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INDONESIA
Indonesian Journal of Pharmacology and Therapy
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 2745455X     DOI : https://doi.org/10.22146/ijpther.10147
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology
Indonesian Journal of Pharmacology and Therapy (IJPTher ) is a scientific journal which published by Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI). IJPTher is an open-access, and double-blind peer-reviewed journal published three Issues a year. IJPTher aims to communicate high-quality articles in the fields of pharmacology. IJPTher publishes original articles, review articles, case reports and book reviews in the fields of pharmacology including basic pharmacology, clinical pharmacology, pharmacotherapy, pharmacoepidemiology, pharmacogenetics, pharmacogenomics, pharmacoeconomic, toxicology and toxicogenomics.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 107 Documents
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Physical properties and stability of grapeseed oil (Vitis vinifera L.) skincare formula with gelling agent combination of Na-CMC-carbopol and HPMC-carbopol Abdul Karim Zulkarnain; Chairunnisa Nurul Ichsani; Candriya Lael Judiantoro
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.8279

Abstract

Skincare products made from natural ingredients have become the choice of many people. Grapeseed oil contains ingredients that act as a moisturizer. Na-CMC-carbopol and HPMC-carbopol are gelling agents that are widely used in preparations due to their compatibility with various materials. All three are combined to cover their respective deficiencies. This study aimed to evaluate the effect of the combination of Na-CMC-carbopol and HPMC-carbopol on the physical properties and stability of grapeseed oil gel and to determine the optimum formula. The research method was carried out by optimizing the levels of Na-CMC (2-2.5%), HPMC (2-20%), and carbopol (0.5-1%) with the Simplex Lattice Design method. Eight runs of the resulting formula were gelled and tested for their physical properties to determine the optimum formula. The optimum formula obtained was verified with statistical analysis and tested for physical stability. The stability data were analyzed statistically, 95% confidence level. The optimum formula for NaCMC-carbopol was at a concentration of 2.220% Na-CMC and 0.780% carbopol, pH 6.246 ± 0.057, spreadability 12.96 ± 0.48 cm2, adhesion 6.33 ± 0.48 sec, viscosity 166.00 ± 4.88 dPas. HPMC-carbopol at both concentrations of 1% had a pH of 4.973 ± 0.172, a viscosity of 175.20 ± 5.44 dPas, a spreadability of 18.12 ± 1.61 cm2, and an adhesion of 6.94 ± 1.68 sec. All preparations were not significantly different between predictions and experiments. The optimum gel formula had good physical properties and was stable during 3 cycles of cycling stability test.
The role of angiotensin I - converting enzyme (ACE) insertion/deletion gene polymorphism in hypertension and ACE inhibitor therapy: a narrative review Handani, Dewa Ayu Sri; Zullies Ikawati; Hermawan, Adam
Indonesian Journal of Pharmacology and Therapy Vol 4 No 3 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.8281

Abstract

Primary hypertension is the most prevalent type of hypertension, which is primarily attributed to genetic factors. The angiotensin-converting enzyme (ACE) gene has emerged as a prominent candidate among the genetic factors influencing blood pressure regulation. The ACE gene encodes the ACE, which plays a crucial role in the renin-angiotensin system. The ACE gene insertion/deletion (I/D) polymorphism is a variation of the ACE gene that affects blood pressure regulation. Individuals with II, ID, and DD genotypes may exhibit distinct ACE plasma concentrations, potentially contributing to variations in blood pressure levels and response to ACE inhibitor therapy. This article aimed to provide a comprehensive overview of the relationship between the ACE I/D gene with hypertension and angiotensin-converting enzym inhibitor (ACEI) effectiveness. This article presents a narrative review encompassing relevant studies published between 2013 and 2023. A systematic search was conducted using reputable databases such as PubMed, Science Direct, and Scopus. Inclusion criteria were applied, resulting in the selection of 25 articles that met the predefined criteria. The analysis included 25 studies, comprising 5 articles that investigated the impact of ACEI therapy and 20 articles that examined the ACE I/D gene polymorphism in hypertensive populations without ACEI therapy. It can be concluded that compared to the I allele, the D allele of the ACE I/D gene is associated with a higher level of essential hypertension and a reduced ACEI response.
The role of family caregivers in medication adherence of elderly in Asian setting: a scoping review Wiedyaningsih, Chairun; Widyakusuma, Niken Nur; Sri Suryawati
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.8379

Abstract

Family caregivers for elderly play a very important role in implementing drug adherence, especially in Asian countries. Various determinants of medication adherence included caregivers as family support. Although the relationship between family support is not always significant, understanding the factors of family caregivers on medication adherence is important, especially when improving adherence in Asian countries. The following scoping review was conducted to provide an overview of caregivers, and its relationship to medication adherence in Asian settings. PRISMA-ScR guideline and checklist was used for the search process and to guide reporting. Review selection and characterization were performed by reviewers independently. In total, 22 papers were included in the review, published from 2011 to 2021. The studies varied in terms of purpose, methodology, and detail of reporting. Family caregiver is an important determinant of medication adherence, especially for areas where extended family culture is still strong, such as in Asia. Understanding the local culture, aspects of family burden and economic, as well as the role of the health profession, especially pharmacists in health services are needed to improve adherence. Therefore, further research with quality methods is needed.
The safety of fondaparinux, enoxaparin, and unfractionated heparin in COVID-19 patients Siti Aulia Musyrifah; Endro Nugroho, Agung; Fita Rahmawati
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.8481

Abstract

The coagulopathy, a hematological disorder affecting blood clotting, carries an elevated risk of thrombosis and mortality in COVID-19 patients. Fondaparinux, enoxaparin, and unfractionated heparin (UFH) are potential treatments for reducing coagulopathy in COVID-19 patients. Nonetheless, anticoagulant administration increases the risk of bleeding-related adverse effects. This study aimed to evaluate the safety profile of fondaparinux, enoxaparin, and UFH in COVID-19 patients. The safety was evaluated based on the prevalence of major and minor bleeding events from the data of medical records collected retrospectively from October 2022 to December 2021 at Kediri District Hospital. The Chi-square analysis and multiple logistic regression were employed to establish associations between variables. Out of the 315 patients who meet the inclusion criteria, 35 patients (11.1%) exhibited bleeding, 11 patients (3.5%) experienced major bleeding, while 24 patients (7.6%) encountered minor bleeding. No significantly different in bleeding events both major and minor bleeding among the groups receiving fondaparinux, enoxaparin, and UFH were observed (p> 0.05). The UFH emerged as the most common anticoagulant associated with bleeding incidents. The multivariate analysis revealed that age ≥ 60 yr and concomitant medication with ketorolac influenced bleeding incidence. The monitoring of bleeding events on the use of anticoagulants is necessary.
Effectiveness of azithromycin and ciprofloxacin in the treatment of typhoid fever: a systematic review Mulyono, Bethea Manuela; Ita Margaretha Nainggolan; Linawati Hananta; Lucky Hartati Moehario
Indonesian Journal of Pharmacology and Therapy Vol 4 No 3 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.8945

Abstract

Typhoid fever or commonly referred to as enteric fever is a systemic disease caused by Salmonella typhi. It often occurs in developing countries due to poor sanitation. Second-line antibiotics, including ciprofloxacin, have been widely used as the first choice treatment for typhoid fever. However, S. typhi has increased resistance to second-line antibiotics, so azithromycin has become an alternative treatment for the typhoid fever. This systematic review assessed the effectiveness of azithromycin and ciprofloxacin against typhoid fever in adults. This research used the PRISMA protocol with predefined Pubmed, Proquest, and EBSCO keywords. After removing duplicates and selecting studies according to inclusion and exclusion criterias, 17 studies about the effectiveness of azithromycin and ciprofloxacin in typhoid fever in adults from 1988-2020 were gathered. Studies were evaluated using JBI Critical Appraisal Tools. The results showed that administration of azithromycin and ciprofloxacin for typhoid fever yields average length of fever (3.5 d and 4.2 d) and average length of stay (9.3 d and 10 d), respectively. The susceptibility of S. typhi to azithromycin was 99.9%, whereas a significant decrease in its susceptibility to ciprofloxacin was observed in 2017-2020, from 4% to 2%. Azithromycin showed better effectiveness than ciprofloxacin in treating typhoid fever in adults based on S. typhi’s susceptibility, average length of fever and average length of stay from 17 studies reviewed.
Thyroid medications and patient adherence: understanding prescription patterns and factors influencing treatment compliance Poojary, Bhavya; Wilson, Merlin Maria; Jose, Riya; Sam, Sona P; George, Ann Elizabeth
Indonesian Journal of Pharmacology and Therapy Vol 4 No 3 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9375

Abstract

Thyroid problems are common in India affecting around 42 million people. Early diagnosis and therapy play an important role in managing this endocrine disorder. Hypothyroidism and hyperthyroidism are the most common thyroid disorders and are treated with thyroid hormone replacement therapy and antithyroid drugs. However, medication adherence, side effects, and misunderstanding of the importance of medication lead to inconsistent intake. This study aimed to evaluate the pattern of prescribing and adherence to thyroid medication. This cross-sectional study was conducted over 6 months in a tertiary care hospital, involving 188 patients with thyroid disorders. Data was collected using a validated form and medication adherence rationing scale. The collected data, including MARS scores, were entered into Microsoft Excel and analyzed using IBM SPSS Version 25. Quantitative data were analyzed using the mean and standard deviation, while categorical data were summarized using frequencies and percentages. The Chi-square test was used to evaluate associations, with a significance level of p < 0.05. In our study, 163 participants diagnosed with hypothyroidism exhibited a notable adherence rate of 89.57%. The 25 hyperthyroid patients showed strong adherence to the recommended drugs, with those provided methimazole having the highest adherence rate (52.0%). No statistically significant connections were found when examining the variables affecting drug adherence. Levothyroxine and methimazole were the preferred medications for managing hypothyroidism and hyperthyroidism, respectively. A high adherence rate among patients indicates heightened awareness and understanding of their condition, as well as consistent adherence to the medication schedule. These findings emphasize the importance of early diagnosis, appropriate prescription patterns, and patient adherence in effectively managing thyroid disorders.
Single nucleotide polymorphism of AGT rs699 in the pathogenesis of hypertension and ACE inhibitors response: a narrative review Hartienah, Septiayu Dwi; Ikawati, Muthi'; Zullies Ikawati
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9395

Abstract

Hypertension is a chronic cardiovascular disease that affects more than one billion people in the world. Angiotensinogen in the renin-angiotensin-aldosterone system (RAAS) is the main precursor encoded by angiotensinogen (AGT) gene and plays an important role in the development of hypertension. Single nucleotide polymorphism (SNP) of AGT gene is thought related to the pathogenesis of hypertension and angiotensinogen levels in plasma that may affect response to ACE inhibitors. This article reviewed the association of SNP AGT rs699 with the pathogenesis of hypertension and ACE inhibitors response. A total of 14 articles published from 1995 to 2023 were collected from databases including NCBI, Google Scholar, PubMed and Science Direct. Several studies in different populations have been conducted and showed various results. The T allele or TT genotype of AGT rs699 was associated in the pathogenesis of hypertension. However, the association between AGT rs699 and ACE inhibitor response shows inconsistent results, thus further research is needed.
Current progress of nanotechnology in medicine: application in drug delivery, diagnostic, tissue engineering, and nanobots Febriofca Galih Yatalaththov; Fadhlurrahman, Ahmad Ghitha; Rahma, Alifia Hetifa; Husna Fitri
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9467

Abstract

The integration of nanotechnology into medicine has resulted in rapid advancements, and revolutionized in the diagnosis, treatment and management of diseases. Through complex manipulation of materials at the nanoscale, nanotechnology has ushered in a new era of precision medicine. Their benefits include increasingly in earlier and more precise diagnosis, as well as in optimal treatment of diseases. This review explores the applications of nanotechnology in medicine, with a focus on drug delivery, diagnostic tools, tissue engineering, and the world of futuristic nanorobots. By investigating the complex workings of nanotechnology in medicine, we aim to highlight its innovative applications, the benefits it brings to diagnosis, and treatment, and its potential to reshape the landscape of contemporary medical practice.
Development of the smartphone application for patients with dementia: a literature review Utami, Pinasti; Rahmawati, Fita; Astuti; Zullies Ikawati
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9596

Abstract

Primary technological developments are advancing rapidly, and dementia patients and caregivers are becoming more open to online interactions for enhancing dementia care. However, most existing applications only focus on patients, and there is a need to expand their scope to include caregivers. Ideally, the application should be designed with the caregiver in mind, and considering the impact they experience while caring for dementia patients. Families are specifically targeting caregivers who are at the highest risk of experiencing caregiver burnout, such as those caring for patients. This literature review described the necessary functions and content for dementia caregivers, serving as a reference for designing, developing, and implementing smartphone solutions that meet user needs. This review utilized articles from three databases i.e. PubMed NCBI, ScienceDirect, and Tandfonline. The Boolean approach method was used to generate the exact keywords. The inclusion criteria for this study encompassed smartphone applications for dementia patients, focusing on function and content, published in English-language journals within five last years, with an emphasis on original research and free full access. In this review, six articles were obtained. From these six articles, four findings related to functions and content were identified i.e. education, interactive health promotion, interaction stakeholder, and referencing information sources. These four aspects could serve as references for developing comprehensive smartphone applications for caregivers, and facilitating integrated health care.
Clinically significant of drug-drug interactions among children: a review Ridhayani, Firda; Sari, Ika Puspita; Andayani, Tri Murti
Indonesian Journal of Pharmacology and Therapy Vol 5 No 3 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9663

Abstract

Drug-drug interactions among children are a getting along concern in health care settings, specifically intensive care units, as sources of adverse drug events that may affect patient condition. Children admitted to pediatric intensive care unit are more prone to drug-drug interactions owing to the diseases and medications complexity. This condition could put the patient at high risk of harm, particularly with his critical condition, so need intense considerations from clinical practitioners to prevent adverse drug events caused by potential drug-drug interactions. This article’s review attempts to explore the important drug-drug interactions among children, including explaining the drug combination, mechanism, and related adverse drug events to help health practitioners recognize it earlier before prescribing the medication. This article’s review explored previous research results from PubMed and Google Scholar as literature resources and PRISMA flow chart as protocol for article selection process. A total of 9 articles discussed comprehensively about the type of drug combinations, mechanism of drug-drug interactions, and associated adverse drug events with significant drug-drug interactions that commonly occurred in children’s patient during the treatment. The drug-drug interaction including midazolam-phenobarbital, cannabidiol-clobazam, Paxlovid-tacrolimus, inhaled fluticasone propionate-lopinavir/ritonavir, rifampicin-warfarin, clofazimine-moxifloxacin, benzatropine-haloperidol, and enalapril-spironolactone. In conclusion, gaining a better understanding of drug-drug interactions among children will empower healthcare professionals to develop useful strategies to recognize, manage, and prevent various types of pharmacokinetic and pharmacodynamic interactions. Especially at different stages in terms of age, physiology, and complexity of the disease in children.

Page 7 of 11 | Total Record : 107

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