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INDONESIA
Jurnal Kesehatan Andalas
Published by Universitas Andalas
ISSN : 23017406     EISSN : 26151138     DOI : -
Core Subject : Health,
Health Professions
Jurnal Kesehatan Andalas merupakan Jurnal yang diterbitkan oleh Fakultas Kedokteran Universitas Andalas.
Arjuna Subject : -
Articles 1,294 Documents
 105   106   107   108   109 
Hubungan Nilai Laju Endap Darah (LED) dengan Kadar C-Reactive Protein (C-RP) pada Pasien Positif Covid-19 Yumna Tahani Tsamarah; I Gusti Ayu Nyoman Danuyanti; Siti Zaetun
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1771

Abstract

SARS-CoV-2 infection is a systemic infection that significantly affects hematopoiesis and the patient's immune response. Drastic increase in the production of proinflammatory cytokines like interleukin-6 (IL-6) play a role in mechanism of lymphopenia in COVID-19. Some indicators of inflammation markers include Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP). Objectives: To determined the correlation between Erythrocyte sedimentation rate (ESR) and C-Reactive Protein (C-RP) levels in patients with covid-19. Methods: This research was an analytic observational study with a cross-sectional approach. The samples in this research were 10 ESR and 10 CRP data in a patient with positive COVID-19 at the Mataram University Hospital. Results: A minimum value of 0.50 was obtained from 10 samples of CRP examination, while the maximum value was 79.90 with an average value of 32.24 and a standard deviation of 30.36. The Erythrocyte sedimentation rate (ESR) examination obtained a minimum value of 6.00 from 10 samples, while the maximum value was 103.00 with an average value of 53.60 and a standard deviation of 36.40. Conclusion: There is no correlation between the value of Erythrocyte sedimentation rate and C-Reactive Protein levels in patients with Covid-19.Keywords: Covid-19,  C-reactive protein, erythrocyte sedimentation rate 
Miliary Tuberculosis in Immunocompromised Patient Induced by Imatinib and Steroid Randa Fermada; Fauzar Fauzar; Roza Kurniati; Irza Wahid
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1821

Abstract

Miliary tuberculosis occurs due to the hematogenous spread of Mycobacterium Tuberculosis from the primary complex.  The use of steroid and cytotoxic drugs increases the incidence of miliary tuberculosis.  Typical manifestations of miliary tuberculosis is snowstorm appearance seen on chest x-ray and evidence of tuberculosis microorganism from the microbiological examination.  It has been reported a 33 years old male patient was admitted to the hospital due to breathlessness, chronic coughing, fever, anorexia, weight loss and night sweating with a "damp shadow sign".  Due to chronic myelogenous leukemia and autoimmune hemolytic anemia, the patient is known under imatinib and steroid therapy.  There was no specific sign found from the physical examination.  Chest x-ray showed snowstorm appearance.  The patient underwent GeneXpert MTB/RIF, with the result low MTB detected.  The patient was treated with a 2(HRZE)/4(HR) tuberculosis drugs regimen.  Imatinib and steroid therapy was discontinued.  2-4 weeks of steroid usage with a daily dose equivalent to prednisone 15 mg increases the risk of activating a latent tuberculosis infection.  Imatinib affects the response of T cells to Mycobacterium, thereby triggering tuberculosis reactivation.  In this case, the diagnosis has been made from typical manifestations of tuberculosis, snowstorm appearance from the chest x-ray, and low MTB detected from GeneXpert MTB/RIF.  It has been recommended to detect latent tuberculosis infection before using steroid and cytotoxic drugs.Keywords:  imatinib, miliary tuberculosis,  steroid
Sikap Ibu Terhadap Pemberian Imunisasi Measles Rubella Secara Tepat Waktu Selama Pandemi Covid-19 Dianti Oktadevi; Ayun Sriatmi; Wulan Kusumastuti
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1832

Abstract

The timeliness of Measles-Rubella (MR) immunization is still low among other immunization services for infants, including at the Tempuran Health Center, Magelang Regency. Attitude is something that influences a person's actions. Objectives: To analyzed the mother's attitude towards MR immunization services on time during the covid-19 pandemic in the working area of the Tempuran Health Center, Magelang Regency. Methods: It was quantitative research with a cross-sectional approach. The research population was mothers who have babies aged 9-12 months with a sample of 100 mothers using cluster sampling technique in each village. The research instrument was a questionnaire. The data were analyzed univariately and bivariate with the Chi-square test. Results: The timeliness of MR immunization was still low. 74% of mothers were not punctual in immunizing MR to their children even though most mothers had a good attitude (65%). The Chi-square test showed a relationship between the mother's attitude and timeliness of MR immunization (p=0.004). Conclusion: The mother's attitude was not optimal because there were various problems with the mother's attitude, so it is hoped that the mother will increase knowledge, share experiences with peer groups, and if unable to attend, ask for family assistance, while health center is expected to carry out promotions, education about measles-rubella immunization and also coordinate with health office regarding vaccine stockKeywords:  immunization, measles-rubella, timeliness
Limfopenia dan Rasio Neutrofil-Limfosit pada Infeksi Severe Acute Respiratory Syndrome Coronavirus 2 Hevrina Yufani; Rikarni Rikarni; Zelly Dia Rofinda
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1734

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause cytokine storm characterized by the excessive release of pro-inflammatory cytokines, leading to lymphopenia and neutrophilia. Lymphopenia and high Neutrophil-Lymphocyte Ratio (NLR) on admission were associated with the severity of the disease. Objectives: To found out lymphopenia and high NLR in SARS-CoV-2 infection. Methods: This was a cross-sectional descriptive study on all patients infected with SARS-CoV-2 who met the inclusion and exclusion criteria at Dr. M. Djamil Hospital Padang from March until August 2020. Lymphocyte count and neutrophil count on admission were examined by flowcytometry method and NLR was calculated. Lymphopenia is a lymphocyte count of <1.5x103/mm3 and high NLR is ≥ 3.13.  Results: The study samples were 123 patients, with 58.5% women. The mean age was 47.80 (15.59) years. Lymphopenia was present in 39% of patients with mean lymphocyte count was 1.84 (0.83) x103/mm3. High NLR was present in 48% of patients with a mean NLR was 5.06 (4.87). Conclusion: Lymphopenia was present in 39% of patients infected with SARS-CoV-2 and high NLR was present in 48% of patients infected with SARS-CoV-2.Keywords:  lymphopenia, neutrophil-lymphocyte ratio, SARS-CoV-2
Sakit Kepala pada Variasi Anatomi Hidung dan Sinus Paranasal Dolly Irfandy; Tika Hakikah; Dolly Irfandy; Bestari Jaka Budiman
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1919

Abstract

The anatomical variations of the nasal and sinus paranasal can cause headaches. The most common variants have deviated septum, concha bullosa, and agger nasi cells. These variations can cause narrowing of the osteomeatal complex. Computed tomography was the primary modality for evaluating anatomical variations of the nasal and paranasal sinuses in diagnosis and management. Functional endoscopic sinus surgery was generally performed to restore the sinuses' drainage and ventilation in anatomical variations. It has been reported a 45-year-old woman with a congested left nostril and headache that has gotten worse since 2 months ago and computed tomography of the paranasal sinuses show thickening of the bilateral maxillary sinus mucosa, bilateral anterior ethmoid, left septum deviation, concha bullous, and right inferior turbinate hypertrophy. Functional Endoscopy Sinus Surgery was performed, found anatomical variations namely, deviation septum, concha bullosa, agger nasi cells and supra agger cells. The operation gave satisfactory results. Correct evaluation of anatomical variations based on history, physical examination and investigations can assist in patient management and avoid errors during surgery. The operation gave a satisfactory result for managing symptoms on patient with anatomical variation of nasal and paranasal sinuses when compared with medicamentosa.Keywords: anatomical variations,  agger nasi cells , concha bullosa,  deviated septum, headache, supra agger cell
Analisis Pencapaian Program Imunisasi Dasar Lengkap Pada Masa Pandemi COVID-19 di Kabupaten Pesisir Selatan 2021 Ahmad Adi Trianto; Hardisman Dasman; Yuniar Lestari
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1820

Abstract

Basic complete immunization coverage has decreased during the COVID-19 pandemic in Pesisir Selatan Regency. Objectives: To analyzed related factors of acceptance of basic complete immunization programs during the COVID-19 pandemic in Pesisir Selatan Regency. Methods: This research used qualitative methods with explanative design in three clusters of health center areas with 25 informants. The data were analyzed using the triangulation method through in-depth interviews and Focus Group Discussions (FGD). Results: The complete basic immunization has decreased in coverage during the COVID-19 pandemic because of the implementation of un maximum implementation due to lack of personnel accompanied by limited information media in remote areas causing lack of socialization, budget efficiency and no cooperation in each cluster, perceptions of halalness in rural areas, busyness parents in urban areas, non-compliance with health protocols in rural and remote areas, perceptions of no benefit in urban and remote areas, worry and fear of contamination COVID-19 in each cluster. Conclusion: The diversity of perceptions of each cluster causes a coverage has decreased of complete basic immunization during the COVID-19 pandemic in Pesisir Selatan Regency so that clustering on the implementation of complete basic immunization is needed.Keywords: complete basic immunization, coverage achievements, COVID-19
Korelasi Glukosa Kapiler Metode Glucose Dehidrogenase-Nicotinamide Adenine Dinucleotide Dengan Glukosa Serum Metode Heksokinase Syarifah Tridani Fitria; Rismawati Yaswir; Efrida Efrida
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1827

Abstract

Rapid and accurate measurement of capillary glucose level using point-of-care testing (POCT) is needed to maintain the patient’s normoglycemic status in obtaining adequate management. The glucose POCT method should be evaluated to determine analytical performance by comparing with the hexokinase method as a reference method to provide accurate and reliable results. Objectives: To determined the correlation between capillary glucose using glucose dehydrogenase-nicotinamide adenine dinucleotide (GDH-NAD)  and serum glucose hexokinase methods. Methods:  This analytic cross-sectional study on 42 outpatients who underwent fasting blood glucose examination at Dr. M Djamil Padang General Hospital. This study was conducted from February until September 2020. Capillary fasting blood glucose was measured using glucose POCT GDH-NAD method and serum glucose with hexokinase method. The Spearman correlation test was used to analyze data, significant if p<0.05. Results: The subjects were 28 male (66.7%),14 female (33.3%) with mean age and hematocrit level was 56.12±12.97 years and 40.90±2.42%, respectively. The median capillary glucose GDH-NAD method and serum glucose hexokinase method were 100.00 mg/dL each, with a median difference was 3.00 mg/dL. Spearman correlation test showed very strong positive correlation and statistically significant (r=0,961;p=<0,001). Conclusion: Capillary glucose GDH-NAD method had a very strong positive correlation with serum glucose hexokinase method.Keywords:  hexokinase, fasting glucose level, GDH-NAD, glucose POCT
Hubungan Kecemasan pada Visit Pre-Anestesi dengan Tekanan Darah sebelum Tindakan Anestesi di Rumah Sakit Universitas Sumatera Utara Christine Christine; Cut Meliza Zainumi; Tasrif Hamdi; Husnul Fuad Albar
Jurnal Kesehatan Andalas Vol 10, No 3 (2021): Online November 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1860

Abstract

Preoperative anxiety is frequently correlated with anesthesia procedures, resulting in the anesthesiologist being the most suitable person to decrease the patient's anxiety through effective doctor–patient communication during pre–anesthesia visits. During anxiety, one of the body responses is the release of epinephrine to the blood vessel resulting in increased blood pressure. Objectives: To knew the correlation between pre-anesthesia visit anxiety and blood pressure before anesthesia procedure. Methods: This study used a cross-sectional design that was conducted at Universitas Sumatera Utara General Hospital from September until October 2019. The sample was collected by consecutive sampling techniques, which meet inclusion and exclusion criteria. This study used primary data then was analyzed using Fisher’s Exact Test. Results: From 67 patients going through elective surgery, there are 41 patients (61,2%) with mild anxiety, 17 patients (25,4%) with moderate anxiety, and nine people (13,4%) with severe anxiety. There is no significant correlation (p>0,05) between anxiety with sex, types of anesthesia, PS ASA and heart rate. There is a significant correlation (p<0,05) between anxiety with blood pressure and types of surgery. Conclusion: There is a correlation between anxiety during the pre-anesthesia visit with blood pressure before anesthesia procedures.Keywords:  anesthesia, anxiety, blood pressure, pre-anesthesia visit
Review Literatur: Faktor Resiko Depresi dan Kecemasan Pada Tenaga Kesehatan Selama Wabah COVID-19 Esti Widiani; Lingling Marinda Palupi
Jurnal Kesehatan Andalas Vol 11, No 1 (2022): Online March 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i1.1923

Abstract

COVID-19 has created a state of anxiety and depression in health workers. Objectives: To identified what factors influence depression and anxiety. Methods: This literature summary used the PEOS framework. Search for articles through the ScienceDirect, PubMed, and Ovid databases in January 2021. The keywords used for the search for articles were (((((related factors) OR (risk factors)) AND (health workers)) OR (medical staff)) AND (anxiety)) AND (depression)) AND (covid 19). Results: The risk factors identified included age, gender, hours of work, front-line health workers, mental health, grade professional title, COVID-19 outbreak news or information, history of physical illness, negative experiences and social rejection, and fear of being exposed and transmitting COVID-19, and having children at home. Other risk factors included problems in the work environment, marital status, knowledge of COVID-19, quality of rest and sleep, living in the countryside, personal protective equipment, caring for family members, being infected with COVID-19, and bad family relationships. Many risk factors can trigger depression and anxiety. Conclusion:  Health policymakers must take steps to control these risk factors.Keywords:  depression; anxiety; COVID-19; healthcare worker
Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia Nita Afriani Azmal; Shinta Ayu Intan; Tofrizal Tofrizal
Jurnal Kesehatan Andalas Vol 11, No 1 (2022): Online March 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i1.1982

Abstract

 Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. Objectives: To reveal the expression of SOCs2 protein in 37 paraffin block samples in Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records and histopathology was assessed by HE. SOCs2 expression was evaluated by immunohistochemistry using SOCs2 polyclonal antibody (bs-1896R). Cytoplasmic expression was counted using Image J software. Results: The average of age was 56.57 years, 21 samples (55.8%) were male, depth of invasion was mostly in the tunica muscularis (T3), and 7 cases of malignancy (18.9%) were poorly differentiated. SOCs2 expression was  5 cases (13.5%).   Conclusion: There was SOCs2 expression in a small proportion of colorectal adenocarcinoma.Keywords:  SOCs2 protein, cytoplasmic inhibitor, JAK-STAT, cell signaling

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