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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Distribution of Human Papilloma Virus (HPV) in Cervical Adenocarcinoma and Adenosquamous Carcinoma Mastutik, Gondo; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Harjanto, Budi
Folia Medica Indonesiana Vol. 57, No. 2
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Abstract

Approximately 20-30% of all cervical cancer cases are adenocarcinoma and adenosquamous carcinoma. Around 70% of all of these types of cancer are related to infection of Human Papillomavirus (HPV). This study evaluated the distribution of HPV genotype in cervical adenocarcinoma and adenosquamous carcinoma. A cross-sectional study was conducted at the Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2015. The sample were 22 formalin-fixed paraffin-embedded (FFPE) of cervical adenocarcinoma tissues and adenosquamous carcinoma tissues. FFPE was used for DNA extraction and followed with HPV genotyping to detect 40 genotypes of HPV, including low risk (LR) and high risk (HR) HPV. The histopathological types of adenocarcinomas were adenocarcinoma NOS and mucinous adenocarcinoma, while the adenosquamous carcinoma types were adenosquamous carcinoma and adenosquamous carcinoma glassy. All of the specimens were infected by HPV. In cervical adenocarcinoma, the infection was by HPV 6, 11, 16, 18, 31, 45, 68B, and 72, and in adenosquamous carcinoma by HPV 6, 16, 18, 45, and 59. HPV 18 was predominant, which was found in 13/22 (59.1%) in adenocarcinoma and 19/22 (86.4%) in adenosquamous carcinoma. Single infection and multiple infections in adenocarcinoma were 13/22 (59.1%) and 9/22 (40.9%), while in adenosquamous carcinoma were 21/22 (95.5%) and 1/22 (4.5%) respectively. The most common HR HPVs found in this study were HPV 18, HPV 45, HPV 16 and LR HPV are HPV 11, HPV 6.
Nutritional Knowledge and Body Mass Index among Students at Novena University, Ogume, Nigeria Andrew, Udi Onoriode; Godswill, Okoro Ogheneyebrorue; Mamerhi, Enaowho Taniyowho; Boma, Douglas
Folia Medica Indonesiana Vol. 59, No. 1
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Abstract

Highlights: • Interviews were conducted on the correlation between nutritional knowledge and BMI among students at Novena University, Ogume, Nigeria. • Most of the students had adequate nutritional knowledge and a low obesity prevalence rate. Abstract: Body mass index (BMI), which is calculated using height and weight, is a rough indicator of body fat. This study aimed to investigate whether there is a significant correlation between nutritional knowledge and BMI among students at Novena University, Ogume, Nigeria. This study was done using a cross-sectional survey. Interviews were conducted with 50 participants from the sample, whose nutritional knowledge and weight status were assessed. The results showed that the students' BMI ranged from 15 to 39, with a mean and standard deviation of 23.93±5.46 cm. There was a positive correlation between the students' nutritional knowledge and their BMI. In conclusion, the majority of Novena University students are knowledgeable about obesity, which likely accounts for their low obesity prevalence rate.
The Implication of Mastectomy Flap Fixation in Decreasing the Incidence of Seroma on Breast Cancer Patient Kustono, Patric Christ Ardhika; Purwanto, Heru
Folia Medica Indonesiana Vol. 57, No. 4
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Highlight: • Modification of radical mastectomy with flap fixation treatment in seroma production in breast cancer patients was analyzed. • The number of seromas from the drain removal time in patients undergoing modified radical mastectomy with flap fixation was reduced. Abstract: Seroma is the most common complication after mastectomy procedure. This study was conducted to analyse the treatment of flap fixation in seroma production after modified radical mastectomy in breast cancer patients. An interventional prospective clinical study in 35 female patients with breast cancer who underwent modified radical mastectomy with flap fixation in the period August-December 2018 and 35 patients without flap fixation through historical data of patient who underwent modified radical mastectomy in the period 2016-2017 at RSUD Dr. Soetomo Surabaya. Data of characteristic patients will be presented descriptively and analyzed statistically using the appropriate test. The result of the statistical test using Chi Square with a 95% significance level obtained a value of p = 0.000 (p <0.05), it was said statistically that there was a significant relationship between the treatment of flap fixation and the time of releasing drain in this study. The treatment of flap fixation will reduce drainage time by <10 days. The results of the odds ratio (OR) obtained OR = 16 and CI: 95% (4.094 – 62.528) which means that the treatment of flap fixation will reduce the releasing time of the drain 16 times more effectively than not performing flap fixation. Correlation between the treatment of flap fixation and the time of releasing drain was considered to be moderately positive (Contingency Coefficient Chi Square = 0.476). There was a significant reduction in the number of seroma assessed from the time of releasing drain faster in patients who underwent modified radical mastectomy with flap fixation.
Impact of Stone Size, Location, and Stone Composition on the Efficacy of Extracorporeal Shock Wave Lithotripsy for Residual Stone after Percutaneous Nephrolithotomy Sawal, Zuhri; Soebadi, Doddy M
Folia Medica Indonesiana Vol. 56, No. 2
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Abstract

This study aimed to determine the impact of stone size, location and stone composition the efficacy of extracorporeal shock wave lithotripsy (ESWL) in the management of residual stone after percutaneous nephrolithotomy (PCNL). The design of this study was a retrospective that conducted between January 2012 until December 2016. The population in this study were all patients with residual stones post PCNL. Exclusion criteria were patients with multiple stones and patients with a history of previous treatment for residual stones such as nephroscopy, flexible ureterorenoscopy, ESWL or medical therapy). The variables studied in this study were stone size, stone location, and stone composition. Before ESWL was carried out, all patients underwent Kidney Ureter Bladder (KUB). After ESWL, all patients underwent ultrasonography (USG) and KUB to determine the stone clearance status. The sample of this study was 125 patients. The overall stone-free rate (SFR) of ESWL in managing post-PCNL residual stones is 72%. SFR based on stone size variable are 73.7% and 71.3% respectively for stones with a size = 5 mm and >5 mm (p = 0.78). SFR based on stone location variable was 67.1%, 75.8%, and 81.8% respectively for the residual stone located at the upper pole, middle pole and lower pole. There are no significant differences in the entire variable. This study concludes that ESWL can be used as effective additional management to treat post-PCNL residual stones with satisfactory SFR.
Relation between length of stay and anti-filarial igg4 level in pondok gede sub-district, bekasi district, west java Susatyo, Jeffry Adijaya; Wibowo, Heri
Folia Medica Indonesiana Vol. 53, No. 3
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Filariasis is a contagious disease caused by worms of the genus Filaria which transmitted through the bite of various species of mosquitoes. In Indonesia, the existence of filariasis cases are still very concerning. Jati Sampurna and Jati Karya villages in Pondokgede Sub-district, Bekasi District, West Java have been known as filariasis endemic area. Length of stay is presumed as one of many factors that affects filariasis occurrence in those villages. This study aimed to determine the distribution of anti-filarial IgG4 on the region and its comparison with the length of stay and residence status. This study was based on secondary data. Secondary data were obtained from primary research data done by cross-sectional method. These data were used to assess the correlation of filarial infection risk factors in pregnant women living in endemic areas based on the distribution of anti-filarial IgG4 in Pondok Gede, Bekasi district, West Java. The study showed that there was an increase in anti-filarial IgG4 against residence status (p=0.017) and a positive correlation between the number of anti-filarial IgG4 with length of stay in years (p=0.003).
The Effect of Citrulline Supplementation on Lactic Acid Blood Level and Oxygen Saturation (SaO2) in Submaximal Physical Activity Fastabiqi, Ibrah; Asnar, Elyana; Harlina, Harlina
Folia Medica Indonesiana Vol. 56, No. 4
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Abstract

An achievement in sport is one of the benchmarks of success of every athlete. One of the causes of the performance degradation is fatigue due to the formation of lactic acid. Supplements are proved to improve the performance in athletes. The purpose of this study was to determine the effect of citrulline supplementation on lactic acid levels and oxygen saturation on submaximal physical activity. Fatigue can be seen from lactic acid levels in subjects who have performed physical activity. This research method used randomized group pretest postest group design. The subjects used were male students of pencak silat airlangga university, and divided into two groups. The first group was given placebo and the second group was given citrulline. Each group was given the same treatment of three minutes of submaximal physical activity using an ergocycle. Before and after doing the activity the blood lactic acid and oxygen saturation of the subject was checked. The result of the data showed that lactic acid and oxygen saturation in both groups had p<0,05. Citrulline supplementation had effect on lactic acid and oxygen saturation. The results of the research showed that the group given with citrulline had significant effect on lactic acid and oxygen saturation before and after treatment.
Ethanol extract of mangosteen peel reduces histological count of alveolar macrophage and pulmonary alveolar space size in male white rats (rattus norvegicus) exposed to cigarette smoke Santoso, Anna Lewi
Folia Medica Indonesiana Vol. 51, No. 4
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This study aims to analyze histological alveolar macrophage cell number and width of pulmonary alveolar space white male rats given ethanol extract of mangosteen peel and then exposed to cigarette smoke. Smoking can reduce antioxidant and increases free radicals, so it is recommended increasing the antioxidants found in many mangosteen rind. This research was an experimental laboratory using the randomized post test-only control group design. White rats male were chosen randomly into 5 groups (K1, K2, P1, P2, P3). K1 (control-), only the Na-CMC 0.5%, K2 (control+) given Na-CMC 0.5% solution and smoke, P1, P2, P3 given the ethanol extract of mangosteen rind (50, 100, and 200mg/kg wt) and smoke. The data were tested normality and homogenity. Then they were analyzed with one-way Anova, LSD. Data that are not normally tested with Robust tests – (Brown-Forsythe) and Tamhane's. Correlation test with Pearson and Spearman. Robust test results, the number of alveolar macrophages, value p=0.000 (p
Back Matter Vol. 55, No. 2 June (2019) Matter, Back
Folia Medica Indonesiana Vol. 55, No. 2
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Hypoxia Inducible Factor-1-Alpha Expression on Preeclampsia Mice Model With L-Arginine Administration Anggraini, Nutria Widya Purna; Sulistyowati, Sri; Bachnas, Muhammad Adrianes; Yuliantara, Eric Edwin; Prabowo, Wisnu; Budihastuti, Uki Retno
Folia Medica Indonesiana Vol. 57, No. 3
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Preeclampsia is hypertension in pregnancy that affects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This study was an experimental study with a parallel-group post-test only design. Thirty-six preeclamptic mice models were divided into 2 groups. The control group (K1) 18 preeclamptic mice model without treatment and the treatment group (K2) 18 preeclamptic mice given L-Arginine. The independent variable was the administration of L-Arginine and the dependent variable is the placental HIF-1-A expression. Statistical analysis used unpaired t-test on normal data distribution, and Mann Whitney test on abnormal data distribution. The mean of placental HIF-1-A expression K1 was 2.47 ± 1.65 with a minimum value of 0.4 and a maximum value of 6.6. At K2 0.93 ± 0.55 with a minimum value of 0.0 and a maximum value of 2.0. Statistical tests showed that the placental HIF-1-A expression in the treatment group was significantly lower than that in the control group (p <0.001). In conclusion, the expression of HIF-1-A in preeclamptic mice model placenta decreased with L-Arginine administration.
Impact of preparation using conventional and modified density gradient centrifugation methods on sperm concentration, motility and number of normal motile sperm recovery (nmsr) Yudiwati, Rina; Pramesti, MPBD; Agustinus, Agustinus; Pradana, E; Purwanto, Bambang
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

Some preparation techniques, either conventional or advanced, have been provided. Advanced technique may overcome the limitations of conventional techniques. Recently, not all fertility clinics in Indonesia are able to provide advanced preparation techniques. Some techniques require expensive equipments and can only be used for intracytoplasmic sperm injection (ICSI). Some fertility clinics use a modified procedure, namely the combination of density gradient centrifugation with a swim-up method for the preparation of the sperm to be used in ART. This study aimed to determine whether the modified density gradient centrifugation, which is density gradient centrifugation followed by a swim-up, is able to yield better results than conventional density gradient centrifugation. This study was a laboratory experimental pre and pos-test control group design. Population was all adult men aged 21-40 years old and the sampling unit was the man donor's semen which fulfilled inclusion criterias, collected during the periode of the study. Sample size was eight. Sperm analysis were done before and after preparation in conventional and modified group. Descriptive comparation analysis have been used. This study obtained NMSR 7.9+5.5 million/ejaculate and recovery rate (RR) 27.66+11.8 %. RR was lower compared to RR obtained conventional DGC method. RR might be lower because in modified DGC samples undergo two steps selection while conventional DGC only one step selection. But conventional DGC samples should be centrifuged twice, therefore sperms might experience more trauma. Lower RR sperm does not exclude the possibility to be used for ART, because still within the required number for all TRBs. In conclusion, modified DGC preparation method obtained lower NMSR and RR, nevertheless harvested sperms can still be used in all kind of ART.

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