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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 808 Documents
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Development of standardized kaffir lime fruit peel extract as a gel for antioxidant and anti-acne Darsono, Farida Lanawati; Soegianto, Lisa; Jessica, Maria Anabella
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27076

Abstract

This study aimed to determine the effect of increasing the concentration of the condensed extract of kaffir lime fruit peel in a gel dosage form on its physical quality and effectiveness. The condensed extract was obtained by maceration with 95% ethanol as a solvent. The dosage form chosen is a hydrophilic-based gel with a modification of the addition of a penetrant enhancer (IPM) and a solubilizer (Glycerin). The concentration of the condensed extract of kaffir lime fruit peel used were F1 (10%), F2 (15%), and F3 (20%). Gel preparations were tested for physical quality and effectiveness, consisting of antioxidant activity (IC50) and antibacterial (Zone Inhibition). Furthermore, the One Way ANOVA statistical method will analyze data from parametric experiments between batches and between formulas. If there is a significant difference in the statistical analysis between the formulas, then the test is continued using the Tukey Post-Hoc test method. The experimental results showed that increasing the concentration of kaffir lime peel extract (Citrus hystrix) affected the pH value, viscosity, dispersion, and effectiveness as an anti- acne and antioxidant. It was concluded that the anti-acne gel of extract F1, F2, and F3 were physically stable during storage, and based on the physical quality and effectiveness test it was known that F3 had the greatest zone inhibition (ZI): 13.87 ± 0.18 mm and IC50 :14.9049 mg/mL
The Optimation of Fermentation Time, Antibacterial Activity and Profiling Secondary Metabolite of Symbiont Fungi from Sponge Gelliodes fibulata Rusmalina, Siska; Mahfur, Mahfur; Hasanah, Nunung; Wiyono, Mochamad Ardy; Ekayanti, Nonik Nur; Nathania, Jacinda Caroline
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27137

Abstract

Symbiont fungi are organisms that live in sponges tissue. Sponges are known to contain many metabolites which have the potential to be used as raw materials for medicine. Sponge Gelliodes fibulata is belongs to category demospongiae. The purpose of this study was to determine the optimal time to obtain the best secondary metabolite profile results in the sponge symbiont fungus Gelliodes fibulata. This research is included in experimental research. Beginning with the fungi culture of the sponge Gelliodes fibulata. Followed by a fermentation process with variations in time 2, 4, 6, 8, 10, 12, and 14 days to get the secondary metabolites produced. A liquid extraction process is carried out to obtain secondary metabolites produced during fermentation. The final stage is to carry out qualitative analysis with TLC and antibacterial testing with the well-diffusion method. The results obtained show that the long fermentation time influences the secondary metabolites obtained, and the metabolites possessed influence their antibacterial activity. The profile of secondary metabolites from TLC showed that the 10th day of fermentation had the most complex secondary metabolites and the highest yield 0.086%. The results of antibacterial activity showed that the 10th day of fermentation had the largest inhibition zone with 7.75 ± 0.44 mm compared to the other days of fermentation.
Ethanol-based solvent system for recovery antioxidant activity Centella asiatica L. Urban and its application in sleep-deprived Rats Wardatun, Sri; Sofihidayati, Trirakhma; Afifah, Nida; Juhroh, Juju
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27277

Abstract

Antioxidants have the ability to eliminate free radicals by donating electrons to oxidants. Preclinical and clinical studies show that Centella asiatica L. Urban has antioxidant activity. Ethanol was the best solvent for extracted antioxidant compounds from Centella asiatica L. Urban. The concentration of ethanol solvents effect to the compounds extracted and its antioxidant activities. The objective of study to determine ethanol based solvent systems for best recovery of antioxidant activities and in vivo antioxidant activity of the most active extract using stress induced sleep-deprived rats with glutathione (GSH) concentration parameters. Ethanol based solvent system show different recovery antioxidant activity of Centella asiatica L. Urban. Ethanol 70% had the highest recovery of antioxidant activity with an IC50 value of 76.76 ppm. Ethanol 70% Centella asiatica L. Urban extract given in sleep-deprived rats at 300 mg/kg were not significantly different in glutathione levels from those group rats that received the positive control solution (ascorbic acid). The 70% ethanol extract of C. asiatica L. Urban has the potential to ameliorate the stress induced by sleep deprivation.
Study of kinetic and adsorption isotherm of ibuprofen on mcm-41 synthesized with rice husk Hartono, Olyvia Azzahra Putri; Purnomo, Frida Octavia; Waluyo, Dyah Ayuwati; Alam, Tunas; Madiabu, Mohammad Jihad
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27393

Abstract

Rice husk is one of the abundant wastes, especially in agricultural countries. Rice husk waste has asilica content of 95.80%, where the silica content can be utilized to make an adsorbent. One of theadsorbents that can be made is Mobil Composition of Matter 41 (MCM-41), a material with ahexagonal structure with a surface area to adsorb ibuprofen. Based on the results of the research thathas been done, MCM-41 synthesized with rice husk has the same characterization results as MCM-41synthesized with commercial materials tetraethyl orthosilicate (TEOS). Fourier Transform InfraredSpectroscopy (FTIR) characterization results show the absorption peak is at wave number 1068.58 cm1 which shows asymmetric Si-O-Si stretching vibrations and at 799.60 cm-1region is symmetric Si-OSi stretching vibrations. X-ray diffraction (XRD) characterization results show an hexagonal crystalform at 20 = 20o-30o. Scanning Electron Microscope (SEM) characterization results show particle of2,664 um. Based on the results of the research that has been done MCM-41 synthesized from rice huskcan adsorb ibuprofen with Langmuir isotherm approach and Pseudo Second Order kinetics, and themaximum adsorbing capacity is 34.48 mg/g
Medication-related burden of chronic renal failure patients at regional general hospital Sleman Yogyakarta Supadmi, Woro; Fitriana, Elinda; Muhlis, Muhammad
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27646

Abstract

Patients with chronic renal failure must undergo lifelong treatment. The condition raises treatment-related responsibilities and may affect their treatment adhesion. The aim of this study was to determine the correlation between the burden of medication and the level of medication adherence among chronic kidney failure patients at Sleman Regional Hospital in Yogyakarta. This study took the form of observational study with a cross-sectional design. Data were collected using LMQ (Living with Medicine Questionnaire) and Visual Analog Sacle (VAS) overall burden to determine the burden and MARS (Medication Adherence Rating Scale) to determine medication adherence level. The samples in this study were 60 patients from all patients  undergoing hemodialysis who met the inclusion criteria. Sampling was taken using a consecutive sampling technique with inclusion criteria of patients willing to complete the questionnaire and patients diagnosed with chronic renal  failure aged more than 18 years. To determine the relationship between medication burden and medication adherence, data was examined using the Spearman test.  The results of this study showed that 40 patients (66.7%) had moderate medication burden and 50 patients (83%) had moderate medication adherence. There was a significant correlation between the LMQ score and MARS (correlation-coefficient = 0.581, p=0.000) and a significant correlation between the VAS score and MARS (correlation-coefficient= 0.651, p=0.000). Thus, it can be concluded that there is a positive relationship between treatment burden and the level of treatment compliance, where the higher the burden, the higher the level of compliance in chronic kidney failure patients.
Demographics, knowledge, and attitudes toward fe supplementation for stunting prevention at public health center, Ciamis-Indonesia Sari, Andriana; Meyleni, Reni
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27665

Abstract

Stunting has been linked to malnutrition in children from prenatal to before five years old, a condition with 24% prevalence, according to the 2021 Indonesian Nutrition Status Survey. Ciamis (West Java, Indonesia) reported 2,334 cases (3.4%) of stunting problems in 2022. The government has introduced Fe tablets to pregnant women, but this specific intervention can only be effective if accompanied by their adequate knowledge and positive perception of its usefulness, which can be influenced by their experience, education level, and sociocultural environment. This study aimed to determine the relationship between demographic characteristics and knowledge and attitudes toward Fe supplementation. This quantitative research adopted the analytical survey and cross-sectional designs and used demographics, knowledge, and attitudes questionnaires as the research instruments. Cluster sampling in the operational area of the Sadananya Public Health Center in Ciamis obtained 151 respondents. Data were analyzed using a chi-square test in SPSS. Results show that the majority of the sample size had low knowledge (118 respondents; 77.6%) and less positive attitudes (103; 67.8%) toward Fe supplementation. There was a significant relationship between age and knowledge (p=0.044), while none was observed between knowledge and education (p=0.100) and obstetric history (p=0.057). Moreover, age, education, and obstetric history were not statistically related to attitudes toward Fe supplementation (p=0.645, 0.951, 0.792). From these findings, it can be concluded that knowledge is strongly linked to age but not to education and obstetric history. Also, there is no significant relationship between attitudes toward Fe supplementation and age, education, and obstetric history.
In-vivo study of oleic acid and tween-80 on patch transdermal A.paniculata as anti-diabetic Wahyuningsih, Iis; Fadilah, Nur Aini; Widyaningsih, Wahyu
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27851

Abstract

Sambiloto (Andrographis paniculata) has been known empirically as a plant that has benefits as a traditional antidiabetic Javanese medicine to treat diabetes mellitus (DM). The main compound contained in sambiloto is andrographolide which has a hypoglycemia effect. Andrographolide has low solubility in water and poor bioavailability due to biotransformation by P-glycoprotein in the intestinal tract which causes andrographolide to metabolize more quickly in the duodenum and jejunum. To overcome this extract ethanol of sambiloto (EES) formulated to patch transdermal. Enhancers can affect the characteristics of transdermal patch preparations which affect the pharmacological activity of transdermal patch preparations. The critical point of transdermal patch preparation is the selection of enhancers which is one of the compounds to increase the penetration of active substances in the skin by disrupting the permeability of the stratum corneum. The aim of this research is to determine the effect of variations in the combination of oleic acid and tween 80 as an enhancer on the physical characteristics of EES patches.The methods of extraction sambiloto use soxhetation with ethanol 96% as solvent. The formulation of EES patch transdermal using solvent casting technique with various concentration enhancer tween-80 and oleic acid. This research was conducted by making 3 formulas, where F1  (1:1), F2 (1:3) and F3 (1:3). The evaluations include weight uniformity, thickness, water content, pH and folding endurance of the patch. The result of visual appearance the patch EES has a dark green with aroma specific of EES. The characteristics of EES transdermal patches were affected by the ratio of tween-80 and oleic acid as the enhancers. The combination of oleic acid and tween 80 as a permeation enhancer has an influence on physical characteristics (weight and thickness) of EES patches.
The antiviral activity of Laportea decumana methanolic extract against NDV virus Tee, Albert; Pho, Duc Khiem; Beatrix, Musung Anastasia; Dorothy, Wijaya; Sutejo, Richard
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28083

Abstract

The avian species virus that causes Newcastle disease is an extremely contagious illness. Avian paramyxovirus 1, or Newcastle disease virus (NDV), is a virus that brings harm to poultry's central nervous system and digestive tract. The NDV outbreak was initially documented in 1928 in Java, Indonesia. Newcastle disease does not currently require therapy. One popular and useful strategy for preventing and treating viral infections, such as Newcastle disease, is vaccination. With a variety of native medicinal plants and an abundance of biodiversity, Indonesia presents a promising area for biotechnology and pharmaceutical research. Laportea decumana, is a native plant in the Eastern part of Indonesia that contains alkaloids, glycosides, steroids, flavonoids, tannin, and saponin. Its cytotoxic, analgesic, antioxidant, and antibacterial properties have all been demonstrated. The antiviral properties of L. decumana have not been extensively researched. Thus, the purpose of this study is to examine L. decumana's antiviral activity, particularly against NDV, using a variety of techniques, including the plaque assay, cytotoxicity test, and gene expression experiment. L. decumana extracts at 100 mikrogram per mL or less is a safe concentration to consider, as it still has 65 persen and above cell viability based on the results of the cytotoxic assay.
Controlled release kinetics of furosemide from chitosan matrix tablets with hydroxypropyl methylcellulose phthalate coated Samran, Samran; Suprianto, Suprianto; Sumardi, Sumardi; Ritonga, Ahmad Hafizullah; Kusumastuti, Melati Yulia
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28097

Abstract

Sustained-release dosage forms were critical in drug delivery, ensuring controlled and prolonged release for optimal therapeutic outcomes. Chitosan (CH) has become pivotal in sustained-release tablet formulation due to its biocompatibility and mucoadhesive properties. This study aims to explore the release kinetics of furosemide (FS) from CH matrix tablets in a concurrent medium. The formulation involves a core tablet and coated tablet, with CH matrix as a binder and Hydroxypropyl Methyl Cellulose Phthalate (HPMCP) as a film-coated for the core tablet, and both are made using the wet granulation method. Assessment parameters include tablet hardness, disintegration, and FS release profiles across various media, analyzed using spectrophotometric methods to comprehend drug release kinetics with multiple models such as zero-order, first-order, Higuchi, and Korsmeyer-Peppas employed. In the press-coated tablet comprising core tablet CH as matrix uncoated with 20 mg CH per tablet core, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h, which displayed first-order release kinetics within 2-6 h and 6-16 h in concurrent media of pH 5.8 and 7.4. Notably, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h. Press-coated tablets incorporating CH matrix with HPCMP coated (CH-HPCMP), also containing 20 mg CH per tablet, exhibited diverse drug release kinetics. These tablets showed Korsmeyer-Peppas, zero-order, and first-order kinetics in pH 1.2, 5.8, and 7.4, respectively. The study suggests that a Press-coated tablet incorporating CH-HPMCP is suitable as the candidate for sustained-release formulations. The observed versatility in release kinetics across varying pH environments underscores the potential adaptability of these formulations in addressing diverse therapeutic needs.
Inhibition breast carcinogenesis via PI3K/AKT pathway using bioactive compounds of Strychnine tree (Strychnos nux-vomica): in silico study Rispriandari, Aulia Ayu; Sarmoko, Sarmoko; Setyono, Joko; Wisesa, Sindhu
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28242

Abstract

Breast cancer poses a significant global health challenge, with a notable prevalence in Indonesia. Given the intricate nature of breast cancer progression and classification, precise treatment strategies are imperative, particularly targeting signaling pathways like PI3K/AKT, pivotal in cell growth, proliferation, survival, and apoptosis. Bioactive compounds from the Strychnine tree demonstrate potential in enhancing apoptotic effects and inhibiting breast carcinogenesis. This potential is explored through in silico studies. This research aims to analyze potential targets of Strychnine tree compounds, along with binding energy and stability between ligands and receptors. Employing bioinformatics target analysis, molecular docking, and molecular dynamics simulation, the study reveals AKT1 as a potential target of Strychnine tree compounds. These compounds inhibit AKT1 at both active and allosteric sites, displaying notably low binding energy scores. For example, brucine exhibits a binding energy of -10.83 kJ/mol at the active site, surpassing the standard capivasertib. However, lupeol, with a binding energy of -11.14 kJ/mol, falls short of the MK-2206 standard at the allosteric site. Molecular dynamics simulations expose fluctuations in parameters like RMSD, RMSF, and binding energy within the initial 5 ns. In conclusion, Strychnine tree compounds, such as brucine and lupeol, showcase potential AKT1 inhibition at both active and allosteric sites, enhancing apoptotic effects. However, the stability of these compounds in binding to their receptors within the first 5 ns of the simulation warrants further investigation for prolonged interactions.   

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