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Jurnal Bioteknologi & Biosains Indonesia (JBBI)
Published by Badan Pengkajian dan Penerapan Teknologi
ISSN : 24422606     EISSN : 2548611X     DOI : -
Core Subject : Health, Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions
JBBI is published twice annually and provide scientific publication medium for researchers, engineers, practitioners, academicians, and observers in the field related to biotechnology and bioscience. This journal accepts original research papers, review articles, case studies, and short communications. The articles published are peer-reviewed by no less than two referees, and cover various biotechnology subjects related to the field of agriculture, industry, health, environment, bioinformatics, as well as life sciences in general.
Arjuna Subject : Umum - Umum
Articles 20 Documents
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Search results for , issue "Vol. 11 No. 1 (2024)" : 20 Documents clear
THE RELATIONSHIP OF TNFα -308 G/A POLYMORPHISM WITH THE INCIDENCE OF CERVICAL CANCER IN ASIAN WOMEN: A META ANALYSIS OBSERVATIONAL STUDY Saraswati, Henny; Nurmalasari, Mieke
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.2546

Abstract

Cervical cancer is a malignancy with high mortality rates in women, and its incidence continues to rise. The main etiological factor for cervical cancer is infection with Human Papillomavirus (HPV), which disrupts the regulation of apoptosis in cells. Several studies have shown a correlation between TNFα polymorphisms, including the -308 position (TNFα -308 G/A), and the incidence of cervical cancer.This gene have a role in proliferation of cancer cells. This study investigates the impact of TNFα-308 polymorphism on the risk of cervical cancer in Asian female populations. A meta-analysis of five sources was conducted to determine potential associations. Findings reveal that neither allele A (OR 95%CI = 1.20 [0.70-2.03], p = 0.51) nor genotype AA (OR 95%CI = 0.85 [0.37-1.91], p = 0.69) were significantly linked with an elevated risk of cervical cancer in Asian women. The same result was seen for the G allele (OR 95%CI = 0.84 [0.49-1.42], p = 0.51) and GG genotype (OR 95%CI = 0.80 [0.44-1.48], p = 0.48). The study results indicate that the TNFα-308 polymorphism is not associated with cervical cancer in Asian women. Further research is needed to investigate the role of other gene polymorphisms in cervical cancer susceptibility in Asian women.
IDENTIFICATION OF INDONESIAN ETHNOMEDICINAL PLANTS AS POTENTIAL DRUG CANDIDATES FOR ACUTE RESPIRATORY INFECTION USING COMPUTER-AIDED DRUG DESIGN AND SIMRS MODEL Jackson, James; Tanaya, Davina Nadine; Setiawan, Stefanus
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.2949

Abstract

In 2023, Indonesia’s air quality deteriorated, with its Air Quality Index (AQI) tripling clean air standards, causing health sector losses, including a surge in Acute Respiratory Infection (ARI) cases. One of the ARI treatments is the consumption of cefuroxime, yet it can cause side effects. Indonesia’s floral biodiversity in ethnomedicinal plants can be utilized as a more natural drug candidate for ARI drugs. To determine this, an in silico approach is performed through molecular docking, and Pre-ADMET prediction. Based on the compound selection’s results, lanosterol is the most promising compound, with a binding energy value of -8.11 kcal/mol and an efficiency of 78.81%, while cefuroxime as a reference ligand has a binding energy value of -5.92 kcal/mol with an efficiency of 67.87%. After undergoing compound selection, a time series analysis through the Susceptible Infected Medicine Recovered Susceptible (SIMRS) model is conducted. In this analysis, it is found that cefuroxime and lanosterol require the same amount of time, which is 33 days to restore Indonesia to its pre-ARI outbreak condition, indicating that lanosterol can be used as an alternative drug candidate.
ANALYSIS AND POTENTIAL THE ECO-ENZYME OF SEVERAL TYPES OF FRUIT PEELS IN LEACHATE REMEDIATION Rasyidah; Nasution, Rizki Amelia
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3021

Abstract

This research aims to determine the potential of ecoenzymes from several types of fruit peel in the process of reducing TDS levels of COD, BOD, ammonium and phosphate as well as the number of bacterial colonies in leachate water. So the research involved activities to make ecoenzymes from 4 types of fruit peel, namely banana, dragon fruit, pineapple and orange. Next, the ecoenzyme results were applied to leachate water to test its remediation potential in a ratio of 1:2 (10% ecoenzyme). This research uses a descriptive method, which uses parameters namely TDS, COD, BOD, phosphate, ammonium, and counting bacterial colonies. The results show that ecoenzymes have the potential to remediate leachate waste during five days of incubation, where it can be seen that ecoenzymes can reduce ammonium and phosphate levels but not BOD and COD. From the results, the average reduction in ammonia levels was higher for ecoenzymes from banana peel and pineapple fruit with an average value (mg/l) of P1=14.6; P2=0.55; P3=1.44; P4=0.675 and P5=2.44 (P1: Leachate; P2: Leachate + banana peel ecoenzyme; P3: Leachate + Dragon Fruit peel ecoenzyme; P4: Leachate + Pineapple Peel; P5: Leachate + Fruit peel Orange). Meanwhile, the highest reduction in phosphate was found in remediation using ecoenzymes from orange peel where the average value was P5=3.05 < P1=8.2. The results of ecoenzyme remediation from four types of fruit peel only have the potential to reduce ammonia levels, and likewise the reduction in phosphate occurs after adding orange peel ecoenzymes.
SYNTHESIS AND CHARACTERIZATION OF CHITOSAN MEMBRANES OF CASSAVA PEEL (Manihot esculenta) AND LERI STARCH COMBINATION AS A BIODEGRADABLE PLASTIC: English Dewi, Pande Putu Indira Prima; Widhiantara, I Gede; Sandhika, I Made Gde Sudyadnyana; Wiradana, Putu Angga; Susilo, Raden Joko Kuncoroningrat
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3080

Abstract

Problems related to landfills of plastic packaging waste are a source of environmental pollution. This research provides innovation in utilizing biodegradable plastic from cassava and leri peel starch with the addition of chitosan. This study aimed to analyze the results of the synthesis and characterization of chitosan membranes with a combination of cassava and leri peel starch and determine the biodegradation time of biodegradable plastic in EM-4 bioactivation. This study characterized biodegradable plastic membranes using test parameters, namely the SEM, FTIR, Swelling, and tensile strength tests. The biodegradation test was carried out by immersing biodegradable plastic membranes in an EM-4 bioactator for 7 days. Based on the results obtained from the characterization of biodegradable plastic membranes, namely the swelling test with concentrations of 5:3, 7:3, and 9:3, with yield values ​​of 62.9921%, 69.8902%, and 71.4286%. The SEM test obtained the best results at a concentration of 7:3. FTIR test on biodegradable plastic membranes containing hydroxyl (O-H) and carbonyl (C-O) groups. The tensile test obtained optimum results at the concentration of biodegradable plastic membranes, namely 9:3. As for the biodegradation test that has been carried out, the start time for degradation is 3 days.
THE EFFECT OF THE HEALTH CARE INFECTION CONTROL COMMITTEE IN PATIENTS WITH URINARY CATHETERS ON COST CONTAINMENT Amirah, Asriwati; Fitriani, Arifah Devi; Suarayasa, Ketut; Suharto, Teguh; Asepty, M.Rizky Priyanka
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3086

Abstract

The high prevalence of healthcare-associated infections threatens hospital services. Urinary tract infections associated with the use of catheters could reach 0.2–4.8 per 1000 catheters/day. In response to this, the Centers for Disease Control and Prevention recommends using the Healthcare Infection Control Practices Advisory Committee (HICPAC) to reduce the incidence of infection in hospitals. To determine the effect of implementing HICPAC on reducing hospital costs for patients with urinary catheters at Delia Hospital, Langkat Regency, in 2019. At the Delia General Hospital in Langkat Regency, Malaysia, quantitative research using a quasi-experimental technique was carried out, in which all patients with urinary catheters were included as respondents. The paired t-test was used to evaluate the data using SPSS software. The results revealed a significant effect of the HICPAC application on the incidence of Catheter-Associated Urinary Tract Infection (CAUTI) in patients during treatment (p = 0.08). The HICPAC method can also reduce the risk of CAUTI by 3.902 times. This study did not evaluate the morbidity and mortality attributable to CAUTI. An assessment of the length of stay, cost analysis, and antibiotic resistance is needed to assess the benefits of the HICPAC guidelines. The use of HICPAC in patients with urinary catheters can reduce the cost of treatment at Delia Hospital, Langkat Regency.
EFFECT OF COLCHICINE TREATMENT ON PLANT GROWTH AND FLOWER DEVELOPMENT IN Zinnia elegans Kusumawati, Eni; Haryanto, Haryanto; Wijaya, Nur Iman; Alaudin, Ahmad Muzaki Nurrah-man; Nurhayati, Sari; Fitri, Fadillya Maulidilla
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3112

Abstract

Refugia is a flowering plant that is intended to trap and destroy insects. Colchicine is reported to induce polyploidy in plants. This study aims to determine germination, growth, and refugia performance of colchicine induced Zinnia elegans at different immersion concentrations and times. This research was conducted experimentally with a completely randomized design. The treatment was immersion in colchicine solution at different times duration. Colchicine concentration 0.01% with immersion time of 6,12,24,48, and 72 hours. Colchicine induction with different immersion times showed a decrease in sprouts height (p<0.05), resulting in abnormal sprouts with three leaves and wider leaf area (correlation test r=0.560). The longer the colchicine immersion showed plant height (correlation test r=0.618). Morphologically, control and colchicine induction results were relatively the same, but flowers resulting from colchicine induction had higher flower heights (correlation test r=0.772) and flower diameter (correlation test r=0.815). Induction of colchicine immersion had a different effect on the growth and reproduction performance of Z. elegans.
POTENTIAL OF ENCAPSULATION Bacillus cereus BTH-22 AGAINTS BACTERIAL WILT DISEASE ON EGGPLANT: - Purnawati, Arika; Triwahyu P, Endang; Fari A, Haidar
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3736

Abstract

Endophytic bacteria are a group of bacteria that live in plant tissues, potentially as biological agents of plant diseases, especially wilt disease caused by Ralstonia solanacearum and as an inducer of eggplant (Solanum melongena) plant growth. One of these bacteria is Bacillus cereus BTH-22 which was isolated from healthy eggplant stems in Kediri. The purpose and formulation of the problem are to obtain an encapsulation formulation of B. cereus BTH-22 which has the potential as a biological agent against wilt disease caused by R. solanacearum and as an inducer of eggplant (S. melongena) plant growth. The novelty of the research is the encapsulation formulation of B. cereus which is applied to eggplant plants with wilt, because the application generally uses root soaking, watering to the soil surface, mixing with fertilizer, liquid and powder formulations but all are easily washed away by rain. The research method is as follows: (1) Making encapsulation formulation: 75% Na-alginate with 10% aloe vera extract (Na-1) and 75% Na-alginate, 0.875% zeolite and 0.875% sago flour (Na-2), (2) Sterile soil, inoculate R. solanacearum and prepare 1 month old plants, (3) Application of encapsulation formulation was carried out 3 days after inoculation of R. solanacearum (107CFU/mL) using a Completely Randomized Design with 3 replications. Observations were made on days 7, 14, 21, 28, 35, 42, 49 including : disease intensity, plant height, number of leaves, number of flowers. The results of the study showed: viability in the Na-1 and Na-2 treatments was higher than control at the 48th to 96th hours, disease intensity in the Na-1 and Na-2 treatments was lower than control at the 7th to 49th day, plant height in the Na-1 and Na-2 treatments was higher than control at the 14th to 49th day.
KIDNEY MICROANATOMY OF WHITE RATS ON THE ADMINISTRATION OF ETHANOL EXTRACT OF Spatholobus littoralis STEM ACUTE DOSE Rousdy, Diah; Azkiya, Tiara; Wardoyo, Elvi Rusmiyanto Pancaning
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3743

Abstract

Tampala bajakah stem (Spatholobus littoralis Hassk) is empirically used by the Indonesian people to recover from disease and maintain health, but the use of tampala bajakah has not been tested for doses that are safe for consumption. The purpose of this study was to determine the type of damage caused by acute doses of bajakah tampala stem extract on white rat kidney microanatomy (Rattus norvegicus Berkenhout). This study used bajakah stem derived from Ambawang, extraction using ethanol solvent, and Wistar strain white rat (± 150g) test as a test animal. The method used a Complete Randomized Design with 4 treatments namely normal control using distilled water, treatment of doses of 300, 2000, and 5000 mg/kg BW of bajakah tampala stem extract. Each group was given 5 replicates. The extract was shown in a single dose orally and observations were made for 14 days. The results obtained that doses of 2000 and 5000 mg/kg BW caused damage to white rat kidney tissue in the form of microanatomy dilatation of tubules and loss of the brush border, and doses of 300, 2000, and 5000 mg/kg BW caused necrosis and haemorrhage. The most severe damage to kidney microanatomy is the dose of 2000 and 5000 mg/kg BW. The administration of acute doses of bajakah extract has the potential to cause damage to kidney tissue.
OPTIMIZING AMOUNT AND IDENTIFICATION OF YEAST IN SALAK YEAST WATER (Salacca edulis Reinw cv Pondoh) Khumaira, Annisa; Annaziha, Salma; Baihaqi, Muhammad Azizan Azmani; Anindita, Nosa Septiana; Bimantara, Arif; Probowati, Wiwit
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3809

Abstract

Salak fruit is a tropical fruit spread across Southeast Asia and can potentially be a source of natural yeast by processing fruit yeast water. Salak fruit is known to be rich in carbohydrates, making it a potential natural habitat for microbial communities, especially yeast. This research aims to optimize the growth of yeast in the salak yeast water system by varying the sugar concentration treatment, the composition of the amount of fruit flesh, and the fermentation time, as well as identifying the yeast in the salak yeast water. The method used is to count the number of yeast colonies using the Total Plate Count method. The most optimal treatment results are then tested for pH, total sugar, alcohol, isolation and yeast identification. The research results showed that the composition of salak meat was 30%, adding 1% sugar, and fermentation for 6 days resulted in the most optimal growth of the microbial community with an amount of 3.1×10⁶ cfu/ml. The pH test showed a result of 3.01, the alcohol content, namely ethanol, was 0.066855%, no methanol was detected, the total sugar test result in the yeast water was 2.08%, and it was identified in the yeast water that there were Hanseniaspora opuntiae and Candida sorboxylosa. The results show that salak yeast water (Salacca edulis Reinw cv Pondoh) can be used as a yeast water product to ferment food.
THE SORUS MORPHOLOGY OF FERNS OF THE FAMILY Dryopteridaceae AND THE FAMILY Polypodiaceae THE TATANGGE UNIVERSITY FOREST, SSOTHEAST SULAWESI Munir, Asmawati; Damhuri; Samai, Suarna; Lisdayanti, Hikma; Lizawarni
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.4845

Abstract

This study aims to determine the morphology of the sorus of ferns (Pteridophyta) Dryopteridaceae and Polypodiaceae families in the Tatangge Education Forest area of Rawa Aopa Watumohai National Park, Southeast Sulawesi. This research involved exploration in the Tatangge University Forest area of Rawa Aopa Watumohai National Park, Southeast Sulawesi to collect samples, then identifying and observing sorus characteristics in the Laboratory of the Biology Education Department, Faculty of Teacher Training and Education, Halu Oleo University, Kendari. The research data were processed and analysed descriptively, regarding the characteristics of the sorus of ferns (Pteridophyta) Dryopteridaceae family including location, shape, colour, and annulus. The results of the study found 5 (five) species of ferns (Pteridophyta) Dryopteridaceae family, and 5 (five) species of Polypodiaceae family that have different sorus characteristics. The Dryopteridaceae family consists of the species Dryopteris celsa, Dryopteris filix-mas, Dryopteris marginalis, Nephrolepis biserrata (Sw) Schoot, and Polistichopsis hasseltii. The family Polypodiaceae consists of the species Drynaria sparsisora (Desv.) T. Moore Pyrrosia longifollia (Burm. f), Pyrrosia lanceolata L Farw, Pyrrosia piloselloides M.G. Price, and Polypodium glycyrriza Licorice Fern.

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