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Suryani Dyah Astuti
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Postgraduate School of Universitas Airlangga Airlangga Street No. 4-6, Campus B of Universitas Airlangga , Airlangga Street, Gubeng District, Surabaya, East Java, Indonesia Postal Code 60286 Telephone 031-5041566, 5041536 Facsimile 031-5029856
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Jurnal Biosains Pascasarjana
Published by Universitas Airlangga
ISSN : 14121433     EISSN : 26214849     DOI : http://dx.doi.org/10.20473/jbp.v22i1.2020.1-10
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology
Jurnal Biosains Pascasarjana is published not only for the publication of research results from graduates, as one of the graduation requirements but also for public that contains a discussion of the natural content, responses of living things, and their environment.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 10 Documents
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Search results for , issue "Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA" : 10 Documents clear
RECENT DEVELOPMENT OF POTENTIAL THERAPY FROM NATURAL COMPOUNDS IN Helicobacter pylori INFECTION: A SYSTEMATIC REVIEW Susanti; Afifudin, Alfin Fatwa M.
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.76-90

Abstract

This work performs a systematic literature review on potential Natural Product in Helicobacter pylori (H. pylori) and discusses the development of potential therapy from various natural resources. A search method was used to locate papers published between 2019 and 2024 in Web of Science and PubMed databases, and 14 studies were selected. Reports on potential Natural Product in H. pylori, in vitro and in vivo study design are included. Articles not written in English or whose full text could not be accessed were excluded. The remaining publications were checked and evaluated to determine whether they contain supportive natural product in H. pylori infection. The majority of articles are used non RCT study design and Minimum Inhibitory Concentration (MIC) was the most commonly utilized parameter in these studies. These studies generally focus on in vitro investigation using natural product such as licorice root extract, C. striata extract, propolis extract, and virgin olive oil extract on the certain strains of H. pylori. Different extracts of natural products were reported to have different particular effects on H. pylori including antimicrobial activity, the regulation of inflammatory cytokines and genes, and the association of protection and histopathology effects.There has been numerous research on potential Natural Product in H. pylori infection, but it is not yet applicable in health practice. In the future, the potential Natural Product studies expected to reach the clinical study stage and to contribute to the invention on the treatment of H. pylori infection.
THE RELATIONSHIP OF HEAT SHOCK PROTEINS TO TUBERCULOSIS INFECTION: A SYSTEMATIC REVIEW Muim, Rosyinta; Marviella, Sephia Tiara; Zuhri, Fuad Minan
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.91-104

Abstract

ABSTRAK Tuberculosis infection is a global health problem that occurs in almost every part of the world. HSPs are expressed by MTB when stimulated by stress in response to physiological pressure. We used PubMed, MDPI, and Scopus database to select eligible studied for systematic review published between January 1, 2019 and March 02, 2024. We investigated potential publication bias by examining quality assessment using the SCIRAP tool. From the articles reviewed, it was found that HSPs can play a role in TB infection both as therapeutic agents, biomarkers, and as new diagnostic agents to support the control of TB infection which is still an endemic infection. Types of HSPs that are known to play a role in TB infection are: HSPX, HSP16.3, HSP70, HSP27, and HSPR. This research concluded that HSPs are expressed by MTB under stress, and the expressed HSPs are then used as biomarker for effective diagnostic testing of TB infection, especially latent TB infection, as well as their development as therapeutic agent for making drugs for TB infection.
POTENTIAL OF SACHA INCHI (Plukenetia volubilis L.) AS AN ANTICANCER : A SYSTEMATIC REVIEW Fadhilah, Nadiah Farah; Nastiti, Chyntia Tresna; Zuhri, Fuad Minan
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.105-118

Abstract

Cancer is the leading cause of death worldwide. WHO estimated 20 million new cancer cases and 9.7 million deaths in 2022. The increasing incidence of cancer encourages development of new therapeutic agents for higher patient survival rate. Plant products are widely studied, one of which is Sacha Inchi (Plukenetia volubilis L.) extract. Sacha Inchi is known to have contents with anticancer potential, but information regarding its effectiveness is still limited. This systematic review aims to provide in-depth review on studies focus on anticancer potential of Sacha Inchi. The searching process was conducted in 4 databases such as National Library of Medicine (MEDLINE-PubMed), Scopus, Springerlink, and Sciencedirect. Keywords used were combination of "sacha inchi”, "plukenetia volubilis”, "anticancer”, "antineoplastic”, "antiproliferative”. Studies selection and data extraction obtained 17 studies provided information on extracts of Sacha Inchi plants and their anticancer-potential contents, both in vitro and in vivo. Polyunsaturated fatty acids and phenolic compounds were the most identified compounds. Other identified substances were tocopherols, peroxides, amino acids, steroids, terpenoids, flavonoids, proteins. Included studies showed antioxidant and anticancer potential of Sacha inchi.
EFFECTIVENESS TEST OF BIDARA LEAF EXTRACT (Ziziphus mauritiana) AS ANTIBACTERIAL AGAINST Staphylococcus aureus AND Escherichia coli Qudsiyyah, Farida
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.119-130

Abstract

Bidara leaf extract is known to have potential immunomodulatory activity, this suggests that it may provide a response to infections caused by bacteria. The results of phytochemical screening of bidara leaves taken from Klagen village, showed that there were secondary metabolite compounds in the form of flavonoids, tannins, and saponins. The inhibition zone test with the disc diffusion method using extract concentrations of 40%, 50%, 60%, 70%, 80%, 90%, and 100% as well positive control and negative control. The results showed that the diameter of the inhibition zone test was the widest of the two bacteria at Staphylococcus aureus was 10.97 ± 2.47 mm, while in Escherichia coli it was 5.26 ± 0.45 mm. The next test is the MIC test using concentrations of 100%, 50%, 25%, 12.5%, and 6.25% which is then followed by the MBC test. The results of the MIC test with the micro dilution method are known by observing changes in media turbidity after incubation. Then continued with the MBC test as confirmation of the presence of microbes after the incubation period through the pour plate method. The KHM value was obtained at a concentration of 50%, on Staphylococcus aureus bacteria with a total colony of 1.2 x 106 CFU/mL and on Eschericia coli with a total colony of 1.0 x 107 CFU/mL. The KBM value obtained on Staphylococcus aureus and Eschericia coli test bacteria is at a concentration of 100%.
EFFECT OF DIETARY INTAKE CONTAINING VITAMINS A, C AND E ON TUBERCULOSIS PATIENTS Yasmin, Ratri; Zuhri , Fuad Minan
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.131-143

Abstract

Tuberculosis is a chronic infectious disease that is almost universally natural, caused by Mycobacterium tuberculosis. TB has a strong relationship with vitamins A, C, and E. This is due to the modulating action of these vitamins in the inflammatory process. Data was collected through literature review from electronic databases such as PubMed and SCOPUS. The keywords are "Ascorbic Acid", "Vitamin A", "Vitamin E", "tocopherol", "tocotrienol", and "Tuberculosis". Of the 167 selected articles, 4 were analyzed Intake of foods containing vitamins A, C and E can strengthen the immune system in killing Mycobacterium tuberculosis by modulating the maturation and migration of T cells, inducing hydroxyl radicals due to tuberculosis disease. Intake of foods containing vitamins A, C and E in people with tuberculosis can affect the risk of developing tuberculosis disease and can accelerate healing in people with tuberculosis. Deficiencies in vitamins A, C and E can worsen TB disease and can lead to drug resistance.
ANALYSIS OF ANTIBIOTIC COST IN BROILER MANAGEMENT PRACTICE IN SUBANG REGENCY, WEST JAVA, INDONESIA Sugiyono; Sabdoningrum, Emy Koestanti; Hidanah, Sri; Lokapirnasari, Widya Paramita; Luqman, Epy Muhammad; Hestianah, Eka Pramyrtha
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.144-149

Abstract

Broiler farms are generally susceptible to disease attacks caused by viruses, bacteria, parasites, fungi, the environment, and deficiencies in nutritional elements. The use of antibiotics in the livestock industry generally aims to treat livestock so as to reduce the risk of death and restore livestock to a healthy condition. There are three patterns for rearing broiler chickens in Indonesia, especially in West Java, namely modern rearing using a closed house system, semi closed house and conventional rearing using open house system. This study aims to prove the analysis of the cost of antibiotics and their market potential needs to be known so that rational and balanced use of antibiotics can be illustrated with the benefits to the results of raising broiler livestock. The design used in this research was a purposive sampling. The variables in this research are the closed house, semi closed house and open house broiler farming systems. The independent variables in this research are the cost of antibiotics each bird per period. Descriptive analysis is used to obtain stewardship antibiotics based on the existing medication program. The antibiotic cost each bird per period from closed house amount is Rp. 70,49 + 38,65, semi closed house is Rp. 100,20 + 42,28, and open house is Rp. 130,32 + 64,68. The means of antibiotic cost each birds per period amount is Rp. 100,34 + 54,17 use a factor for forecasting market potency of antibiotic. The market potency per year in Subang regency amount Rp. 5.799.005.710 + 3.130.677.091, West Java Province amount Rp. 74.165.707.957 + 40.039.429.938, Indonesia amount Rp. 312.461.530.889 + 168.686.875.905. Apart from that, antibiotic stewardship on a broiler farm scale is also needed to get an idea regarding the appropriate use of antibiotics in broiler farms, especially in the Subang district area of West Java Province.
THE RELATIONSHIP BETWEEN OCCUPATION, PREVENTIVE BEHAVIORS, AND ENVIRONMENTAL CONDITIONS ON THE INCIDENCE OF MALARIA IN MEKAR SARI VILLAGE Sofiyana, Ririn Hariani; Azmi, Fahriana; Utary, Dewi; Indriyani, Ni Putu Dewi
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.150-159

Abstract

Malaria is a disease that often causes health problems globally, including in Indonesia. The increasing prevalence of malaria cases can have a broad impact on the quality of life and economy and even threaten the safety of human life. This study aims to determine the relationship between occupation, preventive behavior and environmental conditions around the house to the incidence of malaria in Mekar Sari Village, West Lombok. This study used analytic observation method with cross-sectional design. The population of this study were all Mekar Sari Village residents who indicated malaria. The sampling technique used was purposive sampling using certain considerations. The data obtained were analyzed univariately and bivariately with Chi Square. The results of this study showed that most respondents had gardening jobs, a total of 26 people or (29.5%), adequate prevention behavior, a total of 39 people or 44.3%, unfavorable environmental conditions, a total of 60 people or 68.2%, and most respondents had malaria, a total of 46 people or 52.3%. There is a relationship between occupation (p-value 0.039), preventive behavior (p-value <0.001) and environmental conditions around the house on the incidence of malaria (p-value 0.019). There is a significant relationship between occupation, preventive behavior and environmental conditions on the incidence of malaria in Mekar Sari Village, West Lombok. Keywords: Occupation, Preventive Behavior, Environmental Conditions, Malaria Incidence
IDENTIFICATION OF METABOLITE COMPOUNDS IN EXTRACT AND EXTRACT FRACTIONS OF MORINGA LEAVES (Moringa oleifera) USING THIN LAYER CHROMATOGRAPHY (TLC) METHOD Khairi, Widayatul; Safwan; Hendriyani, Irmatika
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.175-182

Abstract

Moringa oleifera, known in Indonesia as "kelor," is often referred to as "the miracle tree" due to its natural nutritional and medicinal properties. Compounds found in Moringa leaf extract have been confirmed to include flavonoids. These compounds contain -OH groups attached to benzene rings, which contribute to their antioxidant, anti-inflammatory, and antimicrobial properties. The aim of this study was to identify secondary metabolites in Moringa leaves using the Thin Layer Chromatography (TLC) method. The results showed that flavonoids, tannins, alkaloids, and saponins were present in the ethyl acetate fraction, while tannins were found in both the extract and aqueous fraction. Additionally, steroids were detected in the n-hexane fraction. In conclusion, Moringa oleifera contains secondary metabolite compounds.
PROXIMATE ANALYSIS AND NUTRITIONAL PROFILE OF FISH FEED BASED ON DRIED TUBIFEX WORMS (Tubifex sp.) AND PAPAYA LEAF EXTRACT Wahidi, Budi Rianto; Hafidz, Muhammad Fernanda Pratama; Insivitawati, Era
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.160-165

Abstract

This study aimed to analyze the nutritional content of fish feed with a novel formulation, combining dried Tubifex worms and papaya leaf extract, to enhance growth and production efficiency in freshwater fish. Proximate tests revealed significant differences between fresh and papaya leaf extract-enriched dried Tubifex worms. Although the protein content of dried Tubifex worms was lower, the addition of papaya leaf extract potentially improved nutritional efficiency through proteolytic enzymes. Dried Tubifex worms enriched with papaya leaf extract offer advantages in storage, buoyancy, and nutritional efficiency, making them a promising feed alternative in aquaculture. Further research is needed to validate their effectiveness at a culture scale.
BIODIVERSITY OF GROUND SURFACE INSECTS IN SWEET ORANGES IN MOUNT RINJANI NATIONAL PARK Andini, Baiq Yuni; Sazali, Munawir
Jurnal Biosains Pascasarjana Vol. 27 No. 2 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i2.2025.166-174

Abstract

This study aims to identify the diversity of surface-dwelling insects in Jeruk Manis, located within Gunung Rinjani National Park, and to analyze species diversity, dominance, and evenness indices. A survey method employing stratified random sampling based on habitat type was applied. Insect sampling was conducted at eight observation points on April 26, 2025. The study identified seven species of surface-dwelling insects: Largidae, Pachycondyla, Tapinoma sessile, Calliptamus italicus, Gray bird grasshopper, Pyrrhocoridae, and Thanasimus formicarius. Data analysis using the Shannon-Wiener Diversity Index yielded a diversity value (H') of 2.70, indicating a moderate level of species diversity. The Dominance Index (C) of 0.126 suggests that no single species dominates the community. However, the Evenness Index (J'), which varies between 0.126 and 7.397, reveals an uneven distribution of individuals among species, with certain species exhibiting significantly higher abundance than others. This research contributes to a deeper understanding of the insect ecosystem in the region and highlights the crucial role of surface-dwelling insects as bioindicators of environmental health.

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