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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Examination of Micro Vascular Density on Metastatic Colorectal Cancer of RAS Mutant-Type as Anti Vegf Therapy Predictor Sulistyo, Heru; Budipramana, Vicky Sumarki
Folia Medica Indonesiana Vol. 57, No. 2
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Abstract

According to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) on Colon Cancer Version 2.2019, mCRC patients with mutant type RAS were treated with anti-VEGF. However, the use of the targeting therapy still had inconsistent results. Neoangiogenesis studies had been used as a basis to assess the prognosis of mCRC. Microvascular density (MVD) had become the morphological gold standard to assess neovascularization in human tumors. This study proved the existence of low microvascular density (MVD) in mCRC patients with mutant type RAS status as a predictor of failure of anti-VEGF therapy. There were 29 patients at Dr. Soetomo Academic Hospital from 2015-2018 who had their RAS status checked and tested for microvascular density (MVD). The results of this study were analyzed using SPSS 23.0. In the Mutant-type of RAS group, this study examined microvascular density (MVD). 11 (73%) research subjects with high MVD scores and 4 (27%) research subjects had low MVD scores. Besides, 27% microvascular density (MVD) was low, in the mutant-type of RAS mCRC patient which could be a predictor factor for the failure of anti-VEGF therapy.
Body Mass Index, Waist-Hip Ratio and Fasting Blood Glucose Levels amongst the University Students Oktariza, Rury Tiara; Kalanjati, Viskasari Pintoko; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 57, No. 1
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Overweight and obesity have been correlated to the higher risk for developing metabolic diseases in later life, i.e. DM type 2. We study the body mass index (BMI), the waist to hip ratio (WHR) and the fasting blood glucose levels (FBG) in the seemingly healthy male and female university students to comprehend these variables amongst the youth in Indonesia in 2019. The BMI and WHR of 150 male and female students aged 18-22 years old of the IIKBW, Kediri were measured by standardised anthropometry. The FBG was measured after 8 hours-minimum of fasting from the capillary blood drop using glucometer. Data was then analysed using SPSS 17 with level of significance of p<0.05. According to Asia-Pacific BMI classification, students were 30.7% obese with males significantly higher than females (p=0.016), 18% overweight (significantly higher in females, p=0.04), 36% normal and 15.3% underweight.When compared between genders, the WHR is significantly higher in males (p<0.001); whilst no significant differences in FBG (p=0.6). Four males and 5 females with FBG ≥ 100 mg/dl, whereas others were within normal limits. There are positive significant correlations between BMI and WHR in males and females (r=0.777, p<0.001; r=0.54, p<0.001, respectively). There is a significant positive correlation between the BMI and FBG with r=0.217, p=0.008; and between the WHR and FBG with r=0.21, p=0.01 amongst all students. In this study, male students have significantly higher BMI and WHR than females. Higher FBG was well observed in students with either higher BMI or WHR.
Mediastinal Non-Hodgkin's Lymphoma Metastatic to Right Atrium Mimicking Right Atrial Myxoma Khusnurrokhman, Gemilang; Wulandari, Laksmi
Folia Medica Indonesiana Vol. 57, No. 4
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Highlight: • A 32-year-old male patient suffered mediastinal non-hodgkin's lymphoma metastatic to the right atrium which mimicked right atrial myxoma. • The patient died of suspected mediastinal NHL thromboembolism that spread in the right atrium. Abstract: In this case report, the anatomical pathology results in the form of B cell type LNH, but at the age of 32 years and the risk factor in this patient was a former active smoker. In the anatomical pathology results, the results of the B-High Grade Cell Type LNH were also obtained. B-cell type non-hodgkin's lymphoma can be mutated in the MYC gene (v-myc avian myceloctomatosis viral oncogene homolog) and the BCL-2 and BCL-6 (B-cell lymphoma) genes. If this morphology is found, then the patient's prognosis is poor. Most of these patients were males and the incidence was in the mediastinal area. Mediastinal NHL could develop and enlarge to involve the heart and pericardium. The spread could occur directly and lymphogens. These metastatic tumors were often misdiagnosed with atrial myxoma. In this case report, exploration of the right atrium and open mediastinal biopsy was performed. An open biopsy of the mediastinum revealed a mediastinal mass that enlarged to enter the right atrium. Atrial myxoma was not found. Primary lymphoma growth could also occur in the heart. This condition was called primary cardiac lymphoid (PCL). This case was very rare and was often considered an atrial myxoma. The patient died 10 days after discharge from the hospital. While the patient was eating, the patient had a seizure and the patient was immediately taken to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, and entered the ER (Resuscitation) ER room, but the patient died after being assisted for approximately two hours. Most likely the cause of the patient's death was a thromboembolic tumor in the right atrium that was released, so that it entered the bloodstream of the brain, causing the patient to have seizures. It was suspected that the cause of the patient's death was the presence of a tumor thrombus that separated into an embolism from the right atrium due to the large size of the tumor. Patients suffering from high rate NHL had a greater percentage of suffering from tumor thromboembolism as many as 10.6% compared to the Low type and Hodgkins lymphoma (LH) (5.8% and 7.25%).
Analysis of changes in the serum level nt-probnp after ace inhibitors therapy in patients with heart failure Hartoto, Halla Hisan; Zulkarnain, Bambang Subakti; Aminuddin, Muhammad
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

BNP secreted by left ventricle as response to wall stress in patient with heart failure. Elevated concentration of NT-pro-BNP correlate with severity of heart failure across all stages of the condition and left ventricle ejection fraction in patient. Several clinical trials have demonstrated that neurohormonal modulation on the RAAS decreases NT-proBNP level and results in favorable outcomes. One of the drug used for blocked RAAS system is ACE inhibitor, decrease of NT-proBNP level show response to therapy include therapy with ACE inhibitors. To analize changes in the levels serum NT-proBNP levels after ace inhibitor therapy in patients with heart failure and monitoring creatinine serum. This study was a observational, prospective, non-randomized trial involving patient age 21-75 years, with NYHA class II-III HF, using ACE inhibitor therapy plus other therapy maximum 3 months before study without ARB or beta blocker. We compared serum NT-pro-BNP and creatinin serum parameters before and after two months treatment with ACE inhibitor. This study conducted in cardiovascular ambulatory patient dr. Soetomo hospital Surabaya. Between August-November 2015, 13 patient (38-63 years, 6 woman, 7 men) include in this study. The mean baseline level of NT-proBNP is 2166.92±1236.73 pg/ml, and creatinin serum 1.023±0.601 mg/dL. The NT-pro-BNP were significantly decreased after two months of treatment with ACE inhibitors 1508.23±651 pg/mL (p=0.025), there were no significant differences creatinin serum between two groups 0.951±0.0365 mg/dL (p=0.111). The results demonstrated the benefits of ACE inhibitor on the neurohormonal profile in patients with HF. If necessary we could measure NT-proBNP level to support prognosis data and monitoring effectivity therapy especially ACE inhibitor which had antiremodelling effect towards patients with HF.
High Risk of Failed Skin Graft on Major Burn Patients with Complication of Hypernatremia Hariani, Lynda; Budi, Agus Santoso; Wulandari, Ephora Christina
Folia Medica Indonesiana Vol. 57, No. 2
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Abstract

The rate of failed skin graft in Dr. Soetomo General Academic Hospital Surabaya was around 26% of the cases, and it became a concern because skin graft was the main procedure to close large burn wounds. Many problems might affect this event; one of them was electrolyte imbalance. Hypernatremia was found in major burn patients. This condition disrupted the wound healing process of skin graft. This cross-sectional study evaluated patients with burns admitted to the Burn Centre of Dr. Soetomo Hospital between January 2014 and December 2018. 143 subjects participated in this study. Hypernatremia was found in 16% of all subjects (23 subjects), 19% with hypernatremia (28 subjects), and the majority of it, 65% with normonatremia (92 subjects). This study found that the risk of failed skin graft was higher on hypernatremia than normonatremia subjects. This risk was higher if the skin graft procedure took more than 10%.
Back Matter Vol. 55, No. 3 September (2019) Matter, Back
Folia Medica Indonesiana Vol. 55, No. 3
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Plague disease remains a public health problem in the world. According to the International Health Regulations (IHR), an outbreak is an infectious disease that has the potential to cause an outbreak. The purpose of this study was to analyze a significant relationship between human behavior and the environment with the density of the number of rats in the focus, threatened and outbreak-safe areas in Tutur Regency, Pasuruan Regency, in 2016. This was an observational analytic study with cross correlation sectional where the research variables are population behavior, environment, and the number of rat densities observed once at a time. The results showed that there was no significant relationship between the behavior (knowledge, attitude, and practice) of the population with the density of rats in the focus area of the Surorowo hamlet outbreak, in the endangered outbreaks of the Ngaro hamlet, and in the outbreak-safe area of the North Ngandong hamlet in Tutur District. Whereas, there is a significant relationship between environmental conditions and the amount of rat density in the focus area of the outbreak of the Surorowo hamlet (p: 0.047 or p <0.05), the threatened area of the Ngaro hamlet (p: 0.036 or p <0.05), and at outbreak-safe areas in Andong Utara hamlet (p: 0.047 or p <0.05). Conclusion: Environmental conditions are associated with the amount of rat density either in the outbreak, in focus, threatened, or in safe areas. That it is necessary to control environmental risk factors to reduce the amount of rat density.
Prostate-Specific Antigen and Time to PSA Nadir as Prognostic Significance in Castration-Resistant Prostate Cancer Pranata, Firmantya Hadi; Djatisoesanto, Wahjoe; Soebadi, Doddy M.
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Assessing the survival rate in castration-resistant prostate cancer was descriptived. • PSA level between survivor and non survivor was significant but not for PSA nadir level, TTN and TTC. • Initial PSA level can predict survival prognosis rate of castration-resistant prostate cancer patients. Abstract: High mortality rates was often found in castration-resistant prostate cancer (CRPC). Our aim on this research was to assess the PSA level and time to PSA nadir as a prognostic tool for survival in CRPC patients. Several factors are considered to be useful as prognostic marker in CRPC patients. This study was a descriptive study assessing the survival rate in castration-resistant prostate cancer. Evaluation data included sex, age, initial PSA level, final PSA level, time to PSA nadir (TTN), time to CRPC progression (TTC), and survival status. A total of 24 patients with CRPC were evaluated in this study. There was significant difference found of initial PSA level between survivor (445.7 + 165.6 ng/mL) and non-survivor (200.7 + 144.9 ng/mL). There were no significant differences were also found in PSA nadir level, TTN and TTC between survivor and non-survivor groups. This study revealed that there was association between initial PSA level on survival rate of CRPC patients. Initial PSA level could be used to predict survival prognosis in CRPC patients.
Red Rosella (Hibiscus sabdariffa Linn.) Petal Brew is Able to Reduce the Sprague Dawley MDA Rate in Rats Exposed to Waste Cooking Oil Ulilalbab, Arya; Maskanah, Eni
Folia Medica Indonesiana Vol. 54, No. 3
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Abstract

Food and snacks sold are usually fried using oil that has been used for frying repeatedly. Oil that is repeatedly used for frying is often called waste cooking oil. Waste cooking oil is a source of exogenous free radicals that can trigger oxidative stress. To prevent this, sufficient antioxidant intake is needed. One source of antioxidants is red rosella. The purpose of this study was to analyze the effect of giving red rosella petals on the conditions of oxidative stress in Sprague dawley rats exposed to waste cooking oil through MDA testing. The research method used was Completely Randomized Design (CRD). The sample consisted of 24 male rats which were randomly selected and divided into 4 groups: negative control (no treatment), positive control (administered with waste cooking oil of 8.92 meq/kg as much as 2 ml/kgBW), treatment 1 (administered with waste cooking oil of 8.92 meq/kg as much as 2 ml/kgBW and red rosella petal brew dosed of 540 mg/kgBW, and treatment 2 (administered with waste cooking oil of 8.92 meq/kg as much as 2 ml/kgBW and red rosella petals brew dosed of 810 mg/kgBW). The results of the one way ANOVA analysis (a=1%) and the Tukey HSD test showed the p value of MDA=0.00, indicating that all treatments had significant effect. In further tests, it was found that all treatments contained differences in MDA values. The best value in the treatment was by giving a dose of 810 mg/kgBW (serum MDA of 2.22 nmol/ml). It can be concluded that the administration of red rosella petal in doses of 540 mg/kgBW (EC50=407.52 ppm) and 810 mg/kgBW (EC50=247.82 ppm) can improve the oxidative stress of Sprague dawley rats.
Detection of Escherichia Coli Using PCR Analysis Without DNA Extraction Widodo, Wimbuh Tri; Huda, Choirul
Folia Medica Indonesiana Vol. 57, No. 2
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This study aimed to detect Escherichia coli directly without DNA extraction. The nucleus membrane and cell membranes of the Escherichia coli are composed of a phospholipid bilayer, damaged if heated at 950C. Pre-denaturation and denaturation of PCR were carried out at 950C. The two stages are thought to break down the Escherichia coli cells, so that the DNA that comes out of the cells can directly become a template in the PCR analysis. In this study, PCR analysis was carried out using Escherichia coli culture, Escherichia coli bacteria culture incubated at 950C, and Escherichia coli bacteria cultures incubated at 650C + on ice as templates. The results showed that PCR analysis using Escherichia coli culture directly and Escherichia coli culture incubated at 650C + on ice as templates produced very thin DNA bands with a size of 580 bp. while PCR analysis using Escherichia coli bacteria culture incubated at 950C as a template produced thick DNA bands with a size of 580 bp. This study's results are very useful for saving time and costs in the detection of Escherichia coli bacteria. The sample to be tested does not need DNA isolation as usual, but only needs to be incubated at 950C for 10 minutes.
Potency of cv12 acupuncture as obesity prevention through modulation of  and  estrogen receptors expression on the adipose tissue of ovariectomized mice Rejeki, Purwo Sri; Wiyasihati, Sundari Indah; Atika, Atika
Folia Medica Indonesiana Vol. 53, No. 1
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This study aims to determine the potency of CV 12 acupuncture as prevention of weight gain in ovariectomizedmice (OVX). Female mice strain BALB/c, 28 mice, 3-4 weeks, 25-35 grams were divided into four groups; namely K1 (n = 8, sham and vehiculum injection), K2 (n = 8, OVX and vehiculum injection), K3 (n = 7, OVX and injection of estrogen intraperitoneal 10 mg/kg/day) and K4 (n = 6, OVX and CV12 acupuncture with a frequency of 2 Hz in 10 mA of continuous spike current wave).Injection and acupuncture given every day for four weeks. Weight change in K1 (0.75 ± 2.8) grams, K2 (2.71 ± 2.4) grams, K3 (0.71 ± 0.95) g and K4 (0.93 ± 2.40) gram with a significant difference in the K2 and K4 (p = 0.011). a receptor expression in K1 (12.25 ± 2.96), K2 (5.43 ± 2.64), K3 (18.86 ± 1.57), K4 (17 ± 2.00) with a significant difference to the K2 K1, K3 and K4 with p<0.05. b receptor expression in K1 (11.38 ± 1.92), K2 (4 ± 1.41), K3 (16.86 ± 1.86), K4 (14.17 ± 5.24) with significantly different a receptor expression in visceral fat mass on the group K2 to K1, K3 and K4 with p<0.05. CV 12 acupuncture increases the expression of a and b estrogen receptor in visceral adipose tissue of OVX mice equivalently and able to prevent the increase of weight due to the estrogen withdrawal. This point could potentially be used as one of the management ofobesity prevention in menopause.

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