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The Journal of Pure and Applied Chemistry Research
Published by Universitas Brawijaya
ISSN : 23024690     EISSN : 25410733     DOI : http://dx.doi.org/10.21776/ub.jpacr
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 307 Documents
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Synthesis and Characterization of Cellulose Acetate and Nanocellulose Acetate from Sengon Agroindustrial Waste (Paraserianthes falcataria) Nur Ikhtiarini; Masruri MASRURI; Siti Mariyah Ulfa; Widodo Widodo
The Journal of Pure and Applied Chemistry Research Vol 11, No 3 (2022): Edition September-December 2022
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2022.011.03.644

Abstract

Synthesis and characterization of cellulose acetate and nanocellulose acetate have been carried out. Cellulose was isolated from sengon wood powder waste using 6% NaOH solution and bleached with NaOCl. The cellulose was hydrolyzed with 60% formic acid to obtain nanocellulose. Cellulose and nanocellulose were then modified with acetic anhydride. The synthesized products were characterized by FTIR to identify organic functional groups, powder XRD to measure crystallinity, and SEM to observe surface morphology. Solubility tests in several types of solvents were also performed. The degree of substitution (DS) of cellulose acetate and nanocellulose acetate was carried out based on Indonesia’s SNI 0444:2009 method. The DS calculation show that the cellulose acetate and nanocellulose have DS of 2.9 and 2.1, respectively.
Study Direction to Oxidize a Local Pine Rosin with Potassium Permanganate Widia Edy Kuncoro; Moh. Farid Rahman; Masruri MASRURI, Ph.D; Siti Mariyah Ulfa
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.3298

Abstract

Pine rosin acid or Gondorukem is a solid resin obtained from pine sap. It is yielded as residue from a high temperature distillation process. In industry, rosin acid is widely used and modified as raw material in paint, ink, adhesive, resin, thermoplastic, and thermosetting polymer. Modification process generally is undergone to generate rosin acid with specific properties and for certain purposes. This paper report, potassium permanganate oxidation reaction of pine rosin acid under acidic process at low temperature. Product identified as 13,14-seco-13-oxoabiet-7-ene-dioic acid (0.52%), 7,8-dihydroxy-abietic acid (6.62%), and 7-oxo-dehydroabietic acid (1.49%). The crude product was isolated as a pale to white solid. Under high temperature a yellowish product was resulted. In overall, the yield isolated in between 46.4% and 86.0%.
Properties of Bacterial Cellulose/Polyvinyl Composite Membrane for Polymer Electrolyte Li ion Battery qolby sabrina; Hilwa Kamilah; Christin Rina Ratri; Titik Lestariningsih; Sitti Ahmiatri Saptari
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.663

Abstract

High ionic conductivity and more porous have extraordinary significance to solid polymer electrolyte in Li ion battery application. In this study, bacterial cellulose (BC) based polymer was modified by polyvinyl pyrrolidone (PVP) and polyvinyl acetate (PVA) to get composite solid polymer electrolyte. Blending the polymer host is one more approach to work on the morphology pore and electrochemical properties of polymer electrolytes. The slurry of BC is rich in fibers that contribute to forming the pore template of the solid electrolyte membrane. Polyvinyl work to make more pore and increases the polymer segmental ion lithium mobility. Pore morphology of BC PVA composite membrane homogeneously distributed by SEM observations. The presence of many pores makes the tensile strength of the BC PVA membrane lower, for use in solid electrolytes it does not affect battery performance. The presence of pores that contribute a lot to the absorption of electrolytes. Enhancement of the conductivity upon addition of salt is correlated to the enhancement of more pore of polymer electrolyte. The conductivity of BC PVA composite 8.45 x 10-7 Scm-1 higher than PVP at room temperature. In the future, PVA can be relied on to be a mixed material for solid electrolyte membranes based on cellulose.  
Comparison of Fabrication Technique and Carrier Oil to Curcumin Nanoemulsion Properties Zubaidah Ningsih; Sepriana Puspita Dewi Syaiful; Maria L.A.D Lestari; Diah Mardiana; Budi Kamulyan
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.701

Abstract

Turmeric (Curcuma longa L.) is included in the rhizome plant containing curcumin which has various therapeutic properties. However, curcumin has poor bioavailability. The manufacture of nanoemulsion is expected to increase curcumin bioavailability. This study aims to compare 3 methods (wet-ball milling, ultrasonication and microfluidic) and 3 carrier oils (soybean, virgin coconut, and olive oil) in the production of curcumin nanoemulsion. Wet-ball milling reduces particle size through grinding process using milling beads in liquid medium. Microfluidic decreases the particle size via collision of emulsion components in microchannel while ultrasound utilizes sound-wave energy to break down the particle size. Parameters compared were particle size, polydispersity index and entrapment efficiency. Particle size and polydispersity index were observed using Particle Size Analyzer with Dynamic Light Scattering technique while entrapment efficiency was measured based on the curcumin absorbance in UV-Visible spectrophotometer at 420 nm. Our study concludes that microfluidic is the most effective and efficient fabrication method which produces the smallest particle size and polydispersity index compared to ultrasonication and microfluidic. The resulting particle sizes using microfluidic are 154, 140 and 132 nm with polydispersity index of 0.224; 0.200and 0.208 insoybean,virgin coconut, and oliveoil respectively. However, entrapment efficiency is best achieved using wet-ball milling method with the average value of 49±10%. Soybean oil appears to be the most curcumin solubilizing oil compared to olive and virgin coconut oil. Thus, it can be concluded that fabrication methods and carrier oils determine curcumin nanoemulsion properties.
Potential Cytotoxic Activity of Methanol Extract, Ethyl Acetate, and n-Hexane Fraction from Clitoria ternatea L. on MCF-7 Breast Cancer Cell Line and Molecular Docking Study to P53 Rollando Rollando; Marsha Anggita Amelia; Muhammad Hilmi Afthoni; Kestrilia Rega Prilianti
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.705

Abstract

Breast cancer is a condition where the cells in breast tissue lose control and multiply uncontrollably. In this study, MCF-7 breast cancer cells were tested for cytotoxic activity using the MTT assay and the active compound's interaction with the p53 protein was tested in silico. The most active fraction was found to be the ethyl acetate fraction, with an IC50 value of 1.730 μg/mL and a selectivity index of 2.485. However, the selectivity index was less than 3, and Vero cells showed changes in morphology with the addition of the ethyl acetate fraction. GC-MS was used to identify 19 compounds in the ethyl acetate fraction, and in-silico tests were performed on 5 potential anticancer compounds. Lipinski's Rule of Five test showed that only 3 of these compounds could undergo molecular docking. The results indicated that Anethole compound can interact with p53 protein, while Cinnamaldehyde, (E)- can interact with p21 protein.
Sargassum aquifolium Extract Prevents Elevated Cholesterol Levels and Blood Vessel Thickening in Rats Fed an Atherogenic Diet Muhamad Firdaus; Rahmi Nurdiani; Aulia Savira; Firyal Hanifah
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.711

Abstract

Hypercholesterolemia is a health disorder in which cholesterol in the blood increases beyond normal limits. This disorder chronically can cause atherosclerosis. Sargassum aquifolium contains bioactive that can prevent an increase in blood cholesterol levels. This study aimed to prevent the increasing cholesterol levels and changes in the blood vessel profile of rats fed an atherogenic diet by S. aquifolium extract. S. aquifolium was obtained from Ekas Bay. Rattus norvegicus 2-3 months ages used in this study. Normal rats were fed an atherogenic diet for four months to produce an animal hypercholesterolemia model. The phytochemical profile was screened based on the Harborne method. Identity of bioactive determined by HPLC-HRMS. The parameters observed were cholesterol levels and blood vessel profiles. The juice of S. aquifolium contained steroids, saponins and tannins and their bioactive showed anticholesterolemic. Rats given an atherogenic diet had increased cholesterol levels. Administration S. aquifolium juice twice a day can reduce cholesterol levels and prevent the thickening of the aorta and arteries. In conclusion, S. aquifolium juice contains bioactive compounds and administration of S. aquifolium juice twice a day prevents an increase in cholesterol and damage to the aortic and arterial profiles.
Antibacterial Activity of Legundi Leaf (Vitex trifolia) Essential Oil Using In-Vitro and In-Silico Methods Retno Indriatie; Masruri Masruri; Warsito Warsito
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.738

Abstract

Staphylococcus aureus causes many severe diseases, such as meningitis, lung infection, and hematogenous osteomyelitis. The prolonged use of antibiotic drugs leads to antimicrobial resistance (AMR), decreasing their effectiveness against S. aureus. Therefore, novel drugs isolated from natural products have been the focus of many researchers to solve that problem. The essential oils isolated from Vitex trifolia leaf have many pharmacological activities, including antibacterial and antifungal activities. In this research, essential oil was isolated by distillation, followed by GC-MS analysis. The antibacterial activity of the essential oil was conducted using a disk diffusion test (Kirby-Bauer) and by molecular docking study. The essential oil yield from distillation was 0.13%, containing major compounds such as sabinene, eucalyptol, terpinen-4-ol, α-terpineol, limonene, and caryophyllene. The essential oil gave intermediate inhibition against S. aureus with a 6.91 ± 0.03 mm inhibition zone in 20 mg/mL of the sample. Using molecular docking study, caryophyllene and α-terpineol were the key compounds for inhibiting the active site of tyrosyl-tRNA synthetase, sortase A, and dihydrofolate reductase that are responsible for the S. aureus growth and development.
Potential Cassava Skin Waste (Manihot esculenta C.) In the Production of Bioethanol by Enzymatic Hydrolysis and Fermentation Using Zymomonas mobilis Bacteria Permatasari, Nur Umriani; Dali, Seniwati; Wahyuni, Eka Sry
The Journal of Pure and Applied Chemistry Research Vol 12, No 2 (2023): May-August 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.02.3304

Abstract

Cassava is one of the most widely produced agricultural products in Indonesia with cassava peel waste of 20%. Cassava peel contains carbohydrates and stores a high cellulose content so that it has a potential to be a bioethanol. This study aims to utilize cassava peel waste for bioethanol production with an alkaline pretreatment process, cellulase enzyme hydrolysis and fermentation by using Zymomonas mobilis bacteria. Alkaline pretreatment with 14% NaOH is used to hydrolyze lignocellulose. The hydrolysis optimization process enzymatically applies the Surface Response Method (RSM) to determine the optimum conditions at hydrolysis pH in the range of 2-10 and hydrolysis temperature in the range of 30-70 °C by analyzing glucose levels using the Dinitrosalicylic Acid (DNS) method and UV-vis spectrophotometry instruments. Surface Response Method (RSM) is likewise implemented to decide the greatest conditions of the fermentation process. The pH measurement ranges 2-10, and fermentation time takes 6 to 168 hours. Based on the results of research, it results a lignin content of 6.68% (b/b), cellulose content of 58.4% (b/b), and hemicellulose content of 27.3% (b/b). The optimum conditions of the hydrolysis process obtained an optimum glucose level of 9.22mg/mL at pH 2 and a hydrolysis temperature of 50°C. The optimum conditions of the fermentation process use Zymomonas mobilis at pH 6 while fermentation time takes 168 hours analyzed using a refractometer produced a bioethanol content of 37.75% (v/v) and a gas chromatography produced a bioethanol content of 54.94% (v/v).
Phytochemical screening, antioxidant, antishigella and antileishmanial activities of ethanolic extract of Rourea coccinea (Schumach & Thonn.) Benth leaves Basile Goueti; Benedicta Kpadonou-Kpoviessi; Raymond Fatondji; Bardieu Atchade; Paul Djouonzo Toukam; Salomé Dossou Sika KPOVIESSI
The Journal of Pure and Applied Chemistry Research Vol 12, No 2 (2023): May-August 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.02.3314

Abstract

Rourea coccinea is a widely used medicinal plant worldwide, especially in West Africa. The phytochemical screening of the ethylanolic extract of leaves carried out according to the method of Houghton and Raman with some modifications, revealed the presence of alkaloids, phenolic compounds, terpenenoids, tannins, coumarines, anthocyanins and anthraquinones. The antiradicalar tests were performed using DPPH (2,2-diphenyl-1-picryhydrazyl), ABTS (2,2-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diamum salt) and FRAP (Ferric Reducing Antioxidant Power) with a Scavenging concentration 50 (SC50) of 101,19 µg/mL, 34.73 µg/mL and 88.93 µg/mL respectively. The antishigella activity of the extract determined by the microdilution method was low. According to Jair Siquera-Neto et al., the antileishmanial assay using the colorimetric resealing method showed activity against promastigous strains of Leishmania donovani with an inhibitory concentration of IC50=32.26 µg/mL. The traditional use of Rourea coccinea, in the treatment of several diseases, would be justified by these pharmacological properties tested.
Effects of Preparation Temperature and Liquid-Solid Lipid Composition to Curcumin-Nanostructured Lipid Carrier Characteristics Fabricated by Microfluidic Technique Ridho Arief Al Rasyid; Diah Mardiana; Ridho Firmansyah; Zubaidah Ningsih
The Journal of Pure and Applied Chemistry Research Vol 12, No 2 (2023): May-August 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.02.3317

Abstract

Nanostructured Lipid Carriers (NLC) are lipid-based carrier that uses a combination of liquid and solid lipids which is believed to deliver a higher amount of active substance to the human body. This study aimed to obtain the best formulation and evaluate the stability of curcumin-loaded NLC (C-NLC) using microfluidic technique at temperature of 40oC and 60oC with the ratios of liquid:solid lipids were 2 : 1 ; 3.5 : 1 ; 4 : 1 ; 6 : 1% w/w. Our results showed that the increase of process temperature and liquid lipid concentration reduced particle size. There was a non-linear relationship between lipid ratio and temperature to encapsulation percentage. At ratio of soybean oil:stearic acid 6 : 1 and, at 40°C, particles size (PS) obtained was 143.87 ± 3.36 nm, polydispersity index (PDI) obtained was 0.44 ± 0.01, zeta potential (ZP) obtained was -33.3 ± 6.53 mV with encapsulation percentage of 20.62%. At the same ratio at 60°C, the PS obtained was 60.21 ± 2.55 nm, PDI obtained was 0.72 ± 0.03, ZP obtained was -26.10 ± 1.83 mV and encapsulation percentage of 31.45%. Stability test showed that C-NLC produced at 60°C was more stable since the change of particle size and pH were lower than C-NLC produced at 40°C.

Page 26 of 31 | Total Record : 307

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