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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Evaluation of sperm quality in male rats treated with Sauropus androgynus (L.) merr. leaf fractions Ni Putu Ermi Hikmawanti; Numlil Khaira Rusdi; Silvy Yulida
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sauropus androgynus (L.) Merr. or katuk is one of the medicinal plants broadly used in Indonesia as it has active compounds that can, among others, stimulate reproductive hormones. This study was aimed to determine which active fraction of S. androgynus leaves that have the potential to improve the sperm quality of male rats based on three parameters, namely sperm count, viability, and motility. It employed fractionation using the liquid-liquid technique with n-hexane, ethyl acetate, and water solvents to obtain the fractions. Twenty-four mature Sprague-Dawley male rats were divided into four equal groups: the normal group (untreated group) received 0.5% Na-CMC suspense, and the three fraction groups were given the n-hexane, ethyl acetate, and water fraction p.o., respectively, at the dose of 11.85 mg.Kg-1 BW daily for seven days. Sperm count, viability, and motility were measured on Day 8 (after treatment) from the sperm samples collected at the cauda epididymis of the sacrificed test rats. The results showed that compared with the normal group, the n-hexane and ethyl acetate fractions significantly increased the three parameters (p<0.05). Therefore, the S. androgynus leaf fractions have the potential as a natural material that can increase the fertility of male rats.Â

Effects of carbon and nitrogen sources on the antibacterial activity of Bacillus tequilensis BSM-F symbiotic with Halichondria panicea sponge from the Cabbiya Coast, Madura, Indonesia Achmad Toto Poernomo; Sonia Khoirun Nisa; Zahratus Silmi Aliyah; Isnaeni Isnaeni
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sponges form obligate symbiotic associations with antibiotic-producing microorganisms. Many factors, including climate change, anthropogenic pollution, introduced species, and nutrient enrichment, have all been linked to the specific character of marine-symbiotic microorganisms. This recent study investigated the effects of carbon and nitrogen sources on the antibacterial activity of Bacillus tequilensis BSM-F in solid fermentation media, Zobell Marine Agar (ZMA), ZMA was added with various carbon and nitrogen sources at different concentrations to evaluate the effect of enrichment media on the antibacterial activity. The carbon sources used were glucose, glycerol, lactose, and starch, while the nitrogen sources were beef extract, soybean meal, malt extract, and casein. Each of which was added to ZMA at 0.5%, 1%, 1.5%, and 2% w/v. The inhibitory activity was denoted as the activity index, i.e., the ratio of the diameter of zone of inhibition to the diameter of the bacterial colony. B. tequilensis BSM-F exhibited the highest inhibitory activity against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 when cultured in media containing glycerol and casein. The optimum condition was achieved when glycerol and casein were each added to ZMA at 1.5% w/v.

The effect of Zingiber cassumunar Roxb rhizome extract on in vitro phagocytic activity and lymphocyte proliferation Nurkhasanah Mahfudh; Nanik Sulistyani; Dinda Anindya Sabillah
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Zingiber cassumunar Roxb (bengle) is one of the plants with the potential as an immunomodulator. It contain curcumin and some volatile compounds which previously reported to be potential as immunomodulator. This study aims to examine and determine the effect of ethyl acetate fraction of bengle extract on phagocytic activity of macrophages and lymphocyte proliferation in vitro. The bengle rhizome is macerated with 96% etanol solvent and then followed by ethyl acetate fractionation. The macrophage and lymphocyte were used in this study was isolated from male Balb/C strain mice. The macrophage phagocytosis activity was carried out using latex bead assay, and lymphocyte proliferation assay was carried out using MTT assay method. The concentration of extract was used in this study were 25, 50 and 100 Î¼g/mL. The effect of treatment was compared to negative control group. Â The results showed that ethyl acetate fraction of bengle extract can increase the phagocytic activity of macrophages was shown by increasing of active phagocytes cells (SFA) and phagocytosis index. The highest percentage of SFA and phagocytic index results were shown at a concentration of 100 Î¼g/mL. The results showed that ethyl acetate fraction of bengle extract could increase lymphocyte proliferation significantly compare to the negative control (p<0.05). This study showed the potential of bengle as immunomodulatory agent.

Risk factors of adverse drug reactions of first-line antiretroviral therapy in HIV patients at RSUD Dr. Moewardi Ana Amalia; Fita Rahmawati
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acquired Immuno Deficiency Syndrome (AIDS) is an infection caused by the Human Immunodeficiency Virus (HIV). The antiretrovirals (ARVs) combination is the basis for the management of therapy in HIV/AIDS patients, but it often raises problems like adverse drug reactions (ADRs). This study was conducted to determine the risk factors for the occurrence of ADRs in the use of first-line ARVs. It employed a cross-sectional design with retrospective data collection in patients visiting the Voluntary Cell Counting (VCT) room of RSUD Dr. Moewardi in November-December 2018. The data collected were sociodemographic, behavioral, and clinical characteristics, laboratory test results, and ARV profiles. Findings show that the risk factors for ADRs in the use of first-line ARVs are CD4 of <200 and 0-24 months of taking ARVs.

Camellia sinensis extract phytosomes inhibit body weight gain in Sprague-Dawley rats Dwi Kurnia Putri; Iskandarsyah Iskandarsyah; Effionora Anwar
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

A phytosome is a kind of nanovesicle lipids to increase the absorption of active substances. Green tea extract was formulated into phytosome to find out its ability to inhibit weight gain. There were three formulas with thin layer hydration. Furthermore, phytosome complex formation, morphology, particle size, zeta potential, and polydispersity index, and absorption efficiency test were characterized. Phytosomes and green tea extracts were tested for absorption in vitro. A total of 25 rats were divided into five test groups, which were the normal group, placebo group, orlistat group, green tea extract group, and phytosome group. For 8 weeks they were orally induced using 10% of fructose + 2% of cholesterol, and test treatment. The best characteristics of FIII were formed complex, spherical morphology, Dv90 782.67 Â± 39.7 nm, polydispersity index of 56 Â± 0.11, zeta potential of -70.83 Â± 1.67 mV, and adsorption efficiency of 97.77 Â± 2.66 %. The test on the animals at week 8 resulted in percentage of weight gain in normal treatment of 46.47 Â± 17.48%, placebo of 101.17 Â± 10.37%, orlistat of 42.51 Â± 25.13%, green tea extract of 92.73 Â± 36.43%, and phytosomes of 45.09 Â± 15.56%. Green tea extract flux was 2316.2 Â± 1309.8 Î¼g/cm2/hour, while phytosome flux was 3125.3 Â± 2071.8 Î¼g /cm2/hour. To sum up, phytosomes can inhibit weight gain and are better than to green tea extracts (p < 0.05).

Anti-inflammation and anti-platelet aggregation activities of the ethanolic extract of Graptophyllum pictum leaves in Wistar rats Yulia Ratnasari; Susanti Susanti; Binar Asrining Dhiani
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Graptophyllum pictum is a well-known folk medicine in Indonesia. The red leaves are widely used for their anti-inflammatory properties to relieve hemorrhoids. However, little is known about to what extent these properties can affect platelet aggregation. This study was aimed to determine the anti-inflammation and anti-platelet aggregation activities of the ethanolic extract of Graptophyllum pictum (EEGP). Apart from the ear and hind-paw edema assay, anti-platelet aggregation and bleeding time assay were also performed on male Wistar rats. The test animals were grouped into six groups: three treatment groups termed EEGP100, EEGP600, and EEGP3000 (received 100, 600, and 3000 mg/kg BW of EEGP, respectively), one control-solvent group (1% CMC-Na), and two positive control groups (aspirin and Na-diclofenac). Based on the percentage of edema inhibition, absorbance change, and bleeding time, EEGP600 and EEGP3000 produced a comparable percentage of edema inhibition to that of Na-diclofenac, which was not found in EEGP100. Also, EEGP600 and EEGP3000, but not EEGP100, inhibited platelet aggregation as effective as aspirin (positive control). In conclusion, if administered at 600 and 3000 mg/kg BW, the ethanolic extract of Graptophyllum pictum can function as an anti-inflammatory agent that inhibits platelet aggregation.Â

Structure, activity, and drug-likeness of pure compounds of Sumatran lichen (Stereocaulon halei) for the targeted ACE2 protein in COVID-19 disease Purnawan Pontana Putra; Surya Sumantri Abdullah; Risma Rahmatunisa; Junaidin Junaidin; Friardi Ismed
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sumatran lichen has the potential as antiviral, pure isolates that have been isolated and developed as prospective compounds for COVID-19 treatment. Computational methods were used to accelerate the discovery and screening of potential new compounds. The molecular structures of the isolated compounds such as Lobarin, Atranorin, Methyl 2,4-dihydroxy-3,6-dimethylbenzoate, Methyl 3â€formylâ€2,4â€dihydroxyâ€6â€methylbenzoate, Ethyl 3-formyl-2,4-dihydroxy-6-methylbenzoate, and Lobaric acid were drawn, then their activities were analyzed, processed by docking with ACE2 protein, and tested for Druglikeness. The activities and druglikeness were determined in the Swiss ADME program, while the ACE2 docking was processed by Blind Docking in Arguslab, AutoDock Vina, Open Babel, and Discovery Studio Visualizer programs. All compounds bound to the ACE2 protein, as apparent from the number of hydrogen bonds between the two. The Gibbs free energy was in the range of -5.6 to -7.0, and the best one was obtained from atranorin. As for lobarin, this compound was found to be non-drug-like.

Antioxidant and antiaging activity of rutin and caffeic acid Ermi Girsang; I Nyoman Ehrich Lister; Chrismis Novalinda Ginting; Ika Adhani Sholihah; Martinus Ahmad Raif; Sidharta Kunardi; Hendy Million; Wahyu Widowati
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Aging is a complicated process occurring due to the combination of incremental alterations of the skin and accumulated extrinsic factors that causes both structural and functional disruptions. The extrinsic factor of skin aging is mostly caused by free radicals, UV exposures, and pollution. Prevention is possible by escalating antioxidant intake to scavenge ROS in the skin aging process. Rutin and caffeic acid are recognized for their free radical trapping effects and reported to have potential antiaging activities. This study aimed to identify the potentials of rutin and caffeic acid as antioxidant and antiaging. Rutin and caffeic acid were tested for their antioxidant properties using the DPPH, H2O2, ABTS radical scavenging, and FRAP assays. Meanwhile, their antiaging activities were examined by collagenase, elastase, hyaluronidase, and tyrosinase inhibitory assays. The study drew on the evidence of antioxidant and antiaging properties from the scavenging, ferric ion reducing, and inhibitory activities of rutin and caffeic acid (in ascending order): in scavenging DPPH free radicals (IC50 of rutin = 5.79 Âµg/mL, IC50 of caffeic acid = 8.72 Âµg/mL), scavenging H2O2 ( IC50 rutin = 12.09 Âµg/ml, IC50 caffeic acid = 15.23 Âµg/mL), reducing ABTS (IC50 caffeic acid = 6.23 Âµg/mL, IC50 rutin = 16.59 Âµg/mL), reducing ferric ions at 50 Âµg/mL (FRAP of rutin = 480.08 ÂµM Fe(II)/Âµg, FRAP of caffeic acid= 526.50 ÂµM Fe(II)/Âµg), inhibiting collagenase (IC50 caffeic acid = 74.42 Âµg/mL, IC50 rutin = 104.70 Âµg/mL), inhibiting elastase (IC50 rutin = 46.88 Âµg/mL, IC50 caffeic acid = 76.95 Âµg/mL), inhibiting tyrosinase (IC50 rutin = 55.65 Âµg/mL, IC50 caffeic acid = 145.91 Âµg/mL), and inhibiting hyaluronidase (IC50 rutin = 114.07 Âµg/mL, IC50 caffeic acid= 244.45 Âµg/mL). Rutin and caffeic acid have the potentials as antiaging and antioxidant.

The relationship between NFÎºÎ²-p65 and PGE2 gene expression in osteoarthritis synoviocyte cells after mesenchymal stem cell Wharton Jelly Treatment Vivi Sofia
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The genes involved in cartilage degradation in the pathogenesis of osteoarthritis ( OA) are the Nuclear Factor Kappa Beta (NFÄ¸Î²) gene, which plays a vital role in modulating cartilage damage involving activation of pro-inflammatory cytokines, including prostaglandin E2 (PGE2). This pure experimental research aimed at analyzing the relationship between the expression of NFÄ¸Î² genes after administration of mesenchymal stem cells in osteoarthritis synoviocytes in vitro from Wharton's Jelly (WJ-MSCs). The samples were isolated from synovial tissues of patients with osteoarthritis who underwent Total Knee Replacement (TKR) surgery and then divided into six treatment groups, each with four replicates. Groups I and II were the synoviocyte-control classes of 24h and 48h (synoviocytes, incubated for 24 and 48 hours respectively). Groups III and IV were control groups of 24h and 48h WJ-MSCs (mesenchymal stem cells derived from the Wharton's Jelly, incubated for 24 and 48 hours respectively). Finally, Groups V and VI were the 24-hour and 48-hour co-cultural treatment groups (synoviocyte co-culture and WJ-MSCs, Incubated, for 24 and 48 hours respectively). Using qPCR, PGE2 gene and NF NFÎºÎ² gene expressions were observed in each population. Tests showed 0.61 and 0.61, respectively, after the administration of WJ-MSCs, the expressions of the NFÎºÎ²-p65 and PGE2 genes in the 24h classes. In the 48h group, meanwhile, both numbers fell to 0.15 and 0.47, respectively. These indicate a strong correlation between the NFÎºÎ²-p65 gene and PGE2 gene expressions in OA synovial cells after the administration of MSC-WJ (r = 0.903).

Effect of virgin coconut oil (VCO) on the physical stability of sweet potato leaf extract (Ipomoea batatas (L.) Lam) creams and antibacterial activity test against Staphylococcus aureus ATCC 25923 Mauritz Pandapotan Marpaung; Dani Prasetyo
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

VCO (virgin coconut oil) has benefits for skin health such as softening the skin, maintaining skin health, and protecting the skin from radiation and free radicals. VCO as one of the raw materials for making cream preparations can affect its physical stability. This study aimed to analyze the effect of VCO on the physical stability of sweet potato leaf extract creams and antibacterial activity test against Staphylococcus aureus ATCC 25923. The creams were made with five formulas namely base, extract cream 2%, and VCO 1%, 3%, 5% added to the extract cream 2% respectively. Physical stability test included storage for six weeks at room temperature. Stability parameters were organoleptic observation, homogeneity, pH, spreadability, adhesivity, and cream type. Statistical analysis was carried out with the Anova and Kruskal Wallis tests. The organoleptic test results of the cream extract showed a distinctive odor, green color, with semisolid and homogeneous texture. Increasing the concentration of VCO will increase the spreadability of extract cream but did not affect pH and adhesion. The conclusion of this study was that extract cream 2% without the addition of VCO was the most stable cream formulation. Besides that, all the cream formulas did not show antibacterial activity against Staphylococcus aureus ATCC 25923.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA