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Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Published by Lembaga Pengembangan Kinerja Dosen
ISSN : 2809235X     EISSN : 28092090     DOI : 10.55606
Core Subject : Health,
Medicine & Pharmacology Nursing Public Health
Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan diterbitkan 3 (tiga) kali dalam satu tahun yaitu Edisi Januari, Mei, dan September. Jurnal Ilmiah Kedokteran dan Kesehatan menyajikan hasil penelitian dan tinjauan pustaka sehingga jurnal ini bermanfaat bagi dokter, pengambil kebijakan, tenaga kesehatan, dosen serta mahasiswa yang tertarik dengan publikasi ilmiah terkait Ilmu Kedokteran dan Kesehatan
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 429 Documents
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Pemberian Infra Red dan Terapi Latihan pada Kasus Pasca Dislokasi Shoulder Sinistra
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5126

Abstract

Shoulder dislocation is a fairly common musculoskeletal injury, particularly in individuals who engage in high-impact physical activity or sports involving extreme shoulder joint movements, such as athletes. This condition can cause significant pain, limited range of motion (ROM), decreased muscle function, and impact daily functional activities. Physiotherapy plays a crucial role in the rehabilitation process after a shoulder dislocation, with the primary focus being on reducing pain, restoring ROM, improving muscle function, and preventing recurrence. This study aimed to evaluate the effectiveness of a combination of infrared therapy and isometric hold-relax exercises in reducing pain and increasing ROM in patients with left shoulder dislocation. The study design used a case study approach with a single patient as the subject. The physiotherapy intervention consisted of six phased and scheduled sessions. Infrared therapy was administered to help relax muscle tissue, improve local blood circulation, and reduce pain intensity. Meanwhile, isometric hold-relax exercises were applied to increase muscle flexibility, expand ROM, and restore shoulder joint function. Evaluations were conducted before and after the intervention, measuring pain levels using a subjective pain scale and assessing range of motion (ROM) using a goniometer. The results showed a significant reduction in pain and a significant increase in joint mobility after undergoing the physiotherapy program. These findings indicate that the combination of infrared therapy and isometric hold-relax exercises can be an effective method in shoulder dislocation rehabilitation, supporting functional recovery and potentially reducing the risk of re-injury. This study also emphasizes the importance of a multimodal therapeutic approach in the management of musculoskeletal injuries for optimal outcomes.
Hubungan Kepatuhan Minum Obat terhadap Kualitas Hidup Pasien TB Paru di Rumah Sakit Budiasih
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5129

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, which generally attacks the lungs, although it can affect other organs. The World Health Organization (WHO) identifies TB as a leading cause of death worldwide, with millions of new cases each year. A crucial factor in TB treatment is patient compliance with treatment, as irregular treatment can lead to drug resistance and weaken the patient's condition. This study aims to determine the relationship between medication adherence and quality of life of pulmonary TB patients at Budiasih Hospital. The method used is an observational study with a cross-sectional approach. The study population was pulmonary TB patients, with a sample consisting of patients who met the inclusion and exclusion criteria. The questionnaires used included the MMAS-8 to measure compliance and the WHOQOL-BREF 1996 to measure quality of life. Data analysis was performed using the chi-square test to examine the relationship between variables. The second variable is said to have a significant relationship if the p-value is less than 0.05. The results showed that the fulfillment of drinking water for pulmonary TB patients was categorized as high at 54.0%, and the quality of life of most pulmonary TB patients was categorized as moderate at 69.8%. The analysis also revealed a significant relationship between medication adherence and the quality of life of pulmonary TB patients at Budiasih Hospital, with a p value of 0.000 (p<0.05). This study provides important insights into the importance of implementing treatment to improve the quality of life for pulmonary TB patients. In addition, this study also showed that although the majority of patients had a good level of medication fulfillment, the majority of patients still experienced a moderate quality of life.
Uji Aktivitas Anti Diabetes Ekstrak Umbi Bawang Dayak (Eleutherine Bulbosa) pada Tikus Putih (Rattus Noverginus ) yang Diinduksi Aloksan
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5142

Abstract

This study aims to examine the antidiabetic activity of ethanol extract of Dayak onion (Eleutherine bulbosa) bulbs in white rats (Rattus norvegicus) induced by alloxan. Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. This condition can lead to various serious complications, such as kidney damage, cardiovascular disorders, neuropathy, and impaired wound healing. As the prevalence of diabetes increases globally, the search for safer and more affordable alternative therapies has become a crucial need, especially in developing countries. In recent years, the use of medicinal plants as alternative therapies for diabetes mellitus has received increasing research. Dayak onion is a herbal plant that has long been traditionally used by the people of Kalimantan to treat various diseases, including diabetes. The content of secondary metabolites in Dayak onion bulbs, such as flavonoids, alkaloids, tannins, saponins, and glycosides, is believed to act as a hypoglycemic agent. Flavonoids, for example, are known to have antioxidant activity that can protect pancreatic beta cells from oxidative damage, while saponins can inhibit glucose absorption in the intestine. This study used an experimental method with a post-test only control group design approach. Rats were induced with a certain dose of alloxan to create hyperglycemic conditions, then divided into several groups, including a negative control group, a positive control group (given standard drugs such as metformin), and a treatment group that received ethanol extract of Dayak onion bulbs at varying doses. Blood glucose levels were measured on days 0, 7, and 14 after treatment. It is hoped that the results of this study can provide strong scientific data regarding the potential of Dayak onion extract as an effective and relatively safe antidiabetic agent, as well as become the basis for the development of phytopharmaceutical drugs based on local Indonesian plants.
Uji Aktivitas Ekstrak Etanol Daun Bandotan terhadap Penyembuhan Luka Sayat pada Tikus Putih Diabetes Melitus (Rattus norvegicus)
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5143

Abstract

The wound healing process in individuals with diabetes mellitus is generally slower due to disruption of the inflammatory, proliferation, and regeneration mechanisms. Diabetics experience chronic metabolic disorders that impact immune cell function, blood circulation, and the regenerative capacity of fibroblasts and keratinocytes. Consequently, the wound healing process in diabetic patients is often more complex and takes longer. One approach to accelerating the wound healing process in this condition is the use of natural ingredients with anti-inflammatory, antimicrobial, and regenerative properties. One potential plant in this regard is the bandotan leaf (Ageratum conyzoides), which is known to contain active compounds such as flavonoids, alkaloids, and tannins that play a role in the wound healing process. This study was conducted to assess the effectiveness of bandotan leaf extract in accelerating wound healing in an animal model of diabetes mellitus. A total of 30 male white rats (Rattus norvegicus) that had been induced to become diabetic with streptozotocin were divided into six groups of five rats each. The groups included: a normal control group (healthy mice without diabetes), a negative control group (diabetic mice without treatment), a positive control group (given Metcovazin ointment as a standard), and three treatment groups that received topical application of bandotan leaf extract at graded concentrations of 10%, 15%, and 20%. A circular wound with a diameter of approximately 6 mm was made aseptically using a punch biopsy tool on the back of each mouse after being given ketamine anesthesia. Treatment was given daily for twelve consecutive days. The main parameters observed included daily measurements of the wound area to determine the rate of wound contraction.
Efektivitas Ekstrak Etanol Bunga Telang (Clitoria Ternatea L ) sebagai Nefroprotektor terhadap Tikus Putih Jantan (Rattus Norvegicus) yang Diinduksi Gentamisin
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5147

Abstract

Nephrotoxicity is a disorder of kidney function that can occur due to exposure to drugs, environmental chemicals, or other toxic substances. One aminoglycoside antibiotic known to have nephrotoxic effects is gentamicin, which is often used in the treatment of bacterial infections, but can cause kidney damage if used in high doses or for long periods. Therefore, it is important to find agents that can protect the kidneys from the side effects of this drug. Butterfly Pea Flower (Clitoria ternatea L.) is a plant known to contain secondary metabolites with antioxidant activity that have the potential to act as nephroprotective agents. These compounds can help combat oxidative stress that occurs in the kidneys due to exposure to toxic substances. This study aims to determine the optimal dose of Butterfly Pea Flower ethanol extract in protecting the kidneys of white rats from gentamicin-induced damage. A total of 25 male white mice were divided into five treatment groups: a normal control group (given distilled water), a negative control group (given only gentamicin 100 mg/kgBW), and three test groups given Butterfly Pea Flower extract at doses of 100, 200, and 400 mg/kgBW. Evaluation was carried out by measuring serum creatinine levels as an indicator of kidney function and histopathological analysis of kidney tissue to assess structural damage to the rats' kidneys. The results showed that administration of gentamicin caused a significant increase in serum creatinine levels and relative kidney weight, indicating acute kidney damage. Conversely, administration of Butterfly Pea Flower extract, especially at a dose of 400 mg/kgBW, provided the most effective protection against kidney damage. This was indicated by a decrease in creatinine levels approaching normal control values and improvement in histological damage to kidney tissue, such as repair of the structure of kidney tubules damaged by the effects of gentamicin.
Uji Efek Nefroprotektif Ekstrak Kulit Buah Mangga Arumanis (Mangifera Indica L. ) terhadap Fungsi Ginjal Tikus Putih Jantan yang Diinduksi Rifampisin
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5149

Abstract

This study aimed to evaluate the nephroprotective effect of mango peel extract (Mangifera indica L.) on the kidney function of male white rats (Rattus norvegicus) induced by rifampicin. Rifampicin is a first-line antibiotic used to treat tuberculosis, but its repeated use can cause side effects, including nephrotoxicity. This nephrotoxic effect can damage kidney function and disrupt the body's balance. Therefore, the search for agents that can protect the kidneys from damage caused by rifampicin is important. One potential natural nephroprotective agent is mango peel extract, which is known to contain bioactive compounds with antioxidant and anti-inflammatory activities, such as flavonoids, tannins, and saponins. This study was conducted experimentally with five treatment groups. The normal control group was given distilled water, the negative control group was given rifampicin, and three treatment groups were given mango peel extract at doses of 100, 200, and 400 mg/kgBW. The parameters observed included serum creatinine levels in rats before and after treatment, as well as histopathological features of kidney tissue to assess the presence of structural damage to the kidneys. The results showed that rifampicin administration increased serum creatinine levels, indicating impaired kidney function, and caused structural damage to kidney tissue. However, administration of arumanis mango peel extract, especially at a dose of 400 mg/kgBW, significantly reduced serum creatinine levels, approaching normal control values, and improved kidney histological structure. The damage score in kidney tissue in the group given arumanis mango extract also showed significant improvement compared to the negative control group. This nephroprotective effect is thought to be related to the content of bioactive compounds in arumanis mango extract, which have antioxidant and anti-inflammatory activities, which can reduce oxidative stress and inflammation in the kidneys.
Hubungan Pengetahuan Diet dengan Kadar Gula Darah Pasien Diabetes Melitus Tipe 2 di Klinik Mutiara Delima
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5164

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by decreased insulin production or decreased sensitivity of body cells to insulin. As a result, blood glucose levels increase significantly and can lead to various serious complications if not properly managed. Management of T2DM requires a multidisciplinary approach, one of which is proper dietary management. A controlled diet plays a crucial role in maintaining stable blood sugar levels, preventing complications, and improving the patient's quality of life. Therefore, patient understanding of a special diabetes diet is crucial. A good understanding of dietary principles will help patients choose the right types and amounts of food to avoid triggering blood glucose spikes. Furthermore, continuous nutrition education also plays a crucial role in developing healthy eating habits in T2DM patients. This study aims to analyze the relationship between patient knowledge about diabetes diets and blood sugar control in T2DM patients. The research method used was a quantitative approach with a correlational and cross-sectional design. A total of 40 respondents were selected using consecutive sampling. The independent variable in this study was the level of knowledge of diabetes diets, while the dependent variable was blood glucose control. Data were collected through questionnaires and observation sheets. Univariate analysis was used to describe respondent characteristics, while bivariate analysis using the Spearman Rank test was used to examine the relationship between variables. The test results showed a significance value of p = 0.0002, indicating a significant relationship between dietary knowledge and blood sugar control in people with T2DM.
Tinjauan Literatur terkait Peran Aspek Etika Tenaga Medis dalam Penerapan Budaya Keselamatan Pasien di Rumah Sakit
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5186

Abstract

Hospitals are healthcare facilities aimed at improving health recovery and maintenance. Patient safety is a top priority in hospitals, and it is related to issues of quality and image, ranging from cases of malpractice, negligence in patient care, discrimination against patients, to other criminal acts. To date, patient safety has not fully become an integral part of healthcare practices. This is reflected in the continued occurrence of ethical violations in the form of malpractice, discrimination, and other forms of behavior. Every healthcare profession has a code of ethics that serves as a guideline for professional behavior. The existence of a code of ethics should be the foundation for building a patient safety culture. Law Number 44 of 2009 concerning Hospitals explicitly states that patient safety is a top priority in healthcare. This study used a literature review method by examining various online scientific publication sources. The results of the literature search were then analyzed and processed to produce in-depth discussions and conclusions relevant to the research topic. The results of the study indicate that the implementation of a professional code of ethics by medical personnel plays a significant role in building a patient safety culture. This culture can only be realized if supported by an ethical organizational climate, open communication, and patient safety-oriented leadership. Therefore, professional ethics must be a core component of a hospital service system oriented toward patient safety. Furthermore, it is important to recognize that implementing a patient safety culture relies not only on medical personnel but also involves all elements within the hospital, including management, administrative staff, and other support personnel. Commitment from all parties to consistently implementing patient safety principles can strengthen the desired safety culture.
Uji Efek Nefroprotektor Ekstrak Etanol Kulit Manggis (Garcinia Mangostana L.) terhadap Kerusakan Histologis Sel Ginjal Tikus Putih yang Diinduksi Gentamicin
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5209

Abstract

Gentamicin is an antibiotic widely used in medicine to treat serious bacterial infections, particularly urinary tract, respiratory tract, skin, and soft tissue infections. This drug belongs to the aminoglycoside class, which works by inhibiting bacterial protein synthesis, preventing bacterial survival. Despite its high efficacy, gentamicin has significant side effects, particularly on the kidneys. Long-term or high-dose use of gentamicin can cause nephrotoxicity, which is damage to kidney tissue characterized by decreased filtration function, impaired glomerular and tubular structure, and increased blood creatinine and urea levels. This occurs because gentamicin tends to accumulate in the proximal tubules of the kidneys, triggering oxidative stress and inflammation. To reduce the toxic effects of gentamicin on the kidneys, nephroprotective agents are needed. One potential natural ingredient is mangosteen rind extract (Garcinia mangostana). Mangosteen rind is known to contain active compounds such as xanthones, which have antioxidant, anti-inflammatory, and antimicrobial properties. This compound is capable of neutralizing free radicals and suppressing the inflammatory response, which is one of the causes of kidney tissue damage. This study aimed to determine the effect of mangosteen peel extract on the histological appearance of the kidneys of rats treated with gentamicin. Histological analysis was performed to observe changes in kidney structure, such as tubular cell degeneration, necrosis, or inflammatory cell infiltration. It is estimated that administering mangosteen peel extract can minimize or prevent kidney tissue damage, making it an alternative complementary therapy to gentamicin. This research also marks the first step in the development of safe and effective herbal-based phytopharmaceuticals to support kidney health.
Gambaran Masa Pemulihan Sistem Kardiovaskular Berdasarkan Indeks Masa Tubuh pada Mahasiswa Fakultas Kedokteran XYZ
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5226

Abstract

Physical activity includes all body movements performed in working, playing, or traveling, while physical inactivity is characterized by minimal movement and low energy expenditure. Body Mass Index (BMI) and recovery heart rate are important indicators in assessing fitness status and health risks. This study aims to determine the difference in cardiovascular system recovery time after physical activity based on BMI category in students of the Faculty of Medicine, Gunadarma University. Students in this study are classified as late adolescents to early adults with typical lifestyles, such as lack of sleep, irregular eating patterns, academic stress, and low physical activity, which can impact the cardiovascular system. This study applied a cross-sectional design with purposive sampling technique among students who met the inclusion criteria. The research procedure was carried out in two stages, namely measuring blood pressure, pulse rate, O₂ saturation, and BMI before and after a six-minute walking test, then continued with measuring the pulse recovery time after a ±20-minute rest. Data were analyzed using paired T-test and One Way ANOVA according to data distribution. The majority of respondents were women (92.5%) from the class of 2019 (77.4%), with an average age of 20.79 years. The results showed a significant increase in systolic blood pressure and pulse rate after the physical test (p=0.001), while diastolic blood pressure showed no significant change (p=0.622). No significant difference was found in recovery time based on BMI categories (p=0.516). Therefore, it can be concluded that physical activity significantly influences several physiological parameters, particularly systolic blood pressure and pulse rate. However, BMI status was not shown to affect the speed of cardiovascular recovery after physical activity.

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