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ISSN : - EISSN : 25408844 DOI : -

Core Subject : Health,

Medicine & Pharmacology

JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.

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Articles 1,040 Documents

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EFFECT OF SENAM SEHAT ANAK INDONESIA IN MAXIMUM OXYGEN CONSUMPTION IN CHILDHOOD OBESITY Arniari, Gek Yun; Isma AP, Rahmi; Setiawati, Erna; Nency, Yetty Movieta
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Obesity is one of the causal factors of chronic diseases such as heart disease, diabetes, hypertension, asthma, arthritis, and cancer. The change in lifestyle and lack of physical activity in children increase the incidence of obesity, accompanied by a decrease in physical fitness. One of the parameters that can be used to determine the level of physical fitness is the maximum oxygen consumption (VO2max). VO2max in children can be increased through aerobic physical exercise, such as Senam Sehat Anak Indonesia (SSAI). SSAI combines aerobic movements and joyful music in order to motivate children to be more excited in gymnastics. Methods: An Experimental study with the pre-post test design among 23 samples who fulfill the inclusion and exclusion criteria. The exercises were administered twice a week for six weeks. VO2max data were measured before and after the exercise in the first week and week 12. Data of VO2max were analyzed using the data normality test with Shapiro-Wilk, then continued with Wilcoxon test to determine the difference of VO2max. Results: There is significant difference of VO2max between before and after SSAI (p < 0.05). Conclusion: There is an increase in the maximum oxygen volume (VO2max) after the SSAI exercise in childhood obesity.

THE EFFECT OF HONEY PINEAPPLE JUICE (Ananas comosus var. cayenne) ON TOOTH ENAMEL HARDNESS Fadiah Annisa Safirah; Gunawan Wibisono; Ainun Rahmasari Gumay; Muflihatul Muniroh
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: The habit of drinking juice containing high acid in a certain time affects tooth erosion by inducing the dissolvement of enamel hydroxyapatite crystal. Honey pineapple juice is known to have a high acid content and lower pH. However, there have been no reports of honey pineapple juice on tooth enamel hardness. Aim: To determine the effect of honey pineapple juice on tooth enamel hardness. Methods: This study used an experimental laboratory design with a pre- and post-test group design. Twenty-four post extraction maxillary or mandible premolars were divided into 4 treatment groups; where each group was immersed in honey pineapple juice for 30, 60, 90 and 120 minutes. The pH of honey pineapple juice was determined in the early treatment. The hardness test was carried out before and after the treatment using Vickers Hardness Tester with a load of 100 grams for 15 seconds. Data analysis used Wilcoxon and Kruskal Wallis test. Results: The results showed a significant differences in tooth enamel hardness before and after immersion honey pineapple juice for 30 min (p = 0.028), 60 min (p = 0.028), 90 min (p = 0.028), and 120 min (p = 0.046). There was no significant difference in the mean of tooth enamel hardness at each immersion times (p = 0.985). Conclusions: Consumption of honey pineapple juice has an effect on reducing tooth enamel hardness that could be started in a short time consumption.

THE EFFECT OF BREASTFEEDING EDUCATION AMONG POSTPARTUM MOTHERS ON EXCLUSIVE BREASTFEEDING PRACTICE ONE MONTH AFTER DELIVERY Laurentius Juan Wicaksono; Dimas Tri Anantyo; Julian Dewantiningrum; Bambang Hariyana
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Exclusive breastfeeding is a standart of care for newborn. In 2017 within area of Semarang City, only 19,5% women who practiced exclusive breastfeeding .One of the problems was low level of mother’s knowledge because lack of breastfeeding education especially by the health services institutions. The aim of the study is to asses the effect of breastfeeding education among postpartum mothers on exclusive breastfeeding practice in one month after delivery. Method: A quasi experimental study design was conducted among postpartum mother in purposively selected health institutions of Semarang city. All eligible women were placed into intervention (n=25) and control (n=25) group. The intervention group received standart education with educational media and control group received standart education only which lasts for 15 minutes. Data were collected through interviewer-administered questionnaire at one month after education session. Results: The number of mothers who practiced exclusive breastfeeding for a month was greater in intervention group than the control group (p=0,025). The level of knowledge also greater in intervention group (p=0,016). Also, there were no significant relationship between age, working status, maternal parity and exclusive breastfeeding while there was significant relationship between maternal education and exclusive breastfeeding practice. Conclusion: Breastfeeding education with educational media increases the mother’s knowledge about exclusve breastfeeding and practice of exlusive breastfeeding up to 1 month.

Cover-Daftar isi DMJ Juli 2020 Daftar Isi, cover
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Cover - Daftar Isi DMJ Volumen 9 Nomor 4 Juli 2020

THE EFFECTS ON FLAXSEED (LINUM USITATISSIMUM) ON THE SEVERITY LEVEL OF ACNE VULGARIS. Devi Saviera Firnanda; Asih Budiastuti; Aryoko Widodo; Dhega Anindita Wibowo
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Introduction. Acne vulgaris is the formation of blackheads, papules, pustules, nodules, or cysts which were the result of the blockage and inflammation of the pilosebaceous unit. In general, there are several factors associated with the occurrence of Acne vulgaris, namely the abnormal activity of the bacterium Propionibacteria acnes, increased sebum production, hyperkeratinization of the pilosebaceous duct, and also the inflammatory process. Objectives. The primary objective of this research is to know the effect of flaxseed (Linum usitatissimum) on the severity level of Acne vulgaris. Methods. The design of this research is experimental research with a one-group pre-test post-test design. This research will be conducted from October to November 2019. And will be implemented in the city of Semarang. The population in this research is female college students (preferably Diponegoro University students) aged 18-23 years old who suffered from various severity degrees of Acne vulgaris which fulfills the inclusion and exclusion criteria. Subjects are determined using purposive sampling methods. Results. The research sample was mostly females aged 18-23 years of 2016 at Diponegoro University who suffered from various degrees of Acne vulgaris. After a paired T-test, p <0.05 was obtained. Because the results obtained are p <0.05, it can be concluded that there is a significant difference between the degree of Acne vulgaris during the pre-test and post-test. Conclusion. there is an effect of Linum usitatissimum seeds on the severity of Acne vulgaris.

CLINICAL AND HISTOPATHOLOGICAL CHARACTERISTICS OF PRIMARY BRAIN TUMOR DISEASE IN RSUP DR. KARIADI SEMARANG Madani Hastutyosunu; Trianggoro Budisulistyo; Arinta Puspita Wati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Introduction: Primary brain tumour is one of the non-communicable diseases that ranks 17th of all types of cancer in the world with an estimated 256,000 new cases each year. The incidence in North America, Europe and Australia is quite high with an estimated 4-8 new cases per 100,000 population per year. The incidence in continental countries of Asia and Africa is less compared to developed countries. The low incidence and mortality of brain tumours in the continents of Asia and Africa, especially in Indonesia, is thought to be due to the low reports of brain tumour disease from some of these countries, so as to increase knowledge and management of brain tumour plenary services in Indonesia, accurate hospital clinical data is needed. Objective: This study aims to look at the frequency of events, symptoms and clinical signs, histopathological characteristics, the stage at diagnosis, and compare the incidence of primary brain tumours in men and women. Methods: This study used a descriptive observational study design that uses data on primary brain tumour patients in the period of January 2017 - December 2018. Data collected includes clinical symptoms and signs, histopathological characteristics, and tumour tissue characteristics. Results: From 72 patients with primary brain tumour, only 36 (50%) of data can be used as samples due to the completeness of the medical record. The most common clinical symptoms and signs are headache, followed by limb disorders, and visual impairment. The most common histopathological features are Astrocytic tumour with a ratio of 17: 5 for men and women respectively. Conclusion: Primary brain tumours in RSUP Dr. Kariadi Semarang is often found with symptoms of headache followed by limb disorders and visual impairment, with a type of Astrocytic tumour that is more commonly found in men.

ANTIMICROBIAL EFFECT OF ARROWROOT (Maranta arundinacea L.) METHANOLIC EXTRACT AGAINST Staphylococcus aureus BACTERIAL GROWTH Syahputra, Muhammad Ghaza; Antari, Arlita Leniseptaria; Winarto, Winarto; Lestari, Endang Sri
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Introduction: Staphylococcus aureus is a spherical gram-positive bacterium that forms clusters and is frequently resistant to antibiotics. Methicillin-Resistant Staphylococcus aureus (MRSA) is a strain of S. aureus that is resistant to beta-lactam and cephalosporin groups of antibiotics, it is one of the biggest problems in resistant bacteria. Plants that have flavonoids in their extract can inhibit the growth of bacteria by impairing their cytoplasmic membrane. Arrowroot is an example of plants that have flavonoids in their extracts. Objectives: This research aims to determine the antimicrobial effect of arrowroot (Maranta arundinacea L.) methanolic extract against the growth of Staphylococcus aureus in vitro. Methods: This is true experimental research with a post-test control group design with two control groups and eight experimental groups. The sample of this research utilizes the MRSA strain of S. aureus received from the Microbiology Laboratory of Diponegoro University Faculty of Medicine that was eligible with the inclusion criteria. The research was conducted by using arrowroot extract concentrations 6.5%, 12.5%, 25%, 50%, and 100% to determine the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and inhibitory zone diameter. Results: MIC and MBC of arrowroot methanolic extract against MRSA is 100%. The arrowroot methanolic extract to have yielded an inhibitory zone diameter is 100% with a mean inhibitory zone diameter of 15.5mm. Conclusion: Arrowroot methanolic extract can inhibit the bacterial growth of MRSAKeywords: Staphylococcus aureus, growth, M. arundinacea L. methanolic extract

THE EFFICACY OF TOPICAL CLINDAMYCIN GEL ON SEVERITY DEGREE OF ACNE VULGARIS AMONG FEMALE COLLEGE STUDENTS Hapsari, Rani Puspita; Widayati, Retno Indar; Afriliana, Liza; Hadi, Purnomo
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)

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Background: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous follicle of the skin as the result of Propionibacterium acnes colonization. Clindamycin is an antibiotic that is effective against most gram-positive anaerobic bacteria such as the strain of Â Propionibacterium sp. Clindamycin in topical form inhibits P. acnes lipase enzyme resulting in the decrease of free fatty acid on the skin surface and the decrease of the Propionibacterium acnes population. Â Aim: To know the effect of topical clindamycin gel application on the severity degree of acne vulgaris among female college students of Diponegoro University. Methods: The study has done on 34 female college students of Diponegoro University who were diagnosed with Acne Vulgaris. All of the subjects underwent a face skin examination where the acne lesions were counted before and after the treatment. The treatment given was the application of clindamycin topical gel once a day for four weeks. The counted acne lesions were classified into the severity degree of acne vulgaris by Plewig and Kligman. The study compared the severity degree of acne vulgaris before and after the treatment. Statistical analysis of this study used the Wilcoxon test. Result: The result of pre and post-treatment data showed a significant decrease in the severity degree of acne vulgaris after the treatment application (p=0.000). The decrease of severity degree was marked by the decrease of acne lesion count after having four weeks of treatment. This significant result indicated an effective recovery of acne vulgaris after being given the treatment of topical clindamycin. The antibiotic and anti-inflammation effects of clindamycin were discovered effectively healing the lesions of acne vulgaris, therefore, decreasing its severity. Conclusion: Topical clindamycin can effectively reduce the severity degree of acne vulgaris among female college students of Diponegoro University.

ASSOCIATION BETWEEN ADULT TUBERCULOSIS TREATMENT STATUS WITH CHILDREN TUBERCULOSIS STATUS WHO HAD HOUSEHOLD CONTACT Agnes Emanuella; Moh. Syarofil Anam; Nahwa Arkhaesi; Dodik Pramono
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Bacground: Tuberculosis (TB) is one of the ten types of diseases that cause the quite high death rate in the world. Indonesia is ranked number three in TB cases. Tuberculosis can spread from adult tuberculosis patients to others including children who have a history of household contact. Adult TB patients who have been diagnosed immediately receive treatment to cure and reduce transmission. Tuberculosis treatment is divided into intensive phase, advanced phase and successful treatment. Aim: This study aims to analyze the relationship between treatment status of tuberculosis on adult who contact with tuberculosis status on children in the houshold. Methods: This study was an observational analytic study with a cross sectional study. The subjects of this study were 35 adult TB patients who were in contact with 58 children aged 0-18 years. Data collection was carried out at RSUP Kariadi and four puskesmas in Semarang from September 2019 to October 2019. Children tuberculosis status was classified as being TB exposure, TB infection and TB disease based on tuberculin tests and clinical symptoms. Statistical tests using the Chi-Square and Fisher Exact hypothesis tests. Results: Based on the results of statistical analysis, there was no significant relationship between the status of tuberculosis treatment on adult (p = 0.848) with status of tuberculosis for children that are in household contact. Conclusion: The status of tuberculosis treatment on adult has no statistical relationship with the status of tuberculosis for children in household contact.

COMPARISON OF THE EFFECTIVENESS OF CURCUMA DOMESTICA EXTRACT AND CURCUMA XANTHORRIZA EXTRACT AGAINST LIVER FUNCTION AND HEPATIC CELL INFLAMMATION ON STREPTOZOTOCIN-INDUCED DIABETES MELLITUS MICE Amira Naufal; Alfin Ihza Trimahendra; Astika Widy Utomo; Vega Karlowee; Awal Prasetyo; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Diabetes mellitus can cause complications including liver damage, which has an impact on increasing levels of SGOT and SGPT in the blood, as well as inflamation and hepatic steatosis. Turmeric (Curcuma domestica) and java turmeric (Curcuma xanthorizza) are known to have high levels of curcumin and xanthorizzol as an antioxidant and proven to improve liver function. Antioxidant therapy in patients with NAFLD is known to improve liver function and histopathological features. The effects of turmeric and java turmeric extract on liver function in streptozotocin-induced diabetes mellitus mice are still unknown. Objective: Comparing effects of administered turmeric and java turmeric extract on liver function and histopathologic features of streptozotocin-induced diabetes mellitus mice. Method: Research design Post Test Only Control Group Design are used. Male swiss mice around 25-30 gram are used. Streptozotocin-induced diabetes mellitus mice with a total samples (n = 20) divided into 4 groups, Control+PBS, Control+STZ, STZ+Turmeric, and STZ+Java Turmeric (an = 5). Blood glucose, weight, SGOT, SGPT levels and histopathologic features including percentage of inflamation and hepatic steatosis were examined at day 21. All the research data were analyzed using statistics program. Result: Turmeric and java turmeric extract cannot significantly reduce blood glucose level. Administration of java turmeric extract significantly reduce SGPT level against control+STZ group (84,12±17,53 vs. 36,3±27,4 u/L, p=0,018). Administration of turmeric extract significantly reduce hepatic cell inflamation against control+STZ group (30(26-68) vs. 20(15-30)%, p=0,035). Conclusion: Each turmeric and java turmeric extract can improve liver fuction and decreasing hepatic cell inflamation on streptozotocin-induced diabetes mellitus mice, but may not mediated by decreasing blood glucose level.

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