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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
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REVIEW: PROCESS OF FLUID BED GRANULATOR PARAMETERS AT THE TIME OF SCALE UP IN GRANUL PRODUCTION Diki Zaelani; Yoga Windhu Wardhana; Anis Yohana Chaerunisaa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.836

Abstract

Scaling up is one of the difficulties faced by the production process of the pharmaceutical industry. We must manufacture in higher quantities than a laboratory size with set requirements as we scale up. Understanding the crucial variables that affect the final product's specifications will aid in choosing appropriate upgrade settings. Fluidized-bed granulation is one of the most frequently used techniques to increase the scale of the pharmaceutical industry. The complex fluidized bed granulation process is influenced by several factors. The most important process variables were the intake air temperature and humidity, concentration of the binder solution, spray rate, atomizing air pressure, and air flow rate. Numerous investigations have examined the effects of large-scale fluid bed granulation. An improved fluid bed granulation technology was employed based on the relative droplet size and moisture content of the powder in the bed after the spraying cycle. These values are comparable, demonstrating that the granulation procedure can be enhanced by considering only the moisture content of the powder and relative droplet size. Keywords: fluid bed granulation, process parameters, scale up
TEST ANTINFLAMMATION CAPSULE COMBINATION OF MORINGA LEAVES (Moringa oleifera L) AND KARUK LEAVES (Piper sarmentosum Roxb. Ex. Hunter) EXTRACT TEST AGAINST MICE (Mus musculus) Nia Kurniasih; Nurhidayati Harun; Ade Egie Prayogi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.837

Abstract

Empirically utilized medicinal plants include Moringa leaves (Moringa oleifera L) and Karuk leaves (Piper sarmentosum Roxb. Ex. Hunter). Moringa leaves contain active compounds, such as vitamins, carotenoids, polyphenols, phenolic acids, flavonoids, alkaloids, glucosinolates, isothiocyanates, tannins, saponins, and oxalates. The leaves of karuk contain polyphenols, flavonoids, saponins, and tannins. This study aimed to assess the anti-inflammatory activity of combination capsules of Moringa and Karuk leaf extracts in mice (Mus musculus). Anti-inflammatory agents are drugs that can suppress or reduce inflammation. The aim of the experimental method used in this study was to determine the optimal concentration for anti-inflammatory activity. Carrageenan as an inflammatory mediator in mouse paws. The anti-inflammatory test involved five groups of animals, each consisting of five mice. The negative control group received Na-CMC, the positive control group was administered diclofenac sodium, and the test samples involved a combination capsule of Moringa and Karuk leaf extract at doses of 350, 700, and 1,050 mg. Measurements were performed every hour for 6 hours after carrageenan induction. Data analysis employed the One-way ANOVA method to ascertain whether variations in the dose of the combination capsule of Moringa and Karuk leaf extracts affected anti-inflammatory activity in mice. The results indicate that the greatest inflammation inhibition occurs with the 1,050 mg dose, resulting in 23% inhibition, followed by 22% at 700 mg and 13% at 350 mg. Statistical analysis yielded a p-value of 0.048, which was less than 0.05. This suggests a significant difference in the anti-inflammatory activity among the test groups ...
ANTIBACTERIAL POTENTIAL OF EGGPLANT FRUIT (Solanum melongena L) ETHANOL EXTRACT AGAINST Propionibacterium acnes BACTERIAL GROWTH Irfan Zamzani; Islan Nor; Muhammad Raihan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.840

Abstract

Acne is one of the skin problems that, without our realizing it, can reduce self-confidence, despair, and even depression among teenagers and young adults. The incidence of bacterial infections is increasing with the increasing cases of resistance of bacteria, such as Propionibacterium acnes, to the side effects of anti-acne drugs. Indonesia has many plants that are beneficial to humans and have properties for treating and improving health, one of which is the eggplant. The purpose of this study is to test whether eggplant has antibacterial activity against P. acnes. The eggplant was extracted using a maceration extraction method. For antibacterial activity, well diffusion agar was used with extract concentrations of 60%, 70%, 80%, and 90%. The inhibition zones of the ethanol extract of S. melongena at 60%, 70%, and 80% concentrations were 13,76 mm, 18,63 mm, and 20,79 mm, respectively, with the highest inhibition zone at 90% concentration at 20,64 mm. The ethanolic extract of S. melongena has a strong inhibitory effect on P. acnes.  Keywords: antibacterial activity, Solanum melongena L, maceration, Propionibacterium acnes.
POTENSI RESVERATROL DALAM MENGURANGI KEPARAHAN MALARIA SEREBRAL PADA MENCIT YANG TERINFEKSI Plasmodium berghei ANKA Faizal Hermanto; Puspa Sari Dewi; Fahmy Ahsanul Haq; Nur Melsandy
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.842

Abstract

Malaria serebral (MS) adalah komplikasi neurologis yang parah dari infeksi Plasmodium falciparum menyebabkan ensefalopati dan bertanggung jawab atas sebagian besar kematian terkait malaria secara global. Tujuan dari penelitian ini adalah mengevaluasi potensi resveratrol dalam mengurangi keparahan malaria serebral pada mencit yang terinfeksi Plasmodium berghei ANKA. Mencit dikelompokkan menjadi beberapa kelompok yaitu kelompok normal (tidak terinfeksi), sedangkan mencit yang terinfeksi P. berghei dan menunjukkan gejala neurologis malaria serebral kemudian dikelompokan menjadi kelompok kontrol; klorokuin 20 mg/kg; resveratrol dosis 25, 50, dan 100 mg/kg. Parameter pengamatan meliputi parasitemia, gejala neurologis, indeks otak, dan evaluasi integritas sawar darah otak. Hasil menunjukkan setelah pemberian resveratrol berbagai dosis terjadi hambatan pertumbuhan parasit, penurunan gejala neurologis, penurunan indeks otak, dan mengurangi kerusakan sawar darah otak akibat infeksi P. berghei dibandingkan dengan kelompok kontrol. Kesimpulan dari penelitian ini adalah resveratrol dapat mengurangi keparahan malaria serebral pada mencit yang terinfeksi P. berghei ANKA. Kata kunci : malaria serebral, Plasmodium berghei, Resveratrol.
A LITERATURE REVIEW: THE POTENTIAL OF NATURAL INGREDIENTS AS ANTIDEPRESSANTS Ranatri Puruhita; Arifah Sri Wahyuni; Andi Suhendi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.843

Abstract

Changes in mood, physical well-being, and behavior, such as sleep and hunger patterns, psychomotor abilities, concentration, anhedonia, exhaustion, hopelessness, helplessness, and suicidal thoughts, define a mental illness known as depression. Alternative therapies that can be used to avoid these side effects include herbal medicines from several types of plants. This literature review aims to determine the potential of natural ingredients that have antidepressant activity in plant biomarkers, methods of obtaining biomarkers, effective dose, and their mechanisms of action. Article searches use keywords ("Herbal plant" OR "Medicinal plant" OR "Herbal" OR "Plant Extract" OR "Plant Extracts") AND ("Antidepressant" OR "Antidepressive") AND ("Mechanism of antidepressant") using the Science Direct, PubMed, and Google Scholar databases. The final results included eight research articles in the systematic review that met the inclusion criteria. Plants that have antidepressant potential include flowers of Viola odorata L, Crocus sativus, Impatiens glandulifera, and Leptadenia hastata (Pers.) and Alpinia zerumbet, seeds of Nigella sativa, root of Panax ginseng, and Achyranthes aspera. Keywords: Antidepressants, Natural Ingredients, Literature Review
DETERMINATION OF THE MINIMUM INHIBITORY CONCENTRATION OF THE ETHANOLIC EXTRACT OF KIPAHIT LEAVES ON THE GROWTH OF Propionibacterium acnes Joko Priyanto Wibowo; Noor Aida; Islan Nor; Irfan Zamzani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.844

Abstract

Acne is a skin disorder characterized by inflammation in the form of comedones, papules, pustules, and nodules. The disease is caused by the gram-positive bacterium,  Propionibacterium acnes. Treatment of the disease using antibiotic agents such as erythromycin and clindamycin has been reported to cause some side effects. Therefore, alternative antibacterial agents derived from natural products are required to reduce the occurrence of side effects. Kipahit (Tithonia diversifolia A. Gray) is one of the plants with pharmacological activities, such as antibacterial and antiprotozoal activities. The aim of this study was to determine the minimum inhibitory concentration (MIC) of a 96% ethanolic extract of kipahit leaves on the growth of P. acnes. Kipahit leaves were extracted through the ultrasound-assisted extraction (UAE) method. Minimum inhibitory concentration (MIC) was determined using the liquid dilution method. A serial dilution was performed to prepare a series of extract concentrations: 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, and 0.39%. Whereas, clindamycin and DMSO 1% were used as positive and negative controls, respectively. Phytochemical  screening showed  that  the 96% ethanolic extract of kipahit leaves contains flavonoids, alkaloids, saponins, steroids/triterpenoids, tannins, and phenolic compounds. In addition, the extract showed   inhibitory activity against P. acnes at concentrations ranging from 25% to 1,56%. In contrast, the extract showed  no inhibitory activity at concentrations of 0.78% and 0.39%. Further experiments confirmed that kipahit leaf extract acted as a bacteriostatic agent (inhibiting bacterial growth) at a minimum concentration of 1.56%.  Keywords: Acne, Propionibacterium acnes, Kipahit, MIC
MEDICINES PLANNING AND PROCUREMENT MANAGEMENT AN ACADEMIC HOSPITAL IN YOGYAKARTA, INDONESIA: A QUALITATIVE STUDY Elmiawati Latifah; Elfride Irawati Sianturi; Prasojo Pribadi; Indriyati Hadi Sulistyaningrum; Rakhmundia Aryo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.845

Abstract

Inventory management remains a critical issue for hospital pharmacies. Thus, there is a need for pharmaceuticals to meet economic resources. Moreover, the decision to make drug requests available should be considered, and the complexity of the problem lies in the random nature of and the various constraints that must be considered in any decision. This study aimed to analyze drug management during the planning and procurement stages of medicine in a teaching hospital in Yogyakarta. The qualitative method was used to his type of research is descriptive-analytical with a case study design of one of the public, academic hospitals in the Yogyakarta area. Data collection was conducted through interviews using a content analysis approach. The analysis technique was carried out by reducing data, analyzing data, identifying themes, and extracting data interpretation with the help of NVIVO 12 software. Overall, interviews were conducted with six participants to obtain information on drug management during the planning and procurement stages in the hospital, following the standards of home pharmacy services. The stages also included budget allocation by volume of services, increasing the competence of human resources, which supports the improvement of drug management performance, implementation of e-prescribing to facilitate monitoring evaluation, and availability of complete standard operating procedures. However, the accuracy of drug planning still needs to be improved so that an integrated management information system can support optimal drug management in a teaching hospital pharmacy installation. Keywords: Drug management, drug planning, drug procurement, public academic hospital
REVIEW: TONIC POTENCY OF ZINGIBERACEAE FAMILY HERBAL PLANTS IN IMPROVING BODY WELLNESS Nabilah Azka Nihlah; Imam Adi Wicaksono; Keri Lestari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.846

Abstract

Body wellness is closely related to health; it is the ability of a person to perform activities without fatigue. Herbal plants can be used to help improve body health and endurance. The Zingiberaceae family is widely found and used by the Indonesian people. This family is widely used as an ingredient in herbal medicines and seasonings. Herbal plants with the potential to improve body wellness can be seen in their tonic effects. Testing the tonic effect can use several methods, namely, the natatory exhaustion test, hanging test, sleep induction test, and rotarod test in mice. Among these, the natatory exhaustion method is the simplest and can be performed quickly. The method used in preparing this article is to collect and understand the primary literature from online databases, such as Google Scholar. This review article aims to provide scientific information to the public regarding herbal plants from the Zingiberaceae family, which have the potential to help maintain a healthy body. Plants that can be used as health enhancers include Red Ginger, Gajah Ginger, Temu Kunci, Temu Giring, Lempuyang Gajah, and Cardamom. Keywords: Herbal Plant, Zingiberaceae, Tonicum, Health 
REVIEW: MEDICINAL PLANTS WITH PHARMACOLOGICAL ACTIVITY AS ANTIPYRETIC Nurdiani Adiningsih; Dika Pramita Destiani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.847

Abstract

Fever is a medical condition characterized by an increased body temperature beyond the normal range of 36 – 37°C. If not managed appropriately, fever may lead to complications in therapy. The conventional treatment for fever involves using antipyretics such as paracetamol/acetaminophen, and ibuprofen. However, prolonged use of these synthetic medications may have adverse side effects. Consequently, more patients are turning to herbal medicine to manage fever. This review aims to identify medicinal plants with pharmacological activity as antipyretics. We conducted a systematic literature review using Google Scholar as the search engine database. Our search keywords were “tanaman herbal”, “antipiretik", “penurun demam", and "uji aktivitas antipiretik". In this review, a total of 18 articles were meticulously analyzed. The collective findings from these studies demonstrated that all tested medicinal plants exhibited antipyretic activity. Flavonoids, tannins, and terpenoids were the primary constituents responsible for the observed antipyretic activity. Medicinal plants with alkaloids and steroid content were also believed to exhibit antipyretic activity. Keywords: fever, antipyretics, medicinal plants
ANTIMICROBIAL ACTIVITY TEST OF 96% ETHANOL EXTRACT OF FLOWERS, LEAVES, AND STEM BARK OF TIGARUN (Crateva magna DC.) AGAINST Staphylococcus aureus and Malassezia furfur Najwi Hasani; Rika Hartati; Elin Julianti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.848

Abstract

Staphylococcus aureus and Malassezia furfur One of the microbes that can cause folliculitis is the inflammation of the skin in the hair follicles. The use of natural ingredients as antimicrobials must be developed as an alternative to overcome the resistance and side effects of chemical drugs. Tigarun (Crataeva magna DC.) is a typical plant in South Kalimantan that can be developed as a natural antimicrobial agent for the treatment of skin infections. Previous studies have reported that tigarun has antimicrobial activity, but no studies have reported its potential antimicrobial activity against folliculitis-causing microbes. Therefore, this study aimed to determine the antimicrobial activity of 96% ethanol extracts of the flowers, leaves, and stem bark of tigarun (Crataeva magna DC.) against microbes that cause folliculitis, including Staphylococcus aureus and Malassezia furfur. Extraction was performed by the maceration method using 96% ethanol. The antimicrobial activities of the extracts were tested using the agar diffusion method. Based on the results of the antimicrobial activity test using the agar diffusion method, the tigarun flower extract showed better antimicrobial activity than the leaf and tigarun bark extracts. Flower extract activity at 200 mg/mL concentrations against Staphylococcus aureus (10.65 ± 0.25) and the fungus Malassezia furfur (7.40 ± 0.40) with moderate inhibition zone ketogenic  Keywords: Folliculitis, tigarun, antimicrobial, agar diffusion

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