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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Diuretic Effect of Combination of Watercress (Nasturtium officinale) and Purslane (Portulaca oleraceae) Sutjiatmo, Afifah Bambang; Yuliartati, Ni Luh Ade; Yulianti, Maulidya; Suryani, Suryani; Vikasari, Suci Nar
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.36330

Abstract

Watercress (Nasturtium officinale) and purslane (Portulaca oleracea) are used to increase urination.This preclinical study aims to prove the diuretic effect of a combination of watercress and purslaneextracts. Simplisia of watercress and purslane herbs mixed with various combinations A (1:9), B(1:3) and C (1:1), then extracted in 50% ethanol. The animals were divided into five groups: control,furosemide 3.6 mg/kgBW, A 38 mg/kgBW, B 28 mg/kgBW, and C 10 mg/kgBW. Diuretic assay wascarried out using the modified Lipschitz method with the parameters observed were cumulative urinevolume for 6 and 24 hours, and potassium levels in 24-hour urine. The results showed the onset ofdiuretic effect of furosemide at 60 minutes, A at 150 minutes, B at 240 minutes and C at 90 minutes.Percent effectiveness of the diuretic in the furosemide was 718%, A 212%, B 231%, and C 368% whencompared to the controls. All combinations of extracts increased sodium and potassium secretion whencompared to controls, but this effect was not as strong as furosemide. All combinations of watercressand purslane herbs have a diuretic effect but weakly saluretic when compared to furosemide and thecombination that gives the best effect is combination C.
Pengetahuan, Sikap, dan Tindakan dalam Memilih Swamedikasi antara Obat Konvensional dan Herbal selama tahun 2021 sampai 2022 di Kelurahan Pademangan Barat Hasbi, Fatwa; Surahman, Surahman
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52644

Abstract

Perintah lockdown yang diberlakukan oleh pemerintah Indonesia memaksa masyarakat untuk bisa melakukan swamedikasi yang baik agar dapat menjaga kesehatan maupun mengobati diri sendiri. Sejak tahun 1998 terdapat >60% penduduk Indonesia yang melakukan pengobatan sendiri dan selama masa pandemi (2020) terdapat 72,19% penduduk. Obat herbal juga digunakan masyarakat untuk swamedikasi selama masa pandemi COVID 19. Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan antara tingkat pengetahuan masyarakat terhadap sikap dan tindakan dalam pemilihan swamedikasi. Penelitian ini menggunakan metode deskriptif observasional dengan model penelitian survei yang menggunakan pendekatan cross sectional. Pengambilan sampel dilakukan menggunakan dengan metode consecutive sampling pada beberapa RW di Kelurahan Pademangan Barat, Jakarta Utara, Indonesia dengan jumlah 100 responden. Responden diberikan kuesioner untuk menilai tingkat pengetahuan, sikap, dan tindakan mereka dalam memilih pengobatan sendiri. Hasil penelitian menunjukkan bahwa mayoritas responden mempunyai sikap positif terhadap kedua jenis pengobatan mandiri, baik konvensional maupun herbal (89% & 97%). Terdapat 21% responden yang memilih menggunakan obat konvensional dan 17% memilih obat herbal. Sedangkan 58% responden memilih menggunakan kedua jenis pengobatan mandiri dan 4% tidak menggunakan pengobatan mandiri. Namun tidak terdapat hubungan yang signifikan antara tingkat pengetahuan dengan sikap dan tindakan responden (p value >0,05). Dapat disimpulkan bahwa sebagian besar responden mempunyai pengetahuan yang baik dan sikap yang positif, hal ini menunjukkan bahwa responden mempunyai kecenderungan untuk melakukan pengobatan sendiri dengan menggunakan obat konvensional atau herbal, namun hasil pengujian tidak ditemukan adanya hubungan antar variabel.
Tea Fermentation of A. malacencis with Lactobacillus plantarum as a starter : Total Phenol Content, Total Flavonoids Content And Antioxidant Activity, In vitro study as a functional drink Apridamayanti, Pratiwi; Sari, Rafika
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38426

Abstract

Some herbal teas contain antioxidant compounds that neutralize the free radicals involved in ageing processes and various diseases. Fermentation can increase the antioxidant activity in herbal teas due to the metabolic outputs of the microorganisms involved in the fermentation process. Aquilaria malaccencis is used to make teas in Indonesia and other countries and has been identified as demonstrating antioxidant properties. This study aimed to determine the characteristics of tea made from A. malaccencis leaves and fermented with Lactobacillus plantarum for 48 hours, 96 hours and 192 hours. The features investigated were antioxidant activity measured via DPPH assay and total phenol and flavonoid content measured spectrophotometrically. The fermentation results at 48, 96 and 192 hours were a pale yellow, sour aroma and sour taste and total lactic acid bacteria (LAB) content of 8.49 x 106 CFU/mL, 7.42 x 106 CFU/mL and 2.6 x 1010 CFU/mL, respectively. Antioxidant activity (IC50) at 48 hours was 439.444 µg/ml, at 96 hours was 235.309 µg/ml, and at 192 hours was 190.33 µg/ml. Total phenolic content (mg/g GAE) at 48 hours was 22.561, at 96 hours was 18.173, and at 192 hours was 21.14. Total flavonoid content (mg/g QE) at 48 hours was 1.901, at 96 hours was 1.938, and at 192 hours was 3.76. This research concluded that Lactobacillus plantarum as a starter for fermented tea made from Aquilaria malaccensis Lam. (A. malaccensis) leaves could produce appropriate characteristics for its functional food consumption. The best fermentation time was 192 hours, delivering an IC50 value of 190.33 ± 1.64 µg/ml, total phenol content of 36.346 mg/g GAE, and total flavonoid content of 3.876 ± 0.317 mg/g QE.Keywords: Tea fermentation, antioxidant activity, total phenolic content, total flavonoid content.
Analysis of Drug Related Problems (DRPs) in Patient with Chronic Kidney Disease Stage V, Anemia and Cholelithiasis With Hemodialysis Therapy Kurniawan, Hery
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53852

Abstract

The use of medical therapy in patient with chronic kidney disease stage v, anemia and cholelithiasis needs special attention. The case report aims to discuss the treatment therapy for chronic kidney disease stage v, anemia and cholelithiasis that the patient is currently suffering from. Data collection method is retrospective. The data obtained was then analyzed for Drug Related Problems using a literature review. Based on the results of this analysis, the treatment given to the patient was deemed appropriate. The results of the analysis show that it is necessary to periodically monitor gallstone size, kidney function (serum creatinine and urea) and hemoglobin.
Lama Penyimpanan Mikrokapsul Ekstrak Buah Mengkudu Terhadap Kadar Air, Aktivitas Antioksidan Dan Sebaran Jamur Nurlaeni, Leni; Abun, Abun; Widjastuti, Tuti
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.44673

Abstract

Buah mengkudu mengandung sejumlah senyawa fitogenik. Lama penyimpanan yang berbeda dapat mempengaruhi kualitas produk. Selama penyimpanan berlangsung produk mikrokapsul ekstrak buah mengkudu dapat terjaga kualitasnya dan terlindungi senyawa bioaktifnya dengan metode mikroenkapsulasi. Tujuan penelitian adalah mengetahui pengaruh produk mikrokapsul ekstrak buah mengkudu dengan berbagai penyalut pada lama penyimpanan yang berbeda. Penelitian menggunakan penelitian experimental dengan Rancangan Acak Lengkap yang terdiri dari 10 perlakuan 3 ulangan. Setiap formulasi dilakukan penyimpanan selama 0, 2, 4 minggu. Peubah yang diamati adalah kadar air, aktivitas antioksidan dan sebaran jamur. Proses mikroenkapsulasi ekstrak buah mengkudu memberikan pengaruh yang nyata terhadap kestabilan kadar air, aktivitas antioksidan dan sebaran jamur dibandingkan dengan perlakuan yang tidak dilakukan proses mikroenkapsulasi. Produk mengalami peningkatan kadar air, aktivitas antioksidan dan sebaran jamur seiring dengan lamanya proses penyimpanan.
O-CITRI Soap: Antibacterial Paper Soap Made from Orange Peel (Citrus sinensis L.) and Basil (Ocimum sanctum L.) Fitriyani, Fitriyani; Bustomi, Mochammad Y. A.; Maulina, Novia; Kinasih, Larasati S.; Arriziq, Muhammad A.
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.52344

Abstract

Basil (Ocimum sanctum L.) have a dominant content of citral compounds with antibacterial activity. Another plant suspected to contain antibacterial bioactive components is orange peel. Orange peel (Citrus sinensis L) contains phenolic compounds (phenolic acids, flavonones, and polymethoxylated flavones), carotenoids, and ascorbic acid. Phenolic compounds are known to have several activities such as antimicrobial, antioxidant, anticancer, anti-inflammatory, and anti- allergic. The aim of this research is to prove that the combination of orange peel and basil extracts has antibacterial effects against Staphylococcus aureus, which can be formulated as paper soap which is named O-Citri. This research method is experimental, involving the physical and chemical evaluation of the formulation, as well as antibacterial activity testing. The research results show that the combination of orange peel and basil extracts in the paper soap formulation has antibacterial effects. The highest concentration combination for antibacterial activity is F1 with a ratio of orange peel and basil extract at 5%:15%.
In-Silico Studies of Compounds Derived from Brucea javanica (L.) Merr. as Potential Inhibitors of Influenza A Neuraminidase H5N1 Nuwarda, Rina Fajri
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.51915

Abstract

The H5N1 bird flu virus continues to be endemic in Indonesia, posing continued threats to the poultry farming industry and public health. Classified as an influenza type A virus, the avian influenza virus is a member of the Orthomyxoviridae family. Type A influenza virus is the most lethal strain and frequently evolves resistance. The exploration of novel neuraminidase (NA) inhibitors is imperative due to the development of resistance by the H5N1 virus to NA drugs. Brucea javanica extract inhibits the activity of the H5N1 NA enzyme, according to previous research. Using the molecular docking technique, this study sought to ascertain the in-silico activity of the B. javanica compound in relation to H5N1 NA. By utilizing molecular docking simulation, we conducted the in-silico study and predicted the toxicity and pharmacokinetic profile of compounds, in addition to their drug-likeness according to Lipinski's Rule of Five. The result showed that Bruceantinol had a free binding energy of -8.93 kcal/mol, an inhibition constant of 0.28 M, and interactions with six important amino acid residues. The HIA and CaCo-2 values were 47.935% and 19.871%, respectively, whereas the PPB and BBB values were 39.591% and 0.049%. Neither is this substance carcinogenic nor mutagenic. Low binding energy and the most favored interaction with H5N1 NA were observed for Bruceantinol. Thus, Bruceantinol exhibits potential as a prospective NA inhibitor.
Antioxidant Activity, Sun Protection Factor and Phytochemical Properties of Different Parts Sawo Walanda (Pouteria Campechiana (Kunth.) B.) Extract Fitriansyah, Sani Nurlaela; Fadhilah, Syifa; Ruslan, Komar; Hartati, Rika; Fidrianny, Irda
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.50584

Abstract

AbstractUV radiation can lead production of Reactive Oxygen Species (ROS) on the skin and can cause negative effects1. Sun protector and antioxidant ingredients are needed to protect the skin2. Phenolic compounds and flavonoids have been used as sun protectors and as antioxidants3. Pouteria campechiana is known for its high abundance of phenolic compounds4. This study reported the phytochemical group, total phenol and total flavonoid content, antioxidant activity, and sun protector factor of ethanol extracts of pulp, seed, leaves, and twigs of Pouteria campechiana. Determination of antioxidant activity, sun protection factor, and total phenol and total flavonoid content were carried out using UV-visible spectrophotometry. Crude drugs and extract of pulp, seed, twig, and leaves P.campechiana containing phenolic group, tannin, and flavonoid. The leaf extract had the highest total phenolic content, while the highest total flavonoid content was in the seed extract. All of the extracts tested had very strong antioxidant activity indicated by the Antioxidant Activity Index (AAI) to DPPH value, >2. At a concentration of 1000 µg/mL, the leaf extract showed the highest SPF value, 16.01 ± 0.38.The conclusion, the leaf extract had the potential to further as a natural antioxidant, and sun protector. AbstrakPaparan radiasi UV dapat meningkatkan produksi Reactive Oxygen Species (ROS) sebagai radikal bebas dan dapat menimbulkan efek negatif pada kulit. Dibutuhkan senayawa aktif sebagai fotoprotektor dan senyawa penangkal radikal bebas yang disebut antioksidan untuk melindungi kulit. Golongan senyawa fenol dan flavonoid dapat menyerap radiasi UV dan menangkal radikal bebas. Pouteria campechiana dilaporkan mengandung senyawa fenol. Penelitian ini melaporkan golongan senyawa kimia, kadar fenol dan flavonoid total, aktivitas antioksidan terhadap DPPH dan aktivitas fotoprotektor yang menggunakan parameter nilai Sun Protector Factor (SPF) dari ekstrak etanol daging buah, biji, ranting dan daun Poteria campechiana. Ativitas antioksidan, nilai SPF, kadar fenol total, dan flavonoid total diukur secara spektrofotometri UV-Sinar tampak. Hasil penelitin menunjukkan simplisia dan ekstrak etanol daging buah, biji, ranting dan daun P.campechiana mengandung golongan senyawa fenoli, tanin, dan flavonoid. Ekstrak etanol daun memiliki kadar fenol total tertinggi, sedangkan kadar flavonoid total tertinggi ada pada ekstrak etanol biji. Keempat ekstrak tergolong pada antioksidan sangat kuat, dengan parameter nilai AAI >2. Pada konsentrasi 1000 µg/mL, ekstrak daun menunjukkan nilai SPF tertinggi yaitu sebesar 16,01 ± 0,38. Kesimpulan, ekstrak etanol daun P.campechiana lebih berpotensi untuk dikembangkan sebagai bahan baku aktif antioksidan alami dan fotoprotektor.
Antifungal Activity Testing of Extract and Fractions from Tectona grandis Linn. F Leaves Using the Microdilution Method Anwar, Irvan -; Malina, Rachma -; Nuralifah, Nuralifah -; Parawansah, Parawansah -; U, Wa Ode Hartasyah
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52625

Abstract

Teak leaves (Tectona grandis Linn. F) are one of the plants that have empirically been used as antifungal, antioxidant, antibacterial, and antidiabetic agents, due to their content of secondary metabolite compounds including saponins, tannins, alkaloids, and sterols. This research aims to determine the secondary metabolite compounds present in the extract and fractions of teak leaves (Tectona grandis Linn. F) and the antifungal activity of the teak leaf extract and fractions against Candida albicans using the microdilution method. The ethanol extract was fractionated using a partition method with solvents n-hexane, chloroform, and ethyl acetate. Antifungal testing was carried out against Candida albicans using the Broth Microdilution method to measure the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) values. Based on the phytochemical screening results, teak leaves contain alkaloids, phenolics, flavonoids, and terpenoids. The MIC results for the antifungal activity of the ethanol extract, n-hexane fraction, chloroform fraction, and water fraction against Candida albicans were all >500 µg/mL. In the meantime, the MIC and MFC values for ketoconazole 200 mg against Candida albicans were 64 µg/mL. These results indicate that there is a difference in MIC and MFC values between the samples and the positive control (ketoconazole 200 mg), with the antifungal activity of the samples being weaker compared to the positive control
Preparasi dan Karakterisasi Nanokolagen dari Tulang dan Kulit Belut Sawah (Monopterus albus) yang Berpotensi sebagai Bahan Baku Kosmetik Puspitasari, Dian; Saryanti, Dwi
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.38842

Abstract

Pengembangan bahan baku kosmetik berbasis nanopartikel semakin banyak dikembangkan dengan alasan karena partikel dengan ukuran nano akan lebih mudah untuk diserap dan terdifusi dalam kulit daripada partikel yang memiliki ukuran lebih besar. Hal ini juga lah yang mendasari dikembangkannya nano kolagen dari tulang dan kulit belut sawah yang berpotensi sebagai bahan baku kosmetik. Untuk membuktikan keberhasilan preparasi nano kolagen dari tulang dan kulit belut sawah tersebut maka pada penelitian ini dilakukan karakterisasi nanokolagen yang dihasilkan. Pada Penelitian ini kolagen diisolasi dengan Metode asam basa dilanjutkan dengan pengecilan ukuran partikel secara top down selanjutnya nanokolagen yang diperoleh dikarakterisasi meliputi kadar air, kadar lemak, kadar protein, ukuran partiel, zeta potensial dan analisis gugus fungsi dengan FTIR. Dari penelitian ini diperoleh Nanokolagen dari kulit dan tulang belut sawah dengan rendemen 2,28% yang memiliki karakteristik sebagai berikut kadar air 7,35 ± 0,38 %, kadar lemak 13,22 ± 0,41 %, kadar protein 24,89 ± 0,27 %, ukuran partikel  591,6 ± 77,2 nm, zeta potensial 0.2 mV  dan hasil analisa FTIR menunjukkan puncak serapan khas kolagen yaitu Amida A, Amida B, Amida I, Amida II dan III.

Page 37 of 50 | Total Record : 494

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