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INDONESIA
Indonesian Journal of Cancer Chemoprevention
Published by Indonesian Society for Cancer Chemoprevention
ISSN : 23558989     EISSN : 20880197     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products.
Arjuna Subject : -
Articles 351 Documents
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In Silico Study of Bioactive Compounds from Syzygium malaccense Targeting HER2 and Progesterone Receptors in Breast Cancer Nawadhir Fauzan; Riska Prasetiawati; Meilia Suherman; Dhania Novitasari; Muchtaridi Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp1-14

Abstract

Breast cancer remains one of the most common causes of cancer-related deaths among women, with progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) being key molecular targets in its progression. This study aimed to explore the potential of bioactive compounds from Syzygium malaccense that have exhibited anticancer activities, as targeted inhibitors for PR and HER2, using computational approaches. A total of 155 compounds were initially screened for anticancer potential using the Prediction of Activity Spectra for Substances (PASS), identifying 80 compounds for further analysis. Drug-likeness and pharmacokinetic predictions indicated that several compounds complied with the Rule of Five (RO5) and had favorable absorption and distribution profiles, suggesting their suitability as oral drug candidates. Molecular docking revealed that quercetin exhibited favorable interactions with PR, particularly involving the ARG 766 residue, while myricetin demonstrated strong binding affinity to HER2, surpassing trastuzumab, and interacting with key residues Asp 863, Lys 753, Ala 751, and Leu 796. Molecular dynamics simulations confirmed the stability of the Myricetin-HER2 complex under physiological conditions over 15 ns, supporting its potential as a HER2 inhibitor. These findings highlight myricetin and quercetin as promising natural compounds for breast cancer therapy targeting HER2 and PR, respectively. However, further experimental validation, including in vitro and in vivo studies, is necessary to confirm their therapeutic efficacy and safety. Overall, this study supports Syzygium malaccense as a valuable source of natural bioactive compounds for breast cancer drug discovery.Keywords: in silico screening, Syzygium malaccense, breast cancer, progesterone receptor, HER2.
The Role of Liquid Biopsies in Early Cancer Detection and Monitoring Kirolos Eskandar
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp67-78

Abstract

Liquid biopsies have emerged as a transformative tool in oncology, offering a minimally invasive method for early cancer detection and real-time monitoring of disease progression. This literature review explores the technological advancements and clinical applications of liquid biopsies, focusing on their role in detecting circulating tumor cells (CTCs), cell-free DNA (cfDNA), and other biomarkers. We examine the efficacy of liquid biopsies in early cancer screening, their potential for monitoring treatment response, and their ability to detect recurrence and metastasis. Despite the promising applications, challenges such as technical limitations, biological variability, and cost-effectiveness must be addressed to fully integrate liquid biopsies into routine clinical practice. The future of liquid biopsies looks promising, with emerging trends in multi-omic approaches and artificial intelligence paving the way for more personalized and effective cancer care. This review included 34 peer-reviewed studies identified through a systematic PRISMA-guided search across four databases.Keywords: Liquid Biopsies, Early Cancer Detection, Circulating Tumor Cells (CTCs), Cell-Free DNA (cfDNA), Cancer Monitoring, Multi-omics, Artificial Intelligence in Cancer Diagnostics, Real-time Monitoring.
In Silico Study of Torch Ginger Flower (Etlingera elatior (Jack) R.M.Sm. flos) Bioactive Compounds Targeting TGF-β Receptor Type I (TGF-βR1) as Potential Tumor Suppressor Agents Yohana Faustine Yuarsa; Garneta Izzati Herdy Putri; Valeri Belliana Sanjaya; Akmal Taufiqur Rahman; Shela Salsabila; Nawadhir Fauzan; Muchtaridi Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp15-28

Abstract

Cancer remains one of the leading causes of death worldwide, with an estimated 16.3 million cancer-related deaths projected by 2040. Current cancer therapies still face various challenges such as resistance, toxicity, and high costs, highlighting the need for more targeted approaches in the discovery of new therapies. Torch ginger flower (Etlingera elatior (Jack) R.M.Sm. flos) has been reported to contain bioactive compounds with potential tumor-suppressive activities through modulation of cancer-related pathways. However, in silico evidence evaluating its active compounds as potential inhibitors of transforming growth factor-beta receptor type I (TGF-βR1), a protein involved in tumor proliferation and metastasis remains limited. This study aimed to predict and evaluate the potential of Etlingera elatior compounds as tumor-suppressing agents targeting TGF-βR1 using computational approaches. Lipinski’s Rule of Five and ADME-Tox predictions were performed to assess drug-likeness and pharmacokinetic properties, while pharmacophore screening and molecular docking were conducted to identify hit compounds and predict their binding affinities. Among the tested compounds, kaempferol and quercetin showed the highest pharmacophore fit scores (47.21% and 47.07%, respectively) and the best binding affinities to TGF-βR1 (-7.98 kcal/mol; Ki 1.42 μM for kaempferol and -7.87 kcal/mol; Ki 1.72 μM for quercetin), and although their binding poses were not the most similar to the reference inhibitor LY3200882 (-8.39 kcal/ mol; Ki 0.71 μM), the consistent alignment of favorable pharmacophore fit and binding energy still reinforces their potential. These findings indicate that kaempferol and quercetin have promising potential as candidate natural tumor-suppressive agents targeting TGF-βR1.Keywords: Cancer, TGF-βR1, Torch Ginger Flower, Molecular Docking.
Targeting Androgen Receptor with Boesenbergia rotunda Phytoconstituents: A Computational-based Perspective Najla Yasmintia Widarso; Ari Anggi Mahwati; Irene Ivory Sibuea; Dzava Prawinsyah Fairus Ismail; Bintang Satrio Mahardika; Dhania Novitasari
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp29-43

Abstract

Prostate cancer is characterized by abnormal cell proliferation within the prostate gland, driven in part by the activation of androgen receptor (AR) upon binding with testosterone. The receptor, therefore, represents a critical therapeutic target in prostate cancer management. Boesenbergia rotunda or fingerroot (or temu kunci in Indonesia), a medicinal plant widely used in traditional medicine, has been reported to exhibit diverse pharmacological activities, including anticancer effects. However, despite these promising bioactivities, no molecular level or computational studies have been conducted to explore its interaction with AR. In this study, the anticancer potential of eighteen secondary metabolites from B. rotunda rhizome was investigated in silico against the AR to identify new therapeutic candidates. The test ligands were evaluated for their physicochemical properties in accordance with Lipinski’s rule of five, ADME/Tox predictions, pharmacophore screening, and molecular docking, in comparison with the reference drug bicalutamide. Among the evaluated compounds, boesenbergin A demonstrated the strongest binding affinity to AR, with a binding energy of –11.89 kcal/ mol and an inhibition constant of 1.92 nM. Importantly, boesenbergin A engaged amino acid residues, including TRP: 741, like bicalutamide, indicating comparable binding interactions. These findings suggest that boesenbergin A holds substantial promise as a natural anticancer lead compound targeting the AR and warrants further investigation as a potential therapeutic agent for prostate cancer.Keywords: Boesenbergia rotunda, boesenbergin A, prostate cancer, in silico.
HPLC Analysis with Evaluation of Antioxidant and Antisenescence Activities of Parijoto (Medinilla speciosa Reinw. ex Bl.) Methanolic Extract in Vero Cells Anif Nur Artanti; Sholichah Rohmani; Diyah Tri Utami; Nindita Clourisa Amaris Susanto; M. Fiqri Zulpadly; Annisa Diyan Meitasari; Ulfa Afrinurfadhilah Darojati; Meta Kartika Untari; Heru Sasongko; Dian Eka Ermawati; Feri Setyawan
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp44-56

Abstract

Parijoto (Medinilla speciosa Reinw. ex Bl.) is a traditional medicinal plant rich in polyphenolic compounds that are associated with antioxidant and cytoprotective activities. The present study aims to investigate the phytochemical profile, antioxidant capacity, cytotoxicity, and anti-senescence effects of parijoto methanolic extract. The methanolic extract of parijoto (MEP) was subjected to qualitative thin-layer chromatography (TLC) for the detection of flavonoids, quantitative high-performance liquid chromatography (HPLC) for the determination of quercetin and naringin, and antioxidant activity assessment using the DPPH method. The mobile phase for quercetin analysis was water: acetonitrile (45:55), while for naringin, it was acetonitrile:water: formic acid (21:78.8:0.2). Cytotoxicity was evaluated in Vero cells using the MTT assay, while senescence in normal kidney cells was assessed by senescence-associated β-galactosidase (SA-β-gal) staining. Results showed that the extract contained quercetin (5.76±0.11 ppm). The extract exhibited strong antioxidant activity with an IC₅₀ value of 40.46 ppm. Cytotoxicity testing of MEP on Vero cells revealed low toxicity (529±0.77 μM) at physiologically relevant concentrations, supporting its safety for normal kidney cells. Moreover, in normal kidney cells, the extract conferred cytoprotective effects by reducing oxidative stress–induced damage and attenuating senescence-associated β-galactosidase. Collectively, these findings suggest that MEP exhibits potent antioxidant, cytoprotective, and anti-senescence activity in vitro, warranting further in vivo studies to validate its potential effects on kidney health and age-related cellular damage.
Chemotherapeutic and Supportive Treatment Approaches for Cervical Cancer Patients in Indonesia: A Cross-Sectional Study Sonlimar Mangunsong; Azzahra Nisrina; Sarmalina Simamora; Gunardi Pome; Rosnani Rosnani; Heni Sumastri
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp137-144

Abstract

Cervical cancer is one of the most common cancers in women and ranks as the second leading cause of cancer-related mortality in Indonesia. Its management largely depends on the stage of disease and often requires multimodal approaches. A retrospective cross-sectional descriptive study was conducted using medical records of 185 hospitalized cervical cancer patients from January to December 2024. Data collected included age, disease stage, type of therapy, drug utilization, routes of administration, and histopathological findings. Descriptive analysis was performed and presented as frequency distributions and percentages. Most patients were aged 45–64 years (58.9%) and diagnosed at stage III (49.73%). The most common therapy was surgery (49.73%), followed by brachytherapy (20.54%) and chemotherapy (11.8%). Tranexamic acid was the most frequently prescribed drug (22.01%), while cisplatin paclitacxel and carboplatin were the primary chemotherapeutic agents. The intravenous route dominated drug administration (72.03%). Histopathology most frequently revealed medium-sized tissue lesions (3–5 cm; 21.08%). The majority of cervical cancer patients were diagnosed at advanced stages and underwent surgery as the primary treatment. Cisplatin remains the gold standard chemotherapy agent, administered primarily via the intravenous route. These findings highlight the urgent need for early detection, expanded screening, and HPV vaccination programs to reduce advanced-stage cases.Keywords: malignant carcinoma of cervix, hospitalize patient, drug utilization, histopathology.
Anti-Cancer Activity of Rhizome of Emprit Ginger (Zingiber officinale Rosc.) and Tiwai Onion (Eleutherine palmifolia) through Apoptosis Induction and Cell Cycle Arrest: A Review Aisyah Nur Salsabilan; Annisa Khumaira; Ika Afifah Nugraheni
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp145-162

Abstract

Cancer is a disease caused by the abnormal growth of cells and tissues. One of the main therapeutic approaches for cancer is chemotherapy. The use of plants as an alternative treatment is considered quite relatively effective and efficient. Emprit ginger (Zingiber officinale Rosc.) and tiwai onion (Eleutherine palmifolia) are plants that have potential anticancer properties due to their active compounds. The purpose of this literature review is to examine the various uses of these active compounds and their mechanisms of action as anticancer agents, both in vitro and in vivo, from emprit ginger and tiwai onion. The results of this literature review indicate that emprit ginger contains active compounds, namely gingerol (6-gingerol and 10-gingerol), shogaol (4-shogaol, 6-shogaol, and 10-shogaol), and paradol, which have anticancer activity. Similarly, tiwai onion contains active compounds, namely flavonoids (isoliquiritigenin), polyphenols (oxyresveratrol), and naphtoquinones (elecanacin, eleutherin, eleutherol, eleutherinol, eleutherinon, eleuthoside B, eleutherinoside A), which have anticancer activity. Pre-clinical in vitro and in vivo studies show that emprit ginger and tiwai onion have anticancer activity, including the inhibition of cancer growth through modulation of cell signaling pathways, induction of apoptosis, and cell cycle arrest.Keywords: anticancer activity, apoptosis, cell cycle arrest, emprit ginger (Zingiber officinale Rosc.), tiwai onion (Eleutherine palmifolia).
Chemopreventive Potential of Calotropis gigantea Root Fraction on MCF-7 Cells: In Vitro and In Silico Study Rifki Febriansah; Vidia Noviyanti
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp93-106

Abstract

Cancer remains a major global health issue due to its high mortality rate. Chemotherapy, though commonly used, often causes severe side effects by damaging both cancerous and healthy cells. Therefore, safer and more selective chemopreventive agents from natural sources are needed. This study aims to evaluate the chemopreventive potential of the ethanol fraction of biduri root (EFBR, Calotropis gigantea L.) through in vitro and in silico approaches. Phytochemical screening was used to identify bioactive compounds. Molecular docking using AutoDock Vina assessed calotropin’s interaction with Bcl-2 and HER-2 proteins. Antioxidant activity was measured by the DPPH method, and cytotoxic activity was tested on MCF-7 breast cancer cells and normal Vero cells using the MTT assay. EFBR was found to contain cardiac glycosides, flavonoids, terpenoids, saponins, and tannins. Docking results showed strong binding of calotropin to Bcl-2 (-9.3 kcal/mol) and HER-2 (-8.1 kcal/mol). EFBR showed weak antioxidant activity (IC₅₀: 518.93 μg/mL) but moderate cytotoxicity against MCF-7 (IC₅₀: 159.80 μg/mL), with low toxicity on Vero cells (IC₅₀: 2703.61 μg/mL) and a high selectivity index (SI: 16.91). These results indicate that EFBR has potential as a selective chemopreventive agent against breast cancer.Keywords: Calotropis gigantea L., molecular docking, MTT assay, DPPH, MCF-7.
In Silico Study of Potential Active Compounds in Guava Leaves (Psidium guajava L.) Targeting Beta Estrogen for Breast Cancer Therapy Nazma Mumtaz Sidik; Nabillah Fauziyyah; Nissa Andjani Kusmawidiyanti; Difla 'Afina Ghifari Suhendar; Nawadhir Fauzan; Shela Salsabila; Muchtaridi Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp79-92

Abstract

Breast cancer is a disease that is the main cause of death, especially in women, where malignant cells form in breast tissue. Some breast cancers are sensitive to hormone estrogen. Overexpression that occurs from an estrogen receptor will increase excessive proliferation. ER-β was chosen as a therapeutic target protein because it can inhibit the proliferation and invasion of breast cancer cells and trigger apoptosis. In this in silico study, a test was carried out on the activity of the active compound content of potential secondary metabolites in Guava plants (Psidium guajava L.) in the leaves aimed at the Estrogen Beta receptor (ER-β) for breast cancer therapy. The goal is to obtain new compound candidates to help pharmacological therapy of breast cancer. This can be seen from the results of re-docking of natural ligands (Genistein) and docking of fifty test ligands which are potential secondary metabolite compounds contained in Guava plants (Psidium guajava L.) in the leaves. The compound that has the greatest potential to activate ER-β as an antiproliferation of breast cancer cells is Clionasterol.Keywords: Breast cancer, Psidium guajava L., ER-β Agonist, molecular docking, clionasterol.
Molegro Virtual Docker-Based Prediction of Rhodomyrtus tomentosa Metabolites Targeting Ribonucleotide Reductase as Potential Anticancer Agents Imam Nurjaman; Dini Kesuma; Tegar Achsendo Yuniarta; Nina Dewi Oktaviyanti
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp107-122

Abstract

The increasing number of cancer cases has prompted the search for new drug candidates from natural ingredients, particularly plant-derived compounds considered safer and more effective. Rhodomyrtus tomentosa (Aiton) Hassk. contains various metabolites responsible for various biological activities. This study aimed to predict the anticancer potential of R. tomentosa metabolites against the Ribonucleotide Reductase (RNR) enzyme using an in silico approach. The RNR protein structure (PDB ID: 2WGH) was obtained from the RCSB Protein Data Bank. Molecular docking was performed on 25 compounds previously reported in the literature as metabolites of R. tomentosa using Molegro Virtual Docker (MVD) version 7.0 to evaluate ligand-receptor binding affinity based on MolDock Score values using a validated docking protocol (RMSD≤2.0 Å), followed by interaction analysis and pharmacokinetic evaluation using ADMET parameters. The results indicated that most compounds exhibited favorable binding affinities toward RNR, as reflected by negative MolDock Score values. Rhodomyrtosone B (−137.144 kcal/ mol) showed the best binding affinity, followed by Malvidin-3-glucoside (−135.173 kcal/ mol), Delphinidin-3-galactoside (-132.359 kcal/mol), Rhodomyrtosone I (−130.004 kcal/ mol), and Cyanidin-3-galactoside (-127.741 kcal/mol). Interaction analysis revealed stable interactions with key amino acid residues (Arg256, Asp226, and Ser269) through hydrogen bonding, hydrophobic, and electrostatic interactions. ADMET analysis indicated variability in pharmacokinetic properties, including absorption, distribution, metabolism, and toxicity. In conclusion, Rhodomyrtosone B has potential as a natural product-based anticancer agent targeting RNR, providing a basis for further in vitro and in vivo studies.Keywords: anticancer, Rhodomyrtus tomentosa, molecular docking, Ribonucleotide Reductase; in silico.

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