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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 1,040 Documents
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HUBUNGAN NEUTROPHYL LYMPHOCYTE RATIO DENGAN C-REACTIVE PROTEIN PADA PASIEN STROKE NON HEMORAGIK Mila Niqi Itami; Banundari Rachmawati; Edward Kurnia Setiawan Limijadi; Dwi Retnoningrum
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.616 KB) | DOI: 10.14710/dmj.v9i2.27099

Abstract

Latar Belakang: Stroke merupakan suatu penyakit kegawatan, dapat menyebabkan kematian, dan juga dapat menyebabkan kecacatan. Oleh sebab itu, diperlukan indikator inflamasi berupa Neutrophyl-Lymphocyte Ratio (NLR) dari pemeriksaan hitung jenis leukosit dan C-Reactive Protein (CRP) yang merupakan reaktan tahap akut yang sensitivitasnya tinggi, dapat mendeteksi rendahnya tingkat inflamasi pada pasien stroke non hemoragik. Tujuan : Menganalisis hubungan antara NLR dan  CRP pada pasien penderita stroke non hemoragik Metode : Penelitian  ini  merupakan  penelitian  observasional  analitik  dengan rancangan  cross-sectional. Subjek  penelitian  adalah  34  pasien  stroke  non hemoragik  di  Rumah  Sakit  Nasional  Diponegoro  dan  RSUD  Dr. Adhyatma Semarang. Pengambilan sampel dilakukan dengan cara consecutive sampling yang memenuhi kriteria inklusi dan eksklusi.Uji statistik menggunakan uji Spearman. Hasil : Dari 34 sampel, didapatkan  laki-laki 18 orang  (52,94%) dan  perempuan 16 orang (47,05%), rerata usia 58,06 ± 1,33 tahun. Diperoleh hubungan positif sedang dan bermakna antara NLR dan CRP pada pasien stroke non hemoragik dengan hasil (r= 0,449; p=0,008). Simpulan : Terdapat hubungan positif sedang antara NLR dengan CRP pada pasien stroke non hemoragikKata Kunci: Neutrophyl-Lymphocyte Ratio (NLR), C-Reactive Protein (CRP), stroke non hemoragik.
FAKTOR RISIKO PENDERITA KUSTA TIPE MULTIBASILER DI RSUD TUGUREJO SEMARANG Najla Firda Safira; Aryoko Widodo; Dhega Anindita Wibowo; Asih Budiastuti
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.59 KB) | DOI: 10.14710/dmj.v9i2.27146

Abstract

Latar belakang: Kusta adalah salah satu masalah penyakit endemis di Indonesia, menduduki peringkat ketiga dengan jumlah kasus baru terbanyak di dunia. Buruknya stigma sosial mengakibatkan banyak penderita enggan berobat, terlambatnya diagnosis dan pengobatan sehingga terjadi disabilitas fisik serta penurunan kualitas hidup. Diketahuinya faktor risiko kusta tipe multibasiler (MB) yang menjadi sumber penyebaran penyakit, meliputi data dasar, tingkat pengetahuan dan riwayat kontak fisik diharapkan dapat meningkatkan pengetahuan masyarakat dan tenaga kesehatan dalam pencegahan dan deteksi dini kusta.Tujuan: Penelitian ini bertujuan untuk mengetahui faktor risiko kejadian kusta tipe MB di Poliklinik Kusta RSUD Tugurejo Semarang. Metode: Desain penelitian analitik observasional dengan rancangan cross-sectional dilakukan pada 20 penderita kusta tipe MB dan 11 penderita kusta tipe pausibasiler yang datang berobat ke Poliklinik Kusta RSUD Tugurejo Semarang pada bulan Agustus hingga Oktober 2019 dipilih secara consecutive sampling. Data didapatkan dari kuesioner yang diisi responden. Hasil: Mayoritas responden adalah laki-laki, usia 21-40 tahun, pendidikan terakhir SMA, pekerjaan sebagai karyawan swasta dan berdomisili di Semarang. Terdapat hubungan signifikan antara tingkat pengetahuan mengenai kusta dengan kusta tipe MB dengan nilai p sebesar 0,038 pada uji chi-square, mayoritas tingkat pengetahuan rendah dan tidak ada riwayat kontak fisik. Tidak didapatkan hasil bermakna untuk riwayat kontak fisik. Kesimpulan: Tingkat pengetahuan mengenai kusta merupakan faktor risiko dari kusta tipe MB.Kata Kunci: faktor risiko; kusta tipe multibasiler; riwayat kontak fisik; tingkat pengetahuan
THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS Rona Ayu Hanifah; Farah Hendara Ningrum; Erwin Kresnoadi; Satrio Adi Wicaksono
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.895 KB) | DOI: 10.14710/dmj.v9i2.27080

Abstract

Introduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms in the treatment of pain. The use of paracetamol and codeine as monotherapy has been extensive, but research on the effectiveness of these drugs in combination is still limited, especially about its effect in liver damage. This study was to investigate the effect of paracetamol and codeine analgesic combination Serum Glutamic Oxaloacetate Transaminase levels in male Wistar rats. Method : This was an experimental study using Post-Test Only Control Group Design. The samples were 24 male wistar rats randomized into 4 groups; group I (control group, without treatment), group II receiving paracetamol 32 mg/kgBB, group III receiving codeine 1,9 mg/kgBB, and group IV receiving combination of paracetamol 32 mg/kgBB and codeine 1,9 mg/kgBB. Drugs were administered through oral gastric instillation 4 times a day for 28 days. Blood samples were collected at the 29th day through retroorbital vessel to measure the SGOT levels. The data was analysed using One-Way ANOVA test and Post-Hoc test. Results : The results of this research were obtained from statistical tests where there was no significant increase of the levels of Serum Glutamic Oxaloacetate Transaminase of Wistar rats which received a combination of paracetamol and codeine in the control group (p = 0.005). While in the other group there was not significant differences of the levels of Serum Glutamic Oxaloacetate Transaminase. Conclusion : There is no significant difference of Serum Glutamic Oxaloacetate Transaminase levels between the administration of paracetamol and codeine combination compared to the control group.Keywords : Paracetamol, codeine, paracetamol and codeine combination, SGOT levels, pain
DIET WITH CHOCOLATE OR BLACK TEA? IS IT EFFECTIVE? Elvina Astiningtyas Sudaryanto; Hesti Triwahyu Hutami; Nyoman Suci Widiastiti; Endang Mahati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.56 KB) | DOI: 10.14710/dmj.v9i2.27100

Abstract

Introduction: Based on national research 2018, in Indonesia, 21% of population is obesed. Obesity can lead to various metabolic Syndrome. The consumption of Chocolate and Black Tea can decrease insulin. BMI and Fasting Blood Glucose is use as an assessment to observe the effectivity of Chocolate and Black tea as a method of diet. Methods: This experimental study used pre and post-test control group design. Eighteen male BALB/c obese mice were randomly divided into three groups. Control group did not receive anything, 1st group treated with black tea extract, while 2nd group treated with chocolate extract. Data, such as body weight and glucose fasting level was acquired weekly. Fasting Blood Glucose was assessed with accu check. Data normality were tested using Saphiro-Wilk test. Then, Kruskall-Wallis was employed to determine whether the means of each groups differ significantly. Results: The average weight in P2 groups (31,75±3,40 gram) was significantly lower than Control (36,50±1,97 gram p=0.03) but not significantly lower than P1 (34,40±1,14 gram p=0.137) group. The average weight in P1 was not significantly lower than Control (p=0.089). There was no significant change of  number in the average Glucose fasting level (p=0.21). Conclusion : Chocolate and Black Tea could affect body weight, but could not effect fasting blood glucoseKeyword: Black Tea, BMI, Body weight, Ch ocolate, Glucose fasting level
DIFFERENCE IN BODY'S DYNAMIC BALANCE BEFORE AND AFTER CONDUCTING CIRCUIT TRAINING OF STUDENTS AT MEDICAL FACULTY OF DIPONEGORO UNIVERSITY Kusumaningtyas Ayu Amarihati; Yosef Purwoko; Ferdy Kurniawan Cayami; Endang Kumaidah
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (596.962 KB) | DOI: 10.14710/dmj.v9i2.27075

Abstract

Background: Physical inactivity that happens recently increase the risk of various disease. Circuit training is an exercise that can be completed with a short amount of time and has varied movements. With circuit training, subject expected to have increase in physical fitness in the body’s dynamic balance. The purpose of this study to find out whether circuit training can produce different scores of the body’s dynamic balance of students at medical Faculty of Diponegoro University. Methods: This study used a quasi-experimental design with pre-test and post-test comparison group. The subjects were from the Medical Faculty of Diponegoro University (n = 46) which were divided into control group and treatment group. The treatment group (n = 24) was given circuit training for 6 weeks with increased number of circuits for every 2 weeks, while the control group (n = 22) carried out activities as usual without doing any sports. The measuring of body's dynamic balance was carried out before starting circuit training and after completing 6 weeks of circuit training. Data were collected and then analyzed using the unpaired T-test and the paired T-test for normally distributed data. Meanwhile, the Mann-Whitney test and Wilcoxon test were used for non-normally distributed data. Results: The score of the body’s dynamic balance in the treatment group increased for the right leg with a pre-test score of 75.60 ± 13.74 to 95.75 ± 10.98. The balance score for the left leg also increased with the pre-test score of 78.05 ± 13.12 to 95.95 ± 10.33. The score of the difference between the post-test and pre-test of the treatment group of both legs has a significant value of (p = 0,000). Conclusion: Circuit training with increased number of circuits for every 2 weeks can increase the scores of the body’s dynamic balance of of students at medical faculty of Diponegoro University.Keywords: circuit training, body’s dynamic balance, Y balance test
THE EFFECT OF BEET (BETA VULGARIS L.) TO SPERMATOZOA MOTILITY OF MOSQUITO COIL-EXPOSED WISTAR RATS Wulan Widiasmaran; RR Mahayu Dewi Ariani; Farmaditya Eka Putra; Donna Hermawati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.587 KB) | DOI: 10.14710/dmj.v9i2.27147

Abstract

Background : Mosquito coils contain substances such as allethrin, transflurin, pralethrin, cypenothrin and esbiothrin. Alletrin inhalation will pass into the bloodstream. In the liver, the detoxification occurs and produces metabolites that play a role as free radicals. Beets contain betanin, one of the betalalain groups with functions to binding free radicals in the body system. Objective : To investigate the effect beets on spermatozoa motility of wistar rats exposed by mosquito coils. Methods : In this study used post test only control group design. The number of samples was 20 male wistar rats divided into 4 groups. The Control Group (K-) is a group was given standard feed. The Control Group (K+) is only given exposed to mosquito coils. The P1 group was exposed to to mosquito coils and given 8 ml of beet juice. Group P2 was exposed to to mosquito coils and given 16 ml beet juice. The treatment were done for 56 days. Result : The mean value of motility of spermatozoa are group K (-) = 50; group K (+) = 10; group P1 = 29; group P2 = 46. Oneway Anova test showed significant differences in sperm motility in all groups. Post Hoc test showed  significant difference between group K (+) with K (-) (p = <0,001), group K (+) with P1 (p = 0.005), group K (+) with P2 (p = <0,001).  Conclusion : Beet juice can affect the spermatozoa motility of wistar rats exposed by mosquito coils.Keyword : mosquito coils; beet juice; sperm motility
FAKTOR RISIKO RINITIS ALERGI PADA ANAK USIA 13-14 TAHUN DI SEMARANG Arteria Dewi Nurhutami; Suprihati Suprihati; Dwi Marliyawati; Anna Mailasari Kusuma Dewi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.548 KB) | DOI: 10.14710/dmj.v9i2.27096

Abstract

Latar Belakang : Berdasarkan survey WHO penderita rinitis alergi berjumlah sekitar 400 juta penduduk dunia. Studi ISAAC pada kelompok usia 13-14 tahun didapatkan prevalensi sebesa 1.4 - 39.7%. Rinitis alergi juga dikatakan sebagai masalah global yang selalu mengalami peningkatan dan memerlukan perhatian khusus. Riwayat atopi keluarga, faktor gaya hidup dan keadaan lingkungan merupakan faktor yang berkontribusi terhadap kejadian rinitis alergi. Tujuan : Mengetahui faktor risiko rinitis alergi pada anak usia 13- 14 tahun di Semarang. Metode : Penelitian ini merupakan penelitian analitik observasional dengan desain cross-sectional. Penelitian ini menggunakan kuesioner ISAAC yang diisi oleh 310 responden di SMP Nusa Bhakti dan SMP N 19 Semarang. Sampel dipilih secara consecutive sampling. Hasil : Didapatkan sebanyak 113 (36.5%) siswa yang menderita rinitis alergi. Dimana dari 310 responden didapatkan sebanyak 66 siswa (21%) terpapar asap kendaraan, 204 siswa (66%) terpapar asap rokok, 131 siswa (42%) memiliki hewan peliharaan, 178 siswa (57%) terpapar debu rumah, 29 siswa (9%) menderita asma dan 63 siswa (20%) menderita eksem. Simpulan: Faktor risiko yang bermakna pada penderita rinitis alergi usia 13-14 tahun di Semarang adalah memiliki hewan peliharaan (OR=1.444), terpapar asap kendaraan (OR=2.010) dan menderita eksem (OR=3.163).Kata Kunci : Rinitis alergi, Faktor risiko, Kuesioner ISAAC
HUBUNGAN GULA DARAH PUASA DAN HBA1C DENGAN INDEKS MASSA TUBUH PADA PENDERITA DIABETES MELITUS TIPE 2 Nina Dorothea Budiamal; Indranilla K. Samsuria; Dwi Retnoningrum; Ariosta Ariosta
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.222 KB) | DOI: 10.14710/dmj.v9i2.27143

Abstract

Latar Belakang : Diabetes Melitus tipe 2 merupakan penyakit yang dapat  menyebabkan berbagai komplikasi yang dapat memicu terjadinya beberapa penyakit seperti hipertensi, penyakit jantung koroner, stroke. Status glikemik memiliki pengaruh terhadap IMT pada pasien dengan Diabetes Melitus tipe 2. Tujuan : Membuktikan hubungan antara GDP dan HbA1c dengan IMT pada pasien Diabetes Melitus tipe 2. Metode : Penelitian cross-sectional dengan 30 sampel berdasarkan kriteria inklusi dan eksklusi. Responden dilakukan pengukuran GDP, HbA1c, dan IMT. Analisis data dilakukan menggunakan Spearman’s sebagai uji hipotesis. Hasil : Rerata IMT subjek yaitu 24,35 ± 0,69. Sedangkan rerata untuk kadar GDP dan nilai HbA1c, yaitu 178,73 ± 11,54 mg/dl dan 7,92 ± 0,28%.Tidak didapatkan hubungan yang signifikan antara GDP dengan IMT (p=0,627) dan HbA1c dengan IMT (p=0,987). Simpulan : Tidak ada hubungan antara GDP dan HbA1c dengan IMT pada penderita Diabetes Melitus tipe 2.Kata Kunci : GDP, HbA1c, IMT, Diabetes Melitus tipe 2.
THE INFLUENCE OF CHEESE CONSUMPTION ON THE DEGREE OF ACNE VULGARIS IN STUDENTS OF MEDICINE FACULTY OF DIPONEGORO UNIVERSITY Koncara, Fatan Khalif; Wibowo, Dhega Anindita; Riyanto, Puguh; Wikanta, Edmond Rukmana
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.253 KB) | DOI: 10.14710/dmj.v9i2.27076

Abstract

Introduction : Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles with a polymorphic clinical picture consisting of various skin disorders in the form of blackheads, papules, pustules, nodules, and scar tissue. Four pathogenesis underlying the emergence of AV include polysebaseal follicle hyperproliferation, excess sebum production, inflammation, and the presence of Propionibacterium acnes. The cause of this multifactorial AV, one of which is a factor of consuming fatty foods, especially saturated fat, one of the foods is cheese. Cheese is one of the foods that we usually consume as processed foods that contain lots of saturated fat. Consuming fatty foods on an irregular basis can cause acne vulgaris. Objectives : To determine the relationship of fatty food consumption with the severity of acne vulgaris in Diponegoro University Kedokeran Faculty studentsMethods : This study uses a descriptive observational design with cross sectional design in which the researcher will describe how the incidence of acne vulgaris, the severity of acne vulgaris and the factors that influence acne vulgaris, especially regarding saturated fat consumption in excess cheese in Diponegoro University Medical School students. Samples were taken by purposive sampling to produce 40 students who met the inclusion and exclusion criteria. Assessment is assessed by filling out questionnaires suffering from acne vulgaris and assessing acne vulgaris in respondents. Analysis of the data used in the study is an analysis with the Chi Square test. Result : In conclusion, clustered pimples are a dominant factor in the assessment of acne (p<0,05). Conclusion: In this study it was found that there was no significant relationship between cheese consumption with the severity of acne vulgaris and pimples arising from acne is acne that occurred before the existence of this studyKeywords : acne vulgaris, fat, cheese
Cover-Daftar isi DMJ Maret 2020 cover cover
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (460.858 KB) | DOI: 10.14710/dmj.v9i2.27150

Abstract

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