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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 808 Documents
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Combination of Spirulina platensis powder and Stichopus variegatus powder against Bcl2 expression in the hippocampus of dementia Rats Lisa Agustina Botutihe; Rizka Safira; Sapto Yuliani; Kintoko Kintoko
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.26205

Abstract

Spirulina (Spirulina platensis) and golden sea cucumber (Stichopus variegatus) are known to have antioxidant activity that has the potential to prevent neurodegeneration disease. The aim of this study was to examine the effect of the combination of spirulina and golden sea cucumber on Bcl2 gene expression in pyramidal hippocampus cells of trimethyltin-induced dementia (TMT) rats. The study used Sprague Dawley rats  which were divided into 6 groups, namely the normal control group (CMC-Na and NaCl 0.9%), pain control (CMC-Na and TMT), positive control (citicoline dose 200 mg / kg and TMT) and test control injected with TMT and given a combination of spirulina and golden sea cucumber dose 200 mg/KgBB with three ratios namely 3: 1, 1: 1 and 1: 3. Extract and citicoline were given on day 1 to day 28, while TMT injection was given a single dose of 8 mg/KgBB on day 8. On the 36th day the rats were sacrificed, brains were removed and the right hemispherium cerebri was fed to 10% formalin in pbs. After 6 days the hippocampus was separated for immunohistochemical observation. The test result data was statistically analyzed with a one-way ANOVA test then followed by post hoc tukey to see the differences between groups. Results showed the combination of spirulina and golden sea cucumber can increase the expression of the Bcl2 gene in the hippocampus. The combination of spirulina and golden sea cucumber (ST1: 3) dose of 200 mg / kg body weight was able to increase hippocampus Bcl2 expression with the number of Bcl2 cell expression almost the same as citicoline in both CA1 and CA2-CA3 regions.
The Citrus sinensis peel extract’s increase HDL and reduce LDL levels in cigarette smoke-induced Rats Ika Setyawati; Armellia Sandra Tamara
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.15927

Abstract

Background: Cigarette smoke contains various oxidative substances that can cause oxidative stress and can cause changes in the lipid profile especially in HDL and LDL. Oxidative stress changes can be inhibited by the administration of antioxidants from sweet orange peel which is expected to improve lipid profile. Objective: to find out the effect of sweet orange extract on changes in HDL and LDL levels.Method: Experimental research with pre and posttest group control design. The subjects were 25 white rats (Rattus novergicus) divided into five groups: negative, positive, dose 1 (37,5 mg / kgBW), dose 2 (75 mg / kgBW) and dose 3 (112,5 mg / KgBW) with each group consisting of 5 rats.Results: Statistic analysis of pretest and posttest HLD and LDL levels showed different mean (p = 0,043) for all groups. The highest difference in HDL levels was in the positive control group (37.55 mg / dL) and the lowest in the negative control group (2.66 mg / dL). The highest difference of LDL level was in positive control group (53,57 mg / dL) and lowest in negative control group (3,26 mg / dL). Conclusion: The results of this study can be concluded that the administration of sweet orange peel extract (Citrus sinensis) can inhibit the decrease in HDL cholesterol and increased levels of LDL in white rats (Rattus novergicus) induced by cigarette smoke.
Medication-related burden of chronic renal failure patients at regional general hospital Sleman Yogyakarta Woro Supadmi; Elinda Fitriana; Muhammad Muhlis
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27646

Abstract

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Development of detection method for carcinogenic compounds using radish seeds Raphanus sativus, L via measuring the alkaline phosphatase enzyme activity Nuri Ari Efiana; Mulyadi Mulyadi; Annas Binarjo
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27733

Abstract

Convincing data regarding carcinogenic substances is very useful for handling materials correctly to avoid exposure to cancer-triggering substances in the body. To collect as much carcinogen data as possible, low-requirement carcinogen detection setups need to be developed. In this study, the first steps in the development of carcinogen detection through functional protein expression assessment are reported. Hydrazine sulfate, one of the well-known carcinogens chosen as a model material, was tested on germinating seeds of Raphanus sativus, L, with various concentrations, namely 0 (control), 1 mM, 10 mM, and 100 mM. Within a predetermined germination time, seeds and/or sprouts were observed and germination rate, protein concentration, and alkaline phosphatase activity were measured. The results showed that hydrazine sulfate slowed seed germination, and increased 72-h protein concentration but decreased alkaline phosphatase activity in the control group. This suggests that changes in alkaline phosphatase activity in seeds during germination have the potential to be a marker for cancer. In this research, it can be concluded that the method used can be applied as a first step to prove the carcinogenicity of a compound.
The quality of life of hemodialysis patients in Yogyakarta, Indonesia Siswandi Siswandi; Dyah Aryani Perwitasari; Lamhot B Simanjuntak; Gugun Suhendra; Dewi Wulandari; Haafizah Dania; Imaniar Noor Faridah; Adnan Adnan
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.28449

Abstract

The assessment of quality of life serves as a critical evaluation of the effectiveness of the administered hemodialysis treatment. The measurement of quality of life can be conducted using the Kidney Disease Quality of Life Short Form (KDQoL-SF™) questionnaire. This research aims to gather information concerning the quality of life among patients with hemodialysis due to chronic kidney failure at the dr. S. Hardjolukito Regional Military Hospital in Yogyakarta. The research employed a cross-sectional design. The respondents consisted of 65 patients selected through purposive sampling based on specific inclusion and exclusion criteria. The Independent T-test, Mann-Whitney test, Chi-Square test and Fischer test were conducted to define the association between quality of life and respondent characteristics. Most of the hemodialysis patients was male (50.8%) with average od age was 54.66 years old. The findings revealed that 64.6% of the respondents experienced moderate/poor quality of life, while 35.4% exhibited good quality of life. Statistical analysis established a significant relationship between respondent characteristics and quality of life based on the variables of age and duration of hemodialysis (p<0.05). Hemoglobin levels, number of prescribed medications, gender, education, occupation and income demonstrated no significant relationship with the quality of life. Among the respondents’ characteristics, age and duration of hemodialysis were associated with the quality of life.
EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4 Adikusuma, Wirawan; Bachri, Moch. Saiful
Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v4i2.1574

Abstract

This study was designed to evaluate the hepatoprotective effect of the powder Eurycomalongifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twentyfive male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept asnormal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV weretreated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectivelyand CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BWp.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination ofSGPT-SGOT. The study showed the activity level of SGPT from the rats was treated byEurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groupsare 150.0±5.099 U/L; 113.6±5.508 U/L; 60.5±2.887 U/L; and 129.0±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4±11.165;263.0±1.803; 194.5±7.448; and 451.5±16.759 U/L respectively. The Eurycoma longifoliaJack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)than control group. The results concluded that Eurycoma longifolia Jack. powder hashepatoprotective effect.
Phytochemical and antibacterial analyses of essential oils extracted from the leaves of Euodia suaveolens scheff Sidharta, Boy Rahardjo; Atmodjo, Patricius Kianto
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.25827

Abstract

Euodia suaveolens is one of the plants that ancient people in Indonesia used due to its manifold benefits. Earlier research on this plant was mostly done on its potency as a mosquito repellent. This present study aims to determine the phytochemical and antibacterial analyses of the essential oils (EOs) extracted from the leaves of E. suaveolens. The EOs of the leaves of E. suaveolens were extracted by steam distillation method and were analyzed phytochemically utilizing the GC-MS technique to determine the chemical constituents. The chemical components were tested on four pathogenic bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis utilizing the diffusion agar method. The results showed that the main compounds extracted from the EOs were delta curcumene, evodone, globulol, limonene, linalool, longipinenepoxide, menthofuran, and p-mentha-1,8-diene. The antibacterial analysis of these compounds showed potential activities to inhibit the growth of four pathogenic bacteria tested, but the inhibition zones formed were still lower compared to commercial antibiotic kanamycin. E. suaveolens EOs exhibited diameter of zone of inhibition as follows 2.03 plus minus 0.22, 0.50 plus minus 0.49, 1.38 plus minus 0.10, 1.40 plus minus 0.27 cm to E. coli, P. aeruginosa, S. aureus, and S. epidermidis while kanamycin showed 3.43 plus minus 0.08, 3.25 plus minus 0.08, 3.38 plus minus 0.12, and 3.18 plus minus 0.24 cm respectively. These results recommend that the main compounds extracted from the EOs of the leaves of E. suaveolens be explored further to determine their potencies as new antibiotic medications. 
Antibacterial activity of guava leaf ethanolic extract (Psidium guajava L.) nanosuspension against Escherichia coli bacteria Nurdianti, Lusi; Yuliana, Anna; Raras, Euis; Setiawan, Fajar; Wulandari, Winda Trisna; Firmansya, Ardianes
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.26359

Abstract

Diarrhea is a condition where a person has bowel movements three or more times a day, with consistent stools. One of the common bacteria that causes diarrhea is Escherichia coli. Empirical and preclinical studies have demonstrated the effectiveness of guava leaves (Psidium guajava L.) in treating diarrhea due to their tannin content. Nanosuspension formulations can be created to simplify the use of guava leaves for medicinal purposes. This study aims to investigate the efficacy of guava leaf extract, both in its natural form and as a nanosuspension preparation, against Escherichia coli. Additionally, the study aims to characterize the guava leaf extract nanosuspension used in the experiment. The technique used to make nanosuspension involves ionic gelation methods by using chitosan as a polymer, and subsequent characterization of the resulting product includes organoleptic testing, specific weight, pH, sedimentation volume, and viscosity. After the characterization of the guava leaf nanosuspension, it was found that the optimal formula had a particle size of 245.7 nm at a concentration of 0.01%, a polydispersion index of 0.406, and a zeta potential of +26.9 mV. Guava leaf ethanol extract 1% has a diameter of the inhibitory zone of 4.05±0.45 mm. However, the nanosuspension form of P. guajava L at a concentration of 0.01% has an inhibitory zone diameter of 11.45±0.64 mm. The nanosuspension formulation using P. guajava L has met the evaluation requirements and has antibacterial activity against E. coli bacteria.
The effect of syrup simplex concentration on the physicochemical stability of Gembili’s inulin (Dioscorea esculenta (Lour.) Burkill) nanosilver colloid Ermawati, Dian Eka; Hanuriansyah, Yavi
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.26569

Abstract

Gembili tuber's inulin is a successful bioreductor agent that forms a nanosilver with a size of 481.4 nm and is stable for 30 days at 4 °C storage. That nanosilver has immunomodulatory activity and is proven safe from the results of acute toxicity tests at a dose of 4 mg/kgBB. However, a drug delivery system is needed to be developed as a supplement product. The syrup was chosen because it is free of alcohol, has a better taste, measured dose, and stability of the active substance compared to elixir, solution, and suspension. Simplex syrup as a syrup base affects stability because it has the potential to form crystals during storage. This research aims to determine the effect of simplex syrup concentration on the stability of nanosilver syrup. The research was conducted with the biosynthesis process using gembili's inulin, nanosilver characteristic, modified syrup formula, and stability test. Nanosilver syrup was prepared by modifying the simplex syrup concentration of 20%, 40%, and 60%. Nanosilver was added at 4 mg/KB b.w, then tested the physicochemical; stability, including organoleptic, pH, and viscosity, before and after storage with temperature variations of 4 °C and 40 °C for six cycles. The best formula then analysis of sugar reduction content and FT-IR. Data analysis using SPSS 21.0 Windows with One-way ANOVA test, Post Hoc, and Paired T-Test. The results showed that the concentration of simplex syrup affected consistency, pH, and viscosity. The simplex syrup concentration of 60% met the requirement with a medium thick consistency, pH 5.25±0.03, a viscosity of 92±2.6 cps, reducing sugar content was 20.59% ±0.002, and the FTIR profile showed that it still contained nanosilver which was indicated by the presence of Ag-N groups compared to silver nitrate solution.
Immunomodulator Effect of Cnidoscolus aconitifolius Leaves Extract on CD4+ and CD8+ Expression in Salmonella typhimurium infected mice Hidayati, Sholihatil; Susanti, Dhina Ayu; Destiawan, Rian Anggia; Muflihah, Ahdiah Imroatul; Handayani, Rizka; Anggitasari, Wima
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27050

Abstract

Typhoid fever is a common health problem in the community caused by Salmonella bacteria. The incidence rate of this infection will increase if a person's immune system is weakened. Plant extracts are generally considered to be potential immunomodulatory agents developed, which have smaller side effects. Research shows that Cnidoscolus aconitifolius leaves have medicinal properties including as hepatoprotective, antidiabetic, and anticardiovascular. The results of the antioxidant activity test show the results that Cnidoscolus aconitifolius leaves extract (CAE) has potential as an antioxidant with a very strong category. This study was conducted to determine the effect of giving Japanese papaya leaf extract on CD4+ and CD8+ expression in Babl/c mice induced by Salmonella typhimurium bacteria. The study was started by preparing 70% ethanol extract from Cnidoscolus aconitifolius leaves and preparing 30 Babl/C mice as experimental animals which were divided into 6 groups (healthy control, negative control, positive control and treatment group by giving CAE dose of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw). Induction was carried out by oral infection with Salmonella thypimurium bacteria. After 3 days the infected mice were treated orally once a day for 7 days. Evaluation of CD4+ and CD8+ expression was carried out using the flowcytometer method of the lymph organs. Data analysis was carried out by the Anova test followed by the post hoc test (Tukey) using the SPSS for Windows application. The results showed that giving CAE at doses of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw could increase the expression ratio of CD4+ and CD8+, whereas giving CAE at a dose of 400 mg/kgbw showed significantly different results (p<0.05) to the negative control. This shows that the CAE has potential as an immunomodulatory agent that can improve immune function.

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