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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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APLIKASI METODE OPTIMASI CENTRAL COMPOSITE DESIGN DALAM FORMULASI SEDIAAN GEL NANOPARTIKEL LIPID DENGAN BAHAN AKTIF 4-n-BUTILRESORCINOL Rini Dwiastuti; Ni Kadek Dwi Putri Kusuma Dewi
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.490

Abstract

Lipid nanoparticle is one of the nanoparticle dosage forms that have a particle size of 1-100 nm. Lipid nanoparticle systems aggregation causes an increase in particle size with storage time so that a carrier is needed that can reduce the aggregation. The lipid nanoparticle system formulated in gel preparations can add to the matrix thereby reducing the aggregation. Central Composite Design (CCD) is one part of the experimental design of Response Surface Methodology that can be used to determine the optimization of gelling agents and humectants in the formulation of lipid nanoparticle gel preparations. The aim of this study was to obtain the optimum composition of carbopol 940 and propylene glycol with the active ingredient 4-n-butylresorcinol using the optimization method of Central Composite Design. This research is an experimental study with independent variables, carbopol 940 and propylene glycol and the dependent variable, the physical properties and physical stability of the gel preparation. The results of this study were carbopol 940 of 0.46 grams and propylene glycol of 9.23 mL were determined as the optimum point obtained from the smallest point in the optimum area using the CCD method.
ANALISIS MULTIVARIAT : PENGKAJIAN PENGETAHUAN, SIKAP DAN DETERMINASI NIAT PENERIMAAN VAKSIN COVID-19 PADA WARGA KELURAHAN PEJUANG KOTA BEKASI Adin Hakim Kurniawan; Yetri Elisya; Muhammad Fregi Marsa
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.491

Abstract

One of the efforts of the Indonesian government to fight Covid 19 is to hold vaccinations for all Indonesian people. DKI Jakarta is one of the epicenters of the spread of Covid 19 which was the beginning of starting vaccination activities. There is still many people's rejection of the implementation of complete basic immunization including Covid 19 vaccination. Objective: To determine knowledge, attitudes, acceptance, and factors that influence the acceptance of Covid 19 vaccine. This research type of quantitative descriptive with cross-sectional design. The sampling technique used cluster stratified sampling. The number of research respondents was 136 people. Statistical analysis techniques are chi-square and multiple regression logistic multivariate. Results: This study revealed a good level of knowledge (52.94%), positive attitudes (59.82%), and intention to receive the COVID-19 vaccine (75.70%). From the logistic regression analysis, the factors that had a significant relationship with vaccine acceptance were: a history of degenerative diseases (p-value=0.004); knowledge about the covid 19 vaccine (p-value = 0.010), and an attitude of agreeing to accept Covid 19 (p = 0.026). Vaccine knowledge education and communication from government sources is an important method to reduce negative attitudes towards COVID-19 vaccines.
GAMBARAN PENGGUNAAN ANALGETIKA PADA OPERASI ORTHOPEDI DI INSTALASI BEDAH SENTRAL RSUD dr. LOEKMONO HADI KUDUS Maria Caecilia Nanny Setiawati; Hilda Wulan Suciati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.492

Abstract

Orthopedic surgery is often performed, especially due to traffic accidents. Post orthopedic surgery, patients usually feel pain, thus requiring the administration of analgesics. The Objective of this research is to determine the characteristics of the patient and the description of the use of analgesic drugs, as well as the cost of drugs use in orthopedic surgery at the Central Surgical Installation of RSUD dr. Loekmono Hadi Kudus. This research is descriptive and the data are taken retrospectively. Sampling by purposive sampling method. In the period September-October 2019 there were 101 inpatients who underwent orthopedic surgery and received analgesics. 60.6% were male patients, 63.36% were BPJS users, the most age was between 36-45 years (19.80%), the most pain experienced by patients was moderate pain (69.31%). ). Most of the analgesics used were a combination of ketorolac injection and tramadol injection, as many as 48 patients (47.52%). The method of drug administration was mostly done intravenously (95.22%). The average cost of all drugs for orthopedic surgery is IDR 278,039, with analgesic drug costs as much as 14.4% of the total drug cost . The Conclusion is the most were BPJS patients, male, age between 36-45 years, the most analgesic use was combination tramadol and ketorolac, the use of analgesics and drug costs in orthopedic surgery is quite rational.
PENGEMBANGAN PENYUBUR RAMBUT MENGGUNAKAN KOMBINASI EKSTRAK ETANOL HERBA PEGAGAN (Centella Asiatica (L) Urban) DAN EKSTRAK N-HEKSANA BAWANG PUTIH (Allium Sativum L) Dwi Setyoningsih; Shelly Taurhesia; Teti Indrawati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.495

Abstract

Centella asiatica contains asiaticoside, flavonoid, phytosterol, madecassid acid, madecassoside, Asiatic acid and amino acid which are potentially stimulating hair growth, while Allium sativum has rich nutrient for hair growth such as alkaloid and sterol/terpenoid. Objective: previous study showed each extract has activity to stimulate hair growth but there was no study yet for a combination of these two extracts. The objective of this study was to find right concentration for combination of gotu kola herb extract and garlic extract which can stimulate hair growth, and the best combination will be then formulated into hair tonic and test its activity. Methods: Application on 3 male rabbits for 28 days of combination of 1.25% gotu kola herb extract and 100 ppm garlic extract showed hair growth of 34.10 mm, hair growth acceleration 1.388 mm /day and hair weight 27.816 mg. Then Hair tonic was developed using three different formulas, namely F1 contains of 2.5% gotu kola herb extract and 0.02% garlic extract; F2 contains of 2,5% gotu kola herb extract and 0.04% garlic extract and F3 contains of gotu kola herb extract 5% and garlic extract 0.04%. This hair tonic has green color, distinctive odor, homogeneity, a viscosity of 2.629 cP to distilled water, and pH 5.6. The results showed that Hair tonic of F3 with a concentration of 5% gotu kola herb extract and 0,04% garlic extract gave hair growth of 28,62 mm, rate of hair growth of 1,057 mm/day and hair weight of 28,84 mg, and this hair tonic is stable for 3 months storage at 25oC as well as at 40oC.
FORMULASI DAN EVALUASI SEDIAAN TABLET HISAP DARI EKSTRAK ETANOL BIJI KOPI ARABIKA (Coffea arabica L.) JAVA PREANGER SEBAGAI ANTIOKSIDAN Retty Handayani; Nurul Auliasari; Hisni Uswatun Hasanah
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.496

Abstract

Arabica coffee (Coffea arabica L.) Java Preanger is the best coffee from West Java which is better known internationally as Java Preanger. One of the secondary metabolites found in Arabica coffee beans and efficacious as an antioxidant is chlorogenic acid. Lozenges were made by wet granulation method with various concentrations of coffee extract 5%, 10% and 15%. The resulting preparation was then evaluated for its physical and antioxidant activity. Physical evaluation includes organoleptic tests, weight uniformity, size uniformity, hardness, friability, frictionibility and disintegration time. Meanwhile, the antioxidant activity test was carried out using the ABTS method. Based on the results of the physical evaluation, the formulation that meets the requirements is formula 3 (F3) with a coffee bean extract concentration of 15% and has the highest antioxidant activity with an IC50 value of 27.915 ppm.
PENGARUH PELATIHAN FARMASI KLINIK TERHADAP PENINGKATAN KOMPETENSI APOTEKER DI PUSKESMAS PROVINSI BANTEN DI ERA PANDEMI COVID-19 Yusransyah; Ahmad Sofan; Tuty Sriwahyuni; Lydya Elfira Sari Nasution; Raiyan
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.497

Abstract

Latar belakang: Pelayanan kefarmasian oleh apoteker puskesmas di provinsi Banten belum optimal. Hal ini terlihat dari jumlah penggunaan obat antihipertensi dan prevalensi penyakit hipertensi yang meningkat dari tahun ke tahun serta menjadi salah satu penyebab kematian terbesar di provinsi Banten untuk kategori penyakit tidak menular. Hal ini menuntut apoteker untuk lebih mengoptimalkan peran mereka dengan meningkatkan kompetensi melalui pelatihan. Tujuan: Penelitian ini bertujuan untuk menilai tingkat pengetahuan dan kemampuan apoteker di puskesmas provinsi Banten dan untuk mengetahui apakah terdapat pengaruh yang signifikan sebelum dan sesudah pelatihan farmasi klinik bagi apoteker di puskesmas. Metode: Penelitian ini merupakan penelitian pra-eksperimen dengan desain satu grup yang diberikan pretest dan posttest. Pelatihan mencakup dua topik utama. Topik pertama tentang communication skill dan topik kedua tentang terapi anti hipertensi, dengan berbagai studi kasus di puskesmas. Hasil: Hasil penelitian ini menunjukkan bahwa skor rata-rata setelah pelatihan adalah 71,64 lebih tinggi dari skor sebelum pelatihan yaitu 51,23. Sebanyak 72 apoteker (dari total 73 apoteker) memiliki nilai skor setelah pelatihan yang lebih besar daripada sebelum pelatihan. Nilai konseling peserta pelatihan memang belum memenuhi standar, namun para apoteker peserta pelatihan mendapatkan pengalaman dan teknik konseling yang baik bagi pasien hipertensi di Puskesmas, yang bisa diimplementasikan di tempat kerja masing-masing. Kesimpulan: Pelatihan secara daring di era pandemi terbukti dapat meningkatkan pengetahuan dan kemampuan apoteker dalam memberikan pelayanan kefarmasian tentang anti hipertensi di puskesmas provinsi Banten yang dinilai dari hasil tes sebelum dan setelah pelatihan. Kata Kunci: Antihipertensi, Pelatihan Farmasi Klinik, Tingkat Pengetahuan, Apoteker Puskesmas
AKTIVITAS HEPATOPROTEKTIF EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) PADA TIKUS PUTIH YANG DIINDUKSI PARASETAMOL Anisa Pebiansyah; Nur Rahayuningsih; Ade Yeni Aprilia; Dichy Nuryadin Zain
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.498

Abstract

Parasetamol menyebabkan kerusakan hati jika dikonsumsi melebihi batas normal secara terus menerus. Kerusakan hati ditandai dengan peningkatan kadar enzim Serum Glutamic Pyruvic Transaminase (SGPT) dan Serum Glutamic Oxaloacetic Transaminase (SGOT) dalam darah. Antioksidan dapat mencegah kerusakan hati yang diinduksi parasetamol. Bunga telang (Clitoria ternatea) adalah tanaman yang berpotensi mencegah kerusakan hati karena memiliki aktivitas antioksidan yang tinggi. Penelitian ini bertujuan untuk menelaah aktivitas hepatoprotektif ekstrak etanol bunga telang pada tikus yang diinduksi parasetamol. Tikus dikelompokkan menjadi 6 kelompok terdiri dari kontrol normal tanpa induksi parasetamol, kontrol negatif, kontrol positif, dosis uji 1, 2 dan 3 diberi parasetamol sebanyak 150 mg/200 g BB pada hari ke 1 sampai hari ke 7. Setelah 1 jam, kelompok kontrol positif diberi curliv 37 mg/200 g BB, dosis uji 1, 2 dan 3 diberi ekstrak etanol bunga telang masing - masing 123 mg/200 g BB, 247 mg/200 g BB dan 370 mg/200g BB pada hari ke 1 sampai hari ke 7. Pada hari ke 8 darah tikus diambil kemudian dilakukan pengukuran SGPT dan SGOT dengan metode enzimatis menggunakan alat fotometer. Berdasarkan hasil analisis statistik, Ekstrak etanol bunga telang dosis 1, 2, 3 dan kontrol positif menunjukkan penurunan SGPT dan SGOT yang berbeda nyata dibandingkan dengan kontrol negatif tetapi hanya dosis 2 (247 mg/200 g BB) yang menunjukkan aktivitas hepatoprotektif setara dengan kontrol positif. Kata Kunci : Parasetamol, SGOT, SGPT, Antioksidan, Bunga Telang
AKTIVITAS AGEN TROMBOLITIK DAUN PEGAGAN (Centella asiatica) HASIL FERMENTASI OLEH Acetobacter aceti FNCC 0016 DENGAN METODE CLOT LYSIS SECARA IN-VITRO Adristy Ratna Kusumo; Achmad Toto Poernomo; Riesta Primaharinastiti
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.499

Abstract

Thrombolytic agents are plasminogen activators which can dissolve blood clot that caused cardiovascular disease (CVD). Thrombolytic agents can be obtained from microorganism such as Acetobacter aceti FNCC 0016 and from plants such as Centella asiatica, these thrombolytic agents are combined using fermentation method. Fermentation can improves the pharmacological properties of plants through modification of their metabolites. Fermentation mediated by microorganism has been shown to enhance the therapeutic efficacies of some plants. This research aimed to determine the increase of thrombolytic activity from the fermentation product of Centella asiatica by Acetobacter aceti FNCC 0016. Fermentation was carried out at various times (0 h, 24 h, 48 h, 72 h) at a temperature of 30±1°C. The thrombolytic activity was determined using in-vitro clot lysis method. The results showed a significant increase in thrombolytic activity after 72 hours of fermentation with thrombolytic index of 91,49 compared to Centella asiatica extract (42.93) and Acetobacter aceti FNCC 0016 (19.99). Conclusion: Thus, Centella asiatica that has undergone a fermentation process with Acetobacter aceti FNCC 0016 can increase the thrombolytic activity.
AKTIVITAS ANTIJAMUR KOMBINASI EKSTRAK ETANOL DAUN MANGGA BACANG (MANGIFERA FOETIDA L.) DAN DAUN BIDARA (ZIZIPHUS MAURITIANA L.) TERHADAP CANDIDA ALBICANS Dini Mardhiyani; Kony Putriani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.501

Abstract

Along with increasing life expectancy, the community tries to find solutions to health problems. One of the health problems that occur in humans is caused by fungi. Candida albicans is one of the fungi that can be found in humans. Candida albicans are normal flora in the vagina, digestive tract, and oral cavity. Nevertheless, it can change into a pathogen and cause changes in the host. Based on compound contained in leaf of mango bacang and leaf of bidara, they have antifungal effect. This study aims to determine the antifungal activity of single ethanol extract of mango bacang leaves and bidara leaves with a combination of bidara leaves ethanol extract and ethanol extract of mango bacang leaves against Candida albicans. The method of this study begins with collecting mango bacang leaves and bidara leaves then extracted maceration with ethanol solvents. The antifungal activity is tested with the disk diffusion method using potato dextrose media. Based on the results of the hypothesis test obtained a significance value of 0.010 <0.05, there was a difference in the diameter of the inhibition zone against the growth of Candida albicans due to a single giving and variations in the combination of ethanol mango bacang leaves and bidara leaves ethanol extract. Extract single antifungal activity after combined experienced a minimum increase of 1.2%. The conclusion of this study shows that the combination of ethanol extract of bacang mango leaves with bidara leaves ethanol extract has a larger inhibiting zone than a single extract and shows the synergy effect. The use of bacang mango leaves as anti-fungal is recommended in combination with bidara leaves.
PENGETAHUAN MAHASISWA UNIVERSITAS JEMBER TENTANG HIV/AIDS Sinta Rachmawati; Rizqi Fauzia; Ema Rachmawati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.502

Abstract

Human Immunodeficiency Virus (HIV) is the cause of Acquired Immune Deficiency Syndrome (AIDS). In Indonesia, the number of people infected with HIV reaches 50,282 while the number of people with AIDS is 7,036. East Java is the province with the highest number of HIV infection cases in Indonesia, while AIDS is in the third position. Jember Regency is the fifth largest district/city reporting AIDS cases in East Java Province. Knowledge is closely related to attitude. Good knowledge will affect a positive attitude, and vice versa. Stigma can be formed because there is no knowledge about how HIV/AIDS is transmitted. Ignorance causes fear so that an attitude of rejection is formed towards People Living with HIV/AIDS (PLWHA). This study aims to determine the knowledge of students at the University of Jember towards HIV/AIDS. This research was conducted in 2021 with a cross-sectional research design. Data was collected online based on a questionnaire adapted from Shokoohi et al. (2016). There were 378 students involved in the study. There were 24 questions about HIV/AIDS. The level of knowledge was divided into 3: low (correct score ≤ 12), medium (correct score 13-18) and high (correct score ≥ 19). A total of 80.2% of students have a high level of knowledge. Most of the respondents knew the main routes of HIV transmission and answered correctly about the prevention, diagnosis and treatment of HIV/AIDS. It is necessary to conduct a follow-up reseach in a broader population.

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