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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 651 Documents
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Relationship between BMI and Urine pH in Nephrolithiasis Cases in Indonesia Abdurrahman, Fauzan; Tjahjodjati, Tjahjodjati
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3755

Abstract

In nephrolithiasis/urolithiasis, urine pH is thought to modulate kidney stone formation at various stages, including crystallization, growth, aggregation, and retention. Moreover, numerous studies have demonstrated that an increase in Body Mass Index (BMI) correlates with a decrease in urine pH. This study aimed to determine the relationship between BMI and urine pH in cases of nephrolithiasis at Dr. Hasan Sadikin General Hospital Bandung. This was analytical observational study with a cross-sectional design, followed by correlation analysis is carried out. A total of 100 patients from January 2021 to December 2022 have met the inclusion criteria. From the results of the analysis, it was discovered that of the 21 patients with acidic urine pH, 42.11% had normal BMI, 26.32% were grade 1 obese, 15.79% were grade 2 obese, 10.53% were overweight, and 5.26% were underweight. The majority of patients who had normal urine pH also had a normal BMI (34.18%), followed by 30.38% with grade 1 obesity, 21.52% with grade 1 obesity, and 13.92% with grade 2 obesity. Of the 2 patients with  alkaline urine pH, one person had a normal BMI and another had an overweight BMI. The results of the chi-square test presented a p value of >0.05, thus no significant relationship is observed between urine pH and BMI in nephrolithiasis patients.
Characteristics and Therapy of Patients with Bartholin's Cysts in An Indonesian Tertiary Hospital Djusad, Suskhan; Putra, Dafnil Akhir
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3705

Abstract

A blocked duct of the Bartholin gland causes mucus accumulation and a fluid-filled sac, i.e., a Bartholin cyst, that can develop into an abscess when infected. This study specifically explored the characteristics and treatment Bartholin cysts or abscesses in patients registered at the obstetrics and gynecology clinic of Dr. Cipto Mangunkusumo National General Hospital, a tertiary hospital in Indonesia. This retrospective and descriptive study utilized data from patients registered at the hospital from July 2021 to July 2023. Bartholin cysts were found to be more common in patients aged 40 to 45 (57.1%) with a non-working status (71.4%), and  married (90.5%). Cysts were found to be 1 to 3 cm in size (52.4%) and occured unilaterally (95.2%). Four of the fourteen patients complained of recurring Bartholin cysts. On history and clinical examinations, 20 (95.2%) patients reported the presence of lumps. Antibiotics were the most commonly used treatment, with 15 of 21 Bartholin cyst patients (71.4%) receiving them. Obtaining data on the demographic of patient characteristics is essential when providing appropriate health care. Clinical considerations such as cyst size, patient age, symptoms, and history of recurrent Bartholin cysts or abscesses influence the choice of comprehensive medical and surgical management.
Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma Dewi, Yussy Afriani; Nazar, Ifiq; Farida, Anis
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3729

Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) ranks among the seven most prevalent malignancies globally, associated with significant morbidity and mortality rates. The key risk factors for this malignancy include chronic alcohol consumption, tobacco use, immunosuppression, and infections with oncogenic viruses such as high-risk Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV). This study was a retrospective analysis of HNSCC patients seen at an oncology clinic over a five-year period from January 2015 to December 2020, focusing on the environmental and genetic factors contributing to the disease. A cohort of 1,640 patients was analyzed, assessing their risk factors and diagnostic outcomes. Results indicated that smoking and alcohol consumption were the most significant independent risk factors, displaying a synergistic effect in disease progression. Other variables explored were exposure to air pollution, HPV and EBV infections, age, dietary deficiencies in vegetables, and genetic predispositions. While some factors were statistically significant, others showed weaker associations. This study highlights the importance of preventive strategies focusing on modifiable risk factors, such as lifestyle changes and viral vaccination, to reduce the incidence of HNSCC.
A Case Study on Neurological Outcome in Persistent Neonatal Hypoglycemia in Upper Middle-Income Country Primadi, Aris; Yuniati, Tetty; Aprilia Kadi, Fiva; Reviyani Suryaningrat, Filla; Hudayari, Devatri; Ediwan, Natasha Amalda
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3350

Abstract

In Indonesia, comprehensive management and monitoring of persistent neonatal hypoglycemia, is rarely reported. Despite the fact that there are studies highlighting the risk of neurodevelopmental disorders in neonates with hypoglycemia, there seems to be limited comprehensive case reports detailing both the early diagnosis and the long-term growth and development monitoring in these neonates. A unique case report of a 10-day-old male baby, born at a term weeks gestation via caesarean section, diagnosed with persistent hypoglycemia and suspect of hyperinsulinemia is presented in this study. At birth, the neonate exhibited hypoglycemia with a blood glucose level of 25 mg/dL, accompanied by a one-minute seizure characterized by upward gaze and stiffening of the extremities. The neonate cried after seizure and there was no loss of consciousness and was admitted to the NICU due to worsening respiratory distress. Based on the thoracic X-ray examination, he was diagnosed with transient tachypnea of newborn (TTN). Blood glucose levels were monitored every four hours, and tests for cortisol, thyroid and growth hormone and routine urinalysis were planned. Total parenteral nutrition (TPN) were given with intravenous antibiotics. At 6months of age, the infant was diagnosed with intellectual disability by the growth and development social pediatric unit. At 7 months, the infant  began undergoing physiotherapy. This case was followed for 7 months in total and the findings highlight the challenges in managing neonatal persistent hypoglycemia and the potential long-term developmental implications in neonates with early-life hypoglycemia, emphasizing the need for continual growth and development monitoring.
Effectivity of Carrot (Daucus carota) Seed Oil as Hair Growth Promoter on Rats (Rattus novergicus) Andriyanto, Andriyanto; Aurelia, Sharon; Zylviana, Tengku; Natalie, Gabriela; Putra, Hamdika Yendri
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3634

Abstract

Hair quality and health are important not only for the esthetical reasons but also to maintained the hair’s function in protecting the head. Carrot seed oil (CSO) is rich in vitamin A and beta-carotene, which influence hair quality. CSO also contains carotol, which has anti-fungal properties that treat dandruff. This research aimed to observe the potential of CSO as a hair growth promoter. Twenty male rats were used in the study, with their backs shaved and divided into two areas, each with different frequencies of CSO application. The backs of the rats were given CSO every day for 14 consecutive days with different concentrations, i.e., 25%, 50%, and 75%. Hair growth  was assessed based on its length, root, shaft, and tip thickness on days 9,12, and 14 and the results were recorded. On day 15, the rats were euthanized and their skin was collected to observe the number of follicles. Results showed that the application of CSO with different concentrations had no effect on hair length growth but it did affect the thickness of the root, shaft, and tip of the hair, with the best concentration being 75%. The frequency of application did not seem to affect the growth in terms of the length or thickness of the root, shaft, and tip of the hair; however, the application of CSO with 75% concentration and an application frequency of once a day produced the best amount of follicle regeneration.
Survival Analysis of Trabeculectomy and Phacotrabeculectomy in Primary Angle Closure Glaucoma Gustianty, Elsa; Shalim, Nikho Melga; Virgana, Rova; Prahasta, Andika; Rifada, R. Maula; Umbara, Sonie
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3594

Abstract

Glaucoma is the global leading cause of irreversible blindness. Primary angle closure glaucoma occurs most frequently in Asian populations, including in Indonesian population. Surgical management of Primary Angle Closure Glaucoma (PACG) includes cataract extraction, trabeculectomy, or combined phacotrabeculectomy. Many patients presented in the advanced stages of the disease with significant cataracts, requiring combined surgery. This study aimed to determine whether trabeculectomy alone was better in reducing intraocular pressure compared to phacotrabeculectomy in primary angle closure glaucoma. This was an analytic retrospective observational study reviewing medical records of  PACG patients underwent trabeculectomy or phacotrabeculectomy from January to December 2015, within a 5-year follow-up period of a tertiary eye hospital. The success rates of the two groups were assessed with Kaplan-Meier survival analysis. Success criteria were defined as > 20% reduction of IOP or  IOP <21 mmHg with or without medication. Results showed 104 and 41 eyes underwent trabeculectomy and  phacotrabeculectomy, respectively. The cumulative 5-year survival rate in trabeculectomy group was 58.6%, and 85.4% in phaco trabeculectomy. There was no statistical difference in the success rate between the trabeculectomy and phaco trabeculectomy groups (p=0.102). Postoperative complications observed in the phacotrabeculectomy group were one choroidal detachment,  one malignant glaucoma, and one vitreous prolapse. Thus, the cumulative success rate of phacotrabeculectomy was better than trabeculectomy after 5 years of follow up, albeit not statistically significant.
Differences in Elastin and Collagen Levels in the Levator Ani Muscle of Primiparous and Multiparous Normal Postpartum Women Rada, Annisa Astika; Rahajeng, Rahajeng; Dwijayasa, Pande Made; Gunawan, Didik Agus
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3694

Abstract

The levator ani, comprising the pubococcygeus, puborectalis, and iliococcygeus muscles, is crucial for supporting pelvic organs, maintaining continence, and ensuring pelvic stability. Weaknesses in these muscles or ligaments can lead to pelvic organ prolapse (POP), a condition where the pelvic organs descend and protrude through the vaginal introitus. Collagen and elastin, the key constituents of the extracellular matrix in the levator ani muscle, play a significant role in maintaining its structural integrity and can be influenced by parity. This study aimed to determine the differences in elastin and collagen levels of the levator ani muscle of primiparous and multiparous patients. This was an observational analytical study on 18 postpartum female patients consisting of 9 primiparous and 9 multiparous in January-March 2023. Samples were levator ani muscle biopsies from perineal lacerations of at least grade II from the inpatient Obgyn Department of the Faculty of Medicine, Universitas Brawijaya. Examination was done using the immunohistochemical method. Results showed that the percentage of histological area secreting elastin and collagen was higher in the primiparous group than multiparous, thus the levels were higher (p<0.001; p=0.001; p<0.05). In conclusion, elastin and collagen levels were lower in multiparous women compared to primiparous women. Future studies can evaluate factors affecting the decline in elastin and collagen in multiparous women using a larger sample size.
Vitamin D Supplementation and Colorectal Cancer Patients Outcomes Mulyadi, Noeray Pratiwi; Rudiman, Reno; Purnama, Andriana
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3823

Abstract

Colorectal cancer is the third most encountered malignancy worldwide in 2018. Some earlier studies indicate a significant influence of vitamin D supplementation on the 5-year survival rate and the rate of metastasis progression in colorectal cancer patients. Studies investigating the effects of vitamin D supplementation on the outcomes of colorectal cancer patients are limited in Indonesia. Therefore, a double-blinded Randomized Controlled Trial (RCT) of the effect of vitamin D supplementation on the outcome of colorectal cancer patients was conducted from April 2022 to March 2023 at the digestive surgery outpatient clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. In this study, 36 patients received vitamin D and 34 patients received a placebo. Data analysis performed using the multivariate analysis with multiple regression revealed no significant relationship between vitamin D supplementation and colorectal cancer patient outcomes. Furthermore, ANOVA analysis indicated no relationship between the analyzed independent and dependent variables in this study.  No relationship was found between vitamin D supplementation and the outcomes of metastasis, mortality, and Karnofsky scores in colorectal cancer patients. Further research with a larger population is still needed to determine the benefits of vitamin D supplementation on the outcomes of colorectal cancer patients.
Front Cover, Editorial Team, Table of Contents, and Back Cover back, front
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Effect of Curcumin on Nitric Oxide and Endothelin-1 Levels in L-NAME-Induced Preeclamptic Wistar Rat Rahardjo, Bambang; Dewi, Ratih Frastika; Wiyasa, I Wayan Arsana; Handayani, Puspita; Prasetyorini, Nugrahanti; Wibisono, Hermawan
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3700

Abstract

Preeclampsia is a pregnancy disorder marked by the onset of hypertension after the 20th week, posing risks such as cardiovascular disease. Curcumin, a commonly consumed herbal medicine, has been investigated as a potential antihypertensive agent in mouse models of preeclampsia. This study took place in the Bioscience Laboratory of Universitas Brawijaya from March to August 2023, employing a true experimental design with various groups of mice receiving different treatments. Nitric oxide (NO) and endothelin-1 (ET-1) levels were measured using calorimetry and ELISA. The rats were divided into five groups: positive control, negative control and P1, P2, and P3 as the treatment groups. Treatment grups received fifferent curcumin doses of 30mg/kgBW/day, 50mg/kgBW/day, and 100mg/kgBW/day for P1, P2, and P3, respectively. Data analysis using the One-Way ANOVA and Post Hoc LSD revealed that curcumin at 100mg/kgBW/day significantly increased the NO level of 47.75±22.6 and decreased the ET-1 level of 67.03±24.47 when compared to the positive control (p<0.05). However, the 30mg/kgBW/day and 50mg/kgBW/day doses did not significantly affect the NO and ET levels. In conclusion, curcumin supplementation shows positive effects on NO and ET-1 levels in L-NAME-induced preeclamptic Wistar rats, highlighting its potential as an effective intervention for managing this pregnancy-related disorder.

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