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Journal of Pharmascience
Published by Universitas Lambung Mangkurat
ISSN : 23555386     EISSN : 24609560     DOI : https://doi.org/10.20527/jps.v13i1
Core Subject :
ournal of Pharmascience accepts scientific articles as original reasearch articles and review articles on pharmacy and health. Journal of Pharmascience publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Clinical Pharmacy Community Pharmacy Pharmacology Natural Pharmacy Pharmaceutical Chemistry Pharmaceutical Technology Pharmaceutical Management Pharmaceutical Education Apart from the topics above, the Journal of Pharmascience also accepts other manuscripts in the health field, such as: Validation and development of analytical methods for a variety of samples, including food Implementation and analysis of a variety of surveys related to medical therapy, disease, health procedures, and other aspects of health
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Articles 362 Documents
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Potensi Anti-inflamasi Ekstrak Euphorbia heterophylla Desf.: Penelitian In Vitro dan In Vivo Elis Susilawati; Intan Pertiwi; Aulia Nurfazri Istiqomah; Yasminwar Susilawati; Jutti Levita; Sri Adi Sumiwi
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23814

Abstract

Masyarakat secara tradisional menggunakan daun Kate Mas (Euphorbia heterophylla Desf.) untuk mengatasi kesulitan buang air besar. Penelitian sebelumnya melaporkan daun E. heterophylla memiliki aktivitas antioksidan DPPH dan anti-inflamasi pada tikus diinduksi karagenan. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian ekstrak E. heterophylla (EEH) secara in vitro pada suspensi sel darah merah yang diinduksi larutan hipotonik, serta untuk mengevaluasi efek EEH dalam uji in vivo pada hewan yang diinduksi dengan larutan putih telur 1%. Studi in vitro menggunakan metode HRBC (Human Red Blood Cell) dengan darah yang dirusak larutan hipotonik sebagai media uji yang diukur menggunakan spektrofotometer UV-vis pada panjang gelombang 560 nm. Metode in vivo dilakukan pada tikus yang dibagi secara acak menjadi lima kelompok (n=5): kelompok kontrol positif (Na-CMC), kelompok pembanding (diklofenak natrium 4,5 mg/kg BB), dan tiga kelompok uji (EEH 50, 100, 200 mg/kg BB). Semua kelompok diinduksi dengan putih telur 1% pada telapak kaki tikus. Parameter yang diukur adalah nilai IC50 dan persentase inhibisi edema pada kaki tikus setiap 30 menit selama 180 menit. Hasil: Skrining metabolit sekunder pada EEH menunjukkan adanya flavonoid, alkaloid, saponin, tanin, kuinon, dan steroid/triterpenoid. EEH menunjukkan nilai IC50 yang tergolong aktif sebagai anti-inflamasi dan mampu mengurangi volume edema. Kesimpulan: EEH berpotensi untuk dikembangkan sebagai pengobatan anti-inflamasi. Kata Kunci: Anti-Inflamasi, Euphorbia heterophylla, Putih Telur, Larutan Hipotonik, Human Red Blood Cell The community traditionally uses Kate Mas (Euphorbia heterophylla Desf.) leaves to alleviate constipation. Previous studies reported that E. heterophylla leaves possess DPPH antioxidant and anti-inflammatory activities in carrageenan-induced rats. This study aims to analyze the effect of E. heterophylla extract (EEH) administration in vitro on red blood cell suspensions induced by a hypotonic solution, and to evaluate the effects of EEH in vivo on animals induced with 1% egg white solution. The in vitro study was conducted using the Human Red Blood Cell (HRBC) method, where red blood cells were subjected to damage by a hypotonic solution as the test medium. The measurement was performed using a UV-Vis spectrophotometer at a wavelength of 560 nm. The in vivo method was conducted on rats randomly divided into five groups (n=5): positive control group (Na-CMC), comparison group (diclofenac sodium 4.5 mg/kg BW), and three test groups (EEH 50, 100, 200 mg/kg BW). All groups were induced with 1% egg white on the rat's paw. The parameters measured were the IC50 value and the percentage of edema inhibition in the rat’s paw every 30 minutes for 180 minutes. Results: Secondary metabolite screening of EEH showed the presence of flavonoids, alkaloids, saponins, tannins, quinones, and steroids/triterpenoids. EEH demonstrated an IC50 value classified as active anti-inflammatory and was able to reduce edema volume. Conclusion: EEH has the potential to be developed as an anti-inflammatory treatment.
OPTIMASI DAN UJI AKTIFITAS ANTIOKSIDAN FORMULA TONER MINYAK DAUN SIRIH HIJAU (Piper betle L.) Nesa Agistia; Benni Iskandar; Nofriyanti Nofriyanti
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23886

Abstract

Exposure to free radicals can damage the skin. Green betel leaf oil, which has antioxidant activity, can be formulated into a toner. This study aimed to determine the optimal toner formula and  to evaluate its antioxidant activity. Optimization was performed using a factorial design with two factors: Tween 80 and PEG 400 concentrations. The optimum formula, determined with Design Expert 13, consisted of 10% Tween 80 and 5% PEG 400, with a predicted pH of 5.66 and 99% transmittance. Validation using a One-Sample T-Test showed no significant difference (p > 0.05) between the predicted and actual results. The optimized toner had a pH of 5.69, a transmittance of 99.2%, a particle size of 12.2 nm, and very strong antioxidant activity (IC50 = 43.29 µg/mL). In this research, an optimum toner formula was obtained which has good physical properties and very strong antioxidant activity. 
In Vitro Study of Antibacterial Activity of Patindis Leaf Extract (Urophyllum arboreum) and Microneedle Acne Patch against Propionibacterium acnes and Staphylococcus aureus Hayatun Izma; Deni Setiawan; Putri Helena Junjung Buih; Khoirunnisa Muslimawati; Naila Azizah; Mahfuzatul Ajmi
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24008

Abstract

Acne vulgaris is a cutaneous disorder associated with Propionibacterium acnes and Staphylococcus aureus. This study investigated the antibacterial activity of patindis leaf extract (Urophyllum arboreum) and its microneedle acne patch against both bacteria. The extract was prepared from dried simplicia by maceration using 96% ethanol. Phytochemical screening was conducted using test-tube methods. Antibacterial testing included determination of inhibition zone diameter using the well-diffusion method, as well as the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Clindamycin 1% was used as a positive control, while 20% DMSO and microneedle patches without extract served as negative controls. The U. arboreum leaf extract contained flavonoids, alkaloids, saponins, condensed tannins and terpenoids. At concentrations of 1.25%, 2.5%, and 5%, the extract produced inhibition zones of 12.368, 14.693, 18.403 mm against P. acnes and 14.523, 17.408, 18.840 mm against S. aureus, respectively. The MIC and MBC values against both bacteria were 0.625%. The microneedle acne patch formulations produced inhibition zones of 9.196 mm (F1), 10.140 mm (F2), and 10.713 mm (F3) against P. acnes, but showed no activity against S. aureus. These results indicate that the microneedle acne patch containing U. arboreum leaf extract has potential as an alternative topical antibacterial agent.
Integrative Study on the Binding Energy Calculation: Molecular Docking and Molecular Mechanics with Generalized Born Surface Area Targeting Acetylcholinesterase Ignasius Widya Parahita Putranto; Bonifacius Ivan Wiranata; Enade Perdana Istyastono; Florentinus Dika Octa Riswanto
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24094

Abstract

Alzheimer's disease (AD) imposes a significant global financial burden. Previous studies have reported that acetylcholinesterase (AChE) activity is strongly associated with AD, making it a key target in therapeutic research. Molecular docking and computational techniques are increasingly used to study these associations, yet a surge in publications has led to a departure from strictly designed paradigms. This study evaluates the accuracy of the Gibbs free energy of binding (ΔG) from molecular docking scores, Molecular Mechanics/Generalized Born Surface Area (MM/GBSA), and local Vina scores. The Spearman rank test was applied to compare ΔG predictions and the in vitro results from our previous study. The correlation coefficient for molecular docking was -0.491, the MM/GBSA correlation coefficient calculated at the best molecular docking pose was -0.309, the MM/GBSA correlation coefficient calculated at the last 5 nanoseconds (ns) snapshots was 0.164, and the correlation coefficient of the Vina local score calculated at the last 5 ns snapshots was 0.273. Our findings indicate that the ΔG prediction from the Vina local score for the last 5 ns shows the strongest correlation with in vitro results.
Antibiotic Use Patterns in Obstetric and Gynecological Surgery Patients: A Quantitative Descriptive Study Using ATC/DDD and DU90% Methods Maryamah Azzahra; Difa Intannia; Dita Ayulia Dwi Sandi; Reni Yustiati Saksono; Revina Aditya Yosita; Herningtyas Nautika Lingga
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24199

Abstract

Surgical site infections (SSIs) are common postoperative complications in obstetric and gynecological surgery, with incidence rates up to 20% in cesarean sections. Antibiotics are the primary strategy for SSI prevention; however, antibiotic utilization patterns in this surgical setting remain poorly characterized locally. This study describes the antibiotic use profile, AWaRe classification, DDD/100 patient-days values, and DU90% segment among obstetric and gynecological surgery patients at Ulin Regional General Hospital, Banjarmasin, in 2024. A retrospective, non-experimental quantitative descriptive design was employed. Of 313 medical records reviewed, 137 met the inclusion criteria. A total of 173 antibiotic prescriptions were identified. Ceftriaxone was the most frequently used antibiotic (61.84%), with cephalosporins predominating (91.91%) and parenteral administration in 75.72% of cases. Based on the WHO AWaRe 2022 classification, 85.55% of antibiotics were in the Watch group and 13.29% in the Access group; no Reserve antibiotics were used. Ceftriaxone had the highest DDD/100 patient-days (33.74). Ceftriaxone and cefixime comprised the DU90% segment. These findings highlight a predominance of Watch-group antibiotics and support the need for targeted stewardship interventions
Molecular Basis for the Enhanced CDK2 Inhibition by Artesunate: Superior Binding Affinity to the ATP-Catalytic Site Mohammad Rizki Fadhil Pratama; Evi Mulyani; Suratno Suratno; Punet Kumar; Daryono Hadi Tjahjono; Tutus Gusdinar Kartawinata
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24555

Abstract

This study aimed to identify the most potent CDK2 inhibitor among seven artemisinin derivatives and, critically, to elucidate its binding mechanism and compare its affinity with that of the natural ligand, ATP. Molecular docking was performed using AutoDock 4.2.6 toward inactive and active forms of CDK2. Ligands were optimized using the Hartree-Fock method basis set 6-311G. Blind docking on the active form was used to determine the inhibition mechanism, employing the free energy of binding (ΔG) and dissociation constant (Ki) as affinity markers. Artesunate was the most potent derivative, exhibiting the highest affinity towards the active CDK2 form, with a ΔG of -11.7 kcal/mol and a Ki of 2.66 nM. Blind docking confirmed an ATP-competitive inhibition mechanism. Remarkably, Artesunate's Ki was significantly lower than that of ATP (8.73 nM). This enhanced affinity is attributed to specific interactions between the hemisuccinate side chain and the critical amino acid region, from 13-Gly to 16-Gly. Artesunate is suggested as a potent, ATP-competitive CDK2 inhibitor with an affinity exceeding that of ATP. These hypothesis-generating results suggest anticancer potential, yet require validation via MD or assays; limitations like scoring bias and protein flexibility necessitate cautious interpretation regarding the 13-Gly to 16-Gly target.
Metabolite Profiling of The Antioxidant Properties of The Aquatic Plant Cyperus involucratus Employing UHPLC-HRMS Ari Sri Windyaswari; Fahrauk Faramayuda; Salsa Rizqyana Billa; Maria Tri Miarsih; Inna Puspa Ayu; Niken Tunjung Murti Pratiwi; Majariana Krisanti; Fifi Gus Dwiyanti
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24618

Abstract

The genus Cyperus is widely recognized as decorative flora. Empirically, Cyperus plants have been utilized to treat wounds, inflammation, and digestive disorders. While the genus is reported to exhibit antioxidant properties, scientific data regarding Cyperus involucratus remains limited. This research aimed to identify antioxidant compounds in C. involucratus using Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS). The C. involucratus methanolic extract was obtained through maceration using a 70% methanol solvent. Separation was performed using a UHPLC gradient system with a flow rate of 0.3 mL/min , while compound identification was conducted using a Quadrupole-Orbitrap MS detector in positive mode. The radical scavenging activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The analysis identified 175 metabolites within the methanolic extract. Based on mzCloud library matching with confidence scores of 97.4–100%, 12 primary bioactive compounds were identified: oleamide, α -linolenic acid, kaempferol, scutellarin, hexadecanamide, 1-linoleoyl glycerol, 1-stearoy-rac-lglycerol, adenine, adenosine, L-tyrosine, stearamide and nootkatone. The extract possessed a moderate radical scavenger with an IC50 value of 57.94 μg/mL. These findings provide a scientific foundation for further investigation of C. involucratus as a potential natural antioxidant, although further in vivo studies are required to validate its broader pharmacological outcomes.
Evaluation of the Rationality of the Use of Antibiotics in Paediatric Diarrheal Patients in Hospital Inpatient Facilities in the City of Bandung Linda Purnamawati Suherman; Intan Wulan Putri Pratama; Eni Margayani; Vidya Rachmawati
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24652

Abstract

Diarrhoea in children is often associated with irrational antibiotic use, even though the cause is not bacterial infection. Excessive antibiotic use can increase antibiotic resistance, a significant problem in healthcare. This study aimed to evaluate the rationality of antibiotic use in paediatric inpatients with diarrhoea at a single hospital in Bandung, including demographic characteristics, types of antibiotics used, and appropriate indication, drug selection, dosage, and administration intervals. This study was observational, using a non-experimental descriptive analysis design. Data collection was conducted retrospectively from January to December 2024. Out of a total population of 229 patient medical records, 54 patient medical records met the inclusion criteria and were used as the study sample. The rationality of drug use refers to the Indonesian Ministry of Health’s guideline. The results showed that 55.6% of patients were male, with toddlers (46.2%) being the largest age group. Ceftriaxone was the most commonly prescribed antibiotic (24%). The rationality of antibiotic use was 100% for indications and drug selection, 94.4% for dosage, and 90.7% for the interval between doses. However, the identified discrepancies in dosage (5.6%) and administration intervals (9.3%) require immediate attention to minimize the risk of therapeutic failure and antibiotic resistance. 
Evaluation of Extraction Methods on the Antioxidant Potential of Balik Angin Leaves Ethanol Extract (Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz) Putri Indah Sayakti; Hafiz Ramadhan; Dyera Forestryana; Eka Fitri Susiani; Nadya Aprillinia; Nadhia Khairany; Wardah Izzatul Awwaliyah; Winda Ameilia Dewi; Nur Syifa
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24662

Abstract

Alphitonia incana, also known locally as balik angin, is an endemic natural antioxidant plant of Borneo. The objective of the present work was to compare the effectiveness of maceration and Soxhlet extraction of balik angin leaves with respect to antioxidant activity and phenolic–flavonoid content. Ethanolic extracts were prepared using both extraction methods, and the phenolic-flavonoid content was quantified spectrophotometrically. Antioxidant performance was assessed through DPPH, CUPRAC, and FRAP assays. The findings revealed that the Soxhlet-derived extract contained higher concentrations of phenolic-flavonoid compounds than those produced by maceration. In addition, the Soxhlet-derived extract demonstrated stronger antioxidant activity, as evidenced by lower IC₅₀ and EC₅₀ values in the DPPH (10.872 ppm) and CUPRAC (6.578 ppm) assays compared with the macerated extract (IC₅₀ 13.127 ppm; EC₅₀ 14.034 ppm) and was classified as a very strong antioxidant. The FRAP assay further supported these results, with ferric reducing power values of 1,484.1 mg AAE/g extract for the Soxhlet-derived extract and 1,295.8 mg AAE/g extract for the macerated sample. Overall, the study concludes that Soxhlet extraction is more effective than maceration in enhancing the antioxidant potential of balik angin leaf, a result that is closely associated with their elevated phenolic and flavonoid content.
Acute Oral Toxicity of Methanolic Extracts from the Fruit and Leaf of Parijoto (Medinilla speciosa Blume) in Mice Annisa Farida Muti; Refian Ariesta Eka Maulana; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24762

Abstract

Medinilla speciosa Blume, or parijoto, contains flavonoids, saponins, alkaloids, and tannins with pharmacological potential. However, information regarding its safety profile, particularly acute toxicity data, is still very limited, so research is needed to evaluate its safety level. This study aims to evaluate the acute oral toxicity of M. speciosa leaf and fruit extracts in ddY mice. This study used a true experimental design. M. speciosa leaf and fruit extracts were obtained by ultrasonic-assisted extraction with methanol as a solvent. The acute oral toxicity test was conducted with a fixed-dose method at a single dose of 2000 mg/kgBW. Parameters observed for 14 days included mortality, clinical symptoms of toxicity, body weight changes, relative organ weights, and histopathological analysis of the liver and kidneys. The findings indicated an absence of fatalities across all treatment groups. The LD50 values for both extracts were determined to exceed 2000 mg/kgBW, categorising the fruit and leaf extracts as mildly toxic (category 5). Mild toxic symptoms were only observed in the treatment group receiving the fruit extract. Histopathological analysis of the liver and kidneys revealed mild cellular changes that were not statistically significant. Therefore, a single oral administration of M. speciosa fruit and leaf extracts at doses up to 2000 mg/kgBW is relatively safe.

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