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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Healing of Radiation Dermatitis with Ozonated Aloe Vera Oil by Increasing PDGF and Epidermal Thickness in Sprague-Dawley Rats Utami, Widoasti Putri; , Yan Wisnu Prajoko; Prihharsanti, Christina H.N.; Sadhana, Udadi; Susilaningsih, Neni; Restiwijaya, Maryam; Nur, Muhammad
Folia Medica Indonesiana Vol. 58, No. 4
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Abstract

Highlights: • This study demonstrated the effect of ozonated Aloe vera oil in the healing of radiation dermatitis wound. • Groups that received no treatment was compared with groups that received treatment using 2.5% hydrocortisone ointment and ozonated Aloe vera. • Ozonated Aloe vera oil improves the healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness. Abstract : The long-term use of corticosteroids as a standard treatment for skin disorders, such as radiation dermatitis, can cause many side effects. Alternatively, ozonated Aloe vera oil may replace corticosteroids due to its fewer side effects and benefits in wound healing process. Re-epithelialization and the formation of growth factors, such as platelet-derived growth factor (PDGF), play an important role in the healing of dermatitis wound. This study intended to demonstrate the effect of ozonated Aloe vera oil to improve the healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness. This study used a post-test only control group design. A sample of 36 Sprague-Dawley rats was divided into 6 groups (C1=without treatment, C2=2.5% hydrocortisone ointment, P1=pure Aloe vera (AV), P2=300 mg/mL ozonated Aloe vera (OAV), P3=600 mg/mL OAV, P4=1200 mg/mL OAV. The expression of PDGF was assessed using Allred scoring with immunohistochemical staining, whereas the epidermal thickness was assessed using hematoxylin and eosin (H&E) staining at 400x microscopic magnification. The PDGF expression and epidermal thickness between the control and the treatment groups showed significant differences using a Kruskal-Wallis test (P=0.001) and one-way ANOVA test (P<0.001). The groups that was given ozonated Aloe vera oil had higher average of PDGF expression and thicker epidermis than the other groups. The Spearman's correlation test showed a strong positive relationship (p<0.001 and r=0.709) between the two variables. In conclusion, ozonated Aloe vera oil improves healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness.
The Effect of Orlistat Administration in Change of Glycemic Control and Weight Loss of Obesity or Overweight Patients with Type 2 Diabetes Mellitus Johan, Abu Rizal Dwikatmono; Dewanti, Linda; Putri, Anandia Nafisah; Pantoro, Benny Iswanto; Albab, Chabib Fachry; Hutauruk, Maria Marind Desrianti; Novitasari, Triana
Folia Medica Indonesiana Vol. 58, No. 1
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Hightlight: • The effect of orlistat on glycemic control and weight loss in overweight or obese type 2 diabetes mellitus patients was determined • HbA1c and FPG level in overweight and obese type 2 diabetes mellitus patient can improved by orlistat as an adjuvant therapy. Abstract: Risk of Type 2 diabetes mellitus (T2DM) increases steadily with increasing overweight and obesity, and these two-health problems are emerging epidemics worldwide. Orlistat, a lipase inhibitor for weight loss drug, is often used in T2DM medication as adjuvant therapy, but effectiveness of the drug for improving glycemic control on T2DM patients is unclear. This study was to determine the effect of orlistat on glycemic control and weight loss in overweight or obese patients with T2DM. Term "Orlistat” AND "(obesity OR overweight)” AND "(HbA1c OR A1C)” AND "diabetes” were systematically searched in Pubmed and Science Direct web databases up to March 2021. Only randomized controlled study (RCT) methods studies were included in this study. Collected final samples were presented in a table with narrative review. There were 9 RCT studies with a total 2,175 subjects that met inclusion criteria. Of the sample, 360 mg/day orlistat as an adjuvant therapy, was administered to overweight or obese T2DM patients together with hypocaloric intake (8 studies) or without hypocaloric intake (1 study) intervention. They were examined for 12-52 weeks. From 2 short-term (12 weeks) studies, one study revealed that orlistat improved HbA1c and fasting plasma glucose (FPG) level significantly, while one study showed no significant effect compared to placebo. Seven other studies (long term observation) had found that orlistat significantly improved HbA1c and FPG level. All studies found that orlistat significantly reduced body weight. As an adjuvant therapy, Orlistat improved HbA1c and FPG level in overweight and obese T2DM patients.
Back Matter Vol. 58 No. 2 June 2022 Matter, Back
Folia Medica Indonesiana Vol. 58, No. 2
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Anthropocephalometric Aspects of Frontoethmoid Encephalocele Patients Parenrengi, Arifin
Folia Medica Indonesiana Vol. 54, No. 3
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Frontoethmoid encephalocele (FEE) causes maxillofacial structural abnormalities and also covers some bony landmarks, especially in the glabella region. This study examined the faces of frontoethmoid encephalocele patients before undergoing corrective surgery with the aim of identifying and assessing their facial morphological differences. This was a cross-sectional study from January 1, 2016 to June 31, 2017. A simple anthropocephalometric measurement was performed on the patient's face who would undergo surgery. Periorbital and mid-face measurements showed differences between the patients and normal groups. The midface structure of the patients clearly changed. The age when the procedure was taken also had effect. Preoperative 3DCT is proposed to describe the facial anatomy of EFE patients. Further studies in this field are suggested to produce a comprehensive database of facial morphology changes in FEE populations, both pre- and post-operatively, with the intention of producing a redefinition of FEE cases based on anthropo-cephalometric principles.
Review article: the role of eltrombopag and romiplostim as the thrombopoietin receptor agonist (tpo-ra) in treatment of idiopathic thrombocytopenic purpura (itp): what is tpo-ra, when tpo-ra is used and how to take tpo-ra? Susanto, Jefri Pratama
Folia Medica Indonesiana Vol. 51, No. 3
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Idiopathic thrombocytopenic purpura is a autoimmune disease characterized thrombocytopenia casued by excessive platelet destruction. However, both platelet destruction and reduced thrombopoietin level are occurred in some cases. Therefore, new management of ITP is emerged which target is to increase platelet production rate via eltrombopag or romiplostim as the thrombopoietin receptor agonist (TPO-RA). Eltrombopag is given orally while romiplostim is given subcutaneously or intravenously and dose adjustment is depend on platelet count. Both eltrombopag and romiplostim is indicated in minimal response glucocorticoid or intravenous immunoglobulin or splenetomy treatment.
Effectiveness of betta splendens as a biological predatory against aedes aegypti larvae Permata, Saniya Hanum; Yotopranoto, Subagyo; Kusmartisnawati, Kusmartisnawati
Folia Medica Indonesiana Vol. 51, No. 4
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Dengue Hemorrhagic Fever (DHF) is caused by dengue virus and transmitted by Aedes aegypti mosquito. There are several fish species known to be used as a biological predator of Aedes aegypti larvae, such as Betta splendens. The purpose of this study was to examine Betta splendens as a biological predator of Aedes aegypti larvae. The larvae used were in the fourth stage. The Betta splendens consisted of four replicate groups, 3 and 6 months male age group, and 3 and 6 months female age group. The effectiveness rate of predation was only counted based on the speed of eating of 25 larvae in the aquarium containing 3 liters of water. Statistical test was performed with Annova with the parameters fish body weight and time to prey. The longest mean of preying time was found in 3 months aged male fish group (mean body weight = 1.474 grams), with a mean time of prey = 153.80 seconds. The shortest mean preying time was found ini 6 months aged female fish group (mean body weight = 2.566 grams), with a mean time of prey = 142.41 seconds. In conclusion, female 6 month-aged fish with highest mean body weight is most effective againts Aedes aegypti larvae. The body weight can affect the speed of preying, but body weight is only one of some variables that affect the speed and effectiveness beside gender and age of Betta splendens.
Ampicillin sulbactam and cefotaxime are similarly effective in pediatric pneumonia Puspitasari, Diny; Hasmono, Didik; Rahman, Taufiqur
Folia Medica Indonesiana Vol. 52, No. 2
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Pneumonia is an infection of the lungs that occurs and still cause high mortality in young children today. The main cause is bacterial or viral. Antibiotics still recommended though it is difficult to know the cause is bacterial or viral. Ampicillin be the first option some guideline. Increased resistance worldwide become one of them concerns the effectiveness of antibiotics. The main treatment of toddler pneumonia in Muhammadiyah Hospital Lamongan are ampicillin sulbactam and cefotaxime. The study was conducted to analyze the effectiveness of both antibiotics. This study aims to analyze comparison in the use of ampicillin sulbactam and cefotaxime pneumonia patients aged 3-59 months from November 2013 to March 2014. Patients who met the inclusion criteria were prospectively observed for clinical data, laboratory data, the data microbiology. After it is analyzed to know the difference between the effectiveness of antibiotics. In this study of 29 patients included in the inclusion criteria, 17 patients who received antibiotics ampicillin sulbactam and 12 patients receiving cefotaxime. In the comparison of the mean pulse pulse is known there is a significant reduction in both groups of patients on the second day and was not significantly different between the two groups (p = 0.084). Likewise, the average ratio of temperature (p = 0.117), breath rate (p = 0.839), leukocytes of patients (p = 0.429). Length of stay for ampicillin sulbactam group was 4.77 days and 5.17 days for cefotaxime group. Analysis showed no differences between the two groups for lenght (p = 0.275). Of the 22 patients who were sampled for blood culture examination only 1 patient with positive results. Based on these results we can conclude that ampicillin sulbactam and cefotaxime effective in cases of children pneumonia, and there is no distinction based on the parameters in body temperature, breath rate, pulse, leukocytes and long hospitalization of patients. Regimentation dosage is appropriate based on guidelines, and length of stay less than 10 days. Found no side effects of both drugs.
Case Report: Medical Aspect, Growth, and Quality of Life in Children with 46,XX Testicular Disorder of Sex Development (DSD) Rochmah, Nur; Faizi, Muhammad; Andriani, Irwina Rahma; Pasulu, Soraya Salle
Folia Medica Indonesiana Vol. 54, No. 3
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46,XX testicular disorder of sexual development (DSD) is characterized by male phenotype with 46,XX karyotype. The incidence rate is 1:25,000 in male newborn. Infants with ambiguous external genitals will be confronted with issue of gender assigment and may result in a stressful condition in the parents. Since gender assignment is inevitable, several factors should be considered in DSD management. The management approach for children born with DSD is individualized and multidisciplinary. Gender assignment aims to facilitate the patient to obtain the best quality of life. Adaptation of children with 46,XX testicular DSD as a determinant of quality of life is also influenced by psychological and family conditions. The purpose of this report was to observe medical growth and development aspects of the child with 46,XX terticular DSD as indicated by the aspects of growth and development, and health related quality of life, as well as the influential aspects. PA, 18 months, was diagnosed with 46,XX testicular DSD. The patient routinely visited to endocrinology clinic, urologic surgery, and child psychiatry clinic from the age of 6 months. The parents decided to raise patient as male. The patient had undergone surgery for hypospadias correction, hormone injections, child growth monitoring, and psychological monitoring (medical records of Dr. Soetomo Hospital, Surabaya in 2015). Management should consider individual and multidiciplinary accompaniment of the patient and parents, the importance of group support, and follow-up to adulthood, as well as possible longterm outcomes that will occur in the future so that the patients and the parents need to be prepared.
Case Report: Ventriculoperitoneal Shunt Catheter Migration and Transanal Extrusion in Persistent Vegetative State Adult Patient Fauzi, Asra Al; Parenrengi, Muhammad Arifin; Wahyuhadi, Joni; Subagio, Eko Agus; Turchan, Agus
Folia Medica Indonesiana Vol. 55, No. 4
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Hyaluronic acid (HA) is a glycosaminoglycan with a straight-chain polymer arrangement defined as the extracellular matrix constituent. High molecular weight HA has normal physicochemical, biological, and physiological properties whereas low molecular weight has the property of angiogenesis, inflammation, and suppresses apoptosis. This study occupied the samples of 35 paraffin block from poorly and well differentiated retinoblastoma tissue and 8 normal retinal block which have been collected for 4 years from 2010-2013 at Dr. Soetomo Hospital, Surabaya, Indonesia. Afterwards, the paraffin blocks were immunohistochemically examined for HA staining, expression of cell proliferation (Ki-67), and cell apoptosis to determine intratumoral aggressiveness of retinoblastoma. HA on poorly differentiated retinoblastoma stain with a high immunostaining of 76.2%, while well differentiated retinoblastoma on the highest HA staining was revealed to be at moderate level of 64.3%, and not appear in normal retina. In poorly differentiated retinoblastoma, the location of most HA stain is in the cell cytoplasm (87.5%). In the well differentiated retinoblastoma, the HA immunostaning mainly occurred in the cell membrane (73.7%). Histopathological retinoblastoma grading showed a significant correlation (p <0.01) towards several variables of HA immunostaining, Ki-67, and cell apoptosis. In addition, the histopathological retinoblastoma grading also revealed a significant correlation (p <0.01) towards the location of HA staining (cell membrane and cytoplasm). Both stainings are also play role in retinoblastoma differentiation. The malignancy of retinoblastoma can be proven by the increased HA staining at cytoplasm in poorly differentiated and associated with increased of cell proliferation along with decreased apoptosis.
Differences in Aerobic Capacity and Running Speed Across Various Somatotype Structures and Body Fat Compositions among Professional Football Athletes in Indonesia Ghozali, Dhoni Akbar; Ridhallah, Muhammad Syauqi; Shabrina, Syania; Nurhani, Ahmad Isnaini Shidqi; Hastami, Yunia; Rahayu, Dwi; Aryoseto, Lukman; Handayani, Selfi; Munawaroh, Siti; Wiyono, Nanang; Riyanto, Agus Sugeng; Budiono, Enrico Ananda; Rahma, Annisa Aghnia; Ilyas, Muhana Fawwazy
Folia Medica Indonesiana Vol. 60, No. 2
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Highlights: 1. This study emphasizes the significance of understanding professional football players' various somatotype structures and body fat compositions as an important contribution to the area of sports science. This study lays the groundwork for future research to better understand the intricate interactions between somatotype structures, body composition, and athletic performance. 2. Since a one-size-fits-all approach may not be successful, this study advocates for tailored evaluations of training regimens to cater to athletes' unique requirements and skills, which may lead to higher overall performance. Abstract This study investigated the effects of somatotype structures and body fat composition on professional football athletes' aerobic capacities and running speed. This study used an analytical observational design with a cross-sectional approach. The subjects comprised 27 professional football athletes from Bhayangkara Football Club, located in Bekasi, Indonesia. This study measured several variables, i.e., players' age, playing position, somatotype structures assessed using the Somatotype Rating Form and Heath-Carter Somatochart, body fat composition measured using Brozek and Siri formulas, aerobic capacities determined by the maximum rate of oxygen (VO2 max) through the Yo-Yo Intermittent Recovery Test Level 2, and running speed over a 30 m distance. The data were presented as mean ± standard deviation (SD), frequency (n), and percentage. The Shapiro-Wilk was used to determine the normality of the data distribution. The statistical analyses were conducted using one-way analysis of variance (ANOVA) followed by the post-hoc least significant difference (LSD) test, the Kruskal-Wallis test followed by the post-hoc Mann-Whitney test, as well as the independent t-test, the Mann-Whitney test, and Pearson's or Spearman's correlation tests. A value of p<0.05 was considered statistically significant. The athletes exhibited a predominant somatotype structure of mesomorph-endomorph (88.9%). Notable associations were found between mesomorphy rating and running speed (r=-0.548; p=0.003), body fat composition and aerobic capacity (r=-0.448; p=0.019), as well as age and aerobic capacity (r=-0.515; p=0.006). Notably, differences in aerobic capacity were observed among various age groups (p=0.031). There were also differences in body fat composition (p=0.003) and running speed (p=0.036) between two distinct somatotype structures. These findings underscore the importance of considering individualized training and conditioning programs that account for athletes' unique body compositions and ages.

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