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Journal of Pharmascience
Published by Universitas Lambung Mangkurat
ISSN : 23555386     EISSN : 24609560     DOI : https://doi.org/10.20527/jps.v13i1
Core Subject :
ournal of Pharmascience accepts scientific articles as original reasearch articles and review articles on pharmacy and health. Journal of Pharmascience publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Clinical Pharmacy Community Pharmacy Pharmacology Natural Pharmacy Pharmaceutical Chemistry Pharmaceutical Technology Pharmaceutical Management Pharmaceutical Education Apart from the topics above, the Journal of Pharmascience also accepts other manuscripts in the health field, such as: Validation and development of analytical methods for a variety of samples, including food Implementation and analysis of a variety of surveys related to medical therapy, disease, health procedures, and other aspects of health
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Articles 362 Documents
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Comparison Of HbA1c Levels in Type II Diabetes Mellitus Patients Receiving A Combination of Oral Hypoglycemic Drugs and Insulin Degludec-Aspart Versus Insulin Degludec-Aspart Monotherapy Helmina Wati; Syahrizal Ramadhani; Esty Restiana Rusida; Muhammad Raffyqurrahman
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.22242

Abstract

Diabetes melitus tipe II merupakan penyakit kelebihan glukosa yang disebabkan oleh menurunnya kinerja insulin dalam tubuh. Kriteria utama dalam manajemen glukosa darah adalah kadar HbA1c. Penelitian ini bertujuan mengevaluasi perbedaan kadar HbA1c pada pasien diabetes melitus tipe II yang mendapatkan terapi kombinasi obat hipoglikemik oral dan insulin degludec-aspart dibandingkan dengan pasien yang menerima monoterapi insulin degludec-aspart. Metode yang digunakan dalam penelitian yaitu cross-sectional secara retrospektif pada bulan Januari-Desember 2023 dengan jumlah sampel sebanyak 66 pasien yang dibagi menjadi 2 kelompok. Nilai HbA1c yang diperoleh dari bulan pertama hingga bulan ketiga dianalisis secara statistik menggunakan independent sample t-test dengan uji SPSS versi 21. Hasil penelitian menunjukkan penurunan kadar HbA1c pada kombinasi terapi obat hipoglikemik oral + insulin degludec-aspart sebelum dan sesudah dengan selisih nilai ± SD sebesar (1,565 ± 1,10)% dan penurunan nilai HbA1c ± SD pada monoterapi insulin degludec-aspart sebelum dan sesudah dengan selisih nilai (1,05 ± 0,74)% dengan nilai p (<0,05). Kesimpulan penelitian ini adalah terdapat perbedaan penurunan nilai HbA1c pada kedua kelompok dengan nilai p (<0,05). Hal ini menunjukkan bahwa penggunaan kombinasi oral lebih efektif daripada monoterapi.  Kata Kunci: Diabetes Mellitus Tipe II, HbA1c, Insulin Degludec-Aspart, Obat Hipoglikemik Oral, Kombinasi Terapi. Type II diabetes mellitus is a condition marked by hyperglycemia due to reduced effectiveness of insulin within the body.The main criterion in blood glucose management is HbA1c level. The objective of this research was to assess the difference in HbA1c levels between type 2 diabetes patients treated with a combination of oral hypoglycemic agents and insulin degludec-aspart versus insulin degludec-aspart alone. This research method uses a retrospective cross-sectional research design in January-December 2023 with a total sample of 66 patients divided into 2 groups. HbA1c values collected from the first to the third month were analyzed using the independent sample t-test in SPSS version 21. The Medical Research Ethics Commission of Ulin Banjarmasin Regional General Hospital South Kalimantan has approved this study. HbA1c levels in the combination of oral hypoglycemic drug therapy and insulin degludec-aspart pre- and post- with a difference in ± SD value of (1.565 ± 1.10)% decrease and a decrease in HbA1c ± SD value in insulin degludec-aspart mono-therapy pre- and post- with a difference in value (1.05 ± 0.74)% with a p-value (<0.05).This study concludes that the reduction in HbA1c levels between the two groups differs significantly, as indicated by a p-value of less than 0.05. This implies that the use of oral combination is more effective than mono-therapy.
Cytotoxicity and Pro-Apoptotic Effect of Dichloromethane Fraction of Nauclea subdita Stem Bark on HepG2 Liver Cancer Cell Modeling Chesya Nabila; Masriani Masriani; Rini Muharini
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.22330

Abstract

Kanker hati merupakan salah satu jenis kanker dengan angka kejadian dan kematian yang tinggi di dunia, sehingga penemuan antikanker baru yang aman dan efektif menjadi sangat penting. Nauclea subdita, yang dikenal sebagai bengkal telah digunakan secara tradisional oleh masyarakat Kalimantan untuk mengobati berbagai penyakit. Penelitian sebelumnya menunjukkan bahwa tumbuhan bengkal berpotensi sebagai antikanker. Penelitian ini bertujuan untuk  mengevaluasi sitotoksisitas, induksi apoptosis, dan penghambatan siklus sel dari fraksi kulit  batang dan daun bengkal (Nauclea subdita) terhadap sel kanker hati HepG2. Uji sitotoksisitas dilakukan menggunakan metode MTT, induksi apoptosis dianalisis menggunakan Annexin V-FITC/PI dengan flow cytometry, dan penghambatan siklus sel menggunakan pewarna RNase/PI kit juga dengan flow cytometry. Hasil uji sitotoksisitas menunjukkan bahwa fraksi DCM pH 3 kulit batang N. subdita memiliki aktivitas sitotoksik paling tinggi dibandingkan fraksi lainnya, dengan nilai IC50 sebesar 182,49 ±22,99µg/mL dengan indeks selektivitas 0,80 ± 22,9. Fraksi DCM pH 3 tidak menyebabkan penghambatan siklus sel, namun pada konsentrasi IC50 mampu menginduksi apoptosis pada sel HepG2 dengan persentase apoptosis total sebesar 51,5%. Temuan ini menunjukkan bahwa kulit batang bengkal berpotensi untuk dikembangkan sebagai sumber antikanker baru.  Kata Kunci: Sitotoksisitas, Nauclea subdita, HepG2, Apoptosis, Siklus Sel  ABSTRACT Liver cancer is one of the cancer types with high incidence and mortality rates worldwide, making the discovery of new, safe, and effective anticancer agents critically important. Nauclea subdita, known as bengkal, has been traditionally used by the people of Kalimantan to treat various diseases. Previous studies have indicated that bengkal possesses anticancer potential. This study aims to evaluate the cytotoxicity, apoptosis induction, and cell cycle inhibition of stem bark and leaf fractions of Nauclea subdita against HepG2 liver cancer cells. Cytotoxicity was assessed using the MTT assay, apoptosis induction was analyzed with Annexin V-FITC/PI via flow cytometry, and cell cycle inhibition was evaluated using the RNase/PI kit, also by flow cytometry. The cytotoxicity test results showed that the DCM pH 3 fraction of N. subdita stem bark exhibited the highest cytotoxic activity compared to other fractions, with an IC50 value of 182.49 ±22.99 µg/mL and a selectivity index of 0.80 ± 22.9. The DCM pH 3 fraction did not cause cell cycle arrest, but at the IC50 concentration, it was able to induce apoptosis in HepG2 cells with a total apoptosis percentage of 51.5%. These findings suggest that bengkal stem bark has potential to be developed as a novel source of anticancer agents.
Innovative Gel Mask A. jiringa (Jack) Nielsen: Effects of HPMC and Palm Stem Starch on Physical Characteristics and Antibacterial Activity Nani Kartinah; Arnia Ulpah; Pratika Viogenta; Amalia Khairunnisa
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.22397

Abstract

Kulit jengkol (A. jiringa (Jack) Nielsen) merupakan hasil samping pertanian yang belum memiliki nilai ekonomis tinggi, namun diketahui memiliki aktivitas antioksidan dan antibakteri yang kuat. Potensi ini mendasari pengembangan masker gel antijerawat sebagai sediaan topikal kosmetik. Penelitian ini bertujuan untuk mengevaluasi pengaruh kombinasi hidroksipropilmetilselulosa (HPMC) dan pati batang kelapa sawit terhadap karakteristik fisik serta aktivitas antibakteri masker gel A. jiringa terhadap Propionibacterium acnes. Ekstrak diperoleh melalui metode maserasi dan diuji aktivitas antibakterinya pada konsentrasi 0,25%, 0,30%, 0,35%, dan 0,40%. Konsentrasi optimum yang menunjukkan daya hambat tertinggi diformulasikan ke dalam masker gel dengan rasio HPMC:pati pada Formula 1 (1:2), Formula 2 (1:1), dan Formula 3 (2:1). Evaluasi meliputi viskositas, daya sebar, adhesivitas, pH, waktu kering, dan uji difusi sumur terhadap P. acnes. Hasil penelitian menunjukkan bahwa ekstrak A. jiringa 0,40% memiliki aktivitas antibakteri sedang dengan zona hambat 9,82 ± 0,06 mm. Ketiga formula gel memiliki warna cokelat muda, aroma khas minyak atsiri, tekstur halus dan homogen, viskositas antara 46,67 hingga 736,67 cps, daya sebar antara 4,75–8,92 cm, adhesivitas antara 11,52–17,68 detik, waktu kering 5,27–7,57 menit, serta pH berkisar antara 7,30–7,47. Disimpulkan bahwa kombinasi HPMC dan pati batang kelapa sawit mempengaruhi sifat fisik sediaan, namun tidak meningkatkan aktivitas antibakteri A. jiringa dalam sistem gel. Kata Kunci: A. Jiringa, P. Acnes, Antibakteri, Antijerawat, Pati Batang Kelapa Sawit  The peel of Archidendron jiringa (Jack) Nielsen, commonly known as jengkol, is an agricultural by-product with limited economic value but has been reported to possess strong antioxidant and antibacterial properties. This potential supports the development of an anti-acne gel mask as a topical cosmetic preparation. This study aimed to evaluate the effects of combining hydroxypropyl methylcellulose (HPMC) and palm stem starch on the physical characteristics and antibacterial activity of A. jiringa gel masks against Propionibacterium acnes. The extract was obtained through maceration and tested for antibacterial activity at concentrations of 0.25%, 0.30%, 0.35%, and 0.40%. The optimum concentration, which exhibited the highest inhibitory activity, was formulated into gel masks with different HPMC-to-starch ratios: Formula 1 (1:2), Formula 2 (1:1), and Formula 3 (2:1). Evaluations included viscosity, spreadability, adhesiveness, pH, drying time, and antibacterial activity using the well diffusion method against P. acnes. The results showed that the 0.40% A. jiringa extract exhibited moderate antibacterial activity with an inhibition zone of 9.82 ± 0.06 mm. All three gel formulations had a light brown color, a characteristic essential oil aroma, a smooth and homogeneous texture, viscosities ranging from 46.67 to 736.67 cps, spreadability between 4.75–8.92 cm, adhesiveness ranging from 11.52 to 17.68 seconds, drying time from 5.27 to 7.57 minutes, and pH values between 7.30 and 7.47. It was concluded that the combination of HPMC and palm stem starch influenced the physical properties of the gel formulations but did not enhance the antibacterial activity of A. jiringa in the gel system.
Total Flavonoid Content, Antibacterial Activity and In Silico Toxicity Prediction of Ethanolic Extract from Murraya koenigii Leaves against Streptococcus mutans Haris Munandar Nasution; Nasri Nasri; Ziza Putri Aisyia Fauzi; Zulmai Rani; Ainil Fithri Pulungan; Vera Estefania Kaban
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22436

Abstract

Dental caries is a chronic disease exclusive to humans and remains one of the most prevalent oral health problems worldwide. The increasing emergence of antibiotic resistance and the adverse effects associated with conventional antimicrobials have encouraged the exploration of natural plant-derived compounds for caries prevention. Murraya koenigii leaves are widely used as a culinary ingredient and are known to possess various therapeutic properties, including antioxidant, antibacterial, anti-inflammatory, and hepatoprotective activities. This study aimed to evaluate the total flavonoid content, antibacterial activity, and in silico toxicity profile of the ethanolic extract of M. koenigii leaves against Streptococcus mutans, a primary cariogenic pathogen. Total flavonoid content was determined using the aluminum chloride colorimetric method, while antibacterial activity was assessed using the agar disk diffusion assay. The toxicity profile of major flavonoid constituents was further analyzed using in silico ADMET prediction tools. The results showed that the ethanolic extract of M. koenigii leaves contained a high total flavonoid content (281.83 ± 10.23 mg QE/g extract) and exhibited strong antibacterial activity against Streptococcus mutans, producing inhibition zones ranging from 14.4 to 19.4 mm in a concentration-dependent manner. In silico analysis indicated that the major flavonoid constituents possessed favorable pharmacokinetic characteristics with low predicted toxicity risks. These findings suggest that the ethanolic extract of M. koenigii leaves is rich in flavonoids and demonstrates significant antibacterial potential, supporting its promise as a natural antibacterial agent for oral health applications. Further studies focusing on compound isolation, formulation development, and in vivo validation are recommended.
Analysing Factors Contributing to Length of Stay (LoS) Among Patients with COVID-19 in Indonesian Hospital Setting Sonny Edbert; Yosi Irawati Wibowo; Adji Prayitno Setiadi
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.22557

Abstract

Penyakit COVID-19 masih menjadi ancaman konstan bagi kesehatan masyarakat global. Penggunaan obat dan lama rawat inap (LoS) merupakan indikator utama kualitas pelayanan di rumah sakit. Penelitian ini bertujuan untuk mengamati LoS dan faktor yang mempengaruhinya (termasuk karakteristik pasien dan penggunaan obat) pada pasien rawat inap COVID-19 di Rumah Sakit X di Surabaya, Indonesia. Penelitian observasional dilakukan dengan menggunakan rekam medis pasien rawat inap COVID-19 di Rumah Sakit X selama tahun 2022. Data karakteristik pasien dan profil obat dianalisis secara deskriptif. Kesesuaian terapi obat ditentukan berdasarkan pedoman terapi. Uji korelasi dilakukan untuk hubungannya dengan LoS. Total terdapat 203 pasien rawat inap COVID-19, meliputi: neonatus/anak/remaja (12,32%), dewasa (66,5%), dan lanjut usia (21,2%). Sebagian besar pasien laki-laki (54,2%) dengan keparahan sedang (80,8%), dan 36,4% memiliki komorbiditas. Kesesuaian terapi pada pasien neonatus/anak/remaja, dewasa, dan lanjut usia adalah: 12% (3/25), 76% (103/135), 60% (26/43), secara berurutan. Rata-rata LoS adalah 7,0±3,11 hari, dimana LoS terendah pada neonatus/anak/remaja (6,1±2,43 hari) dan tertinggi pada lansia (7,4±3,02 hari). Faktor yang secara signifikan mempengaruhi LoS adalah status vaksinasi (p= 0,000) dan tingkat keparahan COVID-19 (p= 0,002), namun tidak dipengaruhi oleh kesesuaian terapi (p= 0,864). Hasil penelitian merupakan data awal tuntuk mengembangkan strategi perbaikan kualitas layanan untuk pasien COVID-19 rawat inap. Kata Kunci: COVID-19, Faktor Risiko, Penggunaan Obat, Lama Rawat Inap, Rumah Sakit  ABSTRACT COVID-19 disease remains a constant threat to global public health. Drug use and Length of Stay (LoS) are among main indicators of service quality in hospitals. Object of this research were understanding of LoS and the contributing factors (including patient characteristics and drug use) among COVID-19 inpatients at Hospital X Surabaya, Indonesia. Observational research was conducted using medical records of COVID-19 inpatients at Hospital X in 2022. Data on patient characteristics and drug profiles were analyzed descriptively. Drug therapy conformity was determined based on guidelines. Correlation tests were used to determine factors associated to LoS. The results were 203 COVID-19 inpatients, including: neonate/child/adolescent (12.32%), adults (66.5%) and elderly (21.2% ). Most patients were males (54.2%) with moderate severity (80.8%), and 36.4% had comorbidities. Therapy conformity in neonate/child/adolescent, adult and elderly patients were: 12% (3/25), 76% (103/135), 60% (26/43), respectively. The average LOS was 7.0±3.1 days, where neonate/child/adolescent was the lowest (6.1±2.43 days), and elderly was the highest (7.4 ± 3.02 days). Significant contributing factors to LoS included vaccination status (p= 0.000) and COVID-19 severity (p= 0.002), but not with therapy conformity (p=0.864). The study findings provide a preliminary data to guide the development of strategies to improve service quality for hospitalised patients with COVID-19.
Effectiveness Probiotics as Anti-Aging for Facial Skin: A Systematic Review Putu Adinda Novyta Arsha Putri; Ida Ayu Manik Partha Sutema; I Putu Gede Adi Purwa Hita; I Gusti Ayu Rai Widowati
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22558

Abstract

Premature skin aging is increasingly prevalent among individuals in their mid-20s to 30s, influenced by genetic, lifestyle, and environmental factors. Probiotics have emerged as a promising natural intervention to address this issue. This systematic review aimed to evaluate the effectiveness of oral and topical probiotics in preventing and managing signs of premature skin aging. A systematic search of PubMed and Scopus was conducted for Randomized Controlled Trials (RCTs) published between 2020 and 2025, using PICO-based inclusion and exclusion criteria. Methodological quality was assessed with the JBI checklist. Of 202 articles screened, eight RCTs were included. Results showed that oral probiotics improved skin quality by enhancing collagen production (24%), hydration (18%), and antioxidant activity, while topical probiotics reduced wrinkles (22%) and increased skin density (15%). In conclusion, oral and topical probiotics represent effective dual strategies for combating premature skin aging, though further studies are needed to optimize strain-specific formulations.
Determination of Total Phenolic and Caffeine Content and Their Correlation with Antioxidant Activity in Local Coffee Brews from South Kalimantan Nashrul Wathan; Naura Azmira; Nurul Khasanah Anaini; Nur Aulia Yahya; Dhian Ririn Lestari; Joharman Joharman; Fadlilaturrahmah Fadlilaturrahmah
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22576

Abstract

Coffee brews are widely consumed beverages known to contain bioactive compounds such as phenolic compounds and caffeine that provide health benefits, including antioxidant activity. The objective of this research is to evaluate the antioxidant activity, total phenolic content, and caffeine content of coffee brews made from local coffee beans of South Kalimantan, demonstrating their potential as functional beverages with health promoting properties. The local coffee beans used in this study originated from Pengaron, Aranio, Mataraman and Bati-Bati. The research included sample identification, beverage formulation, antioxidant activity assay using the DPPH method, and analysis of total phenolic and caffeine content using UV-Vis spectrophotometry. The results showed that the antioxidant activity, as indicated by IC₅₀ values, was lowest in coffee from Pengaron (202.962 ± 0.89 ppm), followed by Aranio (166.716 ± 0.358 ppm), Mataraman (150.043 ± 0.345 ppm), and the strongest in Bati-Bati (113.242 ± 0.122 ppm). The total phenolic content ranged from 58.327 ± 0.017 mg GAE/mL in Pengaron, 83.993 ± 0.017 in Aranio, 104.536 ± 0.032 in Mataraman, to 108.646 ± 0.042 in Bati-Bati. Caffeine levels were 123.876 ± 0.331, 139.340 ± 0.238, 175.495 ± 0.715, and 131.833 ± 0.620 mg/serving, respectively. The findings reveal a strong positive relationship between total phenolic content and antioxidant activity, while caffeine content did not consistently align with antioxidant performance. These findings support the significant role of phenolic compounds in determining the antioxidant potential of South Kalimantan’s local coffee beverages. The highest antioxidant activity and phenolic content were observed in coffee beverages made from Coffea liberica beans originating from Bati-Bati, suggesting its superior potential as a functional beverage with health benefits.
Predicted Factors Related to Medication Compliance and Blood Pressure in Hypertension Patients Faridah Baroroh; Imaniar Noor Faridah; Andriana Sari; Yosi Pratama Dewi
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22750

Abstract

Nonadherence to antihypertensive medication is a key factor contributing to treatment-resistant hypertension. The main goal of hypertension treatment is to reduce morbidity and mortality by effectively lowering blood pressure. This study aimed to identify the factors influencing medication adherence and blood pressure regulation in patients with hypertension. This research utilized a retrospective cohort design. Data were gathered using the MARS questionnaire and patient medical records. The study sample consisted of hypertensive outpatients from five community health centers in the Special Region of Yogyakarta, Indonesia. Data analysis was performed using the Chi-square test. A total of 410 respondents met the inclusion criteria, with the majority being female (75.7%), 67.8% of patients adhered to their medication regimen, while 49.5% had controlled blood pressure. Difficulty remembering to take medication (p=0.010) and difficulty taking medication (p=0.049) were significantly associated with non-adherence. Age (p=0.001) and medication adherence (p=0.037) were also significantly associated with blood pressure control. The study's conclusion showed that adherence to taking medication and age are highly correlated to controlled blood pressure in hypertensive patients. Moreover, several factors related to compliance need to be identified to increase patient compliance and therapy outcomes for outpatient hypertension patients at the health center.
Lumbricus Rubellus Earthworm Extract Hydrogel for Treatment of Diabetic Ulcer Wounds Diana Tri Lestari; Muhamad Jauhar; Eko Retnowati
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22880

Abstract

A diabetic ulcer is a complication that requires serious treatment because it is the highest cause of amputation. This condition has an impact on the morbidity, mortality, and socioeconomics of people with diabetes. Therefore, accuracy is needed in managing diabetic ulcers, one of which is natural ingredients that have potential as topical ulcer medicines, namely the Lumbricus rubellus earthworm. This study aims to find out the most effective formula for the treatment of diabetic ulcer wounds. The formula for this drug candidate is made using the hydrogel preparation formulation using an HPMC 940 base with variations in the active ingredient of lumbricus worm extract of 20%, 50%, and 80% to obtain the desired hydrogel preparation. The candidate drug will be tested, namely physical tests including organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesive tests. After that in vivo trial using Wistar rat experiments. The results of the organoleptic test showed that the three formulas were in gel form with a distinctive extract odor, but the three preparations showed different colors, namely brownish yellow, dark brown, and blackish brown. The three formulations appear homogeneous, having a pH between 4.36 and 4.44 and a viscosity between 5,376 cp and 5,894 cp. The spreading power in formulas 2 and 3 is good, and formula 2 has good adhesion. The results of this study demonstrate that the group treated with 50% L. rubellus topical extract experienced the most significant and rapid wound healing among all intervention groups. L. rubellus extract can be used as a topical gel preparation for wound care, with the best formulation at a concentration of 50%.
GC-MS Profiling and Inhibitory Effect on UV-C Exposure Induced Eryrhrocyte Damage of Sungkai Leaf: A Potential Novel Antioxidant Agent Mashuri Mashuri; Eko Suhartono; Noor Muthmainah; Lisda Hayatie; Nadia Salma Nazwa Assyfa; Hanna Dwi Aprilia Husna; Helma Febrianti
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23081

Abstract

Daun sungkai (Peronema canescens Jack.) meruapakan tumbuhan yang dikenal memiliki berbagai manfaat farmakologis, termasuk sebagai antiinflamasi, antimikroba, dan antioksidan.  Tumbuhan ini mengandung senyawa fenolik, flavonoid, tanin, dan saponin yang dapat berperan seabagai antioksidan. Berkaitan dengan hal tersebut, penelitian ini bertujuan untuk menganalisis profil fitokimia dengan GC-MS. Selain itu, juga akan membuktikan aktivitas antioksidan ekstrak daun sungkai dalam menhambat kerusakan membran eritorit akibat pajanan sinar UV. Daun Sungkai diperoleh dari KHDTK Mandiangin diektrak dengan pelarut methanol dengan metode maserasi. Hasil ektrak dilakukan uji GC-MS dan uji penghambatan kerusakan eritrosit akibat sinar UV. Pengujian terdiri atas 2 kelompok, yani 2 kelompok control dan 3 kelompok perlakuan. Kelompok perlakuan menggunakan ektrak metanol daun sungkai masing-masing 10 ppm, 15 ppm, dan 25 ppm. Sementara itu, pemajanan eritrosit dilakukan selama 2 jam. Hasil penelitian ini dapat disimpulkan bahwa berdasarkan  analisis GC MS menunjukkan bahwa ekstrak metanol daun sungkai mengandung senyawa 4-Metoksi-3-trimetilsilil)metil-1-oktena, D-Limonen, Asam tridekanoat, 12-cis-oktadekanoat, asam 13-oktadesenoat, metil ester, asam oleat, dan Glisidil (Z) -9-heptadekanoat yang dapat mengurangi kerusakan eritrosit akibat paparan sinar UV. Selain itu, ektrak metanol daun sungkai dapat menghambat kerusakan membrane eritrosit yang ditandai oleh penurunan %Hb dan kadar MDA pada kelompok yang diberikan ekstrak methanol daun insulin. Kata Kunci: Pajaanan UV, antioksidan, Daun Sungkai, Membrane Eritrosit, Peroksidasi Lipid Sungkai leaf (Peronema canescens Jack.) is a plant known to have various pharmacological benefits, including as anti-inflammatory, antimicrobial, and antioxidant. This plant contains phenolic compounds, flavonoids, tannins, and saponins that can act as antioxidants. In this regard, this study aims to analyze the phytochemical profile by GC-MS. In addition, it will also prove the antioxidant activity of sungkai leaf extract in inhibiting erythrocyte membrane damage due to UV exposure. Sungkai leaves obtained from KHDTK Mandiangin were extracted with methanol solvent by maceration method. The extracts were subjected to GC-MS test and UV light-induced erythrocyte damage inhibition test. The test consisted of 2 groups, 2 control groups and 3 treatment groups. The treatment groups used methanol extract of sungkai leaves at 10 ppm, 15 ppm, and 25 ppm, respectively. Meanwhile, erythrocyte exposure was carried out for 2 hours. The results of this study can be concluded that based on GC MS analysis shows that the methanol extract of sungkai leaves contains compounds 4-Methoxy-3-trimethylsilyl)methyl-1-octene, D-Limonen, Tridecanoic acid, 12-cis-octadecanoic, 13-octadesenoic acid, methyl ester, oleic acid, and Glycidyl (Z)-9-heptadecanoic which can reduce erythrocyte damage due to UV exposure. In addition, sungkai leaf methanol extract can inhibit erythrocyte membrane damage characterized by a decrease in %Hb and MDA levels in the group given insulin leaf methanol extract.

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