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Althea Medical Journal
Published by Universitas Padjadjaran
ISSN : -     EISSN : 23374330     DOI : 10.15850/amj
Core Subject : Health,
Medicine & Pharmacology
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
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Search results for , issue "Vol 11, No 1 (2024)" : 10 Documents clear
Experiences of patients with Breast Cancer in Selecting Conventional and Complementary Therapies in Remote Areas: A Qualitative Study Senudin, Putriatri Krimasusini; Padeng, Eufrasia Prinata; Laput, Dionesia Octaviany; Raden, Natalia Damayanti Putri; Trisnawati, Reineldis E.; Nanur, Fransiska Nova
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3028

Abstract

Background: The selection of therapy is a challenging issue to overcome. The selected therapy must be based on the condition of breast cancer patients and has advantages such as increasing life expectancy, being able to overcome the symptoms and complaints of breast cancer patients and improving the quality of life. This study aimed to explore the experiences of people with breast cancer regarding the reasons for choosing therapy, namely complementary and conventional therapies.Methods: This study was qualitative research with a descriptive phenomenological study approach. Participants obtained using purposive sampling techniques were included until the data was saturated. Research data was collected through in-depth interviews conducted in a semi-structured manner. The thematic analysis used in this study consisted of several stages using the Colaizzi method.Results: This study illustrated that complementary and conventional therapies were beneficial to cancer treatment. The three themes from the analysis results included the benefits of complementary and conventional therapies, access to therapy and treatment costs. The choice of therapy depended on available access and costs for breast cancer treatment.Conclusion: People with breast cancer in remote areas choose complementary therapies, such as herbal medicine, meditation, reflexology, and acupuncture as the first choice and conventional therapies, such as surgery and chemotherapy as alternative therapies. This is because the choice of therapy also depends on the ease of access to treatment and the availability of costs for breast cancer patients.
Viability Test of Mycobacterium Tuberculosis Bacteria Stored in Various Cryopreservation Periods Annisa, Jessi; Susilawati, Neng Rina; Asarina, Shinta; Jihadah, Muti'ah Nurul; Chaidir, Lidya
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.2949

Abstract

Background: The specimen storage room serves as bioarchive for prospective research purposes. Cryopreservation or preservation at very low temperatures has been used to preserve research isolates for decades. A quality assessment must be conducted to ensure the isolates conditions. This study aimed to assess the quality of isolates by testing the level of viability and contamination from different cryopreservation periods.Methods: This was an experimental study with a total sample of 92 Mycobacterium tuberculosis (Mtb) isolates which were sampled randomly using cryopreservation, aged 8–10 years (in Tryptic Soy Broth media, TSB/) and aged 3–5 years (in Middlebrook 7H9) which was re-cultured in Ogawa Medium at the Tuberculosis Laboratory, Universitas Padjadjaran in May–November 2019. After observing confluent growths, the pure isolate was stained using the Ziehl-Neelsen (ZN) method to confirm the presence of Mtb growth or contamination. A Simple ratio was used to count the recovery rate as a viability parameter and contamination rate of each batch.Results: Test results showed a recovery rate of 66.67–100% of positive cultures stored despite they had been cryopreserved for 10 years. There was no significant difference in the percentage of positive cultures between preservation period groups.Conclusion: Mtb isolates can survive and remain viable after being stored for up to 10 years at -80 ° C in cryopreservation media.
Association between Lamp Light During Sleep and Sleep Quality in Medical Students Yurike, Vony; Harjanto, Bernardus Realino; Widjaja, Nelly Tina; Sidharta, Veronika Maria
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3170

Abstract

Background: Sleep quality is influenced by numerous factors, including external factors, such as the sleep environment. One aspect of the sleep environment that can influence sleep is lighting. Light exposure emitted by lamps during sleep can impair sleep quality. The aim of this study was to investigate the association between lamp light during sleep and sleep quality in preclinical medical students.Methods: This cross-sectional observational analytic study was carried out on 386 preclinical medical students who were determined using the cluster sampling method. Data was collected in November 2022. Lamp light during sleep and sleep quality among students were measured using the Indonesian version of the Pittsburgh Sleep Quality Index. The association between lamp light and quality of sleep was analyzed by the Chi-Square test.Results: There were 26.68% of students who used lights when sleeping. Poor sleep quality was detected in 46.37% of students. The association between lamp light during sleep and quality of sleep yielded a p-value of 0.002.Conclusion: There is a significant association between lamp light during sleep and sleep quality in preclinical medical students. Thus, improving sleep quality in preclinical medical students may be achieved by modifying the lamp light during sleep.
Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat Sakinah, Elly Nurus; Supangat, Supangat; Wisudanti, Desie Dwi; Abrori, Cholis; Mustika, Arifa; Wibsono, Sony; Athoillah, Nabil
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3133

Abstract

Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals.Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software.Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p <0.05).Conclusions: There is a relationship between the duration of exposure to chlorpyrifos and butyrylcholinesterase levels in Wistar rats. This fact shows that the longer an organism is exposed to low doses of chlorpyrifos pesticides, the higher the level of neurological system toxicity that occurs in that organism.
Overview of Non-Pharmacological Treatment Option for Adolescent Girls with Dysmenorrhea in Cimahi, West Java, Indonesia Rahmani, Shofiatunisa Firdhausy; Anwar, Ruswana; Sasongko, Elsa Pudji Setiawati; Ritonga, Mulyanusa Amarullah; Arya, Insi Farisa Desy
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3064

Abstract

Background: Dysmenorrhea is a condition of pain during menstruation that may affect daily activities. The phenomenon of dysmenorrhea in West Java has reached 54,9%. When dysmenorrhea is not treated, it can decrease productivity at school. This study aimed to find out which therapy was more widely used, the reasons for using the therapy, and to identify changes in non-pharmacological therapy as seen from the visual analog scale (VAS) assessment.Methods: This research used quantitative data with a descriptive study conducted with a cross-sectional method, and the instrument used was a questionnaire. The study was conducted in July 2022 with a total sample of 457 participants, and 366 samples met the inclusion criteria. This data analysis used Statistical Package for Social Scientists (SPSS version 28) to identify changes before and after non-pharmacological therapy options and the frequency distribution of the data.Results: The non-pharmacological therapy option was preferred by students (n= 366), and the reasons students used this therapy were seen from various aspects. Rest was the most frequently chosen activity by students (n= 329). All students felt a change in the pain scale before and after using non-pharmacological therapy with the visual analog scale (VAS).Conclusion: Students in grades 1 and 2 of SMAN 1 Cimahi prefer non-pharmacological therapy with rest. They have various aspects of reasoning and feeling changed after using the therapy. There is a change in the pain scale after using non-pharmacological therapy.
Turmeric and Mangosteen Extract Modulate Autophagy Gene Expression in High-Fat Diet-Induced Rats Gunadi, Julia Windi; Jasaputra, Diana Krisanti; Pangestuti, Balqist Sriprobo; Wahyudianigsih, Roro; Lesmana, Ronny
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3148

Abstract

Background: High-fat diet (HFD) increases the risk of obesity, metabolic syndrome, coronary artery disease, and chronic kidney disease, resulting in lipotoxicity. Turmeric and mangosteen are two ingredients mostly used in Indonesian food, and are known for their antihyperlipidemic and antioxidant effects. The aim of this study was to explore the effect of turmeric and mangosteen on autophagy gene expression in HFD-induced kidneys in rats model.Methods: The study was an experimental study, including 25 male Wistar rats aged 8 weeks, divided into 5 groups with a completely randomized design; group with a standard diet as negative control group, the group with a high-fat diet as a positive control group, and the HFD groups with turmeric or mangosteen or fenofibrate. The study was conducted in Maranatha Biomedical Research Laboratory from January to November 2022. Autophagy gene expression (LC3, p62) was measured along with the histopathological scoring to observe necrosis, inflammation, and fat degeneration state. Data was analyzed using One Way ANOVA or Kruskal Wallis and post hoc Least Significant Difference or Mann Whitney.Results: There were significant differences in inflammation in groups treated with mangosteen (p=0.007); in fat degeneration in groups treated with mangosteen and fenofibrate (p=0.007). Furthermore, the LC3 gene expression was increased in all HFD groups as well as the p62 gene expression in group treated with turmeric (p=0.020) and fenofibrate (p=0.005).Conclusions: Mangosteen decreases inflammation and fat degeneration scoring, while turmeric  increases autophagy in the kidney of HFD induced Wistar rats.
Maternal Risk Factors among Pregnant Women with Miscarriage Sofia, Norlaila; Fadlyana, Eddy; Irianti, Setyorini; Krisnadi, Sofie; Susiarno, Hadi
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3037

Abstract

Background: Approximately, 4.1% of maternal deaths in Indonesia occur due to miscarriage. Miscarriage might be caused by various factors such as fetal, maternal, and external factors. Monitoring and early detection of maternal factors might prevent miscarriage.  This study aimed to analyze the influence of maternal factors on the incidence of miscarriage. Methods: This was an analytic observational study with a case-control design conducted in Banjar District, South Kalimantan in August–September 2022. Data was collected from the medical records of pregnant women who experienced miscarriage (n=60) and pregnant women who did not (n=120). Data was analyzed using the chi square test and logistic regression. The level of maternal risk factors for the incidence of miscarriage was determined from the odds ratio (OR) value at a 95% confidence interval.Results: The results revealed that parity (p=0.000; OR=2.2), nutritional status (p=0.000; OR=77.1), level of education (p=0.001; OR=3.5), and employment status (p=0.000; OR=8.1) had a significant effect on the incidence of miscarriage.Conclusion: Maternal factors such as parity, nutritional status, education level, and employment status influence on the incidence of miscarriage, therefore, it is essential to educate pregnant women on various factors related to miscarriage.
Clinical Symptoms and Treatment Outcomes of COVID-19 Patients with Stroke Daud, Oskar Yuda; Sinurat, Robert
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3120

Abstract

Background: COVID-19 patients who come to the emergency room often suffer from stroke. This study aimed to examine clinical symptoms and treatment outcomes of COVID-19 patients with stroke.Methods: This study was a retrospective study using secondary data from medical records of COVID-19 patients with stroke, hospitalized at the Universitas Kristen Indonesia Hospital, Jakarta, Indonesia for the period 2020–2022. Patients with PCR test positive for COVID-19 who had clinical symptoms of stroke, confirmed by  CT scan showing brain ischemic or hemorrhage were included. Data on gender, age, Glasgow coma scale (GCS), subtype of stroke, severity of COVID-19, and outcome were recorded and analyzed using paired t-test and the Spearman correlation.Results: Of the 49 patients included, 91.8% were over 45 years old and suffered from severe COVID-19. Men were slightly more (51.1%) than women and 93.9% of patients suffered from ischemic stroke. The GCS scores of 46.9% of patients decreased significantly during hospitalization (p=0.02). Most of patients (65.3%) had used non-rebreathing mask (NRM), 10.2% ventilators, and others used nasal cannulas. As many as 46.9% of patients died, 44.9% recovered with neurological deficits, and only 8.2% recovered completely. Interestingly, oxygen delivery devices were significantly correlated with outcome (p=0.00). Patients receiving the antiviral favipiravir had better outcomes compared with those taking remdesivir (p=0.021).Conclusion: The mortality rate for stroke patients with severe COVID-19 is high, and the outcome of patients using NRM or ventilator is worse than patients using nasal cannulas. The antiviral Favipiravir has better outcomes for stroke patients with severe COVID-19.
Patients Satisfaction with the Chronic Disease Management Program in Indonesia Using the Importance-Performance Matrix Kusumawardana, Ramza Aurum; Sunjaya, Deni Kurniadi; Gondodiputro, Sharon; Raksanagara, Ardini Saptaningsih; Ardisasmita, Mulya Nurmansyah; Widjajakusuma, Anggraini
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.2780

Abstract

Background: Indonesia still has a high prevalence of hypertension and diabetes mellitus. On the other hand, essential health services were disrupted during the COVID-19 pandemic. Hence, the quality of service still needs to be prioritized. The government also obliges the government-owned primary healthcare facilities (Pusat Kesehatan Masyarakat, Puskesmas) to conduct customer satisfaction surveys to evaluate service quality. This study was conducted to analyze patients’ satisfaction with the chronic disease management program (Program Pengelolaan Penyakit Kronis, Prolanis) provided by Puskesmas in Bogor City.Methods: Quantitative research with a survey approach using the CSI-29 questionnaire was conducted from October to November 2021 on 104 Prolanis participants from 6 Puskesmas in Bogor City, West Java, Indonesia. The variables were 9 dimensions of satisfaction based on the CSI-29 questionnaire. Data was transformed using the Rasch model and analyzed using the Importance-Performance Matrix (IPM).Results: Of the 104 participants, there were 78 (75%) were satisfied with the Prolanis services provided by the Puskesmas. The IPM analysis showed that the dimensions of requirements, procedures, costs, type of service products, and attitudes of health workers had low expectations and perceived performance level.Conclusions: Most of the Prolanis participants were satisfied with the Prolanis services provided by the Puskesmas in Bogor City.
Correlation between Gibbus and Neurological Status in Patients with Tuberculous Spondylitis and its impact after Operative Intervention Egypti, Lubna; Rahim, Agus Hadian; Ganiem, Ahmad Rizal; Ramdan, Ahmad; Dian, Sofiati
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.2991

Abstract

Background: Tuberculous (TB) spondylitis is a chronic infectious disease associated with Mycobacterium tuberculosis that affects the spine. This disease is a challenging disease to treat due to its serious complications and high morbidity rate. Neurological deficits and spinal deformities that can occur along with gibbus are some of the most common complications. Early diagnosis and treatment are essential to cure this disease, with the administration of anti-TB drugs and operative intervention. This study aimed to analyze the correlation between gibbus and neurological status as well as the impact of operative intervention on the degree of gibbus and neurological status.Methods: This was an observational-analytic study with a cross-sectional design on 32 medical records of TB spondylitis patients who underwent operative intervention from January 2018 to December 2021 at Dr. Hasan Sadikin General Hospital. Gibbus determined by x-ray analysis and neurological status determined by the American Spinal Injury Association (ASIA) impairment scale (AIS) were examined before and after the intervention. The sample was chosen based on consecutive sampling. All data collected was tested using Spearman's correlative analysis, paired t-test, and Wilcoxon sign-rank test with a p-value <0.05 considered statistically significant.Results: There was a significant correlation between gibbus and neurological status-AIS (r=-0.708; p<0.05); and a significant positive impact of operative intervention on the degree of gibbus (p<0.05) and neurological status-AIS (p<0.05).Conclusion: There is a correlation between gibbus and neurological status-AIS. In addition, operative intervention also has a significant positive impact on the degree of gibbus and AIS, resulting in good clinical and radiological outcomes.

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