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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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ANALISIS KUANTITATIF DAN KUALITATIF EFEK SAMPING OBAT DI RS JANTUNG DAN PEMBULUH DARAH HARAPAN KITA PERIODE JANUARI – JUNI 2021 Dinda Kusuma Hardini; Silvia Wahyu Widiarti; Saur Lumongga
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.503

Abstract

Adverse drug reactions are undesirable effects that can be harmful or detrimental after medication administration when dosage and way of administration are in accordance with the purpose of treatment. Identification of the most common type of adverse drug reaction in Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita (RSJPDHK) was executed through Adverse Drug Reactions Monitoring from January to June 2021. The aim of this study is to obtain real data on adverse drug reactions for the purpose of educating medical colleagues in order to reduce similar adverse drug reactions. The designs of this study were qualitative descriptive research (using Naranjo Algorithm) and quantitative. The number of incoming reports were 102. The reports came from inpatient and outpatient wards. The most common form of adverse drug reactions occurred during this period were gastrointestinal bleeding (31.37%) and prolonged INR (International Normalized Ratio) without sign of bleeding (25.49%). Utilisation of blood-thinning medications that cause bleeding, specifically were warfarin, aspirin, and clopidogrel. The results of the qualitative analysis for the highest incidence of adverse drug reactions in the study period were gastrointestinal bleeding with a Naranjo score of 5-8 and the number was 69.77%. The incidence of adverse drug reactions caused by anticoagulants and antiplatelets are quite high even though these two types of medications are the most widely used in RSJPDHK. Socialization of the results of these reports on a regular basis to medical colleagues is necessary in order to reduce the incidence of adverse drug reactions in RSJPDHK.
PENGARUH PEMBERIAN AROMATERAPI MINYAK MELATI (Jasminum sambac L.) TERHADAP PENURUNAN DERAJAT INSOMNIA PADA LANSIA DI BANJAR GEDE KELURAHAN SEMPIDI Ni Putu Yuliana Assari; Ida Ayu Manik Partha Sutema; I Gusti Made Aman
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.505

Abstract

The humans’ organs function will be decreased when humans are getting older. It caused they to had insomnia. Insomnia is a condition of humans’ sleeping problem. Jasmine oil aromatherapy is an essential oil which is used to decrease insomnia. The research aimed at knowing or prove that jasmine oil aromatherapy can reduce the degree of insomnia in the elderly. The research method was a quasy experimental one group pretest-posttest design. The research subject was 34 elderlies who were selected by the purposive sampling. The degree of insomnia before and after the intervention was measured using the Insomnia Severity Index (ISI) questionnaire. The test result of Friedman showed that there was differences in the degree of insomnia after giving jasmine oil aromatherapy to the elderly (p=0,001). Before giving jasmine oil aromatherapy, the average value was 19,147. Meanwhile, after using jasmine oil aromatherapy on the 8th day, the average value was 13,000 and on the 15th day there was a significant decrease in the degree of insomnia with an average value of 7,147. the administration of jasmine oil aromatherapy can significantly reduced the degree of insomnia in the elderly in Banjar Gede, Sempidi Village started on day 8 (2nd posttest) and day 15 (3rd posttest).
GAMBARAN SISTEM DISTRIBUSI UNIT DOSE DISPENSING (UDD) TERHADAP RETUR OBAT INJEKSI GENERIK DI INSTALASI FARMASI RAWAT INAP SALAH SATU RUMAH SAKIT SWASTA DI KOTA BANDUNG Eva Kusumahati; Dea Anita; Monika Patrisia
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.506

Abstract

Drug returns are one of the jobs in inpatient pharmacy services. The use of an inappropriate distribution system can lead to high drug returns. Objective: to find out the description of the use of the UDD distribution system for generic injection drug returns in one of the inpatient pharmacy installations in the city of Bandung. Observational method with retrospective data collection technique in which data were collected using a UDD individual prescription distribution system. Results: indicates that generic injection drugs are drugs with the highest number of returns. The comparison of the percentage of drug returns before and after the UDD distribution system, namely Ceftriaxone was 3.95% and decreased to 3.61%, Citicoline 9.72% decreased to 5.17%, Dexamethasone was 5.20% down to 3.77%, Ketorolac 11.19% down to 11.14%, Omeprazole 6.55% to 4.23%, Ondansetron 4 mg 5.52% to 4.79%, Ondansetron 8 mg by 8.84% to 5.04%, Pantoprazole 8.09% to 6.47%, Ranitidine by 4.86% to 2.72% and Tranexamic Acid 250 by 20.97% to 4.39 % Conclusion: there is a decrease in the percentage of injection drug returns in hospitalized patients.
POTENSI ANTIPLATELET CAMPURAN EKSTRAK BINAHONG, JAHE DAN KUNYIT PADA MENCIT PUTIH JANTAN Lusi Indriani; Moerfiah Moerfiah; Oktaviana Zunnita; Faisal Pradana
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.509

Abstract

Antiplatelets can inhibit platelets aggregation and have been used in prevention and treatment the trombotic desease. Binahong leaves, ginger dan turmeric have antiplatelets activity. The mixture of these plants are expected to increase the antiplatelets potency. This study aimed to determine the optimum dose of ethanol extracts of binahong leaves, ginger dan turmeric as antiplatelets agent. The antiplatelets testing were carried out by in vivo method using parameter of bleeding and coagulation time. The testing solutions were administered orally once a day for 8 days. There were 7 treatment groups consist of positive control (Acetosal 0.29mg/20gBW), negative control (CMC-Na 0.5%), binahong 10mg/20gBW, mixture 1 of binahong:ginger:turmeric (5:0.5:1mg/20gBW), mixture 2 (10:0.5:1mg/20gBW), mixture 3 (5:1:1mg/20gBW), and mixture 4 (5:0.5:2mg/20gBW). The bleeding and coagulation time were determined at 0, 3rd, 6th and 9th day. The bleeding time was determined by injuring mice tail, the blood that comes out were absorbed with absorption paper. From the first bleeding time until stopped was calculated as bleeding time. The coagulation time was determined by observing the formation of fibrin thread in the broken capillary pipe. The blood from the end tail were absorbed with capillary pipe, and then was broken every 15 seconds. The antiplatelets activity in mice with bleeding time parameter showed that mixture 3 was more effective at 3rd day with an increased of 16.60%, than the positive control group (3.92%). The coagulation time parameter showed that the binahong group was more effective at 9th day with an increased of 203.55%, than the positive control group (89.71%). The mixture of binahong, ginger, and turmeric were the most effective in increasing bleeding time, whereas binahong was the most effective in increasing coagulation time.
UJI EFEKTIVITAS ANTIHIPERGLIKEMIA INFUSA ALGA LAUT COKLAT (Sargassum hystrix) PADA MENCIT JANTAN DENGAN METODE TOLERANSI GLUKOSA Agung Giri Samudra; Nurfijrin Ramadhani; Cyntia Dwi Utami; Nori Wirahmi; Fathnur Sani K
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.510

Abstract

One type of metabolic disease that is always experiencing an increase in sufferers every year in countries around the world is diabetes mellitus. Sargassum hystrix marine algae are the types that are found and quite abundant in Indonesia. This study aims to prove the hypoglycemic effect of Sargassum hystrix infusion in male white mice. The study was conducted using the oral glucose test method in the positive control group (I) given glibenclamide 0.52mg / 20gramBB; group (II) is a negative control given CMC Na 0.5%; group (III) infusion of Sargassum hystrix with a concentration of 2.5% with a volume of 0.2 mL / 20gram BW; group (IV) infusion of Sargassum hystrix with a concentration of 5% by volume of 0.2 mL / 20gram BW. The results were analyzed using One Way Anova which was then followed by Duncan's test. The results showed that Sargassum hystrix infusion had an antihyperglycemic effect (p <0.05) when compared with negative controls. Sargassum hystrix 5% infusion is the best dose with the antihyperglycemic effect statistically the same as the antihyperglycemic effect of glibenclamide.
EFEK DIURETIK SEDUHAN DAUN TEH HIJAU (Camellia sinensis L.) PADA MENCIT JANTAN GALUR SWISS Agustina Susilowati; Nanda Syta Nur’aini
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.511

Abstract

The use of diuretics is needed in all circumstances requiring increased water expenditure, one of which is hypertension. Green tea has has flavonoids and alkaloids and has proven efficacy as a diuretic. This study aims to find the diuretic effect of steeping green tea leaves on Swiss male mice. This study used 25 male swiss mice which were divided into five groups, namely Group I as negative control given 1% CMC Na solution, group II as positive control was given furosemide suspension dose 5.2 mg / KgBW, and groups III, IV and V given the steeping of green tea leaves with a powder weight of 2g, 4g and 6g in 200ml of hot water. Before being given the treatment, each group was given 0.4 ml warm water. Testing of the diuretic effect comparison is done by looking at the volume of urine produced every 1 hour for 6 hours. The results of the urine volume of mice were analyzed with SPSS 24 with a confidence level of 95%.The results of phytochemical screening show that the steeping of green tea leaves contains alkaloids, flavonoids, saponin and tannins. The average cumulative volume of urine for group I was 0.376 mL, group II was 1.119 mL, group III was 0.431 mL, group IV was 0.661 mL and group V was 0.725 mL. Steeping green tea leaves 4g and 6g (p≥ 0,05) can have a diuretic effect in male Swiss mice.
EVALUASI KEPUASAN ANGGOTA PD IAI KALIMANTAN SELATAN TERHADAP PENGGUNAAN APLIKASI SIAP MENGGUNAKAN METODE EUCS (END USER COMPUTING SATISFACTION) Muhammad Ikhwan Rizki; Surya Wahyudi; Herningtyas Nautika Lingga
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.512

Abstract

The Indonesian Pharmacists Association or Ikatan Apoteker Indonesia (IAI) is a professional organization of pharmacists in Indonesia. IAI has management at Central, Regional, and Branches. Organizational services for each IAI member use the Pharmacist Information System Application or Sistem Informasi Apoteker (SIAp). Evaluation of satisfaction in the Information System can use the EUCS (End User Computing Satisfaction) method. The purpose of this study was to determine the level of satisfaction of South Kalimantan pharmacists on the use of the SIAp application and management services. The research method uses an analytical survey with a cross sectional design. The instrument used is a questionnaire that has been tested for validity and reliability. This research has been submitted to the Research Ethics Commission. The population of this research is 1.151 pharmacists in South Kalimantan. Respondents who filled out the questionnaire were 540 pharmacists (95% confidence level). Questionnaires were distributed using a Google form that assessed the SIAP application from the aspects of Content, Accuracy, Format, Easy of User, and Timeliness. The results of the questionnaire were analyzed using a Likert scale, then the percentage of satisfaction levels interpreted with the categories very high (75.01 - 100%), high (58.34-75), less (41.65-58.33), low (24.98 -41.66), and very low (0-24.99). The results showed that members' satisfaction with the SIAp application from the aspect of Content 79.83% (very high), Accuracy 81.47% (very high), Format 82.32% (very high), Easy of Use 78.36% (very high), and Timeliness 75.52% (very high). Member satisfaction with Branches is 79.07% (very high), Regional is 77.93% (very high), and Central is 75.27% (very high). Conclusion: The level of satisfaction of PD IAI South Kalimantan Pharmacists with the SIAp Application is very high. Branch, Regional, and Central Services are very high.
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN PIDADA MERAH (Sonneratia caseolaris L) PADA MENCIT PUTIH (Mus musculus L) Siti Jubaidah; Eka Siswanto Syamsul; Supomo Supomo
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.513

Abstract

The leaves of the red pidada plant (Sonneratia caseolaris L.) are traditionally used by the people of Kalimantan to mix cold powder, treat wounds and have antioxidant properties. The aim was to determine the symptoms of acute toxicity and lethal dose of 50 ethanol extract of red pidada leaf (Sonneratia caseolaris L.) against white mice. Methods: This study used 20 rats which were divided into four groups and given a graded dose of 0.65 g/kgBW, 1.3 g/kgBW, 2.6 g/kgBW, and 5.2 g/kgBW ethanol extract of red pidada leaf with two oral administrations then observed for symptoms of toxicity and the number of deaths in each test animal after 24 hours, then observations were made. body weight for 14 days without treatment. The results showed that the apparent LD50 was: >5.2g/kgBB. Clinical symptoms observed in mice were decreased motor activity at the highest dose and increased grooming frequency. The LD50 of the ethanol extract of red pidada leaves is in the mild toxic category (5-15 g/kgBW).
EFEKTIVITAS KOMBINASI JUS HATI AYAM DAN SERBUK BIJI MELINJO SEBAGAI BAHAN PENGINDUKSI HIPERURISEMIA PADA TIKUS Siti Sadiah; Mawar Subangkit; Jurnila Sari Tanjung
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.515

Abstract

An in vivo test study to prove its effectiveness as an antihyperuricemia requires an animal model with a hyperuricemic condition. Foods that contain high purine bases have the potential to increase uric acid levels in the blood, including chicken liver and melinjo seeds. This study aims to determine the effectiveness of the combination of chicken liver juice and melinjo seed powder in producing hyperuricemia conditions with the most optimal onset and duration in rats in vivo. Six groups of white Sprague Dawley rats (n=5) consisted of a normal group, a positive control group, a chicken liver juice group, a melinjo seed powder group and two groups that were given a combination of chicken liver juice and melinjo seed powder with different compositions. The treatment was given every day for 15 days orally. The parameters observed were uric acid levels which were measured every 3 days and, body weight. The results showed that the combination of chicken liver juice and melinjo powder with a half dose of a single dose each had a better onset and duration. The conclusion of this study is that the combination of chicken liver juice and melinjo seed powder is potent as an inducer of hyperuricemia in rats.
POTENSI ANTIDIABETIK EKSTRAK ETANOL DAUN MATOA(Pometia pinnata) PADA TIKUS PUTIH JANTAN Joni Tandi; Afriani S; Nadira; Handayani KR; Wirawan W; Afrizal; Tien Wahyu Handayani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.521

Abstract

Diabetes Mellitus is a metabolic disease characterized by high blood glucose levels which is commonly called hyperglycemia due to lack of insulin secretion. One of the matoa plants (Pometia pinnata) that has been used as a traditional medicine is matoa leaves which are efficacious as diabetes mellitus. The purpose of this study was to determine the secondary metabolite compounds in the ethanol extract of matoa leaves, as well as to determine the potential dose of ethanolic extract of matoa leaves which was effective in reducing blood glucose levels and on the histopathological description of the pancreas of male white rats induced by Streptozotocin. This study used a laboratory experimental method, divided into 6 treatment groups, each group consisting of 5 rats, namely normal control, negative control, positive control, treatment groups with doses of 100, 200, and 300 mg/kg body weight. Data were analyzed using One Way ANOVA statistical test at 95% confidence level followed by LSD test to see differences between treatments. The results showed that the ethanolic extract of matoa leaves contained secondary metabolites of alkaloids, flavonoids, saponins, tannins, and steroids. at a dose of 300 mg/kg BW showed effective results in reducing blood glucose levels with an average decrease of 99.6 mg/dL and the ethanol extract of matoa leaves had the potential to regenerate pancreatic cells in streptozotocin-induced male white rats of 0. 6±0.54

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