analysis of Hydroxy Chalcones and Flavones from Anisaldehyde and Veratraldehyde as EGFR Inhibitors: Predicting Anticancer Potential ]]>
<![CDATA[Pambudi, Wisnu]]>;
<![CDATA[Haryadi, Winarto]]>;
<![CDATA[Matsjeh, Sabirin]]>;
<![CDATA[Anwar, Chairil]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.8956
<![CDATA[This study aimed to investigate the potential of hydroxy chalcone and flavone derivatives as inhibitors of the epidermal growth factor receptor (EGFR) with anticancer properties. Molecular docking simulations were conducted using Autodock Tools 1.5.6 and Discovery Studio visualizer. The EGFR protein structure with the PDB code 1M17 was utilized as the receptor, explicitly targeting the binding pocket. Redocking of the reference ligand erlotinib yielded a binding energy of -7.51 kcal mol-1 with an RMSD of 0.54 Å, confirming the accuracy of the docking protocol. The hydroxy chalcone and flavone derivatives exhibited binding energies ranging from -6.50 to -7.67 kcal mol-1 when interacting with the EGFR protein. Among the studied compounds, compound 2',5'-dihydroxy-3,4-dimethoxychalcone (1g) displayed the lowest binding energy. Interactions involving amino acids such as Met769, Ala719, Thr766, Lys721, and Glu738 were identified as crucial hydrogen bonding interactions between the ligands and the EGFR protein. These findings suggest that 2',5'-dihydroxy-3,4-dimethoxychalcone holds strong potential as a tyrosine kinase inhibitor, positioning it as a promising candidate for further development as an anticancer agent. The outcomes of the computational analysis conducted through the pkCSM online platform indicated that the chemical 2',5'-dihydroxy-3,4-dimethoxychalcone had favorable pharmacokinetic characteristics and showed low toxicity levels. Keywords: molecular docking, hydroxy chalcone, flavone, egfr, ADMET]]>
<![CDATA[Bioactivity of Papua Red Fruit Extract (Pandanus conoideus L.) Against Superoxide dismutase, Malondialdehyde and Blood Glucose of Rat (Rattus norvegicus L.) Hyperglycemia ]]>
<![CDATA[Mokosuli, Yermia Semuel]]>;
<![CDATA[Migau, Natalina]]>;
<![CDATA[Wurarah, Masje]]>
<![CDATA[ Molekul Vol 19 No 1 (2024) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2024.19.1.9029
<![CDATA[Red fruit (Pandanus conodus L.) is a plant native to Papua, ethnomedical used as a traditional medicine with a wide spectrum of pharmacological effects. However, research on the bioactivity of red fruit is still very poorly reported. The aim of this study was to characterize the bioactive content, antioxidant bioactivity and the effect of lowering blood glucose in hyperglycemic rats. Red fruit has extracted used the maceration method with 95% ethanol. Analysis of active compound content using Gas Chromatography Mass Spectrophotometry (GC MS). Analysis of Malondialdehyde (MDA), Superoxide dismutase (SOD) and blood glucose levels was carried out using the in vivo method using white rats. The research results showed that red fruit ethanol extract contained 173 compounds from six main groups of compounds. Red fruit extract has effective in reducing MDA levels in hyperglycemic mice. K4 and K5 treatments were the best treatments for reducing MDA. Red fruit extract affects the duration of induction of increased SOD in hyperglycemic rats. Treatments K4 and K5 were the best treatments for SOD induction. Red fruit extract affects reducing blood glucose in hyperglycemic mice. Red fruit extract has antioxidant activity and lowers blood glucose. Red fruit extract has the potential to be developed as a source of bioactive antioxidants and antidiabetics. Keywords: Glucose, hyperglycemia, malondialdehyde, superoxide dismutase]]>
